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https://www.readbyqxmd.com/read/29327997/mechanical-thrombectomy-in-basilar-artery-occlusion-influence-of-reperfusion-on-clinical-outcome-and-impact-of-the-first-line-strategy-adapt-vs-stent-retriever
#1
Benjamin Gory, Mikael Mazighi, Raphael Blanc, Julien Labreuche, Michel Piotin, Francis Turjman, Bertrand Lapergue
OBJECTIVE Several randomized trials have been focused on patients with anterior circulation stroke, whereas few data on posterior circulation stroke are available. Thus, new mechanical thrombectomy (MT) strategies, including a direct-aspiration first-pass technique (ADAPT), remain to be evaluated in basilar artery occlusion (BAO) patients. The authors here assessed the influence of reperfusion on outcome in BAO patients and examined whether ADAPT improves the reperfusion rate compared with stent retriever devices...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29327164/incremental-predictive-value-of-carotid-arterial-strain-in-patients-with-stroke
#2
Woo-In Yang, Ki-Woon Kang, Hye Young Lee, Chi-Young Shim, Geu-Ru Hong, Namsik Chung, Jong-Won Ha
Although increased carotid intima-media thickness (IMT) is a well-known risk factor for stroke, carotid IMT alone is not sufficient for risk stratification. The assessment of arterial properties using velocity vector imaging (VVI) represents a new method for quantifying structural changes. We sought to investigate the characteristics and the clinical value of carotid arterial mechanics using VVI in patients with stroke. Fifty male patients (55 ± 5 years) with stroke, 30 healthy age-matched volunteers (54 ± 8 years), and 30 healthy young male volunteers (29 ± 5 years) were evaluated...
January 11, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29322938/mdd-carb-a-combinatorial-model-for-the-identification-of-protein-carbonylation-sites-with-substrate-motifs
#3
Hui-Ju Kao, Shun-Long Weng, Kai-Yao Huang, Fergie Joanda Kaunang, Justin Bo-Kai Hsu, Chien-Hsun Huang, Tzong-Yi Lee
BACKGROUND: Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is related to a number of metabolic or aging diseases including diabetes, chronic lung disease, Parkinson's disease, and Alzheimer's disease. Due to the lack of computational methods dedicated to exploring motif signatures of protein carbonylation sites, we were motivated to exploit an iterative statistical method to characterize and identify carbonylated sites with motif signatures...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29318388/h-atpase-blockade-reduced-renal-gluconeogenesis-and-plasma-glucose-in-a-diabetic-rat-model
#4
Akihiro Tojo, Saaya Hatakeyama, Masaomi Nangaku, Toshihiko Ishimitsu
Vacuolar H+-adenosine triphosphatase (ATPase) plays important roles in urinary acid excretion, vesicular acidification to activate enzymes, and the membrane recycling of transporters in the kidney. As acidosis stimulates renal gluconeogenesis, we investigated the effect of blockade of H+-ATPase on renal gluconeogenesis in diabetic rats. Diabetes mellitus was induced by a single injection of streptozotocin, and a group of DM rats was treated with bafilomycin B1 intraperitoneally for 8 days. In diabetic rats, the renal expression and activity of H+-ATPase were increased with elevated urinary ammonium excretion...
January 9, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29313726/development-and-characterization-of-a-novel-congenic-rat-strain-for-obesity-and-cancer-research
#5
Ann Marie O'Neill, Erin A Gillaspie, Christine M Burrington, Darin T Lynch, Robert T Dauchy, David E Blask, Paul C Tirrell, Brian A Reis, Melissa J Horsman, Michael W Greene
The association between a Western Diet and colon cancer suggests that dietary factors and/or obesity may contribute to cancer progression. Our objective was to develop a new animal model of obesity and the associated pathophysiology to investigate human cancer independent of dietary components that induce obesity. A novel congenic rat strain was established by introducing the fa allele from the Zucker rat into the Rowett Nude rat to generate a "fatty nude rat". The obese phenotype was first characterized in the new model...
January 9, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29310643/galega-officinalis-extract-regulate-the-diabetes-mellitus-related-violations-of-proliferation-functions-and-apoptosis-of-leukocytes
#6
Mariia Nagalievska, Mariya Sabadashka, Halyna Hachkova, Nataliia Sybirna
BACKGROUND: An impaired leukocytes function is the factor causing the susceptibility of patients with diabetes mellitus to infections. The outmost importance for the understanding of the immunological processes involved in diabetes pathogenesis is to give the characteritics of the immunological profile and changes therein, during the course of desease. Long-used in folk medicine to treat diabetes Galega officinalis L. has been chosen for the correction of the immune system dysfunction...
January 8, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29305863/mir-449-overexpression-inhibits-osteogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-via-suppressing-sirt1-fra-1-pathway-in-high-glucose-and-free-fatty-acids-microenvironment
#7
Bo Qu, Kai Gong, Hong-Sheng Yang, Yu-Gang Li, Tao Jiang, Zhi-Mou Zeng, Zong-Rui Cao, Xian-Ming Pan
Diabetic osteoporosis is a chronic complication caused by diabetes mellitus, and However, the exact mechanism of diabetes mellitus-induced osteoporosis is still unknown. In this study, we investigate the effect of miR-449 on osteogenic differentiation and its underlying mechanism in human bone marrow-derived mesenchymal stem cells (hBMSCs) with high glucose (HG) and free fatty acids (FFA) treatment. Results showed that after culturing for 14 days, high glucose (HG) and free fatty acids (FFA) treatment dramatically decreased mineralization of human bone marrow-derived mesenchymal stem cells (hBMSCs) compared with cells treated with osteogenic medium (OM) alone...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29305175/an-overview-of-anti-diabetic-plants-used-in-gabon-pharmacology-and-toxicology
#8
REVIEW
B Bading Taika, M Bouckandou, A Souza, H P Bourobou Bourobou, L MacKenzie, L Lione
ETHNOPHARMACOLOGICAL RELEVANCE: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as primary healthcare. The aim of this review was to collect and present the scientific evidence for the use of medicinal plants that are in currect by Gabonese traditional healers to manage diabetes or hyperglycaemia based here on the pharmacological and toxicological profiles of plants with anti-diabetic activity are presented in order to promote their therapeutic value, ensure a safer use by population and provide some bases for further study on high potential plants reviewed...
January 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29304344/endogenous-reprogramming-of-alpha-cells-into-beta-cells-induced-by-viral-gene-therapy-reverses-autoimmune-diabetes
#9
Xiangwei Xiao, Ping Guo, Chiyo Shiota, Ting Zhang, Gina M Coudriet, Shane Fischbach, Krishna Prasadan, Joseph Fusco, Sabarinathan Ramachandran, Piotr Witkowski, Jon D Piganelli, George K Gittes
Successful strategies for treating type 1 diabetes need to restore the function of pancreatic beta cells that are destroyed by the immune system and overcome further destruction of insulin-producing cells. Here, we infused adeno-associated virus carrying Pdx1 and MafA expression cassettes through the pancreatic duct to reprogram alpha cells into functional beta cells and normalized blood glucose in both beta cell-toxin-induced diabetic mice and in autoimmune non-obese diabetic (NOD) mice. The euglycemia in toxin-induced diabetic mice and new insulin+ cells persisted in the autoimmune NOD mice for 4 months prior to reestablishment of autoimmune diabetes...
January 4, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29304221/type-2-diabetes-and-risk-of-incident-cancers-in-china-a-prospective-study-among-0-5-million-chinese-adults
#10
Xiong-Fei Pan, Meian He, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li
Using data from the China Kadoorie Biobank study, we conducted a prospective investigation on the association between type 2 diabetes mellitus (T2DM) and cancer risk in Chinese adults. A total of 508,892 participants (mean (standard deviation) age = 51.5 (10.7) years) without prior cancer diagnosis at baseline (2004-2008) were included. We documented 17,463 incident cancer cases during follow-up until December 31, 2013. Participants with T2DM had increased risks of total and certain site-specific cancers, and the hazard ratio (HR) was 1...
January 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29303357/the-synergy-of-two-factors-on-insulin-expression
#11
Ying Luo, Yao Xu, Zhen-Yu Wang, Xi Li, Wei-Bing Xing, Tong-Cun Zhang
As a potential cure for diabetes, more and more attentions have been paid to organ transplants to replace insulin therapy. As a result, many researchers have explored out many programs to get insulin-producing cells (IPCs) to replace the defective β cells. Currently, more and more new induction methods are being proposed, and at the same time, more and more possible induction molecular mechanisms are being revealed. The purpose of this study was to explore whether and how the two factors pdx-1 and myocardin affected the differentiation of rat mesenchymal stem cells (rMSCs) into IPCs...
January 5, 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29302582/secondary-primary-prostate-cancer-after-colorectal-cancer-a-nationwide-population-based-cohort-study-in-korea
#12
Hyun Soo Kim, Yoon Jin Choi, Dong Woo Shin, Kyung-Do Han, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
Background: Colorectal cancer (CRC) and prostate cancer frequently occur in developed countries. There are several reports on the association between CRC and prostate cancer; however, the conclusions are inconsistent to investigate the association of the development of secondary primary prostate cancer among patients with prior primary CRC using a nationwide population-based dataset. Methods: Patients registered in the Republic of Korea National Health Insurance System database who were diagnosed with CRC between 2007 and 2012 were followed-up until the end of 2015, and we investigated the new diagnosis secondary primary prostate cancer...
December 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29302468/the-euroaspire-surveys-lessons-learned-in-cardiovascular-disease-prevention
#13
Kornelia Kotseva
The Joint European Societies (JES) guidelines on cardiovascular disease (CVD) prevention published in 1994, 1998, 2003, 2007, 2012 and 2016 defined lifestyle and risk factors targets for patients with coronary or other atherosclerotic disease and people at high risk of developing CVD. Guideline implementation in Europe has been evaluated with four cross-sectional EUROASPIRE surveys starting in mid-1990s. The results showed poor lifestyle and risk factor management in patients with CHD and in high CVD risk people with high prevalences of smoking, obesity, central obesity and diabetes...
December 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29301371/the-sodium-glucose-cotransporter-2-inhibitor-dapagliflozin-prevents-renal-and-liver-disease-in-western-diet-induced-obesity-mice
#14
Dong Wang, Yuhuan Luo, Xiaoxin Wang, David J Orlicky, Komuraiah Myakala, Pengyuan Yang, Moshe Levi
Obesity and obesity related kidney and liver disease have become more prevalent over the past few decades, especially in the western world. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic agents with promising effects on cardiovascular and renal function. Given SGLT2 inhibitors exert both anti-diabetic and anti-obesity effects by promoting urinary excretion of glucose and subsequent caloric loss, we investigated the effect of the highly selective renal SGLT2 inhibitor dapagliflozin in mice with Western diet (WD) induced obesity...
January 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29300762/drug-repurposing-in-vitro-anti-glycation-properties-of-18-common-drugs
#15
Saima Rasheed, Sara S Sánchez, Sammer Yousuf, Stella M Honoré, M Iqbal Choudhary
Drug repositioning or repurposing, i.e. identifying new indications for existing drugs, has gained increasing attention in the recent years. This approach enables the scientists to discover "new targets" for known drugs in a cost and time efficient manner. Glycation, the non-enzymatic reaction of sugars with proteins or nucleic acids to form early glycation (Amadori or fructosamine) products, is a key molecular basis of diabetic complications. Inhibiting the process of non-enzymatic protein glycation is one of the key strategies to prevent glycation-mediated diabetic complications...
2018: PloS One
https://www.readbyqxmd.com/read/29299198/association-of-the-gene-expression-variation-of-tumor-necrosis-factor-%C3%AE-and-expressions-changes-of-dopamine-receptor-genes-in-progression-of-diabetic-severe-foot-ulcers
#16
Hajar Vaseghi, Majid Pornour, Gholamreza Esmaeeli Djavid, Garshasb Rigi, Shahla Mohammad Ganji, Leila Novin
Objectives: Regulation of pro-inflammatory factors such as TNF-α which are secreted by the immune cells through induction of their several receptors including dopamine receptors (especially DRD2 and DRD3) is one of the noticeable problems in diabetic severe foot ulcer healing. This study was conducted to evaluate the alteration of TNF-αin plasma as well as DRD2 and DRD3 changes in PBMCs of diabetics with severe foot ulcers. Materials and Methods: Peripheral blood samples were collected from 31 subjects with ulcers, 29 without ulcers, and 25 healthy individuals...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29297155/brain-iron-deposition-in-type-2-diabetes-mellitus-with-and-without-mild-cognitive-impairment-an-in-vivo-susceptibility-mapping-study
#17
Qifang Yang, Lina Zhou, Chen Liu, Daihong Liu, Yang Zhang, Chang Li, Yongning Shang, Xin Wei, Chuanming Li, Jian Wang
This study was performed to investigate iron deposition in the brain of type 2 diabetes mellitus (T2DM) patients using quantitative susceptibility mapping (QSM) and the associated cognitive impairments. Sixty patients diagnosed with T2DM were subjected to neuropsychological tests to determine their cognitive status, and the results were used to subdivide the patients into a T2DM without mild cognitive impairment (MCI) group (n = 30) and a T2DM with MCI group (n = 30). All patients underwent high-resolution susceptibility-weighted imaging, and data processing was performed using SMART (Susceptibility Mapping and Phase Artifacts Removal Toolbox) software...
January 3, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29295546/zinc-in-wound-healing-modulation
#18
REVIEW
Pei-Hui Lin, Matthew Sermersheim, Haichang Li, Peter H U Lee, Steven M Steinberg, Jianjie Ma
Wound care is a major healthcare expenditure. Treatment of burns, surgical and trauma wounds, diabetic lower limb ulcers and skin wounds is a major medical challenge with current therapies largely focused on supportive care measures. Successful wound repair requires a series of tightly coordinated steps including coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodelling. Zinc is an essential trace element (micronutrient) which plays important roles in human physiology...
December 24, 2017: Nutrients
https://www.readbyqxmd.com/read/29291586/new-insights-into-the-efficiency-of-thymol-synergistic-effect-with-p-cymene-in-inhibiting-advanced-glycation-end-products-a-multi-way-analysis-based-on-spectroscopic-and-electrochemical-methods-in-combination-with-molecular-docking-study
#19
Saleheh Abbasi, Sajjad Gharaghani, Ali Benvidi, Masoud Rezaeinasab
Protein glycation in the body is one of the main reasons of diabetes complications. The electrochemical studies on the inhibitory mechanism of glycation are rather scarce. Thus, it is important to investigate the role of electrochemistry in the glycation process with basic chemometric frameworks. The aim of the current study is to investigate the anti-glycation effects of candidate compounds from thyme species i.e. thymol and p-cymene. To gain this objective, the electrochemical and absorption responses of glycated bovine serum albumin (BSA) in the absence and presence of inhibitors were recorded after 20 day of incubation...
December 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29288268/identification-and-characterization-of-circular-rnas-as-a-new-class-of-putative-biomarkers-in-diabetes-retinopathy
#20
Shu-Jie Zhang, Xue Chen, Chao-Peng Li, Xiu-Miao Li, Chang Liu, Bai-Hui Liu, Kun Shan, Qin Jiang, Chen Zhao, Biao Yan
Purpose: To reveal the expression profile and clinical significance of circular RNAs (circRNAs) in diabetic retinopathy (DR). Methods: Circular RNA microarrays were performed to identify DR-related circRNAs. Gene ontology (GO) enrichment and KEGG analysis was performed to determine the biologic modules and signaling pathway. TargetScan and miRana program was used to predict circRNA/miRNA interaction. Quantitative PCR assays were performed to detect circRNA expression pattern in clinical samples...
December 1, 2017: Investigative Ophthalmology & Visual Science
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