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Preterm rupture of membranes

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https://www.readbyqxmd.com/read/29044425/smad7-regulates-proinflammatory-and-prolabor-mediators-in-amnion-and-myometrium
#1
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth continues to be a significant public health problem. Infection (bacterial and or viral) and inflammation, by stimulating proinflammatory cytokines, adhesion molecules, and matrix metalloproteinase 9 (MMP9), play a central role in the rupture of membranes and myometrial contractions. SMAD7 has been implicated in regulating the inflammatory response; however, no studies have been performed with regard to human labor. In this study, we determined the effect of spontaneous human labor and prolabor mediators on SMAD7 expression in myometrium and fetal membranes...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29037549/long-term-outcome-of-pregnancy-complicating-with-severe-aplastic-anemia-under-supportive-care
#2
Kuan-Ju Chen, Yao-Lung Chang, Horng Chang, Shen-Yuan Su, Hsiu-Huei Peng, Shuenn-Dyh Chang, An-Shine Chao
OBJECTIVES: Pregnancy associated with aplastic anemia (AA) is a rare and heterogeneous disorder. We aimed to identify and evaluate the maternal and pregnant outcomes of pregnancy-associated severe AA treated with supportive care. MATERIALS AND METHODS: A 25-year retrospective study was conducted at in a single center between 1990 and 2014 with pregnancy associated severe AA. In addition, relevant published cases of antenatally diagnosed pregnancy-associated severe AA after 1990 were identified by PubMed...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29037543/amniopatch-treatment-for-preterm-premature-rupture-of-membranes-before-23-weeks-gestation-and-factors-associated-with-its-success
#3
Ji-Hee Sung, Jin-Yi Kuk, Hyun-Hwa Cha, Suk-Joo Choi, Soo-Young Oh, Cheong-Rae Roh, Jong-Hwa Kim
OBJECTIVE: The purpose of this study is to investigate the factors associated with successful amniopatch treatment in patients with iatrogenic preterm premature rupture of membranes (iPPROM) or spontaneous PPROM (sPPROM) before 23 weeks' gestation. MATERIALS AND METHODS: This cohort study included 28 women who received amniopatch treatment due to iPPROM or sPPROM at 15-23 weeks' gestation. Patients' clinical characteristics before performing the amniopatch, factors associated with the procedure, pregnancy and neonatal outcomes were compared between the iPPROM and sPPROM groups, and also between the successful and failed groups...
October 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29033178/predictors-of-thallium-exposure-and-its-relation-with-preterm-birth
#4
Yangqian Jiang, Wei Xia, Bin Zhang, Xinyun Pan, Wenyu Liu, Shuna Jin, Wenqian Huo, Hongxiu Liu, Yang Peng, Xiaojie Sun, Hongling Zhang, Aifen Zhou, Shunqing Xu, Yuanyuan Li
Thallium (Tl) is a well-recognized hazardous toxic heavy metal that has been reported to have embryotoxicity and fetotoxicity. However, little is known about its association with preterm birth (PTB) in humans. We aimed to evaluate the predictors of Tl exposure and assessed its relation with PTB. The study population included 7173 mother-infant pairs from a birth cohort in Wuhan, China. Predictors of Tl concentrations were explored using linear regression analyses, and associations of Tl exposure with risk of PTB or gestational age at birth were estimated using logistic regression or generalized linear models...
October 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29031893/in-an-in-vitro-model-using-human-fetal-membranes-17-%C3%AE-hydroxyprogesterone-caproate-is-not-an-optimal-progestogen-for-inhibition-of-fetal-membrane-weakening
#5
Deepak Kumar, Robert M Moore, Brian M Mercer, Joseph M Mansour, Sam Mesiano, Frederick Schatz, Charles J Lockwood, John J Moore
BACKGROUND: The progestogen 17-α hydroxyprogesterone caproate (17-OHPC) is one of only two agents recommended for clinical use in the prevention of spontaneous preterm delivery, and studies of its efficacy have been conflicting. We have developed an in-vitro model to study the fetal membrane weakening process that leads to rupture in preterm premature rupture of the fetal membranes (pPROM). Inflammation/infection associated with tumor necrosis factor-α (TNF-α) induction and decidual bleeding/abruption associated thrombin release are leading causes of pPROM...
October 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29030612/healing-of-preterm-ruptured-fetal-membranes
#6
Haruta Mogami, Annavarapu Hari Kishore, Yucel Akgul, R Ann Word
Preterm premature rupture of membrane (pPROM) is associated with 30-40% of preterm births. Infection is considered a leading cause of pPROM due to increased levels of proinflammatory cytokines in amniotic fluid. Only 30%, however, are positive for microbial organisms by amniotic fluid culture. Interestingly, in some pregnancies complicated by preterm premature rupture of membranes (pPROM), membranes heal spontaneously and pregnancy continues until term. Here, we investigated mechanisms of amnion healing. Using a preclinical mouse model, we found that small ruptures of the fetal membrane closed within 72 h whereas healing of large ruptures was only 40%...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982710/identification-of-extremely-premature-infants-at-low-risk-for-early-onset-sepsis
#7
Karen M Puopolo, Sagori Mukhopadhyay, Nellie I Hansen, C Michael Cotten, Barbara J Stoll, Pablo J Sanchez, Edward F Bell, Abhik Das, Angelita M Hensman, Krisa P Van Meurs, Myra H Wyckoff
BACKGROUND: Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS: Study infants were born at 22 to 28 weeks' gestation in Neonatal Research Network centers from 2006 to 2014. EOS was defined by isolation of pathogenic species from blood or cerebrospinal fluid culture at ≤72 hours age...
October 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28976078/platelet-indices-in-preterm-premature-rupture-of-membranes-and-their-relation-with-adverse-neonatal-outcomes
#8
Betul Dundar, Burcu Dincgez Cakmak, Gulten Ozgen, Fatma Nurgul Tasgoz, Tugberk Guclu, Gokhan Ocakoglu
AIM: Preterm premature rupture of membranes (PPROM) is not only the most common distinguishable cause of preterm delivery, but is also associated with adverse neonatal outcomes. We determined the platelet indices in PPROM cases and evaluated their relationship to adverse neonatal outcomes. METHODS: Fifty patients with PPROM and 50 patients who experienced spontaneous preterm labor at < 37 gestational weeks were evaluated. Complete blood counts, birth weights, Apgar scores, presence of sepsis and respiratory distress syndrome (RDS) and neonatal intensive care unit admission were recorded...
October 4, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28972984/correction-systemic-and-local-inflammatory-response-in-women-with-preterm-prelabor-rupture-of-membranes
#9
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0085277.].
2017: PloS One
https://www.readbyqxmd.com/read/28971027/hospital-trauma-level-s-association-with-outcomes-for-injured-pregnant-women-and-their-neonates-in-washington-state-1995-2012
#10
John Thomas Distelhorst, Michele A Soltis, Vijay Krishnamoorthy, Melissa A Schiff
BACKGROUND: Trauma occurs in 8% of all pregnancies. To date, no studies have evaluated the effect of the hospital's trauma designation level as it relates to birth outcomes for injured pregnant women. METHODS: This population-based, retrospective cohort study evaluated the association between trauma designation levels and injured pregnancy birth outcomes. We linked Washington State Birth and Fetal Death Certificate data and the Washington State Comprehensive Hospital Abstract Recording System...
July 2017: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/28962704/cigarette-smoke-condensate-affects-the-retinoid-pathway-in-human-amnion
#11
Marion Rouzaire, Aurélie Comptour, Corinne Belville, Damien Bouvier, Vincent Sapin, Denis Gallot, Loïc Blanchon
INTRODUCTION: The preterm premature rupture of membranes (PPROM) is a frequent pathology responsible of more than 30% of preterm births. Tobacco smoking is one of the most frequently described risk factors identified and contributes to the pre term weakening of fetal membranes. As previously demonstrated, all-trans retinoic acid (atRA) regulates several genes involved in the extracellular matrix dynamics, an essential actor in fetal membrane ruptures. We hypothesized that cigarette smoke may affect this pathway in human amnion...
October 2017: Placenta
https://www.readbyqxmd.com/read/28958628/computer-modeling-tools-to-understand-the-causes-of-preterm-birth
#12
REVIEW
Andrea R Westervelt, Kristin M Myers
The mechanical integrity of the soft tissue structures supporting the fetus may play a role in maintaining a healthy pregnancy and triggering the onset of labor. Currently, the level of mechanical loading on the uterus, cervix, and fetal membranes during pregnancy is unknown, and it is hypothesized that the over-stretch of these tissues contributes to the premature onset of contractility, tissue remodeling, and membrane rupture, leading to preterm birth. The purpose of this review article is to introduce and discuss engineering analysis tools to evaluate and predict the mechanical loads on the uterus, cervix, and fetal membranes...
September 25, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28954564/maternal-and-neonatal-outcomes-among-pregnant-women-with-fibromyalgia-a-population-based-study-of-12-million-births
#13
Glenda Gatan Magtanong, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: Fibromyalgia (FM) is a rheumatologic disorder marked by chronic, widespread pain and associated comorbid conditions. The purpose of our study was to evaluate the effect of FM on maternal and neonatal outcomes. METHODS: Using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1999 to 2013, we conducted a population-based retrospective cohort study consisting of women who delivered during that period. Logistic regression was used to compare maternal and neonatal outcomes among pregnancies in women with and without FM...
September 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28952185/pregnancy-after-endometrial-ablation-a-systematic-review
#14
REVIEW
J R Kohn, A A Shamshirsaz, E Popek, X Guan, M A Belfort, K A Fox
BACKGROUND: Pregnancies have been reported after endometrial ablation but there is little data regarding subsequent pregnancy outcomes. OBJECTIVE: To review systematically the available evidence regarding pregnancy outcomes after endometrial ablation, in order to equip physicians effectively to counsel women considering endometrial ablation. SEARCH STRATEGY: MEDLINE, Embase, Cochrane, and ClinicalTrials.gov were searched through January 2017...
September 27, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28949973/vaginal-progesterone-pessaries-for-pregnant-women-with-a-previous-preterm-birth-to-prevent-neonatal-respiratory-distress-syndrome-the-progress-study-a-multicentre-randomised-placebo-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Caroline A Crowther, Pat Ashwood, Andrew J McPhee, Vicki Flenady, Thach Tran, Jodie M Dodd, Jeffrey S Robinson
BACKGROUND: Neonatal respiratory distress syndrome, as a consequence of preterm birth, is a major cause of early mortality and morbidity. The withdrawal of progesterone, either actual or functional, is thought to be an antecedent to the onset of labour. There remains limited information on clinically relevant health outcomes as to whether vaginal progesterone may be of benefit for pregnant women with a history of a previous preterm birth, who are at high risk of a recurrence. Our primary aim was to assess whether the use of vaginal progesterone pessaries in women with a history of previous spontaneous preterm birth reduced the risk and severity of respiratory distress syndrome in their infants, with secondary aims of examining the effects on other neonatal morbidities and maternal health and assessing the adverse effects of treatment...
September 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28945767/chorioamnionitis-following-preterm-premature-rupture-of-membranes-and-fetal-heart-rate-variability
#16
Laurent Vandenbroucke, Matthieu Doyen, Maëla Le Lous, Alain Beuchée, Philippe Loget, Guy Carrault, Patrick Pladys
INTRODUCTION: The objective of this study was to identify prenatal markers of histological chorioamnionitis (HC) during pPROM using fetal computerized cardiotocography (cCTG). MATERIALS AND METHODS: Retrospective review of medical records from pregnant women referred for pPROM between 26 and 34 weeks, in whom placental histology was available, in a tertiary level obstetric service over a 5-year period. Fetal heart rate variability was assessed using cCTG. Patients were included if they were monitored at least six times in the 72 hours preceding delivery...
2017: PloS One
https://www.readbyqxmd.com/read/28939208/discovery-and-characterization-of-human-amniochorionic-membrane-microfractures
#17
Lauren S Richardson, Gracie Vargas, Tyra Brown, Lorenzo Ochoa, Samantha Sheller-Miller, George R Saade, Robert N Taylor, Ramkumar Menon
This study obtained visual evidence of novel cellular and extracellular matrix level structural alterations in term and preterm human fetal amniochorionic membrane. Amniochorions were collected from term cesarean (not in labor) or vaginal deliveries (labor), preterm premature rupture of the membranes, and spontaneous preterm birth. To determine the effect of oxidative stress on membranes at term or preterm labor, term not in labor samples in an organ explant culture in vitro were exposed to cigarette smoke extract...
September 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#18
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28937572/obstetric-care-consensus-no-6-periviable-birth
#19
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28937567/obstetric-care-consensus-no-6-summary-periviable-birth
#20
(no author information available yet)
Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of periviable births in addition to gestational age at birth...
October 2017: Obstetrics and Gynecology
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