Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Chingiz Nurimanov, Yerbol Makhambetov, Karashash Menlibayeva, Nurtay Nurakay, Nursultan Makhambetov, Elena Zholdybayeva, Serik Akshulakov
BACKGROUND: A vein of Galen aneurysmal malformation (VGAM) is a rare congenital cerebral vascular condition with a high mortality rate if left untreated. This study describes the long-term outcomes of patients with VGAM, who were treated with endovascular embolization. METHODS: This retrospective analysis focused on VGAM patients who underwent one or more endovascular embolization sessions between January 2008 and December 2022. The study included newborns and children under 18 years...
August 18, 2023: Diagnostics
#22
JOURNAL ARTICLE
Silvia Buratti, Marisa Mallamaci, Giulia Tuo, Mariasavina Severino, Domenico Tortora, Costanza Parodi, Andrea Rossi, Francesco Pasetti, Lucio Castellan, Valeria Capra, Ferruccio Romano, Patrizia De Marco, Marco Pavanello, Gianluca Piatelli, Dario Paladini, Maria Grazia Calevo, Andrea Moscatelli
BACKGROUND: Vein of Galen aneurysmal malformation (VGAM) is a rare cerebral vascular malformation associated with significant morbidity and mortality. Newborns with VGAM without adequate treatment may develop rapidly deteriorating high output heart failure (HOHF) and are at risk for severe neurological outcomes. OBJECTIVE: To describe the clinical course and management of newborns with VGAM, and identify which echocardiographic and neuroradiologic factors may be associated with severe heart failure at birth and adverse short term outcomes...
2023: Frontiers in Pediatrics
#23
JOURNAL ARTICLE
Flavio Requejo, Dario Teplisky, María Laura González Dutra, Diana Mariela Mouratian, Raghid Kikano, Thanh N Nguyen, Mohamad Abdalkader
Pediatric neurovascular disorders can lead to substantial mortality and morbidity if not diagnosed early and adequately managed. Children with neurovascular diseases cannot be treated as small adults as the vascular and central nervous system anatomy, physiology, and pathologies in children differ greatly from those of adults. In addition, some neurovascular pathologies are seen exclusively in children such as aneurysmal malformation of the vein of Galen, pial fistulas, and dural fistulas in the context of dural sinus disease...
August 3, 2023: Seminars in Neurology
#24
JOURNAL ARTICLE
Erik F Hauck, Jeremy A Yarden, Lily I Hauck, Joseph M Bibawy, Shervin Mirshahi, Gerald A Grant
BACKGROUND: Vein of Galen malformations (VoGMs) in newborns often represent life-threatening emergencies. Outcome is difficult to predict. The authors review 50 VoGM cases to correlate anatomical types with treatment and outcome. OBSERVATIONS: Four distinct types of VoGMs are identified: mural simple (type I), mural complex (type II), choroidal (type III), and choroidal with deep venous drainage (type IV). Seven patients presented with mural simple VoGMs with a "single hole" fistula supplied by only one large feeder...
June 12, 2023: J Neurosurg Case Lessons
#25
JOURNAL ARTICLE
Flavio Requejo, Dario Teplisky, María Laura González Dutra, José Lipsch, Thanh N Nguyen, Mohamad Abdalkader
BACKGROUND AND PURPOSE: Intracranial arteriovenous shunts (IAVS) are rare vascular diseases in infants. They can be categorized into vein of Galen aneurysmal malformation (VGAM), pial arteriovenous fistula (PAVF), and dural arteriovenous fistula associated with dural sinus malformation (DAVF/DSM). We sought to review the clinical presentation, imaging characteristics, endovascular treatment (EVT), and outcomes of IAVS in infants presenting to a quaternary pediatric referral center over one decade...
June 18, 2023: Interventional Neuroradiology
#26
Duc Tan Vo, Tram Bich Thi Ha, Tu Ngoc Ho, Linh Hong Thi Nguyen, Hoa Viet Nguyen
Pial arteriovenous fistula (PAVF) is a rare intracranial vascular lesion where direct communication exists between one or more pial arteries and a cerebral vein, without an intervening nidus and located in the subpial meningeal space. When the drainage of PAVF involves a dilated, but already formed vein of Galen (VOG), it should be distinguished from other vascular lesions located in this area, because their angio-architecture, natural history and treatment options are different. A 33-year-old female was admitted to our hospital with a history of new-onset generalized tonic-clonic seizures...
July 2023: Radiology Case Reports
#27
JOURNAL ARTICLE
Sara Hadad, Shivani D Rangwala, Jeffrey N Stout, Fernando Mut, Darren B Orbach, Juan R Cebral, Alfred P See
Introduction: Computational fluid dynamics (CFD) assess biological systems based on specific boundary conditions. We propose modeling more advanced hemodynamic metrics, such as core line length (CL) and critical points which characterize complexity of flow in the context of cerebral vasculature, and specifically cerebral veins during the physiologically evolving early neonatal state of vein of Galen malformations (VOGM). CFD has not been applied to the study of arteriovenous shunting in Vein of Galen Malformations but could help illustrate the pathophysiology of this malformation...
2023: Frontiers in Physiology
#28
JOURNAL ARTICLE
Christopher S Graffeo, Archis R Bhandarkar, Lucas P Carlstrom, Avital Perry, Bachtri Nguyen, David J Daniels, Michael J Link, Jonathan M Morris
INTRODUCTION: Pediatric cerebrovascular lesions are very rare and include aneurysms, arteriovenous malformations (AVM), and vein of Galen malformations (VOGM). OBJECTIVE: To describe and disseminate a validated, reproducible set of 3D models for optimization of neurosurgical training with respect to pediatric cerebrovascular diseases METHODS: All pediatric cerebrovascular lesions treated at our institution with adequate imaging studies during the study period 2015-2020 were reviewed by the study team...
June 5, 2023: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#29
JOURNAL ARTICLE
S Schwarz, F Brevis Nuñez, N R Dürr, F Brassel, M Schlunz-Hendann, A Feldkamp, T Rosenbaum, U Felderhoff-Müser, K Schulz, C Dohna-Schwake, N Bruns
BACKGROUND AND PURPOSE: Vein of Galen malformation is a rare congenital cerebrovascular malformation. In affected patients, increased cerebral venous pressure constitutes an important etiologic factor for the development of brain parenchymal damage. The aim of this study was to investigate the potential of serial cerebral venous Doppler measurements to detect and monitor increased cerebral venous pressure. MATERIALS AND METHODS: This was a retrospective monocentric analysis of ultrasound examinations within the first 9 months of life in patients with vein of Galen malformation admitted at <28 days of life...
June 2023: AJNR. American Journal of Neuroradiology
#30
JOURNAL ARTICLE
Yahya H Khormi, Alshaymaa M Arishy, Mostafa M E Atteya
INTRODUCTION: Vein of Galen malformation (VOGM) is an exceptionally uncommon form of congenital intracranial vascular malformations. It is highly unusual for this lesion to spontaneously thrombose. The clinical presentation of a patient may range from being asymptomatic to critically ill. The underlying pathophysiological mechanisms that cause spontaneous thrombosis are still poorly understood. METHODS AND RESULTS: The literature on spontaneous thrombosis of VOGM was systematically reviewed, analyzed, and summarized with a focus on its pathophysiology, types, clinical presentations, diagnosis, management, and outcomes...
May 11, 2023: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#31
JOURNAL ARTICLE
Darren B Orbach, Louise E Wilkins-Haug, Carol B Benson, Wayne Tworetzky, Shivani D Rangwala, Stephanie H Guseh, Nicole K Gately, Jeffrey N Stout, Arielle Mizrahi-Arnaud, Alfred P See
No abstract text is available yet for this article.
May 4, 2023: Stroke; a Journal of Cerebral Circulation
#32
JOURNAL ARTICLE
Yu Hu, Lijuan Sun, Li Feng, Jingjing Wang, Yantong Zhu, Qingqing Wu
BACKGROUND: To evaluate the role of a standardized first-trimester scan in screening different kinds of central nervous system malformations and to report a 3-year experience from a tertiary center using an unselected cohort. METHODS: This was a retrospective analysis of prospectively collected data from a single center evaluating first-trimester scans with predesigned standardized protocols performed between 1 May 2017 and 1 May 2020, involving 39,526 pregnancies...
May 3, 2023: BMC Pregnancy and Childbirth
#33
David Liddle, Bishoy Ibrahim, Christopher Isibor, Jennifer Judge, Darren B Orbach, Susan F Saleeb
This case concerns an 18-month-old with masked congestive heart failure (CHF) from an unrepaired vein of Galen malformation and superior sinus venosus defect who progressed to severe, refractory CHF following superior sinus venosus defect repair. Partial transvenous coil embolization of a very-high-risk vein of Galen malformation resolved CHF symptoms. ( Level of Difficulty: Advanced. ).
May 17, 2023: JACC. Case reports
#34
JOURNAL ARTICLE
Francesca Campi, Domenico Umberto De Rose, Flaminia Pugnaloni, Sara Ronci, Monica Calì, Stefano Pro, Daniela Longo, Giulia Lucignani, Laura Raho, Elisa Pisaneschi, Maria Cristina Digilio, Immacolata Savarese, Iliana Bersani, Paolina Giuseppina Amante, Marta Conti, Paola De Liso, Irma Capolupo, Annabella Braguglia, Carlo Gandolfo, Andrea Dotta
BACKGROUND: Despite the latest advances in prenatal diagnosis and postnatal embolization procedures, intracranial arteriovenous shunts (AVSs) are still associated with high mortality and morbidity rates. Our aim was to evaluate the presentation and clinical course, the neurodevelopmental outcome, and the genetic findings of neonates with AVSs. METHODS: In this retrospective observational study, medical records of neonates with cerebral AVSs admitted to our hospital from January 2020 to July 2022 were revised...
2023: Frontiers in Pediatrics
#35
REVIEW
Jacob F Baranoski, Joshua S Catapano, Felipe C Albuquerque, Todd A Abruzzo
Endovascular embolization is the primary strategy in the management for vein of Galen malformations (VOGM). However, despite significant advances in endovascular embolization technologies and techniques, VOGMs remain very technically challenging lesions largely due to the high-flow arteriovenous shunts present in these malformations. A variety of advanced flow-control techniques can be implemented to mitigate the risk of venous escape and increase the safety and efficacy of endovascular treatment. These techniques include regionally targeted strategies (transvenous embolization and balloon-assisted transarterial embolization) and global flow-control methods (pharmacologic cardiac arrest and rapid ventricular overdrive pacing)...
2023: Frontiers in Pediatrics
#36
JOURNAL ARTICLE
Jai Khurana, Darren B Orbach, Kimberlee Gauvreau, Shane L Collins, Joseph B Tella, Pankaj B Agrawal, Helen A Christou, Mary P Mullen
OBJECTIVE: To assess the extent and resolution of pulmonary hypertension (PH), cardiovascular factors, and echocardiographic findings associated with mortality in infants and children with vein of Galen malformation (VOGM). STUDY DESIGN: We performed a retrospective review of 49 consecutive children with VOGM admitted to Boston Children's Hospital from 2007 to 2020. Patient characteristics, echocardiographic data, and hospital course were analyzed for 2 cohorts based on age at presentation to Boston Children's Hospital: group 1 (age ≤60 days) or group 2 (age >60 days)...
July 2023: Journal of Pediatrics
#37
JOURNAL ARTICLE
Matthew Udine, Davide Croci, Jacob Wasserman, Mohammad Hassan A Noureldine, Molly Monsour, Kunal Vakharia, Siviero Agazzi
OBJECTIVE: Vein of Galen Malformations (VoGM) are rare vascular malformations, typically seen in pediatric age groups. Even more rarely, VoGM's may be seen later in adulthood. In this case report and systematic review, we provide a thorough description of the current literature as well as provide a case example exploring the diagnosis, imaging, treatment, and management of VoGM in adults. METHODS: In accordance with PRISMA guidelines, we performed a systematic literature search for all relevant cases and case series of VoGM in adult patients...
May 2023: Clinical Neurology and Neurosurgery
#38
Shujuan Zhao, Kedous Y Mekbib, Martijn A van der Ent, Garrett Allington, Andrew Prendergast, Jocelyn E Chau, Hannah Smith, John Shohfi, Jack Ocken, Daniel Duran, Charuta G Furey, Hao Thi Le, Phan Q Duy, Benjamin C Reeves, Junhui Zhang, Carol Nelson-Williams, Di Chen, Boyang Li, Timothy Nottoli, Suxia Bai, Myron Rolle, Xue Zeng, Weilai Dong, Po-Ying Fu, Yung-Chun Wang, Shrikant Mane, Paulina Piwowarczyk, Katie Pricola Fehnel, Alfred Pokmeng See, Bermans J Iskandar, Beverly Aagaard-Kienitz, Adam J Kundishora, Tyrone DeSpenza, Ana B W Greenberg, Seblewengel M Kidanemariam, Andrew T Hale, James M Johnston, Eric M Jackson, Phillip B Storm, Shih-Shan Lang, William E Butler, Bob S Carter, Paul Chapman, Christopher J Stapleton, Aman B Patel, Georges Rodesch, Stanislas Smajda, Alejandro Berenstein, Tanyeri Barak, E Zeynep Erson-Omay, Hongyu Zhao, Andres Moreno-De-Luca, Mark R Proctor, Edward R Smith, Darren B Orbach, Seth L Alper, Stefania Nicoli, Titus J Boggon, Richard P Lifton, Murat Gunel, Philip D King, Sheng Chih Jin, Kristopher T Kahle
To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and severe congenital brain arteriovenous malformation, we performed an integrated analysis of 310 VOGM proband-family exomes and 336,326 human cerebrovasculature single-cell transcriptomes. We found the Ras suppressor p120 RasGAP ( RASA1 ) harbored a genome-wide significant burden of loss-of-function de novo variants (p=4.79×10 -7 ). Rare, damaging transmitted variants were enriched in Ephrin receptor-B4 ( EPHB4 ) (p=1...
March 21, 2023: bioRxiv
#39
(no author information available yet)
[This corrects the article DOI: 10.3389/fped.2022.1066114.].
2023: Frontiers in Pediatrics
#40
Alper Aykanat, Sinan Balcı, Hatice Kader Karlı-Oğuz, Anıl Arat, Şule Yiğit
BACKGROUND: Despite advanced endovascular methods and comprehensive intensive care in the neonatal vein of Galen aneurysmal malformation, overall mortality ranges between 37-63% in treated patients with 37-50% of survivors possessing poor neurologic outcomes. These findings stress the need for more accurate and timely recognition of the patients who may and may not benefit from aggressive intervention. CASE: This case report presents a newborn with a vein of Galen aneurysmal malformation whom antenatal and postnatal follow-up included serial magnetic resonance imaging (MRI) including diffusion-weighted series...
2023: Turkish Journal of Pediatrics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
