Karima Schwab, Silke Frahm, Mandy Magbagbeolu, David Horsley, Elizabeth A Goatman, Valeria Melis, Franz Theuring, Ahtsham Ishaq, John M D Storey, Charles R Harrington, Claude M Wischik, Gernot Riedel
Alpha-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies, neurodegenerative disorders that include Parkinson's disease (PD). Here, we explored the efficacy of N,N,N',N'-tetraethyl-10H-phenothiazine-3,7-diamine dihydrochloride (LETC), a protein aggregation inhibitor, on α-Syn aggregation. In both cellular models and transgenic mice, α-Syn aggregation was achieved by the overexpression of full-length human α-Syn fused with a signal sequence peptide. α-Syn accumulated in transfected DH60...
March 17, 2024: European Journal of Pharmacology