keyword
MENU ▼
Read by QxMD icon Read
search

gynecologic neoplasms

keyword
https://www.readbyqxmd.com/read/29719746/sister-mary-joseph-nodule-as-a-cutaneous-manifestation-of-metastatic-appendiceal-adenocarcinoma-case-report-and-literature-review
#1
Raghavendra L Girijala, Ryan R Riahi, Philip R Cohen
Sister Mary Joseph nodule (SMJN) is an uncommon pattern of superficial periumbilical tumor metastasis, with the primary tumor most commonly associated with gynecological or gastrointestinal origins. This manifestation can represent extensive tumor development from any of the intra-abdominal or pelvic structures. Therefore, SMJN carries a poor prognosis, with a two-year survival rate of only 13.5 percent regardless of the etiology of primary cancer. In this case, a 67-year-old man with metastatic mucinous adenocarcinoma of the appendix involving the umbilicus presenting more than five years after the initial cancer diagnosis is reported...
February 28, 2018: Curēus
https://www.readbyqxmd.com/read/29704209/neurologic-manifestations-of-elderly-patients-with-cancer
#2
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, Gervith Reyes-Soto, José A Ávila-Funes, Ana P Navarrete-Reyes
BACKGROUND: The incidence of cancer is an age-related phenomenon; therefore, the interest on clinical manifestations, diagnostic approach and treatment strategies for older patients diagnosed with cancer has increased lately. Neurologic symptoms are one of the main reasons for consultation and a common cause of decreased quality of life among cancer patients. AIMS: To identify the neurologic manifestations of patients ≥ 65 years of age diagnosed with cancer and compare them to those presented by a younger population...
April 27, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29700276/endometrial-metastasis-from-ductal-breast-carcinoma-a-case-report-with-literature-review
#3
Maryam Rahmani, Fatemeh Nili, Elnaz Tabibian
BACKGROUND There are few reports of breast cancer cases with uterine metastases; among them, myometrium is more frequently involved than endometrium. The majority of breast cancer metastases to endometrium are lobular type, and there have been only 5 reported cases of ductal type since 1984. Here, we describe a new case of invasive ductal carcinoma with metastases to endometrium and isolated presentation of abnormal uterine bleeding, in addition to reviewing the existing literature on other similar cases. CASE REPORT The patient was a 51-year-old Persian woman with no remarkable past medical or family history of cancer, who presented with a 6-month complaint of menorrhagia to our gynecology clinic...
April 27, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29649025/risk-of-anal-cancer-in-women-with-a-human-papillomavirus-related-gynecological-neoplasm-puerto-rico-1987-2013
#4
Adrianna I Acevedo-Fontánez, Erick Suárez, Carlos R Torres Cintrón, Ana P Ortiz
OBJECTIVE: The aim of the study was to estimate the magnitude of the association between HPV-related gynecological neoplasms and secondary anal cancer among women in Puerto Rico (PR). MATERIALS AND METHODS: We identified 9,489 women who had been diagnosed with a primary cervical, vaginal, or vulvar tumor during 1987-2013. To describe the trends of invasive cervical, vulvar, vaginal, and anal cancer, the age-adjusted incidence rates were estimated using the direct method (2000 US as Standard Population)...
April 11, 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29620586/predictive-histologic-factors-in-carcinosarcomas-of-the-uterus-a-multiinstitutional-study
#5
Eman Abdulfatah, Leonardo Lordello, Muhammad Khurram, Koen Van de Vijver, Baraa Alosh, Sudeshna Bandyopadhyay, Esther Oliva, Rouba Ali-Fehmi
Uterine carcinosarcomas are rare aggressive biphasic neoplasms. Because of its rarity, limited data are available on potential prognostic parameters. While several studies support that carcinomatous components predict outcomes, others do not. In this study, we evaluated the clinical and histopathologic features of 196 uterine carcinosarcomas to identify potential prognostic factors. Patients' ages ranged from 34 to 95 yr (median, 68 yr). Seventy-three (38%) patients experienced tumor recurrence during follow-up...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29620196/combination-of-tp53-and-agr3-to-distinguish-ovarian-high-grade-serous-carcinoma-from-low-grade-serous-carcinoma
#6
Chunping Qiu, Yu Wang, Xiao Wang, Qing Zhang, Yinuo Li, Ying Xu, Chengjuan Jin, Hualei Bu, Wenxin Zheng, Xingsheng Yang, Nan Lu, Beihua Kong
Ovarian high-grade serous carcinoma (HGSC) and low-grade serous carcinoma (LGSC) are distinct gynecologic neoplasms with diverse pathogenesis and characteristic features. They respond differently to same modalities of treatment protocol and have dissimilar prognosis. Thus, it is essential to obtain accurate differential diagnosis of HGSC and LGSC prior to clinical treatment. In the present study, mRNA expression profiles were generated from 5 HGSC and 6 LGSC specimen using HTSeq, and 699 differentially expressed genes (>2-fold difference) were identified using the DESeq R package...
April 4, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29589479/magnetically-assisted-intraperitoneal-drug-delivery-for-cancer-chemotherapy
#7
Milad Shamsi, Amir Sedaghatkish, Morteza Dejam, Mohsen Saghafian, Mehdi Mohammadi, Amir Sanati-Nezhad
Intraperitoneal (IP) chemotherapy has revived hopes during the past few years for the management of peritoneal disseminations of digestive and gynecological cancers. Nevertheless, a poor drug penetration is one key drawback of IP chemotherapy since peritoneal neoplasms are notoriously resistant to drug penetration. Recent preclinical studies have focused on targeting the aberrant tumor microenvironment to improve intratumoral drug transport. However, tumor stroma targeting therapies have limited therapeutic windows and show variable outcomes across different cohort of patients...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29567883/liquid-based-cytology-versus-conventional-cytology-in-fine-needle-aspirates-of-salivary-gland-neoplasms
#8
Madhu Kumar, Shweta Katiyar, Mala Sagar, Malti Kumari, Madhu Mati Goel
Background: Liquid-based cytology (LBC) is a method of retrieving and processing of cytological material for the assessment of both gynecological and nongynecological cases introduced in 1996. Mostly conventional smears (CS) are prepared in Indian scenario; however, due to increasing popularity of LBC in nongynecology specimens, LBC is also used in few centers for diagnosing salivary gland neoplasm. Aim: The aim of this study is to compare CS and LBC in fine-needle aspiration cytology (FNAC) of the salivary gland neoplasms in terms of cytomorphological details, adequacy, ease of interpretation, pitfalls, and diagnostic efficiency...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29505427/inflammatory-myofibroblastic-tumor-associated-with-the-placenta-short-tandem-repeat-genotyping-confirms-uterine-site-of-origin
#9
Nicholas R Ladwig, J Kenneth Schoolmeester, Laura Weil, Jocelyn S Chapman, Charles Zaloudek, Sarah E Umetsu
Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate malignant potential that only rarely involves the gynecologic tract. Several cases of IMT arising in various locations including the lung, bladder, trachea, and breast in association with pregnancy have been reported in the literature, and 3 cases involving the placenta have been previously described. We report 2 cases of IMT identified in association with pregnancy; the first was an intrauterine mass delivered entirely separate from the placenta and fetus, and the second was an incidental mass identified within the placental parenchyma following delivery...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29488126/long-term-risk-of-second-malignancies-in-women-after-breast-conservation-therapy-for-ductal-carcinoma-in-situ-or-early-stage-breast-cancer
#10
Carolyn J Kushner, Wei-Ting Hwang, Shiyu Wang, Lawrence J Solin, Neha Vapiwala
PURPOSE: Women with ductal carcinoma in situ (DCIS) or early-stage breast cancer have an excellent prognosis, but their risk of developing second malignant neoplasms (SMNs) is not well established. We analyzed SMNs in a large cohort with long follow-up after breast conservation therapy. METHODS: The study population comprised 755 women with DCIS (n = 135) or stage I-II breast carcinoma (n = 620). Subjects were aged 25-89 (median 55) years when they underwent breast-conserving surgery followed by radiotherapy to the entire breast (60-68Gray) between 1992 and 2001...
February 27, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29482747/the-usefulness-of-ultrasound-imaging-in-gynecologic-oncology
#11
REVIEW
Courtney A Woodfield
Pelvic ultrasound examination is the primary imaging modality for evaluating a wide range of female pelvic symptomatology, and is often the first imaging test to detect a gynecologic malignancy. Ultrasound imaging is particularly useful for evaluating the thickness and appearance of the endometrium in patients with abnormal bleeding, and in detecting and characterizing ovarian lesions. This article reviews the ultrasound appearance of gynecologic neoplasms grouped by anatomic site of origin, the ultrasound appearance of select benign pelvic pathology not to be misinterpreted as malignancy, as well as available ultrasound imaging-based guidelines for managing potential gynecologic neoplasms...
April 2018: PET Clinics
https://www.readbyqxmd.com/read/29439178/uterine-neoplasms-version-1-2018-nccn-clinical-practice-guidelines-in-oncology
#12
Wui-Jin Koh, Nadeem R Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M Campos, Kathleen R Cho, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J Eifel, Christine M Fisher, Peter Frederick, David K Gaffney, Suzanne George, Ernest Han, Susan Higgins, Warner K Huh, John R Lurain, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W Remmenga, R Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M Yashar, Nicole R McMillian, Jillian L Scavone
Endometrial carcinoma is a malignant epithelial tumor that forms in the inner lining, or endometrium, of the uterus. Endometrial carcinoma is the most common gynecologic malignancy. Approximately two-thirds of endometrial carcinoma cases are diagnosed with disease confined to the uterus. The complete NCCN Guidelines for Uterine Neoplasms provide recommendations for the diagnosis, evaluation, and treatment of endometrial cancer and uterine sarcoma. This manuscript discusses guiding principles for the diagnosis, staging, and treatment of early-stage endometrial carcinoma as well as evidence for these recommendations...
February 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29427549/linking-type-2-diabetes-and-gynecological-cancer-an-introductory-overview
#13
REVIEW
Emanuela Anastasi, Tiziana Filardi, Sara Tartaglione, Andrea Lenzi, Antonio Angeloni, Susanna Morano
Type 2 diabetes (T2D) is a chronic disease with a growing prevalence and a leading cause of death in many countries. Several epidemiological studies observed an association between T2D and increased risk of many types of cancer, such as gynecologic neoplasms (endometrial, cervical, ovarian and vulvar cancer). Insulin resistance, chronic inflammation and high free ovarian steroid hormones are considered the possible mechanisms behind this complex relationship. A higher risk of endometrial cancer was observed in T2D, even though this association largely attenuated after adjusting for obesity...
February 10, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29406332/immunohistochemical-expression-of-different-subtypes-of-cytokeratins-by-endometrial-stromal-sarcoma
#14
Siavash Rahimi, Iolia Akaev, Carla Marani, Mridula Chopra, Chit Cheng Yeoh
Endometrial stromal sarcomas (ESS) are rare and understudied gynecologic mesenchymal neoplasms. These tumors can be confused with many other gynecologic and nongynecologic tumors due to their variegated morphologic appearance and nonspecific immunohistochemical profile. ESS can express cytokeratin (CK) and, therefore, may be misdiagnosed as carcinoma especially in extrauterine locations and when recurrence/metastasis is present. In this study, we investigated the expression of a wide spectrum of CKs consisting of AE1/3, CAM 5...
February 5, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29405995/survey-of-gynecological-carcinosarcomas-in-families-with-breast-and-ovarian-cancer-predisposition
#15
Carla B Ripamonti, Siranoush Manoukian, Bernard Peissel, Jacopo Azzollini, Maria Luisa Carcangiu, Paolo Radice
Carcinosarcomas (CSs) are biphasic neoplasms composed of high grade, malignant, epithelial and mesenchymal elements. The incidence of gynecological CSs (GCSs) is 0.4/100,000 women per year. Patients affected with GCSs have been occasionally reported in Hereditary Breast Ovarian Cancer (HBOC) families, including a few cases with pathogenic variants in BRCA1/BRCA2 genes. The prevalence and the association of GCSs in HBOC families have not been systematically investigated. Thus, we searched for families with GCSs in the HBOC registry of the National Cancer Institute of Milan...
February 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29378033/cervical-cancer-markers-epigenetics-and-micrornas
#16
Vishuda Laengsri, Usanee Kerdpin, Chotiros Plabplueng, Lertyot Treeratanapiboon, Pornlada Nuchnoi
Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary...
March 21, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29356713/pathologic-staging-of-endometrial-carcinomas-selected-areas-of-difficulty
#17
W Glenn McCluggage
Accurate staging of cancers is an important determinant of prognosis and guides optimal patient treatment. Although the International Collaboration on Cancer Reporting recommends that endometrial cancers (including carcinosarcomas) are pathologically staged using the International Federation of Gynecology and Obstetrics (FIGO) 2009 system, in many areas TNM [American Joint Committee on Cancer (AJCC) or Union for International Cancer Control (UICC)] staging is used or even mandated; these latter systems are based on FIGO 2009...
March 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29343557/dicer1-and-associated-conditions-identification-of-at-risk-individuals-and-recommended-surveillance-strategies
#18
Kris Ann P Schultz, Gretchen M Williams, Junne Kamihara, Douglas R Stewart, Anne K Harris, Andrew J Bauer, Joyce Turner, Rachana Shah, Katherine Schneider, Kami Wolfe Schneider, Ann Garrity Carr, Laura A Harney, Shari Baldinger, A Lindsay Frazier, Daniel Orbach, Dominik T Schneider, David Malkin, Louis P Dehner, Yoav H Messinger, Ashley Hill
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord-stromal tumors, particularly Sertoli-Leydig cell tumor, individuals with pathogenic germline DICER1 variants may also develop lung cysts, cystic nephroma, renal sarcoma and Wilms tumor, nodular hyperplasia of the thyroid, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma, genitourinary embryonal rhabdomyosarcoma and brain tumors including pineoblastoma and pituitary blastoma...
January 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29241740/aberrant-pax-8-expression-in-well-differentiated-papillary-mesothelioma-and-malignant-mesothelioma-of-the-peritoneum-a-clinicopathologic-study
#19
Deyin Xing, Natalie Banet, Rajni Sharma, Russell Vang, Brigitte M Ronnett, Peter B Illei
Serous ovarian neoplasms can overlap morphologically with peritoneal mesothelial proliferations, including well-differentiated papillary mesothelioma (WDPM) and malignant epithelioid mesothelioma (MM). Accurate histologic classification of these neoplasms is important for clinical management. The Pax-8 protein is commonly used for differentiating peritoneal MM from serous carcinoma, but the diagnostic value of Pax-8 for distinguishing WDPM from borderline or low-grade serous tumors is unknown. We used immunohistochemistry staining to assess Pax-8 expression in 33 WDPMs, 34 peritoneal MMs, 48 pleural MMs, 11 adenomatoid tumors, 5 peritoneal inclusion cysts, and 51 benign/reactive mesothelium specimens...
February 2018: Human Pathology
https://www.readbyqxmd.com/read/29220296/carcinosarcomas-and-related-cancers-tumors-caught-in-the-act-of-epithelial-mesenchymal-transition
#20
Angela Pang, Mariana Carbini, Andre L Moreira, Robert G Maki
In this review, we outline the biology and management of patients with carcinosarcomas and related malignancies, which are often included under the broader concept of sarcomatoid carcinomas. Carcinosarcomas are unusual tumors that are commonly gynecologic in origin, where they are referred to as malignant mixed Müllerian tumors, but may appear in any anatomic site. Although a variety of hypotheses have been presented as to the biphasic nature of these tumors, carcinosarcomas seem to represent the best example in human cancers of the concept of epithelial-mesenchymal transition (EMT), in which the two parts of the tumor are genomically related to one another, as opposed to the mesenchymal component that represents a second neoplasm or (benign) reactive process...
January 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
keyword
keyword
59132
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"