Julia M Grimsmann, Sascha R Tittel, Peter Bramlage, Benjamin Mayer, Andreas Fritsche, Jochen Seufert, Markus Laimer, Stefan Zimny, Sebastian M Meyhoefer, Michael Hummel, Reinhard W Holl
AIMS: To cluster adults with diabetes using parameters from real-world clinical care at manifestation. MATERIALS AND METHODS: We applied hierarchical clustering using Ward's method to 56,869 adults documented in the Prospective Diabetes Follow-up Registry (DPV). Clustering variables included age, sex, BMI, HbA1c, diabetic ketoacidosis (DKA), components of the metabolic syndrome (hypertension/dyslipidemia/hyperuricemia), and beta-cell antibody status. Time until use of oral antidiabetic drugs (OAD), use of insulin, chronic kidney disease (CKD), cardiovascular disease (CVD), retinopathy, or neuropathy were assessed using Kaplan Meier analysis and Cox regression models...
July 6, 2022: Diabetes, Obesity & Metabolism