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https://www.readbyqxmd.com/read/28633474/interleukin-1-blockade-for-the-treatment-of-pericarditis
#1
Leo Buckley, Michele M Viscusi, Benjamin Van Tassell, Antonio Abbate
Pericarditis is a debilitating condition that results from profound inflammation of the pericardial tissue. Between 10-15% of first episodes of acute pericarditis will be followed by several episodes refractory to conventional treatment. Current standard of care for pericarditis treatment includes high-dose non-steroidal anti-inflammatory drugs, colchicine and systemic corticosteroids, each associated with potentially severe toxicities and nominal efficacy. Interleukin-1 (IL-1), an apical pro-inflammatory cytokine, plays an important role as an autocrine magnifier of systemic inflammation in pericarditis...
June 19, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28633104/transcriptional-and-cellular-effects-of-paracetamol-in-the-oyster-crassostrea-gigas
#2
M J Bebianno, A C P Mello, M A S Serrano, F Flores-Nunes, J J Mattos, F L Zacchi, C E Piazza, M N Siebert, R S Piazza, C H A M Gomes, C M R Melo, A C D Bainy
Acetaminophen (paracetamol) (PAR) is one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs) with analgesic and antipyretic properties consumed worldwide and often detected in the aquatic environment. Due to the fact that PAR induces oxidative stress in mammals, the aim of this study was to evaluate if similar effects were observed in oysters Crassostrea gigas, given their economic and ecological importance and worldwide distribution. Oysters were exposed for 1, 4 and 7 days to two different sublethal PAR concentrations (0, 1 and 100μgL(-1))...
June 17, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28630833/anti-inflammatory-prophylaxis-prevents-heterotopic-ossification-in-contralateral-side-hip-arthroscopy-a-case-report
#3
Yaniv Warschawski, Zachary T Sharfman, Eyal Amar, Ehud Rath
INTRODUCTION: Heterotopic ossification (HO) after hip surgery is the formation of bone in non-skeletal tissue, usually between the muscle and the joint capsule. HO after hip surgery may be associated with clinical sequelae such as pain, impingement and decreased range of motion, compromising surgical outcomes. CASE REPORT: A 20-year-old basketball player presented with a 2-year duration of the left groin pain after a basketball-related injury. Due to continued disability and failure of conservative management the patient underwent hip arthroscopy...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28629289/mania-induced-by-adalimumab-in-a-patient-with-ankylosing-spondylitis
#4
Elias Ghossoub, Mohamad Habli, Imad Uthman, Fadi T Maalouf
Objectives Monoclonal antibodies such as antagonists of tumor necrosis factor-alpha have been shown to have beneficial effects on the well-being of patients with inflammatory illnesses. However, mood episodes triggered by such agents have been reported. We herein report the case of mania induced by adalimumab treatment in an adult with ankylosing spondylitis, which later resolved once adalimumab was discontinued and mood stabilizers were initiated. Methods A 25-year-old man, with prior history of dysthymia, was diagnosed with ankylosing spondylitis and started on adalimumab...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28628468/dapsa-das28-and-mda-predict-long-term-treatment-regime-in-psoriatic-arthritis-the-swedish-early-psoriatic-arthritis-cohort
#5
Ulla Lindqvist, Mona-Lisa Wernroth, Tomas Husmark, Per Larsson, Mats Geijer, Annika Teleman, Elke Theander, Gerd-Marie Alenius
OBJECTIVES: To describe treatment patterns in the Swedish early psoriatic arthritis cohort (SwePsA) of the mono-/oligo-arthritic (M/O) and polyarthritis (P) and identify early predictive factors for treatment with disease-modifying anti-rheumatic (DMARD), non-steroidal anti-inflammatory drugs (NSAID), and tumour necrosis factor inhibition (TNFi) after 5 years. METHODS: Data for 198 M/O and P PsA were obtained within the programme for SwePsA. Multinomial and binary logistic regression analyses were used to assess the association between early predictive factors and treatment after 5 years adjusted for age at inclusion...
June 16, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28627044/adherence-to-treatment-in-patients-with-behcet-s-disease
#6
Alireza Khabbazi, Farid Karkon Shayan, Morteza Ghojazadeh, Hadise Kavandi, Mehrzad Hajialiloo, Kamal Esalat Manesh, Sousan Kolahi
AIM: Behcet's disease (BD) is a chronic, inflammatory disease with multisystem involvement. Adherence to treatment is low in chronic diseases as well as inflammatory and autoimmune diseases. This study assessed factors associated with non-adherence to treatment in patients with BD. METHODS: All the patients with BD who visited in the outpatient clinic of Connective Tissue Diseases Research Center in Tabriz University of Medical Sciences were included in the study...
June 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28622543/quantitative-analysis-of-anti-inflammatory-drugs-using-ftir-atr-spectrometry
#7
Sonia T Hassib, Ghaneya S Hassan, Asmaa A El-Zaher, Marwa A Fouad, Enas A Taha
Four simple, accurate, sensitive and economic Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopic (ATR-FTIR) methods have been developed for the quantitative estimation of some non-steroidal anti-inflammatory drugs. The first method involves the determination of Etodolac by direct measurement of the absorbance at 1716cm(-1). In the second method, the second derivative of the IR spectra of Tolfenamic acid and its reported degradation product (2-chlorobenzoic acid) was used and the amplitudes were measured at 1084...
June 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28619118/serum-levels-of-leptin-and-high-molecular-weight-adiponectin-are-inversely-associated-with-radiographic-spinal-progression-in-patients-with-ankylosing-spondylitis-results-from-the-enradas-trial
#8
Agnes Hartl, Joachim Sieper, Uta Syrbe, Joachim Listing, Kay-Geert Hermann, Martin Rudwaleit, Denis Poddubnyy
BACKGROUND: Previous research indicates a role of adipokines in inflammation and osteogenesis. Hence adipokines might also have a pathophysiological role in inflammation and new bone formation in patients with ankylosing spondylitis (AS). The aim of this study was to investigate the role of adipokine serum levels as predictors of radiographic spinal progression in patients with AS. METHODS: A total of 120 patients with definite AS who completed a 2-year follow up in the ENRADAS trial were included in the current study...
June 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28616396/management-for-non-variceal-upper-gastrointestinal-bleeding-in-elderly-patients-the-experience-of-a-tertiary-university-hospital
#9
Koichiro Kawaguchi, Hiroki Kurumi, Yohei Takeda, Kazuo Yashima, Hajime Isomoto
BACKGROUND: Peptic ulcer bleeding (PUB) is the main cause of non-variceal upper gastrointestinal bleeding (UGIB). Endoscopic treatment and acid suppression with proton-pump inhibitors (PPIs) are most important in the management of PUB and these treatments have reduced mortality. However, elderly patients sometimes have a poor prognostic outcome due to severe comorbidities. METHODS: A retrospective study was performed on 504 cases with acute non-variceal UGIB who were examined in our hospital, in order to reveal the risk factor of a poor outcome in elderly patients...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28616249/quality-of-care-for-patients-with-chronic-kidney-disease-in-the-primary-care-setting-a-retrospective-cohort-study-from-ontario-canada
#10
Danielle M Nash, Scott Brimble, Maureen Markle-Reid, Eric McArthur, Karen Tu, Gihad E Nesrallah, Allan Grill, Amit X Garg
BACKGROUND: Patients with chronic kidney disease may not be receiving recommended primary renal care. OBJECTIVE: To use recently established primary care quality indicators for chronic kidney disease to determine the proportion of patients receiving recommended renal care. DESIGN: Retrospective cohort study using administrative data with linked laboratory information. SETTING: The study was conducted in Ontario, Canada, from 2006 to 2012...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28610818/effect-of-pre-emptive-analgesia-on-clinical-parameters-and-tissue-levels-of-tnf-%C3%AE-and-il-1%C3%AE-in-third-molar-surgery-a-triple-blind-randomized-placebo-controlled-study
#11
A F M Albuquerque, C S R Fonteles, D R do Val, H V Chaves, M M Bezerra, K M A Pereira, P G de Barros Silva, B B de Lima, E C S Soares, T R Ribeiro, F W G Costa
This study aimed to evaluate whether pre-emptive analgesia modifies the tissue expression of tumour necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), and whether there is an association with postoperative surgical outcomes. A triple-blind, randomized, placebo-controlled study of patients undergoing mandibular third molar removal was performed. Volunteers were allocated randomly to receive etoricoxib 120 mg, ibuprofen 400 mg, or placebo 1h before surgery. Twenty-four surgical sites per group were required (95% confidence level and 80% statistical power)...
June 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28603499/campania-preventability-assessment-committee-italy-a-focus-on-the-preventability-of-non-steroidal-anti-inflammatory-drugs-adverse-drug-reactions
#12
Maurizio Sessa, Liberata Sportiello, Annamaria Mascolo, Cristina Scavone, Silvia Gallipoli, Gabriella di Mauro, Daniela Cimmaruta, Concetta Rafaniello, Annalisa Capuano
Purpose: This study aims to investigate preventability criteria of adverse drug reactions (ADRs) involving non-steroidal anti-inflammatory drugs (NSAIDs) by analyzing individual case safety reports (ICSRs) sent through Campania region (Italy) spontaneous reporting system from July 2012 to October 2016. Methods: For all the ICSRs that reported NSAIDs as suspected drug, a trained multidisciplinary team of Campania Pharmacovigilance Regional Centre composed of clinical pharmacologists and pharmacists with pluriannual experience in Pharmacovigilance assessed preventability by using the P-method...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28603011/a-comprehensive-spectroscopic-study-of-the-polymorphs-of-diflunisal-and-their-phase-transformations
#13
Anuradha R Pallipurath, Francesco Civati, Juraj Sibik, Clare Crowley, J Axel Zeitler, Patrick McArdle, Andrea Erxleben
Understanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive high-resolution spectroscopic studies on the polymorphs of the non-steroidal anti-inflammatory drug diflunisal that has four known polymorphs, forms I-IV (FI-FIV), three of which have known crystal structures. Phase transformations during milling, heating, melt-quenching and exposure to high relative humidity were investigated using Raman and terahertz spectroscopy in combination with differential scanning calorimetry and X-ray powder diffraction...
June 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28602580/a-comparison-of-outcomes-in-patients-with-infrapopliteal-disease-randomised-to-vein-bypass-or-plain-balloon-angioplasty-in-the-bypass-vs-angioplasty-in-severe-ischaemia-of-the-leg-basil-trial
#14
M A Popplewell, H O B Davies, J Narayanswami, M Renton, A Sharp, G Bate, S Patel, J Deeks, A W Bradbury
OBJECTIVE: The aim was to compare outcomes in a subgroup of patients with infrapopliteal (IP) disease randomised to infrapopliteal vein bypass (VB) or plain balloon angioplasty (PBA) in the original BASIL trial. METHODS: A comparison of outcomes from patients randomised to VB or PBA undergoing revascularisation for severe limb ischaemia (SLI) because of IP disease with or without femoropopliteal disease. Data were extracted from case report forms from the BASIL trial...
June 8, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28601821/study-protocol-comparison-of-the-effect-of-treatment-with-nonsteroidal-anti-inflammatory-drugs-added-to-anti-tumour-necrosis-factor-a-therapy-versus-anti-tumour-necrosis-factor-a-therapy-alone-on-progression-of-structural-damage-in-the-spine-over-two-years
#15
Fabian Proft, Burkhard Muche, Joachim Listing, Valeria Rios-Rodriguez, Joachim Sieper, Denis Poddubnyy
INTRODUCTION: There is some evidence that non-steroidal anti-inflammatory drugs (NSAIDs), in particular celecoxib, might possess not only a symptomatic efficacy but also disease-modifying properties in ankylosing spondylitis (AS), retarding the progression of structural damage in the spine if taken continuously. In contrast, this remains controversial for tumour necrosis factor alpha (TNF-α) inhibitors, despite their good clinical efficacy. The impact of a combined therapy (a TNF inhibitor plus an NSAID) on radiographic spinal progression in AS is unclear...
June 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28601812/cardiovascular-and-type-2-diabetes-morbidity-and-all-cause-mortality-among-diverse-chronic-inflammatory-disorders
#16
Alex Dregan, Phil Chowienczyk, Mariam Molokhia
OBJECTIVES: The present study aimed to assess the relationship between inflammatory disorders with cardiometabolic diseases and mortality within a community-based population. METHODS: The UK Biobank data were used to conduct two investigations: a cross-sectional study to estimate cardiometabolic risk and a prospective cohort study to estimate mortality risk. Binary regression analyses were used to model the association between coronary heart disease, stroke, type 2 diabetes, venous thromboembolism and peripheral artery disease diagnoses with seven inflammatory disorders (eg, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, ankylosing spondylitis (AS), systemic vasculitis, Crohn's disease and ulcerative colitis (UC))...
June 10, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28601012/diclofenac-affects-kidney-histology-in-the-three-spined-stickleback-gasterosteus-aculeatus-at-low-%C3%AE-g-l-concentrations
#17
Johanna Näslund, Jerker Fick, Noomi Asker, Elisabet Ekman, D G Joakim Larsson, Leif Norrgren
Diclofenac, a commonly used non-steroidal anti-inflammatory drug, is considered for regulation under the European water framework directive. This is because effects on fish have bean reported at concentrations around those regularly found in treated sewage effluents (∼1μg/L). However, a recent publication reports no effects on fish at 320μg/L. In this study, three-spined sticklebacks (Gasterosteus aculeatus) were exposed to 0, 4.6, 22, 82 and 271μg/L diclofenac in flow-through systems for 28days using triplicate aquaria per concentration...
May 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28600350/rheumatoid-arthritis-and-polymyalgia-rheumatica-occurring-after-immune-checkpoint-inhibitor-treatment
#18
Rakiba Belkhir, Sébastien Le Burel, Laetitia Dunogeant, Aurélien Marabelle, Antoine Hollebecque, Benjamin Besse, Alexandra Leary, Anne-Laure Voisin, Clémence Pontoizeau, Laetitia Coutte, Edouard Pertuiset, Gaël Mouterde, Olivier Fain, Olivier Lambotte, Xavier Mariette
OBJECTIVES: Immune checkpoint inhibitors (ICIs) targeting cytotoxic T-lymphocyte-associated protein 4 and programmed cell death protein 1 (PD-1) have demonstrated improved survival for multiple cancers. However, these new drug classes have led to increased immune-related adverse events (IrAE). Rheumatic IrAEs have not been well described in clinical trials. We report here cases of rheumatoid arthritis (RA) and polymyalgia rheumatica (PMR) occurring after ICI treatment. METHODS: This was a retrospective study of patients receiving an ICI in whom symptoms of arthritis or arthralgia developed and revealed a diagnosis of RA or PMR...
June 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28599683/pain-sensitivity-and-analgesic-use-among-10-486-adults-the-troms%C3%A3-study
#19
Per-Jostein Samuelsen, Christopher Sivert Nielsen, Tom Wilsgaard, Audun Stubhaug, Kristian Svendsen, Anne Elise Eggen
BACKGROUND: Increased pain sensitivity is a putative risk factor for chronic pain and consequently for analgesic use. Conversely, analgesic use may be a cause of increased pain sensitivity, e.g., through opioid-induced hyperalgesia. We aimed to study the association between pain sensitivity and analgesic use in a general population, and to test the hypothesis that increased baseline pain sensitivity is a risk factor for future persistent analgesic use. METHODS: The Tromsø Study (2007-08), a population-based health study, was linked with eight years of prescription data from the Norwegian Prescription Database...
June 9, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28597983/celecoxib-for-rheumatoid-arthritis
#20
REVIEW
Mahir Fidahic, Antonia Jelicic Kadic, Mislav Radic, Livia Puljak
BACKGROUND: Rheumatoid arthritis is a systemic auto-immune disorder that causes widespread and persistent inflammation of the synovial lining of joints and tendon sheaths. Presently, there is no cure for rheumatoid arthritis and treatment focuses on managing symptoms such as pain, stiffness and mobility, with the aim of achieving stable remission and improving mobility. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID) used for treatment of people with rheumatoid arthritis...
June 9, 2017: Cochrane Database of Systematic Reviews
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