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Patient Safety and Quality

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https://www.readbyqxmd.com/read/29058296/research-and-application-of-transnasal-transesophageal-echocardiography-probe
#1
Lei Wang, Jing Zhang, Shao-Ping Zheng, Lin He, Jing Wang, Xin-Fang Wang, Ming-Xing Xie
The intubation of conventional transesophageal echocardiography (TEE) probes into patients causes serious esophagus irritation, and thus the use of TEE probes in pediatric practice is limited. In this study, we aimed at the development of a special probe which could be inserted through the nasopharyngeal cavity into the esophagus to obtain the same high-quality echocardiography images as those obtained by conventional TEE and improve patients' experience. During the examination, the patients felt relaxed for a longer time and cooperated with the sonographers in the process of cardiac catheterization conducted in the surgery room or the intensive care unit (ICU), resulting in improved accuracy of the diagnosis and timely administration of appropriate treatment...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058279/comparison-of-treatment-outcomes-of-ticagrelor-and-clopidogrel-among-patients-undergoing-percutaneous-coronary-intervention-a-meta-analysis
#2
Jian Yang, Ping Zeng, Wan-Yin Cai
We performed a meta-analysis of randomized controlled trials (RCTs) to investigate the efficacy and safety of ticagrelor (TIC) vs. clopidogrel (CLO) in patients undergoing percutaneous coronary intervention (PCI). In Jun 2016, a literature search was started and all the studies were conducted from 2010 to 2015. We systematically searched the literature through the MEDLINE database, Cochrane library, and EMBASE database. Quality assessments were evaluated with Jadad quality scale. Data were extracted considering the characteristics of efficacy and safety designs...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058089/evidence-based-treatment-of-neurogenic-orthostatic-hypotension-and-related-symptoms
#3
REVIEW
Sabine Eschlböck, Gregor Wenning, Alessandra Fanciulli
Neurogenic orthostatic hypotension, postprandial hypotension and exercise-induced hypotension are common features of cardiovascular autonomic failure. Despite the serious impact on patient's quality of life, evidence-based guidelines for non-pharmacological and pharmacological management are lacking at present. Here, we provide a systematic review of the literature on therapeutic options for neurogenic orthostatic hypotension and related symptoms with evidence-based recommendations according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE)...
October 22, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29058038/drug-drug-interactions-and-their-harmful-effects-in-hospitalised-patients-a-systematic-review-and-meta-analysis
#4
REVIEW
Wu Yi Zheng, L C Richardson, L Li, R O Day, J I Westbrook, M T Baysari
PURPOSE: Drug-drug interactions (DDIs) are often avoidable and, if undetected, can lead to patient harm. This review aimed to determine the prevalence of potential DDIs (pDDIs), clinically relevant DDIs (DDIs that could lead to measurable patient harm, taking into account the patient's individual clinical profile) and DDIs that resulted in actual patient harm during hospitalisation. METHOD: Four databases were scanned for English papers published from 2000 to 2016...
October 23, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29057669/patient-reported-outcomes-in-moderate-to-severe-allergic-asthmatics-treated-with-omalizumab-a-systematic-literature-review-of-randomized-controlled-trials
#5
Jonathan Corren, Abhishek Kavati, Benjamin Ortiz, Ashok Vegesna, Jennifer A Colby, Kimberly Ruiz, Reynold A Panettieri
OBJECTIVE: Randomized controlled trials (RCTs) have established the safety and efficacy of omalizumab on clinical parameters, and have also evaluated its impact on patient-reported outcomes (PROs). The purpose of this systematic literature review was to review published data based on PRO endpoints in order to determine the benefit of omalizumab as add-on therapy to inhaled corticosteroids in patients with moderate-to-severe persistent allergic asthma. METHODS: A systematic literature review was conducted of reference databases and recent conferences...
October 23, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29057643/monotherapy-in-patients-with-type-2-diabetes-mellitus
#6
Sang Youl Rhee, Hyun Jin Kim, Seung-Hyun Ko, Kyu-Yeon Hur, Nan-Hee Kim, Min Kyong Moon, Seok-O Park, Byung-Wan Lee, Kyung Mook Choi, Jin Hwa Kim
In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain...
October 23, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29057583/a-medical-device-containing-purified-bovine-colostrum-monurelle-biogel-in-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-retrospective-analysis-of-urinary-symptoms-sexual-function-and-quality-of-life
#7
M C Schiavi, C Di Tucci, V Colagiovanni, P Faiano, A Giannini, O D'Oria, G Prata, G Perniola, M Monti, M A Zullo, L Muzii, P Benedetti Panici
OBJECTIVE: This study assessed the effectiveness and safety of a medical device containing purified bovine colostrum (Monurelle Biogel; Zambon, Bresso, Italy) in improving vulvovaginal atrophy (VVA), sexual function, urinary symptoms, and quality of life (QoL) in postmenopausal women. METHODS: In all, 172 postmenopausal women with VVA were included in the study. All women were treated with vaginal Monurelle Biogel daily for 12 weeks. Patients underwent clinical examinations, completed a 3-day voiding diary, and had VVA graded using the Vaginal Health Index (VHI) at baseline and 12 weeks...
October 23, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29057539/comparative-safety-of-systemic-and-low-bioavailability-steroids-in-inflammatory-bowel-disease-systematic-review-and-network-meta-analysis
#8
Stefanos Bonovas, Georgios K Nikolopoulos, Theodore Lytras, Gionata Fiorino, Laurent Peyrin-Biroulet, Silvio Danese
AIMS: Oral systemic corticosteroids have been used to induce remission in patients with active inflammatory bowel disease (IBD) for over 50 years; however, the wide array of adverse events (AEs) associated with these drugs prompted the development of steroid compounds with targeted delivery and low systemic bioavailability. This study assessed corticosteroids' comparative harm using network meta-analysis. METHODS: We searched PubMed, Scopus, Embase, the Cochrane Library, clinical trial registries, regulatory authorities' websites and major conference proceedings, through March 2017...
October 22, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29056973/rationale-and-design-of-the-first-double-blind-placebo-controlled-trial-with-allogeneic-adipose-tissue-derived-stromal-cell-therapy-in-patients-with-ischemic-heart-failure-a-phase-ii-danish-multicentre-study
#9
Jens Kastrup, Morten Schou, Ida Gustafsson, Olav W Nielsen, Rasmus Møgelvang, Klaus F Kofoed, Charlotte Kragelund, Jens Dahlgaard Hove, Andreas Fabricius-Bjerre, Merete Heitman, Mandana Haack-Sørensen, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Annette Ekblond
BACKGROUND: Ischemic heart failure (IHF) has a poor prognosis in spite of optimal therapy. We have established a new allogeneic Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors. It is produced without animal products, in closed bioreactor systems and cryopreserved as an off-the-shelf product ready to use. STUDY DESIGN: A multicentre, double-blind, placebo-controlled phase II study with direct intramyocardial injections of allogeneic CSCC_ASC in patients with chronic IHF...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29056888/effect-of-garlic-supplement-in-the-management-of-type-2-diabetes-mellitus-t2dm-a-meta-analysis-of-randomized-controlled-trials
#10
Juan Wang, Xiuming Zhang, Haili Lan, Weijia Wang
The present study was designed to systematically evaluate the clinical efficacy and safety of garlic supplement in the management of type 2 diabetes mellitus (T2DM). PubMed, EMBASE, the Cochrane Library, and China National Knowledge Internet (CNKI) were searched for relevant randomized controlled trials (RCTs) by using the terms garlic and T2DM up to April 2017. The quality of included RCTs was assessed by the Cochrane tool of risk of bias, and data of outcomes were pooled by REVMAN 5.3. Clinical factors were handled by meta-regression and subgroup analysis, and risk of publication bias was explored by inverted funnel plots...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29056859/efficacy-and-safety-of-transdermal-buprenorphine-versus-oral-tramadol-acetaminophen-in-patients-with-persistent-postoperative-pain-after-spinal-surgery
#11
Jae Hyup Lee, Jin-Hyok Kim, Jin-Hwan Kim, Hak-Sun Kim, Woo-Kie Min, Ye-Soo Park, Kyu-Yeol Lee, Jung-Hee Lee
PURPOSE: Control of persistent pain following spinal surgery is an unmet clinical need. This study compared the efficacy and safety of buprenorphine transdermal system (BTDS) to oral tramadol/acetaminophen (TA) in Korean patients with persistent, moderate pain following spinal surgery. METHODS: Open-label, interventional, randomized multicenter study. Adults with persistent postoperative pain (Numeric Rating Scale [NRS] ≥ 4 at 14-90 days postsurgery) were enrolled...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29056314/surgeon-variation-in-intraoperative-supply-cost-for-pancreaticoduodenectomy-is-intraoperative-supply-cost-associated-with-outcomes
#12
David G Brauer, Kerri A Ohman, David P Jaques, Cheryl A Woolsey, Ningying Wu, Jingxia Liu, Mb Majella Doyle, Ryan C Fields, William C Chapman, Steven S Strasberg, William G Hawkins
BACKGROUND: With increased scrutiny on the quality and cost of healthcare, surgeons must be mindful of their outcomes and resource utilization. We evaluated surgeon-specific intraoperative supply cost (ISC) for pancreaticoduodenectomy and examined whether ISC was associated with patient outcomes. STUDY DESIGN: Patients undergoing open pancreaticoduodenectomy between January 2012 and March 2015 were included. Outcomes were tracked prospectively through postoperative day 90...
October 19, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29056176/care-transitions-between-hospitals-and-skilled-nursing-facilities-perspectives-of-sending-and-receiving-providers
#13
Meredith Campbell Britton, Gregory M Ouellet, Karl E Minges, Marcie Gawel, Beth Hodshon, Sarwat I Chaudhry
BACKGROUND: One in four Medicare patients hospitalized for acute medical illness is discharged to a skilled nursing facility (SNF); 23% of these patients are readmitted to the hospital within 30 days. The care transition from hospital to SNF is often marked by disruptions in care and poor communication among hospital and SNF providers. A study was conducted to identify the perspectives of sending and receiving providers regarding care transitions between the hospital and the SNF. METHODS: Hospital (N = 25) and SNF (N = 16) providers participated in qualitative interviews assessing patient transfers and experiences with unplanned hospital readmissions...
November 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29055461/sativex-in-the-management-of-multiple-sclerosis-related-spasticity-an-overview-of-the-last-decade-of-clinical-evaluation
#14
REVIEW
Sabrina Giacoppo, Placido Bramanti, Emanuela Mazzon
BACKGROUND: Spasticity is a common symptom of multiple sclerosis (MS) affecting about 80% of MS patients. Numerous lines of evidence suggest that spasticity due to its complexity is not adequately managed with conventional anti-spastic therapies. Therefore, in order to improve the outcomes for the majority of MS patients, alternative approaches are needed to be discovered. Over the last years, the use of cannabinoid compounds as a potential treatment for MS-related symptoms has aroused great interest, owing to encouraging preclinical and clinical studies...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29054924/pharmacotherapy-for-patients-with-obesity
#15
REVIEW
Kishore M Gadde, John W Apolzan, Hans-Rudolf Berthoud
BACKGROUND: Although pharmacotherapy is not the cornerstone of obesity treatment, it is a valuable tool that could be considered for patients who have not had adequate benefit from lifestyle interventions or who have difficulty maintaining initial weight loss over longer periods. CONTENT: This review focuses on the role of antiobesity drugs, the mechanisms by which the drugs work, potential pharmacological targets in the neural control of food intake and regulation of body weight, the history of antiobesity drugs, a summary of efficacy and safety data from clinical trials, and the clinical application of pharmacotherapy...
October 20, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29054103/preparedness-education-in-the-baccalaureate-nursing-curriculum-an-authentic-clinical-experience
#16
Dawn M Bowker, Brandi J Tomlinson
Healthy People 2020 supports the preparation of nurse graduates to assess emergency preparedness needs of defined populations and includes preparedness as one of its objectives. Natural disaster preparedness is addressed through the lens of community-centered care that meets the Quality and Safety Education for Nurses domains of patient-centered care and teamwork and collaboration. This article discusses the development of an authentic clinical experience through collaboration between the American Red Cross and a baccalaureate nursing program...
November 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053490/paea-accreditation-task-force-briefing-paper-moving-toward-outcomes-based-accreditation
#17
Mary Jo Bondy, Sara Fletcher, Steven Lane
In anticipation of a revision to the Standards for Accreditation, the Phyisician Assistant Education Association (PAEA) charged a small task force to develop a strategy for engaging its members in the revision process. Rather than focusing on the current Standards, the task force members recommend a backward design approach to determine the desired outcomes of a successful revision to the Standards. Ultimately, the group believes that shifting to an outcomes-based model for accreditation will allow for greater innovation in physician assistant education and reduce the strain on programs facing resource limitations, particularly clinical site shortages...
October 19, 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29053070/relationship-between-patient-safety-indicator-events-and-comprehensive-stroke-center-volume-status-in-the-treatment-of-unruptured-cerebral-aneurysms
#18
Chad W Washington, L Ian Taylor, Robert J Dambrino, Paul R Clark, Gregory J Zipfel
OBJECTIVE The Agency of Healthcare Research and Quality (AHRQ) has defined Patient Safety Indicators (PSIs) for assessments in quality of inpatient care. The hypothesis of this study is that, in the treatment of unruptured cerebral aneurysms (UCAs), PSI events are less likely to occur in hospitals meeting the volume thresholds defined by The Joint Commission for Comprehensive Stroke Center (CSC) certification. METHODS Using the 2002-2011 National (Nationwide) Inpatient Sample, patients treated electively for a nonruptured cerebral aneurysm were selected...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29052117/clinical-impact-of-an-interdisciplinary-patient-safety-program-for-managing-drug-related-problems-in-a-long-term-care-hospital
#19
Oreto Ruiz-Millo, Mónica Climente-Martí, Ana María Galbis-Bernácer, José Ramón Navarro-Sanz
Background Medication reviews intended to identify drug-related problems (DRPs) have been researched in primary care, acute care and nursing homes rather than in long-term care hospitals (LTCHs). Objectives To assess the clinical impact of an interdisciplinary pharmacotherapy quality improvement and patient safety program in elderly patients with polypharmacy admitted to an LTCH. Setting An interventional, longitudinal, prospective study was conducted in a Spanish LTCH Method A total of 162 elderly (≥ 70 years) patients with polypharmacy (≥ 5 medications) were included...
October 19, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29052039/qualitative-evaluation-of-mobile-cancer-apps-with-particular-attention-to-the-target-group-content-and-advertising
#20
Cathleen Böhme, Marc Baron von Osthoff, Katrin Frey, Jutta Hübner
PURPOSE: Medical apps are gaining importance rapidly. Also in the field of cancer care, apps are offered. Yet, so far little is known with respect to their quality. METHODS: In a pilot phase we developed a rating tool based on formal and content-related criteria for the assessment of cancer apps. We used this instrument on cancer apps available in the App Store (iOS) concerning breast, prostate and colorectal cancer. The results were stratified according to target group, content and advertising...
October 19, 2017: Journal of Cancer Research and Clinical Oncology
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