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Duffy antigen

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https://www.readbyqxmd.com/read/29044588/a-uniform-method-for-the-simultaneous-blood-group-phenotyping-of-fy-a-fy-b-jk-a-jk-b-s-s%C3%AC-p1-k-applying-lateral-flow-technique
#1
A Caesar, S Meyer, N Trost, K Neuenschwander, C Geisen, B M Frey, C Gassner, P Schwind
BACKGROUND AND OBJECTIVES: A lateral flow assay for simultaneous blood group typing of ABO, RhD, C, E, c, e, Cw and K with stable end-point and without centrifugation is in routine use since several years (MDmulticard(®) ). The typing of extended phenotype parameters belonging to the Duffy, Kidd, MNSs blood group systems and others, however, has not yet been demonstrated for this technique. Reliable detection of Fy(x) , a weak Fy(b) phenotype with a pronounced quantitative reduction of the number of Fy(b) antigens on the erythrocyte surface, remains a weakness of current serological blood grouping techniques...
October 16, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29043830/red-blood-cell-phenotype-prevalence-in-blood-donors-who-self-identify-as-hispanic
#2
Chelsea A Sheppard, Nicole L Bolen, Beth Eades, Gorka Ochoa-Garay, Mark H Yazer
Molecular genotyping platforms provide a quick, high-throughput method for identifying red blood cell units for patients on extended phenotype-matching protocols, such as those with sickle cell disease or thalassemia. Most of the antigen prevalence data reported are for non-Hispanic populations. Therefore, this study sought to determine the phenotype prevalence in a single blood center's Hispanic population and to compare those results with previously reported rates in non-Hispanic donor populations. We performed a retrospective review of all serologic and molecular typing from donors who self-reported as Hispanic...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29043827/stability-guidelines-for-dithiothreitol-treated-red-blood-cell-reagents-used-for-antibody-detection-methods-in-patients-treated-with-daratumumab
#3
Wendy L Disbro
Daratumumab (DARA), a drug used to treat patients with multiple myeloma, causes interference in pre-transfusion testing. Samples from patients receiving DARA exhibit panreactivity in antibody detection and identification tests with red blood cells (RBCs). Many hospitals are sending these samples to reference laboratories. Dithiothreitol (DTT), a sulfhydryl chemical treatment of RBCs, negates this reactivity. This study investigated the stability of the antigens on DTT-treated RBCs to determine if large quantities of RBCs could be treated at one time, stored, and used for testing at a later time...
September 2017: Immunohematology
https://www.readbyqxmd.com/read/29024716/accelerated-humoral-renal-allograft-rejection-due-to-hla-c14-mediated-allosensitization-to-hla-bw6
#4
Stephen P Persaud, Brian Duffy, Donna L Phelan, Thalachallour Mohanakumar, Rowena Delos Santos, Joseph P Gaut, Chang Liu
OBJECTIVES: To investigate immunological mechanisms underlying accelerated antibody-mediated rejection (AMR) of a living-related renal allograft in a patient with no detectable antibodies to donor human leukocyte antigens (HLA) in pre-transplant sera. METHODS: Pre- and post-transplant HLA antibody specificities were determined by single-antigen bead assay, and crossmatching was performed by flow cytometry- and complement-dependent cytotoxicity-based methods. Intermediate- and high-resolution HLA typing were performed by molecular methods...
October 9, 2017: Human Immunology
https://www.readbyqxmd.com/read/28924231/population-genomics-of-virulence-genes-of-plasmodium-falciparum-in-clinical-isolates-from-uganda
#5
Shazia Ruybal-Pesántez, Kathryn E Tiedje, Gerry Tonkin-Hill, Thomas S Rask, Moses R Kamya, Bryan Greenhouse, Grant Dorsey, Michael F Duffy, Karen P Day
Plasmodium falciparum causes a spectrum of malarial disease from asymptomatic to uncomplicated through to severe. Investigations of parasite virulence have associated the expression of distinct variants of the major surface antigen of the blood stages known as Pf EMP1 encoded by up to 60 var genes per genome. Looking at the population genomics of var genes in cases of uncomplicated malaria, we set out to determine if there was any evidence of a selective sweep of specific var genes or clonal epidemic structure related to the incidence of uncomplicated disease in children...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902417/genetic-variants-related-to-disease-susceptibility-and-immunotolerance-in-the-duffy-antigen-receptor-for-chemokines-darc-fy-gene-in-the-black-lion-tamarin-leontopithecus-chrysopygus-primates
#6
Ashley Ansel, James D Lewis, Don J Melnick, Cristiana Martins, Claudio Valladares-Padua, Beatriz Perez-Sweeney
The DARC (Duffy antigen receptor for chemokines) gene encodes the DARC protein, which serves multiple roles in the immune system, as a binding site for the malarial parasites Plasmodium vivax and Plasmodium knowlesi, a promiscuous chemokine receptor and a blood group antigen. Variation in DARC may play particularly significant roles in innate immunity, immunotolerance and pathogen entry in callitrichines, such as the black lion tamarin (Leontopithecus chrysopygus). We compared amino acid sequences of DARC in the black lion tamarin (BLT) to non-human Haplorhine primates and Homo sapiens...
October 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28875466/native-mass-spectrometry-ion-mobility-and-collision-induced-unfolding-categorize-malaria-antigen-antibody-binding
#7
Yining Huang, Nichole D Salinas, Edwin Chen, Niraj H Tolia, Michael L Gross
Plasmodium vivax Duffy Binding Protein (PvDBP) is a promising vaccine candidate for P. vivax malaria. Recently, we reported the epitopes on PvDBP region II (PvDBP-II) for three inhibitory monoclonal antibodies (2D10, 2H2, and 2C6). In this communication, we describe the combination of native mass spectrometry and ion mobility (IM) with collision induced unfolding (CIU) to study the conformation and stabilities of three malarial antigen-antibody complexes. These complexes, when collisionally activated, undergo conformational changes that depend on the location of the epitope...
November 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28854515/intravenous-immunoglobulin-in%C3%A2-the%C3%A2-management-of-a-rare-cause-of%C3%A2-hemolytic-disease-of-the-newborn-anti-sara-antibodies
#8
R Venkataraman, K Yusuf
Hemolytic disease of newborn (HDN) is a condition that develops in a fetus, when the IgG molecules produced by the mother pass through the placenta and attack the fetal red blood cells. HDN can occur due to Rh and ABO incompatibilities between the mother and the fetus as well as due to other allo-immune antibodies belonging to Kell (K and k), Duffy (Fya), Kidd (Jka and Jkb), and MNS (M, N, S, and s) systems. Role of intravenous immunoglobulin in management of HDN is not clear.SARA red blood cell antigen, first discovered in 1990 is a low frequency antigen...
August 23, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28833064/patterns-of-protective-associations-differ-for-antibodies-to-p-falciparum-infected-erythrocytes-and-merozoites-in-immunity-against-malaria-in-children
#9
Jo-Anne Chan, Danielle I Stanisic, Michael F Duffy, Leanne J Robinson, Enmoore Lin, James W Kazura, Christopher L King, Peter M Siba, Freya Ji Fowkes, Ivo Mueller, James G Beeson
Acquired antibodies play an important role in immunity to P. falciparum malaria and are typically directed towards surface antigens expressed by merozoites and infected erythrocytes (IEs). The importance of specific IE surface antigens as immune targets remains unclear. We evaluated antibodies and protective associations in two cohorts of children in Papua New Guinea. We used genetically-modified P. falciparum to evaluate the importance of PfEMP1 and a P. falciparum isolate with a virulent phenotype. Our findings suggested that PfEMP1 was the dominant target of antibodies to the IE surface, including functional antibodies that promoted opsonic phagocytosis by monocytes...
August 20, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28804644/a-malaria-vaccine-protects-aotus-monkeys-against-virulent-plasmodium-falciparum-infection
#10
Prakash Srinivasan, G Christian Baldeviano, Kazutoyo Miura, Ababacar Diouf, Julio A Ventocilla, Karina P Leiva, Luis Lugo-Roman, Carmen Lucas, Sachy Orr-Gonzalez, Daming Zhu, Eileen Villasante, Lorraine Soisson, David L Narum, Susan K Pierce, Carole A Long, Carter Diggs, Patrick E Duffy, Andres G Lescano, Louis H Miller
The Plasmodium falciparum protein, apical membrane antigen 1 forms a complex with another parasite protein, rhoptry neck protein 2, to initiate junction formation with the erythrocyte and is essential for merozoite invasion during the blood stage of infection. Consequently, apical membrane antigen 1 has been a target of vaccine development but vaccination with apical membrane antigen 1 alone in controlled human malaria infections failed to protect and showed limited efficacy in field trials. Here we show that vaccination with AMA1-RON2L complex in Freund's adjuvant protects Aotus monkeys against a virulent Plasmodium falciparum infection...
2017: NPJ Vaccines
https://www.readbyqxmd.com/read/28800732/the-duffy-binding-protein-pkdbp%C3%AE-ii-of-plasmodium-knowlesi-from-peninsular-malaysia-and-malaysian-borneo-show-different-binding-activity-level-to-human-erythrocytes
#11
Khai Lone Lim, Amirah Amir, Yee Ling Lau, Mun Yik Fong
BACKGROUND: The zoonotic Plasmodium knowlesi is a major cause of human malaria in Malaysia. This parasite uses the Duffy binding protein (PkDBPαII) to interact with the Duffy antigen receptor for chemokines (DARC) receptor on human and macaque erythrocytes to initiate invasion. Previous studies on P. knowlesi have reported distinct Peninsular Malaysia and Malaysian Borneo PkDBPαII haplotypes. In the present study, the differential binding activity of these haplotypes with human and macaque (Macaca fascicularis) erythrocytes was investigated...
August 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28771137/the-duffy-null-genotype-is-associated-with-a-lower-level-of-ccl2-leukocytes-and-neutrophil-count-but-not-with-the-clinical-outcome-of-htlv-1-infection
#12
Maria Clara Fernandes da Silva-Malta, Camila Campos Sales, Jacqueline Cronemberger Guimarães, Poliane de Cássia Gonçalves, Daniel Gonçalves Chaves, Hadassa Campos Santos, Alexandre da Costa Pereira, João Gabriel Ribas, Anna Bárbara de Freitas Carneiro-Proietti, Marina Lobato Martins
PURPOSE: Chemokines are important in the immune response against viral infections, and may play a role in human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis. Polymorphisms in the Duffy antigen receptor for chemokines (DARC), such as rs12075 (A>G; FY*B>FY*A) and rs281477 (-46T>C; GATA-1 box) may influence circulating concentrations of proinflammatory chemokines. We investigate whether Duffy genotypes influence the HTLV-1 proviral load (PVL) level, HTLV-1 infection outcome and chemokine concentrations in HTLV-1 asymptomatic carriers (AC=162), HAM/TSP patients (HAM=135) and seronegative individuals (SN=71)...
August 4, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28754683/darc-extracellular-domain-remodeling-in-maturating-reticulocytes-explains-plasmodium-vivax-tropism
#13
Elina Ovchynnikova, Francesca Aglialoro, Arthur E H Bentlage, Gestur Vidarsson, Nichole D Salinas, Marieke von Lindern, Niraj H Tolia, Emile van den Akker
Plasmodium vivax is the most prevalent parasite species that causes malaria in humans and exclusively infects reticulocytes. Reticulocyte infection is facilitated by P vivax Duffy binding protein (DBP), which utilizes DARC (Duffy antigen receptor for chemokines) as an entry point. However, the selective tropism of P vivax for transferrin receptor (CD71)-positive reticulocytes remained unexplained, given the constitutive expression of DARC during reticulocyte maturation. CD71/RNA double staining of reticulocytes enriched from adult peripheral blood reveals 4 distinct reticulocyte populations: CD71(high)/RNA(high) (∼0...
September 21, 2017: Blood
https://www.readbyqxmd.com/read/28720100/effect-of-seasonal-malaria-chemoprevention-on-the-acquisition-of-antibodies-to-plasmodium-falciparum-antigens-in-ouelessebougou-mali
#14
Almahamoudou Mahamar, Djibrilla Issiaka, Amadou Barry, Oumar Attaher, Adama B Dembele, Tiangoua Traore, Adama Sissoko, Sekouba Keita, Bacary Soumana Diarra, David L Narum, Patrick E Duffy, Alassane Dicko, Michal Fried
BACKGROUND: Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of full treatment courses of sulfadoxine-pyrimethamine plus amodiaquine to children at monthly intervals during the malaria season. However, it is not clear if there is a cumulative effect of SMC over time on acquisition of antibodies to malaria antigens. METHODS: A cross-sectional serosurvey was carried out 1 month after the last dose of SMC in 2016...
July 18, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28719950/isolation-and-characterization-of-vaccine-candidate-genes-including-csp-and-msp1-in-plasmodium-yoelii
#15
Seon-Hee Kim, Young-An Bae, Ju-Young Seoh, Hyun-Jong Yang
Malaria is an infectious disease affecting humans, which is transmitted by the bite of Anopheles mosquitoes harboring sporozoites of parasitic protozoans belonging to the genus Plasmodium. Despite past achievements to control the protozoan disease, malaria still remains a significant health threat up to now. In this study, we cloned and characterized the full-unit Plasmodium yoelii genes encoding merozoite surface protein 1 (MSP1), circumsporozoite protein (CSP), and Duffy-binding protein (DBP), each of which can be applied for investigations to obtain potent protective vaccines in the rodent malaria model, due to their specific expression patterns during the parasite life cycle...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28698207/strict-tropism-for-cd71-cd234-human-reticulocytes-limits-the-zoonotic-potential-of-plasmodium-cynomolgi
#16
Varakorn Kosaisavee, Rossarin Suwanarusk, Adeline C Y Chua, Dennis E Kyle, Benoit Malleret, Rou Zhang, Mallika Imwong, Rawiwan Imerbsin, Ratawan Ubalee, Hugo Sámano-Sánchez, Bryan K S Yeung, Jessica J Y Ong, Eric Lombardini, François Nosten, Kevin S W Tan, Pablo Bifani, Georges Snounou, Laurent Rénia, Bruce Russell
Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date, only a single case of naturally acquired P cynomolgi has been found in humans. In this study, we show that whereas P cynomolgi merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234)...
September 14, 2017: Blood
https://www.readbyqxmd.com/read/28662682/pooled-dna-sequencing-identifies-genomic-regions-of-selection-in-nigerian-isolates-of-plasmodium-falciparum
#17
Kolapo M Oyebola, Emmanuel T Idowu, Yetunde A Olukosi, Taiwo S Awolola, Alfred Amambua-Ngwa
BACKGROUND: The burden of falciparum malaria is especially high in sub-Saharan Africa. Differences in pressure from host immunity and antimalarial drugs lead to adaptive changes responsible for high level of genetic variations within and between the parasite populations. Population-specific genetic studies to survey for genes under positive or balancing selection resulting from drug pressure or host immunity will allow for refinement of interventions. METHODS: We performed a pooled sequencing (pool-seq) of the genomes of 100 Plasmodium falciparum isolates from Nigeria...
June 29, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28614791/human-vaccination-against-plasmodium-vivax-duffy-binding-protein-induces-strain-transcending-antibodies
#18
Ruth O Payne, Sarah E Silk, Sean C Elias, Kathryn H Milne, Thomas A Rawlinson, David Llewellyn, A Rushdi Shakri, Jing Jin, Geneviève M Labbé, Nick J Edwards, Ian D Poulton, Rachel Roberts, Ryan Farid, Thomas Jørgensen, Daniel Gw Alanine, Simone C de Cassan, Matthew K Higgins, Thomas D Otto, James S McCarthy, Willem A de Jongh, Alfredo Nicosia, Sarah Moyle, Adrian Vs Hill, Eleanor Berrie, Chetan E Chitnis, Alison M Lawrie, Simon J Draper
BACKGROUND: Plasmodium vivax is the most widespread human malaria geographically; however, no effective vaccine exists. Red blood cell invasion by the P. vivax merozoite depends on an interaction between the Duffy antigen receptor for chemokines (DARC) and region II of the parasite's Duffy-binding protein (PvDBP_RII). Naturally acquired binding-inhibitory antibodies against this interaction associate with clinical immunity, but it is unknown whether these responses can be induced by human vaccination...
June 15, 2017: JCI Insight
https://www.readbyqxmd.com/read/28599431/the-expression-of-duffy-antigen-receptor-for-chemokines-by-epithelial-ovarian-cancer-decreases-growth-potential
#19
Qinyi Zhu, Lu Jiang, Xipeng Wang
Epithelial ovarian cancer (EOC) is one of the main causes of cancer-associated mortality in females with gynecological malignancies. Duffy antigen receptor for chemokines (DARC) has previously been reported to be involved in tumor growth and the inhibition of tumor metastasis. However, the association between DARC and EOC remains unknown. The aim of the present study was to investigate the expression of DARC in the SKOV3 human epithelial ovarian cancer cell line with the establishment of a subcutaneous model in nude mice...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28587995/duffy-blood-group-system-new-genotyping-method-and-distribution-in-a-brazilian-extra-amazonian-population
#20
Marina Lobato Martins, Adão Rogerio da Silva, Hadassa Campos Santos, Michelle Teodoro Alves, Luciana Cayres Schmidt, Stela Brener Vertchenko, Luci Maria SantAna Dusse, Maria Clara Fernandes da Silva Malta
Duffy blood group system is of interest in several fields of science including transfusion medicine, immunology and malariology. Although some methods have been developed for Duffy polymorphism genotyping, not all of them have been sufficiently described and validated, and all present limitations. At the same time, the frequency of Duffy alleles and antigens in some densely populated regions of the world are still missing. In this study we present new tests for genotyping the major alleles of the Duffy blood system and describe Duffy alleles and antigens in blood donors and transfusion-dependent patients in Minas Gerais, Brazil...
October 2017: Molecular and Cellular Probes
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