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Patient Safety and Quality

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https://www.readbyqxmd.com/read/29913462/curriculum-development-and-implementation-of-a-national-interprofessional-fellowship-in-patient-safety
#1
Bradley V Watts, Linda Williams, Peter D Mills, Douglas E Paull, Jeffrey A Cully, Stuart C Gilman, Robin R Hemphill
OBJECTIVES: Developing a workforce skilled in improving the safety of medical care has often been cited as an important means to achieve safer care. Although some educational programs geared toward patient safety have been developed, few advanced training programs have been described in the literature. We describe the development of a patient safety fellowship program. METHODS: We describe the development and curriculum of an Interprofessional Fellowship in Patient Safety...
June 15, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29912995/an-overview-of-the-burden-of-illness-and-the-role-of-once-weekly-glucagon-like-peptide-1-receptor-agonists-in-the-treatment-of-type-2-diabetes
#2
Stephen A Brunton
Type 2 diabetes (T2D) is a debilitating condition and more people are being diagnosed each year. T2D increases patients' risk of developing disabling micro- and macrovascular complications, significantly reduces patients' quality of life, and is a substantial global economic burden. The efficacy and safety of antihyperglycemic therapies have improved over the years and have increased the lifespan for these patients. Consequently, patients are living longer with the condition and the associated comorbidities, but with a lowered quality of life...
June 2018: Journal of Family Practice
https://www.readbyqxmd.com/read/29912467/trans-disciplinary-advanced-allied-health-practitioners-for-acute-hospital-inpatients-a-feasibility-study
#3
Dina Watterson, Kerrie Walter, Lisa O'Brien, Desiree Terrill, Kathleen Philip, Indi Swan, Lisa Somerville
Objective: To explore cost-efficiency, safety and acceptability of trans-disciplinary advanced allied health (AH) practitioners for acute adult general medicine inpatients. Design: Quasi-experimental feasibility study. Setting: Three acute general medical units in an Australian urban hospital. Participants: Two hundred and fifty-six acute hospital inpatients. Main Outcome Measures: Cost-efficiency measures included AH service utilization and length of stay (LOS)...
June 15, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29912271/randomized-phase-3-and-extension-studies-efficacy-and-impacts-on-quality-of-life-of-naldemedine-in-subjects-with-opioid-induced-constipation-and-cancer
#4
N Katakami, T Harada, T Murata, K Shinozaki, M Tsutsumi, T Yokota, M Arai, Y Tada, M Narabayashi, N Boku
Background: The efficacy and safety of naldemedine (a peripherally-acting µ-opioid receptor antagonist) for opioid-induced constipation (OIC) in subjects with cancer was demonstrated in the primary report of a phase 3, double-blind study (COMPOSE-4) and its open-label extension (COMPOSE-5). The primary endpoint, the proportion of spontaneous bowel movement (SBM) responders, was met. Here, we report results from secondary endpoints including quality of life (QOL) assessments from these studies...
April 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29910605/role-of-etelcalcetide-in-the-management-of-secondary-hyperparathyroidism-in-hemodialysis-patients-a-review-on-current-data-and-place-in-therapy
#5
REVIEW
Claudia Friedl, Emanuel Zitt
Secondary hyperparathyroidism (sHPT) is a frequently occurring severe complication of advanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH)-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease - mineral and bone disorder clinical practice guidelines...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29910600/prospective-multicenter-clinical-trial-to-evaluate-the-safety-and-effectiveness-of-a-new-glistening-free-one-piece-acrylic-toric-intraocular-lens
#6
Mark Packer, Jon I Williams, Gregg Feinerman, Richard S Hope
Purpose: Glistening formation in the intraocular lens (IOL) optic has the potential to impact quality of vision. The enVista One-Piece Hydrophobic Acrylic Spherical IOL Model MX60 (MX60 IOL) is currently the only US Food and Drug Administration-approved IOL with a label of "no glistenings". The purpose of this prospective, multicenter, partially randomized, partially controlled, double-masked, pivotal study was to evaluate the safety and effectiveness of the enVista One-Piece Hydrophobic Acrylic MX60T Toric IOL (enVista MX60T Toric IOL)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29909689/intra-articular-injections-in-the-treatment-of-symptoms-from-ankle-arthritis-a-systematic-review
#7
Christopher Vannabouathong, Gina Del Fabbro, Brendan Sales, Christopher Smith, Chuan Silvia Li, Darryl Yardley, Mohit Bhandari, Bradley A Petrisor
BACKGROUND: Intra-articular (IA) injections are commonly used to treat knee arthritis pain; however, whether their efficacy generalizes to ankle arthritis remains debatable. We aimed to evaluate the evidence for IA therapies in the management of this patient population. METHODS: We performed a literature search for observational and randomized controlled trials (RCTs). Treatments included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), and mesenchymal stem cells (MSC)...
June 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29909445/centers-for-disease-control-and-prevention-2017-guidelines-for-prevention-of-surgical-site-infections-review-and-relevant-recommendations
#8
REVIEW
K Keely Boyle, Sridhar Rachala, Scott R Nodzo
PURPOSE OF REVIEW: The associated patient morbidity and resource-intensive nature of managing surgical site infections (SSI) has focused attention toward not only improving treatment protocols but also enhancing preventative measures. The purpose of this review was to summarize the relevant updated CDC guidelines for the prevention of SSI that were released in 2017. The CDC recommends the integration of the guidelines for improvement in quality metrics, reportable outcomes, and patient safety...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29909284/lean-methodology-in-healthcare
#9
REVIEW
Rubin I Cohen
To improve the delivery of patient care, governments and healthcare institutions adopted quality improvement methods that had been developed decades earlier in manufacturing industries. Many healthcare practitioners are either unaware or are inexperienced about what these practices entail and whether they are successful in healthcare. This article reviews Lean, an improvement philosophy made famous by the Toyota Motor Company. Lean uses a set of instruments and incorporates a long-term vision aiming for continuous improvement...
June 14, 2018: Chest
https://www.readbyqxmd.com/read/29909013/impact-and-prevalence-of-physical-and-verbal-violence-toward-healthcare-workers
#10
Lisa J Rosenthal, Ashley Byerly, Adrienne D Taylor, Zoran Martinovich
BACKGROUND: Threatening and assaultive behaviors against healthcare workers is a growing national concern.1,2,3 To assess the incidence and impact of aggression against healthcare workers, a safety and quality improvement project was initiated in an academic, tertiary care, and urban hospital. METHODS: Through the Northwestern Academy of Quality and Safety Initiatives program, an invitation to complete an online survey was sent to healthcare workers. The survey inquired about prevalence, location, and type of experience of physical or verbal abuse by patients or families...
May 9, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29908148/the-value-of-u-s-pharmacopeial-standards-a-review-of-the-literature
#11
James Heyward, William Padula, Jonothan C Tierce, G Caleb Alexander
While there are many standard-setting health care organizations, the United States Pharmacopeia's (USP) role includes the creation of documentary and physical standards for therapeutics, including chemical drugs, excipients and biologics. Despite the ubiquity of these standards, little work has been done to characterize and quantify their value. We reviewed the peer-reviewed and grey literature relevant to such evaluations. The review yielded 36 articles, focused variously on accreditation and other standards in healthcare, the broad impact of pharmacopeial standards, and evaluations of specific USP standards...
June 13, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29907511/developing-and-assessing-electronic-checklists-for-safety-mindfulness-workload-and-performance
#12
Gregg S Tracton, Lukasz M Mazur, Prithima Mosaly, Lawrence B Marks, Shiva Das
PURPOSE: The aim of this study is to propose a set of innovative principles for the effective design of electronic checklists to enhance safety mindfulness (a specific safety mindful mindset that offers the opportunity to operate more preemptively during routine quality assurance tasks) and discuss some of our preliminary results from testing our proposed electronic checklist with dosimetrists and physicists. METHODS AND MATERIALS: A multidisciplinary team designed, developed, and evaluated the utility of the electronic checklist (vs paper-based checklist) to promote safety mindfulness...
May 16, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29906643/the-efficacy-and-safety-comparison-of-docetaxel-cabazitaxel-estramustine-and-mitoxantrone-for-castration-resistant-prostate-cancer-a-network-meta-analysis
#13
Pan Song, Chuiguo Huang, Yan Wang
AIMS: The aim of this study was to compare the efficacy and safety of docetaxel, cabazitaxel, docetaxel + estramustine, mitoxantrone in the management of castration-resistant prostate cancer (CRPC). METHODS: Electronic databases including PubMed, Cochrance Library and Embase were searched for studies published from when the databases were established to January 1 s t, 2018. Randomized controlled trials (RCTs) that compared docetaxel + prednisone (DP), cabazitaxel + prednisone (CP), docetaxel + estramustine + prednisone (DEP), and mitoxantrone + cabazitaxel prednisone (MP) for CRPC treatment were identified...
June 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29906580/posterior-lumbar-interbody-fusion-vs-dynamic-hybrid-instrumentation-a-prospective-randomised-clinical-trial
#14
C Herren, M Simons, J Bredow, S Oikonomidis, L Westermann, R Sobottke, M J Scheyerer, M Pishnamaz, P Eysel, K Zarghooni, J Franklin, J Siewe
PURPOSE: The purpose of this study was to assess the radiological and clinical outcomes following lumbar fusion intervention and to compare both, the established posterior lumbar interbody fusion (PLIF)-technique and the dynamic hybrid instrumentation ('topping off'). METHODS: In this prospective randomised trial all patients presented with degenerative changes to the lumbar spine (L2-S1) were included and randomised in two groups: patients who underwent the 360°-fusion procedure in PLIF-technique (1, control group) and those patients who underwent fusion surgery with additional hybrid instrumentation (DTO, Zimmer, Inc...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29905899/efficacy-and-safety-of-aripiprazole-for-the-treatment-of-schizophrenia-an-overview-of-systematic-reviews
#15
REVIEW
Esther Letícia Amorim Ribeiro, Tácio de Mendonça Lima, Marcio Eduardo Bergamini Vieira, Sílvia Storpirtis, Patricia Melo Aguiar
PURPOSE: To conduct an overview to summarize the efficacy and safety of aripiprazole for the treatment of schizophrenia. METHODS: A literature search was performed in PubMed, the Cochrane Library, LILACS, and the Centre for Reviews and Dissemination, for articles published until March 31, 2017. We included systematic reviews with meta-analyses of randomized controlled trials assessing the efficacy, and/or the safety of aripiprazole, for patients with schizophrenia...
June 15, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29905893/s093-pneumatic-balloon-dilation-for-palliation-of-recurrent-symptoms-of-achalasia-after-esophagomyotomy
#16
Riley D Stewart, Jeffrey Hawel, Daniel French, Drew Bethune, James Ellsmere
BACKGROUND: Achalasia is a chronic disease affecting the myenteric plexus of the esophagus and lower esophageal sphincter. Treatment is aimed at palliating symptoms to improve quality of life. Treatment options for symptom relapse after esophagomyotomy include botox injection, repeat myotomy, per-oral endoscopic myotomy, or pneumatic balloon dilation (PBD). Data demonstrating the safety and efficacy of PBD for recurrence are scarce. With a lack of published data, guidelines have suggested avoiding PBD for recurrent achalasia because of concern for a high risk of perforation...
June 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29905881/initial-experience-of-endoscopic-radiofrequency-waves-delivery-to-the-lower-esophageal-sphincter-stretta-procedure-on-symptomatic-gastroesophageal-reflux-disease-post-sleeve-gastrectomy
#17
Nesreen Khidir, Luigi Angrisani, Jowhara Al-Qahtani, Sheraz Abayazeed, Moataz Bashah
BACKGROUND: Gastroesophageal reflux disease (GERD) occurs de novo or intensifies after sleeve gastrectomy (LSG). Endoscopic radiofrequency (Stretta) is a minimally invasive, effective tool to treat GERD. However, Stretta safety and efficacy are unknown in patients with GERD after LSG. To evaluate the safety and efficacy of Stretta treatment post-LSG GERD, quality of life, and PPI dose up to 6 months. METHODS: A retrospective review of all patients' data who underwent Stretta procedure in our center...
June 15, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29905627/priorities-related-to-improving-healthcare-safety-through-simulation
#18
John T Paige, Rollin J Terry Fairbanks, David M Gaba
Improving healthcare safety is a worthwhile and important endeavor. Simulation-based activities can help with such a goal through research and training. In this manner, it can focus on education and training, assessment and metrics, process improvement, and culture change to help move forward both patient safety and quality of care.This article will address the following three main topics: (1) designing simulation-based activities to promote high reliability in healthcare, (2) developing simulation-based activities to foster resilience in healthcare systems, and (3) evaluating the impact of adverse events in healthcare and how simulation-based activities can be used to determine and potentially to prevent their cause...
June 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29905624/a-modified-posterior-c1-c2-fusion-technique-for-the-management-of-traumatic-odontoid-type-ii-fractures-by-using-intraoperative-spinal-navigation-mid-term-results
#19
Basem Ishak, Till Schneider, Valerie Gimmy, Andreas W Unterberg, Karl L Kiening
OBJECTIVES: To assess mid-term safety and efficacy of a modified Goel-Harms technique for the treatment of odontoid instabilities. DESIGN: Longitudinal prospective cohort study. SETTING: Urban Level 1 Trauma Center in Southwest Germany. PATIENTS/PARTICIPANTS: Orthopaedic and neurosurgical trauma patients older than 18 years admitted for ≤ 24 hours. MAIN OUTCOME MEASUREMENTS: The outcome was evaluated with respect to neurological outcome, radiological outcome and surgical complications...
June 4, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29905384/clindamycin-phosphate-1-2-benzoyl-peroxide-3-fixed-dose-combination-gel-versus-topical-combination-therapy-of-adapalene-0-1-gel-and-clindamycin-phosphate-1-2-gel-in-the-treatment-of-acne-vulgaris-in-japanese-patients-a-multicenter-randomized-investigator-blind
#20
Nobukazu Hayashi, Ichiro Kurokawa, Obukohwo Siakpere, Akira Endo, Toshiki Hatanaka, Masahiro Yamada, Makoto Kawashima
Adapalene 0.1% (ADA) with clindamycin phosphate 1.2% (CLNP; ADA + CLNP) and the fixed-dose combination containing CLNP and benzoyl peroxide 3% (CLNP/BPO 3%) are strongly recommended for the early treatment of acne vulgaris in Japan. Here, we compare the early efficacy and safety of CLNP/BPO 3% with Japanese standard topical use of ADA + CLNP in the treatment of acne vulgaris. In this phase IV, multicenter study, 351 patients were randomized to receive CLNP/BPO 3% or ADA + CLNP for 12 weeks. The primary end-point was percentage change from baseline in total lesion (TL) counts at week 2...
June 15, 2018: Journal of Dermatology
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