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https://www.readbyqxmd.com/read/29691994/chemical-biochemical-preclinical-and-clinical-studies-of-ganoderma-lucidum-polysaccharide-as-an-approved-drug-for-treating-myopathy-and-other-diseases-in-china
#1
REVIEW
Pengjiao Zeng, Zhihua Guo, Xuan Zeng, Cui Hao, Yiran Zhang, Meng Zhang, Yong Liu, Hui Li, Juan Li, Lijuan Zhang
Ganoderma lucidum is an edible medicinal mushroom known as "Lingzhi" in China and "Reishi or Manetake" in Japan. It is a highly prized vitality-enhancing herb for more than 2000 years. G. lucidum polysaccharide (GLPS) has been identified as one of the major bioactive components and developed into a drug named "Ji 731 Injection" in China since 1973. The large-scale production of the drug began in 1985 and approved by the Chinese FDA as "Polysaccharidum of G. lucidum Karst Injection" (Ling Bao Duo Tang Zhu She Ye) in 2000, which is applied intramuscularly...
April 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29691974/aboriginal-experiences-of-cancer-and-care-coordination-lessons-from-the-cancer-data-and-aboriginal-disparities-candad-narratives
#2
Rachel Reilly, Jasmine Micklem, Paul Yerrell, David Banham, Kim Morey, Janet Stajic, Marion Eckert, Monica Lawrence, Harold B Stewart, Alex Brown
BACKGROUND: Aboriginal people with cancer experience worse outcomes than other Australians for a range of complex and interrelated reasons. A younger age at diagnosis, higher likelihood of more advanced cancer or cancer type with poorer prognosis, geographic isolation and cultural and language diversity mean that patient pathways are potentially more complex for Aboriginal people with cancer. In addition, variation in the quality and acceptability of care may influence cancer outcomes...
April 24, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29691938/hla-drb1-15-03-and-hla-drb1-11-useful-predictive-alleles-for-alloantibody-production-in-thalassemia-patients
#3
P Darvishi, Z Sharifi, A Azarkeivan, A Akbari, A A Pourfathollah
BACKGROUND AND OBJECTIVES: Recently, thalassemia has been introduced as a chronic disease. In spite of prolonging life in thalassemia patients, the quality of their life has not significantly improved. One of the challenges that makes their quality of life poor is alloimmunisation which causes several complications to patients by restricting their options. Some individuals are more susceptible to developing an alloantibody than others. They are categorised as responders and non-responders...
April 25, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29691265/effects-of-a-pharmacist-driven-intervention-program-on-hospital-readmissions
#4
Mariel T Shull, Leonard E Braitman, Shana D Stites, Angelo DeLuca, Deborah Hauser
PURPOSE: Results of a study to determine whether routine use of a multifaceted medication-focused intervention at a safety-net hospital was feasible and could reduce hospital readmissions in a Medicare fee-for-service population are reported. METHODS: A quality-improvement cohort study of 1,059 admissions of 667 patients at an inner-city hospital was conducted. Patients in the intervention groups received some or all components of the multifaceted "Medication REACH" intervention, with direct pharmacist involvement from admission through postdischarge aftercare...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29690950/safety-of-tracheal-intubation-in-the-presence-of-cardiac-disease-in-paediatric-icus
#5
Eleanor A Gradidge, Adnan Bakar, David Tellez, Michael Ruppe, Sarah Tallent, Geoffrey Bird, Natasha Lavin, Anthony Lee, Vinay Nadkarni, Michelle Adu-Darko, Jesse Bain, Katherine Biagas, Aline Branca, Ryan K Breuer, Calvin Brown, Kris Bysani, Guillaume Emeriaud, Sandeep Gangadharan, John S Giuliano, Joy D Howell, Conrad Krawiec, Jan Hau Lee, Simon Li, Keith Meyer, Michael Miksa, Natalie Napolitano, Sholeen Nett, Gabrielle Nuthall, Alberto Orioles, Erin B Owen, Margaret M Parker, Simon Parsons, Lee A Polikoff, Kyle Rehder, Osamu Saito, Ron C Sanders, Asha Shenoi, Dennis W Simon, Peter W Skippen, Keiko Tarquinio, Anne Thompson, Iris Toedt-Pingel, Karen Walson, Akira Nishisaki
IntroductionChildren with CHD and acquired heart disease have unique, high-risk physiology. They may have a higher risk of adverse tracheal-intubation-associated events, as compared with children with non-cardiac disease.Materials and methodsWe sought to evaluate the occurrence of adverse tracheal-intubation-associated events in children with cardiac disease compared to children with non-cardiac disease. A retrospective analysis of tracheal intubations from 38 international paediatric ICUs was performed using the National Emergency Airway Registry for Children (NEAR4KIDS) quality improvement registry...
April 25, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29690898/prevention-of-venous-thromboembolism-in-patients-undergoing-major-orthopedic-surgery-in-china-a-qualitative-study-of-patients-perceptions
#6
Yaping Xu, Jing Zhao, Yuzhao Chen
BACKGROUND: Venous thromboembolism (VTE) is the third leading cause of cardiovascular-associated death worldwide, and VTE prevention is one of the top patient safety strategies that hospitals can adopt. This study aimed to understand patients' perceptions of VTE prevention related to major orthopedic surgery in order to guide the clinical practice of medical staff and improve patient quality of life. Patients undergoing major orthopedic surgery should receive interventions to prevent VTE...
April 24, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29690853/rn-job-satisfaction-and-retention-after-an-interprofessional-team-intervention
#7
Dawon Baik, Brenda Zierler
Despite continuing interest in interprofessional teamwork to improve nurse outcomes and quality of care, there is little research that focuses on nurse job satisfaction and retention after an interprofessional team intervention. This study explored registered nurse (RN) job satisfaction and retention after a purposeful interprofessional team training and structured interprofessional bedside rounds were implemented. As part of a larger study, in this comparative cross-sectional study, pre- and post-intervention data on RN job satisfaction and turnover rate were collected and analyzed...
April 1, 2018: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29690788/reconciling-hospital-acquired-complications-and-chadx-in-victorian-coded-hospital-data
#8
Jennie Shepheard, Elsa Lapiz, Carla Read, Terri J Jackson
BACKGROUND: The Council of Australian Governments has focused the attention of health service managers and state health departments on a list of hospital-acquired complications (HACs) proposed as the basis of funding adjustments for poor quality of hospital inpatient care. These were devised for the Australian Commission on Safety and Quality in Health Care as a subset of their earlier classification of hospital-acquired complications (CHADx) and designed to be used by health services to monitor safety performance for their admitted patients...
January 1, 2018: Health Information Management: Journal of the Health Information Management Association of Australia
https://www.readbyqxmd.com/read/29689035/-biosimilars-italian-medicines-agency-takes-position
#9
Antonio Addis
The Italian Medicines Agency issued a new position paper on biosimilars that clarified several points regarding their correct use. This is a document that has the intent to promote the correct use and prescription of these medicines by answering some of the frequent questions coming from patients and prescribers. The debate surrounding the use of biosimilars is far from being concluded. However, some aspects, such as those regarding the quality, the safety and the efficacy of biosimilars, as well as the possibility of prescribe biosimilars not only to naïve patients naïve, it seems to be well supported...
April 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29688915/clinical-and-microbiological-effect-of-a-multispecies-probiotic-supplementation-in-celiac-patients-with-persistent-ibs-type-symptoms-a-randomized-double-blind-placebo-controlled-multicenter-trial
#10
Ruggiero Francavilla, Maria Piccolo, Antonio Francavilla, Lorenzo Polimeno, Francesco Semeraro, Fernanda Cristofori, Stefania Castellaneta, Michele Barone, Flavia Indrio, Marco Gobbetti, Maria De Angelis
GOALS: The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). BACKGROUND: About 30% of patients with CD adherent to a GFD suffer from IBS-type symptoms; a possible cause resides in the imbalances of the intestinal microbiota in CD. Probiotics may represent a potential treatment. STUDY: CD patients with IBS-type symptoms entered a prospective, double-blind, randomized placebo-controlled study...
April 23, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29688905/impact-of-adoption-of-a-comprehensive-electronic-health-record-on-nursing-work-and-caring-efficacy
#11
Elizabeth Schenk, Ruth Schleyer, Cami R Jones, Sarah Fincham, Kenn B Daratha, Karen A Monsen
Nurses in acute care settings are affected by the technologies they use, including electronic health records. This study investigated the impacts of adoption of a comprehensive electronic health record by measuring nursing locations and interventions in three units before and 12 months after adoption. Time-motion methodology with a handheld recording platform based on Omaha System standardized terminology was used to collect location and intervention data. In addition, investigators administered the Caring Efficacy Scale to better understand the effects of the electronic health record on nursing care efficacy...
April 23, 2018: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29688901/safety-and-efficacy-of-encapsulated-fecal-microbiota-transplantation-for-recurrent-clostridium-difficile-infection-a-systematic-review
#12
Umair Iqbal, Hafsa Anwar, Muhammad A Karim
BACKGROUND AND AIMS: Fecal microbial transplantation (FMT) has been shown to be effective for the treatment of recurrent clostridium difficile infection (CDI). The efficacy and safety of freeze-dried encapsulated FMT for the treatment of recurrent CDI is unclear. We performed a systematic review to evaluate and analyze the current evidence in this respect. MATERIALS AND METHODS: A systematic literature search was performed using the PubMed, Embase, and Medline databases until December 2017 to identify all original studies that investigated the role of administration of encapsulated FMT in recurrent CDI...
April 23, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29688579/evaluation-of-avoralstat-an-oral-kallikrein-inhibitor-in-a-phase-3-hereditary-angioedema-prophylaxis-trial-the-opus-2-study
#13
Marc A Riedl, Emel Aygören-Pürsün, James Baker, Henriette Farkas, John Anderson, Jonathan A Bernstein, Laurence Bouillet, Paula Busse, Michael Manning, Markus Magerl, Mark Gompels, Aarnoud P Huissoon, Hillary Longhurst, William Lumry, Bruce Ritchie, Ralph Shapiro, Daniel Soteres, Aleena Banerji, Mauro Cancian, Douglas T Johnston, Timothy J Craig, David Launay, H Henry Li, Myron Liebhaber, Timothy Nickel, Jacob Offenberger, William Rae, Rik Schrijvers, Massimo Triggiani, H James Wedner, Sylvia Dobo, Melanie Cornpropst, Desiree Clemons, Lei Fang, Phil Collis, William P Sheridan, Marcus Maurer
BACKGROUND: Effective inhibition of plasma kallikrein may have significant benefits for patients with hereditary angioedema due to deficiency of C1 inhibitor (C1-INH-HAE) by reducing the frequency of angioedema attacks. Avoralstat is a small molecule inhibitor of plasma kallikrein. This study (OPuS-2) evaluated the efficacy and safety of prophylactic avoralstat 300 or 500 mg compared with placebo. METHODS: OPuS-2 was a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study...
April 24, 2018: Allergy
https://www.readbyqxmd.com/read/29688202/-multicentre-observational-study-of-phlebodia-600-in-treatment-of-patients-with-ceap-class-c0-c3-chronic-venous-diseases
#14
Iu M Stoĭko, O B Talibov, M N Iashkin, M N Kudykin, S M Belentsov, O V Katel'nitskaia, I A Suchkov, V Iu Tolstikhin, A É Kletskin, K S Sevost'ianova
The purpose of the study was to evaluate efficacy of Diosmin (Phlebodia 600, Innothera, France) in treatment of patients presenting with class C0s-C3 chronic venous diseases (CVD) according to the CEAP classification. Presented herein are the results of a prospective observational study aimed at assessing the outcomes of two-month administration of Phlebodia 600 (600 mg diosmin) in patients suffering from class C0s-C3 CVD according to the CEAP classification. The study comprised a total of 868 patients, including 175 (20...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29688127/the-feasibility-of-a-randomised-controlled-trial-to-compare-the-cost-effectiveness-of-palliative-cardiology-or-usual-care-in-people-with-advanced-heart-failure-two-exploratory-prospective-cohorts
#15
Miriam J Johnson, Paula McSkimming, Alex McConnachie, Claudia Geue, Yvonne Millerick, Andrew Briggs, Karen Hogg
BACKGROUND: The effectiveness of cardiology-led palliative care is unknown; we have insufficient information to conduct a full trial. AIM: To assess the feasibility (recruitment/retention, data quality, variability/sample size estimation, safety) of a clinical trial of palliative cardiology effectiveness. DESIGN: Non-randomised feasibility. SETTING/PARTICIPANTS: Unmatched symptomatic heart failure patients on optimal cardiac treatment from (1) cardiology-led palliative service (caring together group) and (2) heart failure liaison service (usual care group)...
April 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29688112/protection-for-medication-induced-hearing-loss-the-state-of-the-science
#16
Tanisha L Hammill, Kathleen C Campbell
OBJECTIVE: This review will summarise the current state of development of pharmaceutical interventions (prevention or treatment) for medication-induced ototoxicity. DESIGN: Currently published literature was reviewed using PubMed and ClinicalTrials.gov to summarise the current state of the science. Details on the stage of development in the market pipeline are provided, along with evidence for clinical safety and efficacy reported. STUDY SAMPLE: This review includes reports from 44 articles and clinical trial reports regarding agents in clinical or preclinical trials, having reached approved Investigational New Drug status with the Federal Drug Administration...
April 24, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29687891/videolaryngoscopy-vs-fibreoptic-bronchoscopy-for-awake-tracheal-intubation-a-systematic-review-and-meta-analysis
#17
REVIEW
M Alhomary, E Ramadan, E Curran, S R Walsh
Awake fibreoptic intubation is often considered the technique of choice when a difficult airway is anticipated. However, videolaryngoscopes are being used more commonly. We searched the current literature and performed a meta-analysis to compare the use of videolaryngoscopy and fibreoptic bronchoscopy for awake tracheal intubation. Our primary outcome was the time needed to intubate the patient's trachea. Secondary outcomes included: failed intubation; the rate of successful intubation at the first attempt; patient-reported satisfaction with the technique; and any complications resulting from intubation...
April 17, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29687336/clinical-efficacy-and-safety-of-current-interventions-for-choroidal-neovascularization-associated-with-rare-diseases-a-systematic-literature-review
#18
REVIEW
Natalie Bennett, Lokho John, Nishkarsh Likhar, Rumjhum Agrawal, Winfried M Amoaku
INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia. METHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL. RESULTS: The search identified 5 RCTs; no relevant observational studies were identified...
April 23, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29686769/residents-ratings-of-their-clinical-supervision-and-their-self-reported-medical-errors-analysis-of-data-from-2009
#19
DeWitt C Baldwin, Steven R Daugherty, Patrick M Ryan, Nicholas A Yaghmour, Ingrid Philibert
Background : Medical errors and patient safety are major concerns for the medical and medical education communities. Improving clinical supervision for residents is important in avoiding errors, yet little is known about how residents perceive the adequacy of their supervision and how this relates to medical errors and other education outcomes, such as learning and satisfaction. Methods : We analyzed data from a 2009 survey of residents in 4 large specialties regarding the adequacy and quality of supervision they receive as well as associations with self-reported data on medical errors and residents' perceptions of their learning environment...
April 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29685872/comparative-effectiveness-of-a-technology-facilitated-depression-care-management-model-in-safety-net-primary-care-patients-with-type-2-diabetes-6-month-outcomes-of-a-large-clinical-trial
#20
Shinyi Wu, Kathleen Ell, Haomiao Jin, Irene Vidyanti, Chih-Ping Chou, Pey-Jiuan Lee, Sandra Gross-Schulman, Laura Myerchin Sklaroff, David Belson, Arthur M Nezu, Joel Hay, Chien-Ju Wang, Geoffrey Scheib, Paul Di Capua, Caitlin Hawkins, Pai Liu, Magaly Ramirez, Brian W Wu, Mark Richman, Caitlin Myers, Davin Agustines, Robert Dasher, Alex Kopelowicz, Joseph Allevato, Mike Roybal, Eli Ipp, Uzma Haider, Sharon Graham, Vahid Mahabadi, Jeffrey Guterman
BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers...
April 23, 2018: Journal of Medical Internet Research
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