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Duffy antigen

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https://www.readbyqxmd.com/read/27891625/validation-of-the-multiplex-ligation-dependent-probe-amplification-assay-and-its-application-on-the-distribution-study-of-the-major-alleles-of-17-blood-group-systems-in-chinese-donors-from-guangzhou
#1
Yanli Ji, Jizhi Wen, Barbera Veldhuisen, Lonneke Haer-Wigman, Zhen Wang, Martin Lodén-van Straaten, Ling Wei, Guangping Luo, Yongshui Fu, C Ellen van der Schoot
BACKGROUND: Genotyping platforms for common red blood cell (RBC) antigens have been successfully applied in Caucasian and black populations but not in Chinese populations. In this study, a genotyping assay based on multiplex ligation-dependent probe amplification (MLPA) technology was applied in a Chinese population to validate the MLPA probes. Subsequently, the comprehensive distribution of 17 blood group systems also was obtained. STUDY DESIGN AND METHODS: DNA samples from 200 Chinese donors were extracted and genotyped using the blood-MLPA assay...
November 27, 2016: Transfusion
https://www.readbyqxmd.com/read/27869196/t-cell-stimuli-independently-sum-to-regulate-an-inherited-clonal-division-fate
#2
J M Marchingo, G Prevedello, A Kan, S Heinzel, P D Hodgkin, K R Duffy
In the presence of antigen and costimulation, T cells undergo a characteristic response of expansion, cessation and contraction. Previous studies have revealed that population-level reproducibility is a consequence of multiple clones exhibiting considerable disparity in burst size, highlighting the requirement for single-cell information in understanding T-cell fate regulation. Here we show that individual T-cell clones resulting from controlled stimulation in vitro are strongly lineage imprinted with highly correlated expansion fates...
November 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27860263/activation-and-clustering-of-a-plasmodium-falciparum-var-gene-are-affected-by-subtelomeric-sequences
#3
Michael F Duffy, Jingyi Tang, Fransisca Sumardy, Hanh H T Nguyen, Shamista A Selvarajah, Gabrielle A Josling, Karen P Day, Michaela Petter, Graham V Brown
The P. falciparum var multigene family encodes the cytoadhesive, variant antigen PfEMP1. P. falciparum antigenic variation and cytoadhesion specificity are controlled by epigenetic switching between the single, or few, simultaneously expressed var genes. Most var genes are maintained in perinuclear clusters of heterochromatic telomeres. The active var gene(s) occupy a single, perinuclear var expression site. It is unresolved whether the var expression site forms in situ at a telomeric cluster or whether it is an extant compartment to which single chromosomes travel, thus controlling var switching...
November 18, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27814765/antibody-responses-to-the-full-length-var2csa-and-its-dbl-domains-in-cameroonian-children-and-teenagers
#4
Barriere A Y Fodjo, Njika Atemnkeng, Livo Esemu, Emile K Yuosembom, Isabella A Quakyi, Viviane H M Tchinda, Joseph Smith, Ali Salanti, Jude Bigoga, Diane W Taylor, Rose G F Leke, Anna Babakhanyan
BACKGROUND: Antigenic variation of Plasmodium falciparum erythrocyte membrane protein 1 is a key parasite mechanism for immune evasion and parasite survival. It is assumed that the number of parasites expressing the same var gene must reach high enough numbers before the host can produce detectable levels of antibodies (Ab) to the variant. VAR2CSA is a protein coded for by one of 60 var genes that is expressed on the surface of infected erythrocytes (IE) and mediates IE binding to the placenta...
November 4, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27798646/independent-origin-and-global-distribution-of-distinct-plasmodium-vivax-duffy-binding-protein-gene-duplications
#5
Jessica B Hostetler, Eugenia Lo, Usheer Kanjee, Chanaki Amaratunga, Seila Suon, Sokunthea Sreng, Sivanna Mao, Delenasaw Yewhalaw, Anjali Mascarenhas, Dominic P Kwiatkowski, Marcelo U Ferreira, Pradipsinh K Rathod, Guiyun Yan, Rick M Fairhurst, Manoj T Duraisingh, Julian C Rayner
BACKGROUND: Plasmodium vivax causes the majority of malaria episodes outside Africa, but remains a relatively understudied pathogen. The pathology of P. vivax infection depends critically on the parasite's ability to recognize and invade human erythrocytes. This invasion process involves an interaction between P. vivax Duffy Binding Protein (PvDBP) in merozoites and the Duffy antigen receptor for chemokines (DARC) on the erythrocyte surface. Whole-genome sequencing of clinical isolates recently established that some P...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27787763/duffy-blood-group-fy-a-fy-b-analysis-using-surface-plasmon-resonance
#6
Whui Lyn Then, Heather McLiesh, Marie-Isabel Aguilar, Gil Garnier
The most widely known blood groups, ABO and RhD, have been extensively observed as having strong antibody-antigen interactions during blood typing. However, not all interactions show the same binding affinity. The Duffy blood group system, where Fy(a) and Fy(b) antigens are the most clinically significant, are only available with an IgG antibody structure, and display weak binding interactions. While current blood typing techniques are well established, methods for quantifying the binding strength are more limited...
December 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27764243/correction-identification-of-novel-pre-erythrocytic-malaria-antigen-candidates-for-combination-vaccines-with-circumsporozoite-protein
#7
C Speake, A Pichugin, T Sahu, V Malkov, R Morrison, Y Pei, L Juompan, N Milman, S Zarling, C Anderson, N J MacDonald, S Wong-Madden, J Wendler, A Ishizuka, Z W MacMillen, V Garcia, S H Kappe, U Krzych, P E Duffy
[This corrects the article DOI: 10.1371/journal.pone.0159449.].
2016: PloS One
https://www.readbyqxmd.com/read/27759110/plasmodium-vivax-gpi-anchored-micronemal-antigen-pvgama-binds-human-erythrocytes-independent-of-duffy-antigen-status
#8
Yang Cheng, Feng Lu, Bo Wang, Jian Li, Jin-Hee Han, Daisuke Ito, Deok-Hoon Kong, Lubin Jiang, Jian Wu, Kwon-Soo Ha, Eizo Takashima, Jetsumon Sattabongkot, Jun Cao, Myat Htut Nyunt, Myat Phone Kyaw, Sanjay A Desai, Louis H Miller, Takafumi Tsuboi, Eun-Taek Han
Plasmodium vivax, a major agent of malaria in both temperate and tropical climates, has been thought to be unable to infect humans lacking the Duffy (Fy) blood group antigen because this receptor is critical for erythrocyte invasion. Recent surveys in various endemic regions, however, have reported P. vivax infections in Duffy-negative individuals, suggesting that the parasite may utilize alternative receptor-ligand pairs to complete the erythrocyte invasion. Here, we identified and characterized a novel parasite ligand, Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA), that bound human erythrocytes regardless of Duffy antigen status...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27717418/advances-in-blood-typing
#9
N Quraishy, S Sapatnekar
The clinical importance of blood group antigens relates to their ability to evoke immune antibodies that are capable of causing hemolysis. The most important antigens for safe transfusion are ABO and D (Rh), and typing for these antigens is routinely performed for patients awaiting transfusion, prenatal patients, and blood donors. Typing for other blood group antigens, typically of the Kell, Duffy, Kidd, and MNS blood groups, is sometimes necessary, for patients who have, or are likely to develop antibodies to these antigens...
2016: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/27711207/genetic-modifiers-of-white-blood-cell-count-albuminuria-and-glomerular-filtration-rate-in-children-with-sickle-cell-anemia
#10
Beverly A Schaefer, Jonathan M Flanagan, Ofelia A Alvarez, Stephen C Nelson, Banu Aygun, Kerri A Nottage, Alex George, Carla W Roberts, Connie M Piccone, Thad A Howard, Barry R Davis, Russell E Ware
Discovery and validation of genetic variants that influence disease severity in children with sickle cell anemia (SCA) could lead to early identification of high-risk patients, better screening strategies, and intervention with targeted and preventive therapy. We hypothesized that newly identified genetic risk factors for the general African American population could also impact laboratory biomarkers known to contribute to the clinical disease expression of SCA, including variants influencing the white blood cell count and the development of albuminuria and abnormal glomerular filtration rate...
2016: PloS One
https://www.readbyqxmd.com/read/27708211/can-mutations-in-the-gene-encoding-transcription-factor-eklf-erythroid-kr%C3%A3-ppel-like-factor-protect-us-against-infectious-and-parasitic-diseases
#11
Krzysztof Mikołajczyk, Radosław Kaczmarek, Marcin Czerwiński
Transcription factor EKLF (Erythroid Krüppel-Like Factor) belongs to the group of Krüppellike factors, which regulate proliferation, differentiation, development and apoptosis of mammalian cells. EKLF factor is present in erythroid cells, where it participates in regulation of hematopoiesis, expression of genes encoding transmembrane proteins (including blood group antigens), and heme biosynthesis enzymes. It is also a key factor in downregulation of γ-globins and activation of β-globin gene expression...
October 6, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27692771/identification-of-plasmodium-falciparum-reticulocyte-binding-protein-homologue-5-interacting-protein-pfripr-as-a-highly-conserved-blood-stage-malaria-vaccine-candidate
#12
Edward H Ntege, Nobuko Arisue, Daisuke Ito, Tomoyuki Hasegawa, Nirianne M Q Palacpac, Thomas G Egwang, Toshihiro Horii, Eizo Takashima, Takafumi Tsuboi
Genetic variability in Plasmodium falciparum malaria parasites hampers current malaria vaccine development efforts. Here, we hypothesize that to address the impact of genetic variability on vaccine efficacy in clinical trials, conserved antigen targets should be selected to achieve robust host immunity across multiple falciparum strains. Therefore, suitable vaccine antigens should be assessed for levels of polymorphism and genetic diversity. Using a total of one hundred and two clinical isolates from a region of high malaria transmission in Uganda, we analyzed extent of polymorphism and genetic diversity in four recently reported novel blood-stage malaria vaccine candidate proteins: Rh5 interacting protein (PfRipr), GPI anchored micronemal antigen (PfGAMA), rhoptry-associated leucine zipper-like protein 1 (PfRALP1) and Duffy binding-like merozoite surface protein 1 (PfMSPDBL1)...
September 28, 2016: Vaccine
https://www.readbyqxmd.com/read/27658563/microfluidic-enrichment-of-circulating-tumor-cells-in-patients-with-clinically-localized-prostate-cancer
#13
Tilman Todenhöfer, Emily Sunyong Park, Simon Duffy, Xiaoyan Deng, Chao Jin, Hamidreza Abdi, Hongshen Ma, Peter C Black
BACKGROUND: Circulating tumor cells (CTC) have become an important tool in the monitoring of patients with advanced prostate cancer (PC). The role of CTC in localized disease has been addressed by only few studies. However, results of CTC analyses are strongly dependent on the platform used for CTC enrichment and detection. In the present study, a microfluidic platform allowing for antigen-independent enrichment of CTC was investigated for its ability to detect CTC in patients with clinically localized PC...
September 19, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27624125/thrombin-cleavage-of-plasmodium-falciparum-erythrocyte-membrane-protein-1-inhibits-cytoadherence
#14
Mark R Gillrie, Bernard Renaux, Eleanor Russell-Goldman, Marion Avril, Andrew J Brazier, Koichiro Mihara, Enrico Di Cera, Danny A Milner, Morley D Hollenberg, Joseph D Smith, May Ho
UNLABELLED: Plasmodium falciparum malaria remains one of the most deadly infections worldwide. The pathogenesis of the infection results from the sequestration of infected erythrocytes (IRBC) in vital organs, including the brain, with resulting impairment of blood flow, hypoxia, and lactic acidosis. Sequestration occurs through the adhesion of IRBC to host receptors on microvascular endothelium by Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), a large family of variant surface antigens, each with up to seven extracellular domains that can bind to multiple host receptors...
September 13, 2016: MBio
https://www.readbyqxmd.com/read/27579291/toll-like-receptors-in-the-pathogenesis-of-autoimmune-diseases-recent-and-emerging-translational-developments
#15
REVIEW
Laura Duffy, Steven C O'Reilly
Autoinflammatory diseases are defined as the loss of self-tolerance in which an inflammatory response to self-antigens occurs, which are a significant global burden. Toll-like receptors are key pattern recognition receptors, which integrate signals leading to the activation of transcription factors and ultimately proinflammatory cytokines. Recently, it has become apparent that these are at the nexus of autoinflammatory diseases making them viable and attractive drug targets. The aim of this review was to evaluate the role of innate immunity in autoinflammatory conditions alongside the role of negative regulation while suggesting possible therapeutic targets...
2016: ImmunoTargets and Therapy
https://www.readbyqxmd.com/read/27578850/naturally-acquired-binding-inhibitory-antibodies-to-plasmodium-vivax-duffy-binding-protein-and-clinical-immunity-to-malaria-in-rural-amazonians
#16
Vanessa C Nicolete, Sarah Frischmann, Susana Barbosa, Christopher L King, Marcelo U Ferreira
BACKGROUND:  Antibodies to the cysteine-rich domain II of Plasmodium vivax Duffy binding protein (PvDBP) can inhibit binding of this parasite ligand to its receptor on red blood cells, the Duffy antigen/receptor for chemokines. These binding-inhibitory antibodies (BIAbs) also inhibit P. vivax invasion of reticulocytes in vitro. METHODS:  To investigate whether naturally acquired anti-PvDBP antibodies are associated with reduced risk of clinical malaria in a population exposed to low levels of P...
November 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27561786/irregular-antibodies-in-no-hemolytic-autoimmune-diseases-are-able-to-induce-erythrophagocytosis
#17
Paola Ester López-Díaz, María Del Rocío Ruiz-Olivera, Luis Alberto Hernández-Osorio, Jaime Vargas-Arzola, Xareni Valle-Jiménez, Sergio Roberto Aguilar-Ruiz, Honorio Torres-Aguilar
Irregular antibodies are produced by alloimmunization because of pregnancies or blood transfusions. They are called "irregular" due to target erythrocyte antigens from "rare blood systems," those different from the ABO system. Irregular antibodies have been widely investigated in immunohematology since their presence in blood donors may lead to difficulties in blood typing and in blood cross-matching, or to induce hemolytic transfusion reactions. Nevertheless, their incidence and participation in the physiopathology of autoimmune diseases have not been thoroughly studied...
August 25, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27555313/a-novel-erythrocyte-binding-protein-of-plasmodium-vivax-suggests-an-alternate-invasion-pathway-into-duffy-positive-reticulocytes
#18
Francis B Ntumngia, Richard Thomson-Luque, Letícia de Menezes Torres, Karthigayan Gunalan, Luzia H Carvalho, John H Adams
UNLABELLED: Erythrocyte invasion by malaria parasites is essential for blood-stage development and an important determinant of host range. In Plasmodium vivax, the interaction between the Duffy binding protein (DBP) and its cognate receptor, the Duffy antigen receptor for chemokines (DARC), on human erythrocytes is central to blood-stage infection. Contrary to this established pathway of invasion, there is growing evidence of P. vivax infections occurring in Duffy blood group-negative individuals, suggesting that the parasite might have gained an alternative pathway to infect this group of individuals...
2016: MBio
https://www.readbyqxmd.com/read/27442304/the-experience-of-extended-blood-group-genotyping-by-next-generation-sequencing-ngs-investigation-of-patients-with-sickle-cell-disease
#19
Y Fichou, M Mariez, C Le Maréchal, C Férec
BACKGROUND: Patients suffering from haemoglobinopathies may be treated by red blood cell (RBC) transfusion on a regular basis and then exposed to multiple antigens with a recurrent, potential risk of alloimmunization routinely prevented by extended RBC antigen cross-matching. While time-consuming and labour-intensive serological analyses are the gold standard for RBC typing, genotyping by current high-throughput molecular tools, including next-generation sequencing (NGS), appears to offer a potent alternative...
July 21, 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27434123/identification-of-novel-pre-erythrocytic-malaria-antigen-candidates-for-combination-vaccines-with-circumsporozoite-protein
#20
Cate Speake, Alexander Pichugin, Tejram Sahu, Vlad Malkov, Robert Morrison, Ying Pei, Laure Juompan, Neta Milman, Stasya Zarling, Charles Anderson, Sharon Wong-Madden, Jason Wendler, Andrew Ishizuka, Zachary W MacMillen, Valentino Garcia, Stefan H I Kappe, Urszula Krzych, Patrick E Duffy
Malaria vaccine development has been hampered by the limited availability of antigens identified through conventional discovery approaches, and improvements are needed to enhance the efficacy of the leading vaccine candidate RTS,S that targets the circumsporozoite protein (CSP) of the infective sporozoite. Here we report a transcriptome-based approach to identify novel pre-erythrocytic vaccine antigens that could potentially be used in combination with CSP. We hypothesized that stage-specific upregulated genes would enrich for protective vaccine targets, and used tiling microarray to identify P...
2016: PloS One
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