keyword
MENU ▼
Read by QxMD icon Read
search

Non steroidal anti inflammatory

keyword
https://www.readbyqxmd.com/read/28916287/effects-of-anti-inflammatory-compounds-on-sulfur-mustard-injured-cells-recommendations-and-caveats-suggested-by-in-vitro-cell-culture-models
#1
Georg Menacher, Dirk Steinritz, Annette Schmidt, Tanja Popp, Franz Worek, Thomas Gudermann, Horst Thiermann, Frank Balszuweit
Sulfur mustard (SM) is a vesicant agent who had its first military use 100 years ago, in Ypres. Since then it has been used in several conflicts like the Iran-Iraq war in the 1980s. The use of SM in Syria 2015 indicated the still existing threat. Despite decades of research no causal antidote against SM intoxication is available, so far. A SM intoxication is accompanied by necrosis, apoptosis and inflammation. To counteract the SM-induced inflammation, glucocorticoids and non-steroidal anti-inflammatory compounds (NSAIDs) are recommended...
September 12, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28910962/pharmaceuticals-and-other-anthropogenic-chemicals-in-atmospheric-particulates-and-precipitation
#2
Mark L Ferrey, M Coreen Hamilton, Will J Backe, Kurt E Anderson
Air and precipitation samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) and gas chromatography mass spectrometry (GC-MS) for pharmaceuticals, personal care products, and other commercial chemicals within the St. Paul/Minneapolis metropolitan area of Minnesota, U.S. Of the 126 chemicals analyzed, 17 were detected at least once. Bisphenol A, N,N-diethyl-meta-toluamide (DEET), and cocaine were the most frequently detected; their maximum concentrations in snow were 3.80, 9.49, and 0...
September 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28906475/can-we-predict-the-efficacy-of-anti-tnf-%C3%AE-agents
#3
REVIEW
Loris Riccardo Lopetuso, Viviana Gerardi, Valerio Papa, Franco Scaldaferri, Gian Lodovico Rapaccini, Antonio Gasbarrini, Alfredo Papa
The use of biologic agents, particularly anti-tumor necrosis factor (TNF)-α, has revolutionized the treatment of inflammatory bowel diseases (IBD), modifying their natural history. Several data on the efficacy of these agents in inducing and maintaining clinical remission have been accumulated over the past two decades: their use avoid the need for steroids therapy, promote mucosal healing, reduce hospitalizations and surgeries and therefore dramatically improve the quality of life of IBD patients. However, primary non-response to these agents or loss of response over time mainly due to immunogenicity or treatment-related side-effects are a frequent concern in IBD patients...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28903423/mitochondria-sustain-store-operated-currents-in-colon-cancer-cells-but-not-in-normal-colonic-cells-reversal-by-non-steroidal-anti-inflammatory-drugs
#4
Miriam Hernández-Morales, Diego Sobradillo, Ruth A Valero, Eva Muñoz, Daniel Ubierna, Mary P Moyer, Lucía Núñez, Carlos Villalobos
Tumor cells undergo a critical remodeling of intracellular Ca(2+) homeostasis that contribute to important cancer hallmarks. Store-operated Ca(2+) entry (SOCE), a Ca(2+) entry pathway modulated by mitochondria, is dramatically enhanced in colon cancer cells. In addition, most cancer cells display the Warburg effect, a metabolic switch from mitochondrial metabolism to glycolysis that provides survival advantages. Accordingly, we investigated mitochondria control of store-operated currents (SOCs) in two cell lines previously selected for representing human normal colonic cells and colon cancer cells...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28899770/use-of-non-prescription-analgesics-and-male-reproductive-function
#5
B B Høyer, C H Ramlau-Hansen, J P Bonde, S B Larsen, G Toft
We studied the association between intake of non-prescription analgesics and semen quality and male reproductive hormone levels in a cross-sectional study among 1493 men. The men provided one semen (n=1493) and blood sample (n=1056) and filled in questionnaires on use of non-prescription analgesics (paracetamol, NSAIDs and combination drugs (yes/no)). Adjusting for age, study and other covariates, we observed no association between intake of non-prescription analgesics and markers of semen quality. Adjusting for age and time of day of blood sampling, users of non-prescription analgesics had a 10...
September 9, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28895673/the-effect-of-interferential-current-therapy-on-patients-with-subacromial-impingement-syndrome-a-randomized-double-blind-sham-controlled-study
#6
Tuba Nazligul, Pinar Akpinar, Ilknur Aktas, Feyza Unlu Ozkan, Hulya Cagliyan Hartevioglu
BACKGROUND: Although interferential current (IFC) is a common electrotherapeutic modality used to treat musculoskeletal pain, there is not any randomized controlled trial investigating its clinical efficacy in subacromial impingement syndrome (SAIS). AIM: Investigation of effectiveness of IFC treatment in patients with SAIS. DESIGN: Randomized, double-blind, sham-controlled study. SETTING: Physical medicine and rehabilitation outpatient clinic...
September 11, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28895213/supramolecular-synthon-approach-in-developing-anti-inflammatory-topical-gel-for-in-vivo-self-delivery
#7
Parthasarathi Dastidar, Rajdip Roy
A new series of TBA salt of various non-steroidal-anti-inflammatory-drugs (NSAIDs) was synthesized and characterized. Nearly 90% of the salts displayed remarkable gelation ability with various solvents including methyl salicylate. SXRD revealed the existence of 1D PAM synthon in the gelator salts. Structure-property correlation studies based on SXRD and PXRD data established the presence of the 1D PAM synthon in the bulk salts as well as in the corresponding xerogels. A parallel series of salts derived from TRIS and the same set of NSAIDs displayed poor gelation ability (only 33% of the salts)...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28894907/challenges-in-translational-drug-research-in-neuropathic-and-inflammatory-pain-the-prerequisites-for-a-new-paradigm
#8
REVIEW
A Taneja, O Della Pasqua, M Danhof
AIM: Despite an improved understanding of the molecular mechanisms of nociception, existing analgesic drugs remain limited in terms of efficacy in chronic conditions, such as neuropathic pain. Here, we explore the underlying pathophysiological mechanisms of neuropathic and inflammatory pain and discuss the prerequisites and opportunities to reduce attrition and high-failure rate in the development of analgesic drugs. METHODS: A literature search was performed on preclinical and clinical publications aimed at the evaluation of analgesic compounds using MESH terms in PubMed...
September 11, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28893757/effectiveness-and-cost-effectiveness-of-duloxetine-added-to-usual-care-for-patients-with-chronic-pain-due-to-hip-or-knee-osteoarthritis-protocol-of-a-pragmatic-open-label-cluster-randomised-trial-the-duo-trial
#9
Jacoline J van den Driest, Dieuwke Schiphof, Pim A J Luijsterburg, Aafke R Koffeman, Marc A Koopmanschap, Patrick J E Bindels, Sita M A Bierma-Zeinstra
INTRODUCTION: Osteoarthritis (OA) is a highly prevalent painful condition of the musculoskeletal system. The effectiveness of current analgesic options has proven to be limited and improved analgesic treatment is needed. Several randomised placebo-controlled trials have now demonstrated the efficacy of duloxetine, an antidepressant with a centrally acting effect, in the treatment of OA pain. The aim of the current study is to investigate if duloxetine is effective and cost-effective as a third-choice analgesic added to usual care for treating chronic pain compared with usual care alone in general practice...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28893093/practical-approach-to-the-treatment-of-nsaid-hypersensitivity
#10
Natalia Blanca-Lopez, Diana Perez-Alzate, Gabriela Canto, Miguel Blanca
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently involved in drug hypersensitivity reactions (DHR). NSAIDs are prescribed for different processes and some NSAIDs can be obtained over the counter. Areas covered: We analyse the practical approaches for managing and treating NSAID-DHR considering the five major groups of entities recognised, divided into two categories: those responding to strong COX-1 inhibitors and possibly weak COX-1 or selective COX-2 inhibitors named cross-intolerant (CI), and those induced by a single drug or drug group with good tolerance to strong COX-1 inhibitors, known as allergic reactions (SR)...
September 12, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28892866/removal-of-hazardous-non-steroidal-anti-inflammatory-drugs-from-aqueous-solutions-by-biosorbent-based-on-chitin-and-lignin
#11
Sonia Żółtowska-Aksamitowska, Przemysław Bartczak, Joanna Zembrzuska, Teofil Jesionowski
The use of chitin modified with kraft lignin as an effective sorbent of ibuprofen and acetaminophen is described for the first time. It was determined how the parameters (contact time, pH, mass of sorbent and temperature) influence the effectiveness of the adsorption process. The adsorption kinetics were calculated using pseudo-first-order, pseudo-second-order (types 1-4) and intra-particle diffusion models, and thermodynamic parameters were determined. The experimental data better correspond to a pseudo-second-order kinetic model of type 1 in the case of both tested pharmaceuticals (r(2)=0...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28891941/cox-inhibition-profile-and-molecular-docking-studies-of-some-2-trimethoxyphenyl-thiazoles
#12
Smaranda Dafina Oniga, Liliana Pacureanu, Cristina Ioana Stoica, Mariana Doina Palage, Alexandra Crăciun, Laurentiu Răzvan Rusu, Elena-Luminita Crisan, Cătălin Araniciu
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders. In an effort to obtain safer NSAIDs, we assessed the direct cyclooxygenase (COX) inhibition activity and we investigated the potential COX binding mode of some previously reported 2-(trimethoxyphenyl)-thiazoles. The in vitro COX inhibition assays were performed against ovine COX-1 and human recombinant COX-2...
September 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28890382/in-vitro-genotoxicity-and-in-vivo-subchronic-evaluation-of-the-anti-inflammatory-pyrazole-compound-lqfm021
#13
Soraia Santa de Moura, Renato Ivan de Ávila, Lara Barroso Brito, Rhaul de Oliveira, Gisele Augusto Rodrigues de Oliveira, Francine Pazini, Ricardo Menegatti, Aline Carvalho Batista, Cesar Koppe Grisolia, Marize Campos Valadares
Scientific evidences have highlighted 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM021) as a promising anti-inflammatory, analgesic and antinociceptive agent due to its effects on peripheral opioid receptors associated with activation of the nitric oxide/cGMP/KATP pathway. Despite these important pharmacological findings, toxicity data of LQFM021 are scarce. Thus, this study investigated the in vitro genotoxicity of LQFM021 through cytokinesis-block micronucleus assay (OECD Nº 487/2014). Moreover, zebrafish model was used to assess the embryotoxicity potential of LQFM021 using fish embryo toxicity test (OECD Nº 236/2013) with extended exposure to evaluate subchronic larval development...
September 7, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28888712/simultaneous-optimization-of-ph-and-binary-organic-composition-by-grid-form-modeling-of-the-retention-behavior-in-reversed-phase-ultra-high-performance-liquid-chromatography
#14
Tsukasa Sasaki, Kenichiro Todoroki, Toshimasa Toyo'oka
A novel computer-assisted methodology for the simultaneous optimization of aqueous pH and binary organic eluent composition through a broad range of analytical conditions of reversed-phase ultra high-performance liquid chromatography is proposed. Two of nonlinear prediction models were employed to fit into the retention time (tR) on a linear gradient elution with a predefined slope. One model was derived from Bernoulli-type probability distribution to predict the value of tR against the pH value of the aqueous eluent...
September 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28888592/nsaid-resistance-in-dysmenorrhea-epidemiology-causes-and-treatment
#15
REVIEW
Folabomi A Oladosu, Frank F Tu, Kevin M Hellman
Although non-steroidal anti-inflammatory drugs can alleviate menstrual pain, about 18% of women with dysmenorrhea are unresponsive, leaving them and their physicians to pursue less well-studied strategies. The goal of this review is to provide a background for treating menstrual pain when first-line options fail. Research on menstrual pain and failure of similar drugs in the antiplatelet category has suggested potential mechanisms underlying non-steroidal anti-inflammatory drug resistance. Based on these mechanisms, alternative options may be helpful for refractory cases...
September 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28886446/interaction-of-zinc-ii-with-the-non-steroidal-anti-inflammatory-drug-niflumic-acid
#16
Alketa Tarushi, Catherine P Raptopoulou, Vassilis Psycharis, Dimitris P Kessissoglou, Athanasios N Papadopoulos, George Psomas
The reaction of ZnCl2 with the non-steroidal anti-inflammatory drug niflumic acid (Hnif) resulted in the formation of complex [Zn(nif-O)2(MeOH)4], 1. When this reaction was performed in the presence of a N,N'-donor heterocyclic ligand such as 2,2'-bipyridine (bipy), 2,2'-bipyridylamine (bipyam), 1,10-phenanthroline (phen) and 2,2'-dipyridylketone oxime (Hpko), the complexes [Zn(nif-O,O')(bipy)Cl], 2, [Zn(nif-O)(nif-O,O')2(bipyam)], 3, [Zn(nif-O,O')2(phen)], 4 and [Zn(nif-O)2(Hpko-N,N')2], 5 were formed, respectively...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28886223/open-standing-castration-in-thoroughbred-racehorses-in-hong-kong-prevalence-and-severity-of-complications-30-days-post-castration
#17
S Rosanowski, F MacEoin, R J T Y Graham, C M Riggs
BACKGROUND: Complications following open standing castration (OSC) in Thoroughbred racehorses are well recognised but variation in their prevalence and severity between populations is not well documented. OBJECTIVES: To describe the prevalence and severity of complications in the 30-days following OSC. STUDY DESIGN: A retrospective cohort study of veterinary clinical records relating to horses that underwent OSC between July 2007 and July 2012...
September 8, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28885223/prescription-audit-of-nsaids-and-gastroprotective-strategy-in-elderly-in-primary-care
#18
Khalid Ahmed Jassim Al Khaja, Sindhan Veeramuthu, Husain Ahmed Isa, Reginald Paul Sequeira
BACKGROUND: The use of non-steroidal anti-inflammatory drug (NSAIDs) is deemed a major risk factor for peptic ulcer disease in elderly population that requires concomitant therapy with gastroprotective agents (GPAs). OBJECTIVE: This study evaluated the rational prescribing of NSAIDs and GPAs, and extent of adherence to the guideline recommendations in primary care. METHODS: Nationwide audit of prescriptions issued to elderly patients (≥65 years) with hypertension or diabetic hypertension in primary care...
2017: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/28884078/effects-of-topical-flurbiprofen-sodium-diclofenac-sodium-ketorolac-tromethamine-and-benzalkonium-chloride-on-corneal-sensitivity-in-normal-dogs
#19
Raquel de Araújo Cantarella, Juliana Kravetz de Oliveira, Daniel M Dorbandt, Fabiano Montiani-Ferreira
To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two different stages. First, one drop of flurbiprofen sodium 0.03% and diclofenac sodium 0.1% in each eye; second, one drop of ketorolac tromethamine 0...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28883779/users-knowledge-about-adverse-effects-of-non-steroidal-anti-inflammatory-drugs-in-tirana-albania
#20
Dajana Roshi, Ervin Toçi, Genc Burazeri, Peter Schröder-Bäck, Ledjan Malaj, Helmut Brand
AIM: To assess the level of knowledge of the adult users of non-steroidal anti-inflammatory drugs (NSAIDs) regarding their side effects and the socio-demographic factors associated with the use of these drugs in the adult population of Albania. METHODS: This was a cross-sectional study including a representative sample of 199 individuals aged ≥18 years (77% women; overall mean age: 30.3±10.0 years; overall response rate: 90%) who were users of NSAIDs recruited in ten different pharmacies in Tirana municipality during April-May 2015...
June 2017: Materia Socio-medica
keyword
keyword
5916
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"