keyword
https://read.qxmd.com/read/38502447/feto-maternal-interface-organ-on-chip-a-new-technology-to-study-ascending-infection
#21
JOURNAL ARTICLE
Giovana Fernanda Cosi Bento, Márcia Guimarães da Silva, Ramkumar Menon, Lauren S Richardson
Modeling human pregnancy is challenging as two subjects, the mother and fetus, must be evaluated in tandem. To understand pregnancy, parturition, and adverse pregnancy outcomes, the two feto-maternal interfaces (FMi) that form during gestation (i.e., the placenta and fetal membrane) need to be investigated to understand their biological roles, and organ dysfunction can lead to adverse outcomes. Adverse pregnancy outcomes such as preterm rupture of the membranes, spontaneous preterm birth, preeclampsia, intra-uterine growth restriction, and gestational diabetes rates are on the rise worldwide, highlighting the need for future studies and a better understanding of molecular and cellular pathways that contribute to disease onset...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38501507/detection-of-insulin-oligomeric-forms-by-a-novel-surface-plasmon-resonance-diffusion-coefficient-based-approach
#22
JOURNAL ARTICLE
Damiano Calcagno, Maria Luisa Perina, Gabriele Antonio Zingale, Irene Pandino, Nunzio Tuccitto, Valentina Oliveri, Maria Cristina Parravano, Giuseppe Grasso
Insulin is commonly used to treat diabetes and undergoes aggregation at the site of repeated injections in diabetic patients. Moreover, aggregation is also observed during its industrial production and transport and should be avoided to preserve its bioavailability to correctly adjust glucose levels in diabetic patients. However, monitoring the effect of various parameters (pH, protein concentration, metal ions, etc.) on the insulin aggregation and oligomerization state is very challenging. In this work, we have applied a novel Surface Plasmon Resonance (SPR)-based experimental approach to insulin solutions at various experimental conditions, monitoring how its diffusion coefficient is affected by pH and the presence of metal ions (copper and zinc) with unprecedented sensitivity, precision, and reproducibility...
April 2024: Protein Science
https://read.qxmd.com/read/38501359/the-effect-and-mechanism-of-liraglutide-on-the-biological-functions-of-bmscs-in-diabetic-patients
#23
JOURNAL ARTICLE
Yao Wang, Yujie Sun, Bo Yang, Jun Li, Chao Liang
OBJECTIVES: To investigate the effect of liraglutide on osteogenesis in human alveolar bone marrow mesenchymal stem cells (BMSCs) and the influence of liraglutide on implant-bone integration in rats with T2DM. SUBJECTS AND METHODS: Extracting BMSCs from the alveoli of diabetic patients treated with insulin. BMSCs were treated with different concentrations of liraglutide. Osteogenesis and the underlying mechanism were investigated via ALP detection, ALP staining, Alizarin Red S staining, Western blotting, and RT-PCR...
March 19, 2024: Oral Diseases
https://read.qxmd.com/read/38501225/bbr-affects-macrophage-polarization-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-to-protect-against-t2dm-associated-periodontitis
#24
JOURNAL ARTICLE
Siying Xia, Rui Jing, Mingyan Shi, Yanan Yang, Meiting Feng, Li Deng, Lijun Luo
BACKGROUND AND OBJECTIVE: Periodontitis is intimately associated with the development of various systemic diseases, among which type 2 diabetes mellitus (T2DM) has a bidirectional relationship with the pathogenesis of periodontitis. The objective of the present work was to investigate the role of berberine (BBR) in periodontitis with T2DM and related mechanisms. METHODS: The mRNA expression of macrophage polarization-related factors in the microenvironment of periodontal inflammation was detected using real-time quantitative PCR (RT-qPCR)...
March 19, 2024: Journal of Periodontal Research
https://read.qxmd.com/read/38497512/the-association-between-metformin-use-and-new-onset-icd-coding-of-geographic-atrophy
#25
JOURNAL ARTICLE
John Moir, Max J Hyman, Reem Gonnah, Andrea Flores, Seenu M Hariprasad, Dimitra Skondra
PURPOSE: Metformin has been suggested to protect against the development of age-related macular degeneration (AMD) in multiple observational studies. However, the association between metformin and geographic atrophy (GA), a debilitating subtype of AMD, has not been analyzed. METHODS: We conducted a case-control study of patients ages 60 years and older with new-onset International Classification of Diseases (ICD) coding of GA in the Merative MarketScan Commercial and Medicare Databases between 2017 and 2021...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38495785/associations-between-type-2-diabetes-mellitus-and-chronic-liver-diseases-evidence-from-a-mendelian-ranldomization-study-in-europeans-and-east-asians
#26
JOURNAL ARTICLE
Yue Zhao, Di Li, Hanyu Shi, Wei Liu, Jiaojiao Qiao, Shanfu Wang, Yiwei Geng, Ruiying Liu, Feng Han, Jia Li, Wei Li, Fengyun Wu
OBJECTIVE: Multiple observational studies have demonstrated an association between type 2 diabetes mellitus (T2DM) and chronic liver diseases (CLDs). However, the causality of T2DM on CLDs remained unknown in various ethnic groups. METHODS: We obtained instrumental variables for T2DM and conducted a two-sample mendelian randomization (MR) study to examine the causal effect on nonalcoholic fatty liver disease (NAFLD), hepatocellular carcinoma (HCC), viral hepatitis, hepatitis B virus (HBV) infection, and hepatitis C virus (HCV) infection risk in Europeans and East Asians...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38494538/aerobic-training-with-moderate-or-high-doses-of-vitamin-d-improve-liver-enzymes-lxr%C3%AE-and-pgc-1%C3%AE-levels-in-rats-with-t2dm
#27
JOURNAL ARTICLE
Zahra Hoseini, Nasser Behpour, Rastegar Hoseini
Dysregulation of key transcription factors involved in hepatic energy metabolism, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and liver X receptor alpha (LXRα), has been observed in T2DM. The present study aims to investigate the effects of aerobic training and vitamin D supplementation on liver enzyme levels and the levels of PGC-1α and LXRα proteins in hepatocytes, in a rat model of T2DM. The study involved 56 male Wistar rats, divided into two groups: one was non-diabetic and acted as a control group (n = 8), and the other had induced diabetes (n = 48)...
March 17, 2024: Scientific Reports
https://read.qxmd.com/read/38493698/elevated-expression-of-lcn13-through-fxr-activation-ameliorates-hepatocellular-lipid-accumulation-and-inflammation
#28
JOURNAL ARTICLE
Xingliang Qin, Yongyao Tan, Weishu Ren, Weiwei Zhou, Rouxi Niu, Linyue Liang, Jinling Li, Kaiyuan Cao, Guohong Wei, Xun Zhu, Mingxing Huang
BACKGROUND: Lipocalin 13 (LCN13) is a member of the lipocalin family that consists of numerous secretory proteins. LCN13 high-expression has been reported to possess anti-obesity and anti-diabetic effects. Although metabolic dysfunction-associated steatotic liver diseases (MASLD) including metabolic dysfunction-associated steatohepatitis (MASH) are frequently associated with obesity and insulin resistance, the functional role of endogenous LCN13 and the therapeutic effect of LCN13 in MASH and related metabolic deterioration have not been evaluated...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38490331/new-onset-diabetes-after-kidney-transplantation-assessing-urinary-wilm-s-tumor-1-protein-to-predict-renal-allograft-dysfunction
#29
JOURNAL ARTICLE
César Endrigo Silva de Andrade, Karla Simone Costa de Souza, Ony Araújo Galdino, Mabelle Alves Ferreira de Lima, Paulo José de Medeiros, Marcela Abbott Galvão Ururahy, Maurício Galvão Pereira, José Bruno de Almeida, Adriana Augusto de Rezende
PURPOSE: New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication associated with podocyte damage and renal allograft dysfunction. Thus, Wilm's tumor-1 (WT-1) protein, as a podocyte marker, holds promise as an option to evaluate renal allograft dysfunction in NODAT. Therefore, the study aimed to investigate urinary WT-1 levels in NODAT patients during the first year after kidney transplantation (KTx). MATERIALS AND METHODS: KTx patients were categorized into non-NODAT and NODAT groups...
March 13, 2024: Advances in Medical Sciences
https://read.qxmd.com/read/38489707/intensity-of-statin-therapy-and-primary-prevention-of-cardiovascular-in-korean-patients-with-dyslipidemia
#30
JOURNAL ARTICLE
Sun Ok Song, Min Jin Kang, Sunghwan Suh
This study aimed to investigate the association between the intensity of statin therapy and the development of cardiovascular disease (CVD) and diabetes in individuals without prior diabetes who were being treated for dyslipidemia with statins for the primary prevention of CVD, using the National Health Insurance Service-Health Screening database. The database is a longitudinal cohort study of Korean men and women 40 years of age or older who underwent comprehensive biannual screening health examinations by Korean National Health Insurance Service from January 1, 2002, to December 31, 2015...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489223/adaptive-responses-of-the-ileum-of-nod-mice-to-low-dose-fluoride-a-proteomic-exploratory-study
#31
JOURNAL ARTICLE
Juliana S Trevizol, Nathalia R Buzalaf, Aline Dionizio, Aislan Q Delgado, João P Z de Lara, Ana C Magalhães, José R Bosqueiro, Marília A R Buzalaf
Fluoride (F) has been employed worldwide to control dental caries. More recently, it has been suggested that the consumption of low doses of F in the drinking water may reduce blood glucose levels, introducing a new perspective for the use of F for the management of blood glucose. However, the exact mechanism by which F affects blood glucose levels remains largely unexplored. Given that the small gut plays a pivotal role in glucose homeostasis, the aim of this study was to investigate the proteomic changes induced by low doses of F in the ileum of female nonobese-diabetic (NOD) mice...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38488826/the-tao-hong-si-wu-decoction-ameliorates-diabetes-associated-cognitive-dysfunction-by-inhibiting-the-formation-of-amyloid-plaques
#32
JOURNAL ARTICLE
Ming Cai, Zhen Chen, Mengling Zhang, Wenwen Xia, Wentao Dai, Mengdie Zhao, Ruonan Xie, Zhaojie Ji, Lan Han, Daiyin Peng
OBJECTIVES: The herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment of cognitive impairment. However, the underlying mechanisms of THSWD in treating diabetes-associated cognitive dysfunction (DACD) are not entirely explored. This study is aimed to investigate the therapeutic effects of THSWD in DACD model rats and the underlying mechanism. METHODS: Ultra-high-phase liquid chromatography was employed to identify the main compounds contained in the THSWD extract...
March 2024: International Journal of Geriatric Psychiatry
https://read.qxmd.com/read/38488565/global-trends-in-diabetic-eye-disease-research-from-2012-to-2021
#33
JOURNAL ARTICLE
Yuan Yuan, Shangli Ji, Yali Song, Zhaodi Che, Lu Xiao, Shibo Tang, Jia Xiao
JOURNAL/nrgr/04.03/01300535-202410000-00032/figure1/v/2024-02-06T055622Z/r/image-tiff Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries--the United States, China, Japan, the United Kingdom, Spain, Germany, and France--by searching for all global diabetic eye disease journal articles in the Web of Science and PubMed databases, all global registered clinical trials in the ClinicalTrials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38483115/potassium-competitive-acid-blockers-and-acid-related-disorders
#34
JOURNAL ARTICLE
Kevin Z Huang, H Christian Weber
PURPOSE OF THE REVIEW: Potassium-competitive acid blockers (PCABs) represent a new class of compounds for the treatment of acid-related disorders. Recent FDA approval of the PCAB vonoprazan for erosive esophagitis has started an important new approach to acid-related disorders. RECENT FINDINGS: Compared to conventional proton pump inhibitors (PPIs), PCABs provide more rapid, potent, and sustained suppression of gastric acid with faster and more durable symptom relief...
March 15, 2024: Current Opinion in Endocrinology, Diabetes, and Obesity
https://read.qxmd.com/read/38482238/regional-delivery-of-mesothelin-targeted-chimeric-antigen-receptor-t-cell-effectively-and-safely-targets-colorectal-cancer-liver-metastases-in-mice
#35
JOURNAL ARTICLE
Xin Zhou, Minjie Yang, Jiaze Yu, Jingwen Tan, Nan Xu, Yongjie Zhou, Wen Zhang, Jingqin Ma, Zihan Zhang, Alex Friedlaender, Justin Taylor, Lei Yu, Zhiping Yan
BACKGROUND: Liver metastasis is the major cause of colorectal cancer related death. Mesothelin (MSLN)-targeted chimeric antigen receptor (CAR) T-cell therapy has been illustrated effective and safe through regional delivery of breast cancer, ovarian cancer and malignant mesothelioma tumors. Herein, we investigated the safety, efficacy, and immune microenvironment of regional delivery of MSLN (CAR) T-cell in the treatment of colorectal carcinoma liver metastases (CRLM). METHODS: Second-generation MSLN CAR T-cells were administered by portal vein (PV) or caudal vein (CV, systemic administration) delivery in an orthotopic MSLN+ CRLM nonobese diabetic (NOD)/severe combined immunodeficient (SCID)/γc-/- (NSG) mouse model...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38482058/-in-vitro-and-in-silico-studies-reveal-antidiabetic-properties-of-arylbenzofurans-from-the-root-bark-of-morus-mesozygia-stapf
#36
JOURNAL ARTICLE
Katherine Olabanjo Olufolabo, Kai Lüersen, Samuel Ayoolu Oguntimehin, Vaderament-A Nchiozem-Ngnitedem, Emmanuel Ayodeji Agbebi, Kolade Olatubosun Faloye, Divinah Kwamboka Nyamboki, Gerald Rimbach, Josphat Clement Matasyoh, Bernd Schmidt, Jones Olanrewaju Moody
Diabetes remains an important disease worldwide with about 500 million patients globally. In tropical Africa, Morus mesozygia is traditionally used in the treatment of diabetes. Biological and phytochemical investigation of the root bark extracts of the plant led to the isolation of a new prenylated arylbenzofuran named 7-(3-hydroxy-3-methylbutyl)moracin M ( 1 ) and two congeners, moracins P ( 2 ) and M ( 3 ). When compared to acarbose (IC50 = 486 µM), all the isolated compounds are better inhibitors of α-glucosidase with in vitro IC50 values of 16...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38481963/modifying-tacrolimus-related-toxicity-after-liver-transplantation-comparing-life-cycle-pharma-tacrolimus-versus-extended-released-tacrolimus-a-multicenter-randomized-controlled-trial
#37
JOURNAL ARTICLE
Midas B Mulder, Bart van Hoek, Wojtek G Polak, Ian P J Alwayn, Brenda C M de Winter, Sarwa Darwish Murad, Elke Verhey-Hart, Lara Elshove, Nicole S Erler, Dennis A Hesselink, Caroline M den Hoed, Herold J Metselaar
BACKGROUND: The aim of this open-label, multicenter, randomized controlled study was to investigate whether the life cycle pharma (LCP)-tacrolimus compared with the extended-release (ER)-tacrolimus formulation results in a difference in the prevalence of posttransplant diabetes, hypertension and chronic kidney disease (CKD) at 12 mo after liver transplantation. METHODS: Patients were 1:1 randomized to either of the 2 tacrolimus formulations. The primary endpoint was defined as a composite endpoint of any of 3 events: sustained (>3 mo postrandomization) posttransplant diabetes, new-onset hypertension, and/or CKD, defined as estimated glomerular filtration rate <60 mL/min/1...
April 2024: Transplantation Direct
https://read.qxmd.com/read/38480757/ksrp-improves-pancreatic-beta-cell-function-and-survival
#38
JOURNAL ARTICLE
Leticia Barssotti, Gabriela Moreira Soares, Emílio Marconato-Júnior, Bruna Lourençoni Alves, Kênia Moreno Oliveira, Everardo Magalhães Carneiro, Antonio Carlos Boschero, Helena Cristina Lima Barbosa
Impaired insulin production and/or secretion by pancreatic beta cells can lead to high blood glucose levels and type 2 diabetes (T2D). Therefore, investigating new proteins involved in beta cell response to stress conditions could be useful in finding new targets for therapeutic approaches. KH-type splicing regulatory protein (KSRP) is a protein usually involved in gene expression due to its role in post-transcriptional regulation. Although there are studies describing the important role of KSRP in tissues closely related to glucose homeostasis, its effect on pancreatic beta cells has not been explored so far...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38478089/aortic-regurgitation-is-associated-with-african-american-and-asian-race-smoking-renal-disease-and-numerous-autoimmune-diseases-in-addition-to-traditional-cardiovascular-risk-factors%C3%A2-but-has%C3%A2-lower-risk-with-alcohol-intake
#39
JOURNAL ARTICLE
Brandon Timmerman, Mehrtash Hashemzadeh, Mohammad Reza Movahed
BACKGROUND: Aortic regurgitation (AR) is associated with increasing age, rheumatic heart disease, and a bicuspid aortic valve, but its association with other comorbidities and race is less known. The purpose of this study was to investigate any association between AR and comorbid conditions in older adults above 40. METHOD: The large Nationwide Inpatient Sample database was utilized for our study using uni- and multivariate analysis. Data were extracted from available ICD-10 codes for the years of 2016-2020...
March 13, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/38477183/oral-or-injectable-semaglutide-for-the-management-of-type-2-diabetes-in-routine-care-a-multicentre-observational-study-comparing-matched-cohorts
#40
JOURNAL ARTICLE
Gian Paolo Fadini, Benedetta Maria Bonora, Mariangela Ghiani, Roberto Anichini, Elena Melchionda, Bruno Fattor, Stefano Fazion, Giancarla Meregalli, Andrea Giaccari, Angelo Avogaro, Agostino Consoli
AIM: To investigate the real-world utilization and comparative clinical outcomes of injectable and oral semaglutide in individuals with type 2 diabetes (T2D) with the aim of enhancing understanding of the practical implications associated with choosing between these formulations. METHODS: New users of oral or injectable semaglutide were selected from a cohort of 14 079 initiators of glucagon-like peptide-1 receptor agonists. Propensity-score matching (PSM) was employed to create balanced groups, ensuring comparability...
March 13, 2024: Diabetes, Obesity & Metabolism
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