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https://www.readbyqxmd.com/read/27758838/neuroinflammatory-and-morphological-changes-in-late-life-depression-the-nimrod-study
#1
L Su, Y O Faluyi, Y T Hong, T D Fryer, E Mak, S Gabel, L Hayes, S Soteriades, G B Williams, R Arnold, L Passamonti, P Vázquez Rodríguez, A Surendranathan, R W Bevan-Jones, J Coles, F Aigbirhio, J B Rowe, J T O'Brien
We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [(11)C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [(11)C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum...
December 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/27618518/abnormalities-in-functional-connectivity-in-collegiate-football-athletes-with-and-without-a-concussion-history-implications-and-role-of-neuroactive-kynurenine-pathway-metabolites
#2
Timothy B Meier, Melissa A Lancaster, Andrew R Mayer, T Kent Teague, Jonathan Savitz
There is a great need to identify potential long-term consequences of contact sport exposure and to identify molecular pathways that may be associated with these changes. We tested the hypothesis that football players with (Ath-mTBI) (n = 25) and without a concussion history (Ath) (n = 24) have altered resting state functional connectivity in regions with previously documented structural changes relative to healthy controls without football or concussion history (HC) (n = 27). As a secondary aim, we tested the hypothesis that group differences in functional connectivity are moderated by the relative ratio of neuroprotective to neurotoxic metabolites of the kynurenine pathway...
October 13, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27460617/decreased-oligodendrocyte-and-neuron-number-in-anterior-hippocampal-areas-and-the-entire-hippocampus-in-schizophrenia-a-stereological-postmortem-study
#3
Peter Falkai, Berend Malchow, Katharina Wetzestein, Verena Nowastowski, Hans-Gert Bernstein, Johann Steiner, Thomas Schneider-Axmann, Theo Kraus, Alkomiet Hasan, Bernhard Bogerts, Christoph Schmitz, Andrea Schmitt
The hippocampus is involved in cognition as well as emotion, with deficits in both domains consistently described in schizophrenia. Moreover, the whole volumes of both the anterior and posterior region have been reported to be decreased in schizophrenia patients. While fewer oligodendrocyte numbers in the left and right cornu ammonis CA4 subregion of the posterior part of the hippocampus have been reported, the aim of this stereological study was to investigate cell numbers in either the dentate gyrus (DG) or subregions of the anterior hippocampus...
July 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27395897/first-report-of-the-land-planarian-diversibipalium-multilineatum-makino-shirasawa-1983-platyhelminthes-tricladida-continenticola-in-europe
#4
Giuseppe Mazza, Mattia Menchetti, Ronald Sluys, Eduard Solà, Marta Riutort, Elena Tricarico, Jean-Lou Justine, Luca Cavigioli, Emiliano Mori
Introduction of alien species may significantly affect soil ecosystems, through predation or disruption of components of native ecosystems (Winsor et al. 2004; Álvarez-Presas et al. 2014; Justine et al. 2014). Land planarians have been reported as alien species in soils throughout the world and, among those, some species are considered to be successful invaders, e.g. Platydemus manokwari de Beauchamp, 1963, Arthurdendyus triangulatus (Dendy, 1894), Bipalium adventitium Hyman, 1943, Bipalium kewense Moseley, 1878 and Dolichoplana striata Moseley, 1877 (Winsor et al...
2016: Zootaxa
https://www.readbyqxmd.com/read/26945338/anastomosing-hemangiomas-arising-in-unusual-locations-a-clinicopathologic-study-of-17-soft-tissue-cases-showing-a-predilection-for-the-paraspinal-region
#5
Ivy John, Andrew L Folpe
Anastomosing hemangioma, a recently recognized benign vascular neoplasm originally described in the kidney, may be confused with well-differentiated angiosarcoma. Rare cases of anastomosing hemangiomas have been described in the liver and in nonrenal genitourinary sites. We report a series of 17 anastomosing hemangiomas occurring in unusual locations, in particular in the paravertebral soft tissues. The 17 tumors occurred in 10 male and 6 female patients, ranging in age from 2 to 85 years. One patient had bilateral, synchronous tumors involving the right paracaval and left para-aortic soft tissues...
August 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26792429/evaluation-of-intra-aortic-ct-angiography-performances-for-the-visualisation-of-spinal-vascular-malformations-angioarchitecture
#6
Frédéric Clarençon, Federico Di Maria, Nader-Antoine Sourour, Joseph Gabrieli, Aurélien Nouet, Eimad Shotar, Evelyne Cormier, Robert Fahed, Philippe Cornu, Jacques Chiras
PURPOSE: To evaluate the performances of the CT-angiography by direct intra-aortic contrast media injection (IA-CTA) for spinal vascular malformations (SVMs)' imaging. MATERIALS AND METHODS: Thirteen patients (8 males, 5 females, mean age: 56 y) with suspected SVM underwent IA-CTAs by direct intra-aortic iodinated contrast media injection (5 cc/s; 100 cc) via an arterial femoral or humeral access. Two independent observers evaluated the angioarchitecture of the SVMs and the visualisation of both the Adamkiewicz artery and the anterior spinal artery...
October 2016: European Radiology
https://www.readbyqxmd.com/read/26629106/experimental-study-of-the-functional-reserve-of-median-nerve-in-rats
#7
Jianli Cui, Xu Gong, Ziping Jiang, Xin Yu, Yuejiao Liu, Laijin Lu
OBJECTIVE: To study the functional changes of median nerve after removing a certain bundle of it and to explore the functional reserve of median nerves. METHODS: 220 three-month old SD rats were randomly divided into experimental groups and sham groups. And the experimental group was further divided as 1/8 group, 1/4 group, 1/3 group, 1/2 group, and 2/3 group according to ratio of the resection portion, with 22 rats in each group. The section of the lowest level on median nerve trunks were exposed, and a certain portion of it were separated and resected in experimental group, while in sham groups, the nerve was only separated without resection...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26597482/early-glottic-cancer-involving-the-anterior-commissure-treated-by-transoral-laser-cordectomy
#8
Caroline Hoffmann, Nicolas Cornu, Stéphane Hans, Babak Sadoughi, Cécile Badoual, Daniel Brasnu
OBJECTIVES/HYPOTHESIS: Anterior commissure involvement is considered to be a risk factor for poorer outcomes after transoral laser cordectomy (TLC) for early glottic cancer. The objective of this study was to determine the outcomes and relevance of the tumor-node-metastasis (TNM) classification in a large series of patients with early glottic cancer involving the anterior commissure treated by TLC. METHODS: The clinical and surgical parameters, as well as follow-up results, of the patients treated consecutively for early-stage glottic squamous cell carcinoma involving the anterior commissure (Tis, T1a, T1b, and T2) by transoral CO2 laser cordectomy in an urban academic medical center from January 2001 to March 2013 were analyzed retrospectively...
August 2016: Laryngoscope
https://www.readbyqxmd.com/read/26306931/glioblastoma-complicated-by-fatal-malignant-acute-ischemic-stroke-mri-finding-to-assist-in-tricky-surgical-decision
#9
Aymeric Amelot, Flore Baronnet-Chauvet, Edith Fioretti, Bertrand Mathon, Philippe Cornu, Aurélien Nouet, Dorian Chauvet
BACKGROUND: In most cases, glioblastomas are associated with seizures, headaches, neurological deficits, aphasia, or bleeding. But these tumors are rarely associated with cerebral infarction and never so deadly. CASE REPORT: A 40-year-old man presented with sudden morning isolated aphasia. One hour later, he developed a motor deficit at right upper member, quickly completed with a total right hemiplegia. Imaging studies revealed a left frontotemporal enhancing glioblastoma with a perilesional edema which produced an important mass effect on the posterior arm of the external capsule, on the primary motor cortex posteriorly and the entire sylvian valley anteriorly...
October 2015: Neuroradiology Journal
https://www.readbyqxmd.com/read/26229851/anatomical-study-of-the-posterior-cruciate-ligament-with-the-knee-flexed-at-90%C3%A2
#10
Daniel Kyubin Cho, Sthéphano Pellizzaro Rosa, Guilherme Bello Prestes, Luiz Antônio Munhoz da Cunha, Márcio Fernando Aparecido de Moura, Edmar Stieven Filho
OBJECTIVE: To study the anatomy of the posterior cruciate ligament (PCL) and define anatomical parameters with the knee flexed at 90°. METHODS: Eight knees from cadavers were dissected in order to make measurements from the center of the anterolateral band to the roof (AL1), from the center of the anterolateral band to the anterior cartilage (AL2), from the center of the posteromedial band to the roof (PM1), from the center of the posteromedial band to the anterior cartilage (PM2), from the center of the tibial insertion to the medial region of the tibia (TIM), from the center of the tibial insertion to the lateral region of the tibia (TIL), from the center of the medial insertion to the medial meniscus (IMM) and the width of the origin of the PCL (WO)...
September 2014: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/25844546/endocervical-adenocarcinoma-in-situ-presenting-in-fundal-endometrial-polyp-the-mother-of-all-skip-lesions
#11
Jennifer M Roberts, Alyssa M Cornall, Vincent Lamaro, Sepehr N Tabrizi, Peter Russell
A 38-yr-old woman, with a previous history of low grade squamous intraepithelial lesion in the cervix, presented with heavy menstrual bleeding. At hysteroscopy, a fundal polyp was removed from the right cornu which displayed many glands lined by atypical, mitotically active epithelium with features characteristic of endocervical adenocarcinoma in situ (AIS) of intestinal subtype. Subsequent cervical liquid-based cytology and colposcopically directed biopsies revealed no causative lesion, but residual PreservCyt from the ThinPrep vial tested positive for high risk HPV type other than HPV 16 and 18...
May 2015: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25823900/third-instar-larvae-of-flesh-flies-diptera-sarcophagidae-of-forensic-importance-critical-review-of-characters-and-key-for-european-species
#12
Krzysztof Szpila, René Richet, Thomas Pape
Necrophagous Sarcophagidae are among the insects most frequently reported from human corpses. The broad forensic application of flesh flies is restricted by the lack of reliable tools for species identification of larval stages and mass breeding of collected flesh fly larvae to the adult stage, and more recently DNA-based methods are usually recommended for precise species identification. To overcome this situation, the following study was implemented: (1) original larval material was obtained of the European flesh flies of confirmed or potential forensic importance; (2) larval morphology was studied and documented using a combination of standard light microscopy, image-stacking stereomicroscopy and SEM; and (3) larval characters used in previously published keys were critically revised...
June 2015: Parasitology Research
https://www.readbyqxmd.com/read/25564192/altered-functional-connectivity-networks-of-hippocampal-subregions-in-remitted-late-onset-depression-a-longitudinal-resting-state-study
#13
Zan Wang, Yonggui Yuan, Feng Bai, Hao Shu, Jiayong You, Lingjiang Li, Zhijun Zhang
The regional specificity of hippocampal abnormalities in late-life depression (LLD) has been demonstrated in previous studies. In this study, we sought to examine the functional connectivity (FC) patterns of hippocampal subregions in remitted late-onset depression (rLOD), a special subtype of LLD. Fourteen rLOD patients and 18 healthy controls underwent clinical and cognitive evaluations as well as resting-state functional magnetic resonance imaging scans at baseline and at ∼21 months of follow-up. Each hippocampus was divided into three parts, the cornu ammonis (CA), the dentate gyrus, and the subicular complex, and then six seed-based hippocampal subregional networks were established...
February 2015: Neuroscience Bulletin
https://www.readbyqxmd.com/read/25554491/-evolution-of-ideas-and-techniques-and-future-prospects-in-epilepsy-surgery
#14
REVIEW
B Mathon, L Bédos-Ulvin, M Baulac, S Dupont, V Navarro, A Carpentier, P Cornu, S Clemenceau
INTRODUCTION: The aim of this article was to review and evaluate the published literature related to the outcome of epilepsy surgery, while placing it in an historical perspective, and to describe the future prospects in this field. STATE OF ART: Temporal lobe surgery achieves seizure freedom in about 70% of cases. Seizure outcome is similar in the pediatric population. Extratemporal resections impart good results to 40% to 60% of patients, with a better prognosis in the case of frontal lobe surgery...
February 2015: Revue Neurologique
https://www.readbyqxmd.com/read/25514656/high-resolution-7t-fmri-of-human-hippocampal-subfields-during-associative-learning
#15
Nanthia A Suthana, Markus Donix, David R Wozny, Adam Bazih, Michael Jones, Robin M Heidemann, Robert Trampel, Arne D Ekstrom, Maria Scharf, Barbara Knowlton, Robert Turner, Susan Y Bookheimer
Examining the function of individual human hippocampal subfields remains challenging because of their small sizes and convoluted structures. Previous human fMRI studies at 3 T have successfully detected differences in activation between hippocampal cornu ammonis (CA) field CA1, combined CA2, CA3, and dentate gyrus (DG) region (CA23DG), and the subiculum during associative memory tasks. In this study, we investigated hippocampal subfield activity in healthy participants using an associative memory paradigm during high-resolution fMRI scanning at 7 T...
June 2015: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/25081550/delineation-of-hippocampal-subregions-using-t1-weighted-magnetic-resonance-images-at-3%C3%A2-tesla
#16
Kathryn Rhindress, Toshikazu Ikuta, Robin Wellington, Anil K Malhotra, Philip R Szeszko
Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1-3)...
November 2015: Brain Structure & Function
https://www.readbyqxmd.com/read/24954042/hyoid-bone-tenderness-as-a-clinical-indicator-of-laryngeal-pathology
#17
Colin O'Rourke, Sarwar Attique, Aziz Ur Rehman, Jean Saunders, John E Fenton
OBJECTIVES: Hyoid bone tenderness is an underemphasized clinical abnormality and is described as discomfort or pain on gentle palpation of the greater cornu. The primary outcome of this study is to assess if there is any association between hyoid tenderness and laryngeal pathology. STUDY DESIGN: This is a retrospective case-control study. METHODS: Ninety-four subjects were identified. These were divided into two groups, those with hyoid tenderness and those without hyoid tenderness...
November 2014: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/24950819/limbic-versus-cognitive-target-for-deep-brain-stimulation-in-treatment-resistant-depression-accumbens-more-promising-than-caudate
#18
MULTICENTER STUDY
Bruno Millet, Nematollah Jaafari, Mircea Polosan, Nicolas Baup, Bruno Giordana, Claire Haegelen, Stephan Chabardes, Denys Fontaine, Bertrand Devaux, Jérome Yelnik, Philippe Fossati, Bruno Aouizerate, Marie Odile Krebs, Gabriel Robert, Thérèse Jay, Philippe Cornu, Marc Vérin, Sophie Drapier, Dominique Drapier, Paul Sauleau, Julie Peron, Florence Le Jeune, Florian Naudet, Jean Michel Reymann
High-frequency deep brain stimulation (DBS) represents a major stake for treatment for treatment-resistant depression (TRD). We describe a preliminary trial of DBS of two potential brain targets in chronic TRD: the nucleus accumbens (Acb) and, in the event of failure, the caudate nucleus. Patients were followed for 6 months before surgery (M0). From M1 to M5, they underwent stimulation of the Acb target. PET scans allowed us to track metabolic modifications resulting from this stimulation. The caudate target of nonresponders was stimulated between M5 and M9...
August 2014: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/24920451/childhood-maltreatment-altered-limbic-neurobiology-and-substance-use-relapse-severity-via-trauma-specific-reductions-in-limbic-gray-matter-volume
#19
Nicholas T Van Dam, Kenneth Rando, Marc N Potenza, Keri Tuit, Rajita Sinha
IMPORTANCE: Substance use disorders (SUDs) are among the most common sequelae of childhood maltreatment, yet the independent contributions of SUDs and childhood maltreatment to neurobiological changes and the effect of the latter on relapse risk (a critical variable in addiction treatment) are relatively unknown. OBJECTIVES: To identify structural neural characteristics independently associated with childhood maltreatment (CM; a common type of childhood adversity), comparing a sample with SUD with a demographically comparable control sample, and to examine the relationship between CM-related structural brain changes and subsequent relapse...
August 2014: JAMA Psychiatry
https://www.readbyqxmd.com/read/24777127/structure-and-vascularization-of-the-human-hippocampus
#20
REVIEW
Laurent Tatu, Fabrice Vuillier
The hippocampus is a temporal brain structure belonging to the limbic lobe and is fundamentally involved in memory processing, learning, and emotions. It consists of two allocortex laminae: the gyrus dentatus and the cornu ammonis, one rolled up inside the other, creating a bulge in the temporal horn of the lateral ventricle. Arterial vascularization of the hippocampus is dependent on the collateral branches of the posterior cerebral artery and the anterior choroidal artery, forming the network of superficial hippocampal arteries that in turn lead to deep intrahippocampal arteries...
2014: Frontiers of Neurology and Neuroscience
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