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Preterm rupture of membranes

Martina T Ayad, Brandie D Taylor, Ramkumar Menon
PROBLEM: Oxidative stress (OS)-induced, p38 mitogen-activated protein kinase (p38MAPK)-mediated chorioamniotic senescence and inflammation (senescence-associated secretory phenotype [SASP]) are associated with parturition. In response to OS-inducing risk factors, premature senescence contributes to preterm premature rupture of the membranes (pPROM) and spontaneous preterm birth (PTB). We determined the effect of simvastatin, rosuvastatin, and progesterone in downregulating p38MAPK-mediated senescence and SASP...
June 17, 2018: American Journal of Reproductive Immunology: AJRI
Priya Rajan, Srinivas Murki, Suseela Vavilala, Nirupama Surubhotla
Objectives: To study the recent trends in maternal and perinatal outcomes of triplet pregnancy from a perinatal centre in South India. Methods: All triplet pregnancies booked at Fernandez hospital, Hyderabad (a tertiary care perinatal centre in South India), or those referred between 2000 and 2014 were included in the study. The maternal, fetal and neonatal outcome and any interventions like cerclage, steroid administration were studied. Results: There were 82 triplet deliveries over the study period of 15 years (82 per 69,584 live births)...
June 2018: Journal of Obstetrics and Gynaecology of India
Ivana Musilova, Ctirad Andrys, Helena Hornychova, Lenka Pliskova, Marcela Drahosova, Barbora Zednikova, Radka Bolehovska, Tomas Faist, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: To determine changes in the intraamniotic environment during the latency period using paired amniotic and gastric fluid samples in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: A total of 34 women with singleton pregnancies complicated by PPROM prior to 34 weeks were included in the study. Amniotic fluid was obtained by transabdominal amniocentesis at the time of admission. Immediately after delivery, umbilical cord blood and gastric fluid were obtained...
May 31, 2018: Pediatric Research
Maryam Kashanian, Masoomeh Faghankhani, Hasti Hadizadeh, MMasoud Salehi, Masoomeh YousefzadehRoshan, Mohammad EhsaniPour, Ladan Sayyah, Narges Sheikhansari
BACKGROUND: Pregnancy outcomes are affected by many different factors. One of the influential factors on pregnancy outcomes is the male partner as an important person to mother's wellbeing. OBJECTIVE: The aim of the present study was to investigate the effects of male partner's role including socioeconomic support, emotional support, accompanying pregnant women during prenatal care visits (PNC) and labor, and the level of pregnant women's satisfaction from their partners' support and involvement during pregnancy on pregnancy outcomes...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Lícia Vasconcelos Carvalho da Silva, Natassia Javorski, Lucas André Cavalcanti Brandão, Marília de Carvalho Lima, Sergio Crovella, Sophie Helena Eickmann
BACKGROUND: The mannose-binding lectin (MBL2) and nitric oxide synthase 3 (NOS3) genes are associated with the immune response against inflammatory processes, have been reported as possibly related with premature birth. Until now, most of the researches regarding the genetic influence of prematurity have revealed limited results because only investigating the child or the mothers' genotypes, thus not exploring the possible effects of interactions between these genotypes or the interactions with environmental factors related to the duration of pregnancy...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Juan Li, Bo Yu, Wei Wang, Luo, Qian-Ling Dai, Xiao-Qin Gan
OBJECTIVE: To investigate whether intact umbilical cord milking (I-UCM) can aggravate infection or result in other undesirable complications in preterm infants with premature prolonged rupture of membranes (PPROM). METHODS: Neonates vaginally delivered between 28 and 37 weeks' gestation and complicated by PPROM before birth were randomly divided into two groups according to the cord clamping procedure: I-UCM before clamping and immediate cord clamping (ICC). Various parameters of the study participants were compared between the two groups...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Charline Bertholdt, Olivier Morel, Matthieu Dap, Marion Choserot, Hélène Minebois
INTRODUCTION: The primary objective of the study was to evaluate the success of labor induction for indicated moderate and late preterm birth. As secondary objectives, the mode of delivery was assessed. MATERIAL AND METHODS: This is an observational study conducted in a tertiary care unit between 2013 and 2015. All patients who underwent labor induction for indicated preterm birth between 32 + 0 and 36 + 6 weeks of gestation (as premature rupture of membranes, preeclampsia, intrauterine growth restriction, fetomaternal alloimmunization, or intrahepatic cholestasis) were included...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Abeer Omar
BACKGROUND: Activity restriction is extensively prescribed for pregnant women with major comorbidities despite the lack of evidence to support its effectiveness in preventing preterm birth or low birth weight. PURPOSE: To determine the moderation effect of home activity restriction for more than a week on infant's birth weight and gestational age at birth for high-risk women with obstetrical and medical comorbidities. METHODS: A secondary analysis of 2004-2008 New York Pregnancy Risk Assessment Monitoring System was conducted with 1426 high-risk women...
January 1, 2018: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
Young-Joo Lee, Seung-Chul Kim, Jong-Kil Joo, Dong-Hyung Lee, Ki-Hyung Kim, Kyu-Sup Lee
OBJECTIVE: Prediction of delivery latency complicated with preterm premature rupture of membrane (PPROM) is crucial for reducing maternal and neonatal complications. Therefore, we investigated the correlations between latency period and cut-off values of ultrasonographic parameters, ultimately predicting delivery latency. MATERIALS AND METHODS: The retrospective study was performed on 121 PPROM patients enrolled between March 2010 and July 2015. Parameters including amniotic fluid index (AFI), single deepest pocket (SDP) and transvaginal cervical length (TVCL) were measured in 99 singleton pregnancies with PPROM...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
Bibo Feng, Jianjun Zhai, Yu Cai
OBJECTIVE: This study aimed to determine the effect of twin pregnancy chorionic properties on pregnancy complications and fetal outcomes. MATERIALS AND METHODS: A total of 559 subjects with gemellary pregnancy were included in the retrospective analysis, and clinical data, such as monitoring data during pregnancy and maternal and fetal outcomes, were recorded in detail. Based on the ultrasound results and methods of the postpartum pathologic examination of the placental membranes, the subjects were divided into the twin group with monochorionic diamnion (MCDA group, n = 198) and twin group with dichorionic diamnion (DCDA group, n = 361)...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
Song Yi Kook, Kyo Hoon Park, Ji Ae Jang, Yu Mi Kim, Hyunsoo Park, Se Jeong Jeon
OBJECTIVE: To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of intra-amniotic infection and imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL) or preterm premature rupture of membranes (PPROM). METHOD: This was a single-center retrospective cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels immediately after amniocentesis in consecutive women with PTL (n = 148) or PPROM (n = 103) between 23...
2018: PloS One
Michael A Belfort
Premature preterm rupture of the membranes (PPROM) complicates fetal surgery in 23% of open neural tube defect repairs.(Moldenhauer et al. Fetal Diagn Ther 2015) PPROM increases the risk of contractions and delivery as well as the risk of inflammation/infection for both mother and baby. Identification of those patients at risk for PPROM following fetal surgery would clearly be useful. This article is protected by copyright. All rights reserved.
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Antonio Fernandes Moron, Mauricio Mendes Barbosa, Herbene José Figuinha Milani, Stephanno Gomes Sarmento, Eduardo Felix Martins Santana, Italo Capraro Suriano, Patrícia Alessandra Dastoli, Sergio Cavalheiro
OBJECTIVE: Describe outcomes of open fetal surgery for myelomeningocele (MMC) repair in two Brazilian hospitals and the impact of surgical experience on outcome. DESIGN: Retrospective cohort study. SETTING: Sao Paulo, Brazil. POPULATION: 237 pregnant women carrying a fetus with an open spinal defect. METHODS: Surgical details and maternal and fetal outcomes collected from all patients. MAIN OUTCOME MEASURES: Analysis of surgical and perinatal outcome parameters...
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Simin Asadian, Vahid Siavashi, Masoumeh Jabarpour, Azam Sharifi, Masoumeh Esmaeilivand, Pirouz Pourmohammad, Seyed Mahdi Nassiri
The frequency of preterm labour has risen over the last few years. Plasma oestrogen concentrations differ between patients who deliver before term and those who deliver at term. Oestrogen can influence the kinetics of circulating endothelial progenitor cells (cEPCs). Here, we attempted to identify the potential association of cEPCs with the incidence of complications typical of prematurity. The study groups consisted of 60 pregnant women with premature rupture of membranes (PROM; less than 37 weeks) and 50 term pregnant women (more than 38 weeks)...
June 4, 2018: Reproduction, Fertility, and Development
Elsa Lorthe, Héloïse Torchin, Pierre Delorme, Pierre-Yves Ancel, Laetitia Marchand-Martin, Laurence Foix-L'helias, Valérie Benhammou, Catherine Gire, Claude D'Ercole, Norbert Winer, Loïc Sentilhes, Damien Subtil, François Goffinet, Gilles Kayem
BACKGROUND: Most clinical guidelines state that with early preterm premature rupture of membranes, obstetric and pediatric teams must share a realistic and individualized appraisal of neonatal outcomes with parents and consider their wishes for all decisions. However, we currently lack reliable and relevant data, according to gestational age at rupture of membranes, to adequately counsel parents during pregnancy and to reflect on our policies of care at these extreme gestational ages...
May 28, 2018: American Journal of Obstetrics and Gynecology
D M Hannah, C D Taboada, T B Tressler, F J Martinez, D B Peisner, L A Amicone, Y Wert
OBJECTIVE: Identify which obstetrical diagnoses are associated with suboptimal antenatal betamethasone administration. METHODS: We present a retrospective, cohort study of patients who received betamethasone due to a risk for preterm delivery, between 7/2013 and 9/2016 at our institution. Details of betamethasone administration were recorded including the diagnosis leading to betamethasone. Optimal administration was defined as two doses of betamethasone given 24 hours apart, with delivery occurring at greater than 24 hours but less than seven days after completion of the second dose of betamethasone...
May 23, 2018: Journal of Neonatal-perinatal Medicine
Larissa R Brunner Huber, Kenesha Smith, Wei Sha, Tara Vick
INTRODUCTION: Although the definition of a short interbirth interval has been inconsistent in the literature, Healthy People 2020 recommends that women wait at least 18 months after a live birth before attempting their next pregnancy. In the United States, approximately 33% of pregnancies are conceived within 18 months of a previous birth. Pregnancies that result from short interbirth intervals can pose serious risks. The objective of this study was to determine the association between interbirth interval and understudied pregnancy complications and outcomes, including small for gestational age (SGA) infants, premature rupture of membranes (PROM), preterm PROM (PPROM), placenta previa, and gestational diabetes, using Pregnancy Risk Assessment and Monitoring System data from Mississippi and Tennessee...
May 25, 2018: Journal of Midwifery & Women's Health
Tomas Fritz, Karin Källén, Karel Maršál, Bo Jacobsson
INTRODUCTION: The risks of preterm birth are known. We investigated the perinatal and infant mortality and morbidity after iatrogenic or spontaneous onset of extremely preterm birth. MATERIAL AND METHODS: The present study used data from the population-based EXPRESS study comprising all infants delivered before 27+0 gestational weeks in Sweden between 2004 and 2007. All fetuses alive at admission and with known mode of onset of delivery were included (682 live-born infants; 65 intrapartum deaths)...
May 24, 2018: Acta Obstetricia et Gynecologica Scandinavica
Gretchen Bandoli, Laura L Jelliffe-Pawlowski, Sky K Feuer, Liang Liang, Scott P Oltman, Randi Paynter, Kharah M Ross, Christine Dunkel Schetter, Kelli K Ryckman, Christina D Chambers
OBJECTIVE: We hypothesized second trimester serum cortisol would be higher in spontaneous preterm births compared to provider-initiated (previously termed 'medically indicated') preterm births. STUDY DESIGN: We used a nested case-control design with a sample of 993 women with live births. Cortisol was measured from serum samples collected as part of routine prenatal screening. We tested whether mean-adjusted cortisol fold-change differed by gestational age at delivery or preterm birth subtype using multivariable linear regression...
May 24, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Sara Pinto, Maria Filipa Malheiro, Ana Vaz, Teresa Rodrigues, Nuno Montenegro, Hercília Guimarães
PURPOSE: To evaluate neonatal outcomes in preterm infants with less than 34 weeks after spontaneous labor, preterm premature rupture of membranes (PPROM) or iatrogenic delivery and to clarify whether the mechanism of labor onset is a risk factor for adverse short-term neonatal outcome. METHODS: We performed a retrospective case-control study, which included 266 preterm newborns with less than 34-week gestation, between 2011 and 2015. Neonatal outcomes were compared according to the mechanism of labor onset...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
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