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https://www.readbyqxmd.com/read/27891341/clinicopathological-study-of-surface-epithelial-tumours-of-the-ovary-an-institutional-study
#1
Nalini Modepalli, Suguna Belur Venugopal
INTRODUCTION: It is an established fact that tumours of ovary inherit a spectrum of histogenetic background, the variety being more than any other organ. Surface epithelial stromal tumours of ovary being the most common type of ovarian tumours form a complicating and baffling subject in the history of oncology and hence, are an interesting topic for study. AIM: The aim of this study was to categorize the surface epithelial tumours of ovary into benign, borderline and malignant, to study their clinical and histopathological pattern and to compare their incidences with other studies...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889016/is-it-necessary-to-perform-routine-appendectomy-for-mucinous-ovarian-neoplasms-a-retrospective-study-and-meta-analysis
#2
REVIEW
Aoshuang Cheng, Minghao Li, Margaux J Kanis, Ying Xu, Qing Zhang, Baoxia Cui, Jie Jiang, YouZhong Zhang, Xingsheng Yang, Beihua Kong
OBJECTIVES: To evaluate whether routine appendectomy is necessary in all patients with mucinous borderline ovarian tumor (mBOT) or mucinous ovarian cancer (MOC) who undergo gynecologic surgery. METHODS: The database of Qilu Hospital was searched for women who underwent appendectomy in a primary surgery for an ovarian tumor between June 2005 and June 2015 and whose final diagnosis was mBOT, MOC or primary appendiceal tumor. A retrospective review was performed, as well as a meta-analysis of the literature to further validate the findings...
November 23, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27801755/the-fallopian-tube-origin-and-primary-site-assignment-in-extrauterine-high-grade-serous-carcinoma-findings-of-a-survey-of-pathologists-and-clinicians
#3
W Glenn McCluggage, Lynn Hirschowitz, C Blake Gilks, Nafisa Wilkinson, Naveena Singh
Accumulating recent evidence suggests that the majority of extrauterine high-grade serous carcinomas (HGSCs) do not arise from the ovary as historically accepted but from the distal, fimbrial end of the fallopian tube from a precursor known as serous tubal intraepithelial carcinoma. There has been variable acceptance of this evidence among pathologists and clinicians dealing with "ovarian" cancer and this has resulted in wide variation in the assignment of primary site between different institutions when HGSC involves >1 anatomic site...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801734/pd-l1-expression-in-carcinosarcomas-of-the-gynecologic-tract-a-potentially-actionable-biomarker
#4
Andre Pinto, Nicholas Mackrides, Mehrdad Nadji
BACKGROUND: Carcinosarcomas of the gynecologic tract, also known as malignant mixed Müllerian tumors, are aggressive neoplasms with a high recurrence rate and poor prognosis. Despite advances in adjuvant therapies in recent years, the prognosis of these tumors has not improved. In fact, there are currently no consensus guidelines for the treatment of these neoplasms and the search for targetable biomarkers has not been successful so far. Programmed death-ligand 1 (PD-L1) has emerged as a potential target for therapeutics in a number of malignant tumors, including melanoma, lung, and colorectal cancer...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27770810/systematic-assessment-of-her2-neu-in-gynecologic-neoplasms-an-institutional-experience
#5
Jennifer S Woo, Sophia K Apple, Peggy S Sullivan, Jian-Yu Rao, Nora Ostrzega, Neda A Moatamed
BACKGROUND: HER2/neu overexpression and/or amplification has been widely studied in a number of solid tumors, primarily in the breast. In gynecologic neoplasms, determination of HER2/neu status has not been well studied as a predictive biomarker in anti-HER2/neu treatment. METHODS: We systematically evaluated the HER2/neu reactions by immunohistochemistry and fluorescent in situ hybridization in malignant gynecologic neoplasms as experienced in our institution. RESULTS: The HER2/neu overexpression or amplification occurred in 8 % of the cancers of the gynecological organs in our series...
October 22, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27747116/chlamydia-peritonitis-and-ascites-mimicking-ovarian-cancer
#6
Anar Gojayev, Diana P English, Matthew Macer, Masoud Azodi
Background. Pelvic inflammatory disease (PID) rarely results in diffuse ascites. Severe adhesive disease secondary to PID may lead to the formation of inclusion cysts and even pelvic peritoneal nodularity due to postinflammatory scarring and cause an elevation of serum CA-125 levels. The constellation of these findings may mimic an ovarian neoplasm. Case. We report a case of a 22-year-old female who presented with multiple pelvic cysts and diffuse ascites due to Chlamydia trachomatis infection. The initial gynecologic exam did not reveal obvious evidence of PID; however, a positive Chlamydia trachomatis test, pathologic findings, and the exclusion of other etiologies facilitated the diagnosis...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27689526/perivascular-epithelioid-cell-tumor-of-the-uterus-report-of-two-cases-and-mini-review-of-the-literature
#7
Charalampos Theofanakis, Nikolaos Thomakos, Maria Sotiropoulou, Alexandros Rodolakis
INTRODUCTION: Perivascular Epithelioid Cell tumor (PEComa) is a rare neoplasm of mesenchymal origin, with the uterus being the most common site of appearance, regarding the female genital tract. CASE REPORT: We present two cases of PEComas of the uterus in patients aged 57 and 42-years-old, presented to our department with palpable abdominal masses and abnormal vaginal bleeding. During follow up period, both patients are free of recurrent disease one and two years after surgery, respectively, without receiving any adjuvant treatment...
September 24, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27674371/outcomes-in-patients-with-limited-metastases-from-gynecologic-neoplasms-treated-with-targeted-radiation-therapies
#8
N J DeNunzio, D P Bergsma, M T Milano
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27641440/unusual-location-of-a-plexiform-neurofibroma-in-the-fallopian-tube-a-case-report
#9
Piotr Czuczwar, Anna Stepniak, Piotr Szkodziak, Agnieszka Korolczuk, Tomasz Paszkowski, Slawomir Wozniak
It is rare for neurofibromatosis to occur in the female genital tract. We report a case of a plexiform neurofibroma in the left fallopian tube in a 50-year-old postmenopausal woman. The initial diagnosis was a pedunculated leiomyoma or a fallopian tube tumor. Laparotomy was performed and a solid mass approximately 90 x 60 x 40 mm in size was found in the left fallopian tube. Total abdominal hysterectomy and bilateral salpingo-oophorectomy with an appendectomy, lymphadenectomy and omentectomy was performed. The histopathological diagnosis was plexiform neurofibroma...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27505184/indeterminate-but-likely-unimportant-extracolonic-findings-at-screening-ct-colonography-c-rads-category-e3-incidence-and-outcomes-data-from-a-clinical-screening-program
#10
B Dustin Pooler, David H Kim, Perry J Pickhardt
OBJECTIVE: The purpose of this study was to analyze the incidence and outcomes of unsuspected indeterminate but likely unimportant extracolonic findings (CT Colonography Reporting and Data System [C-RADS] category E3) at screening CT colonography (CTC). MATERIALS AND METHODS: Over 99 months (April 2004 through June 2012), 7952 consecutive adults without symptoms of colorectal cancer (4277 women, 3675 men; mean age ± SD, 56.7 ± 7.3 years) underwent first-time screening CTC...
November 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27500710/proton-radiotherapy-for-gynecologic-neoplasms
#11
Vivek Verma, Charles B Simone, Andrew O Wahl, Sushil Beriwal, Minesh P Mehta
BACKGROUND: Proton beam therapy (PBT) is increasingly being used globally to treat a variety of malignancies. This is the first review assessing PBT for gynecologic neoplasms. Dose distribution to organs-at-risk (OARs), particularly bone marrow (BM), is addressed. Clinical outcomes and toxicity data are detailed. MATERIAL AND METHODS: Systematic searches of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology were conducted for publications...
November 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27446471/a-novel-truncated-form-of-hmga2-in-tumors-of-the-ovaries
#12
Antonio Agostini, Ioannis Panagopoulos, Ben Davidson, Claes Goran Trope, Sverre Heim, Francesca Micci
Neoplasms of the ovary are the second most common tumor of the female reproductive system, and the most lethal of the gynecological malignancies. Ovarian tumors are divided into a copious number of different groups reflecting their different features. The present study analyzed 187 ovarian tumors (39 sex-cord stromal tumors, 22 borderline tumors and 126 carcinomas) for the expression of the high-mobility group AT-hook 2 (HMGA2) gene, for mutations in the isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) and telomerase reverse transcriptase (TERT) genes, and for methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27444140/breast-metastasis-from-vaginal-cancer
#13
Neeraja Chandrasekaran, Daniel Scharifker, George Varsegi, Zoyla Almeida
Vaginal cancer is a rare malignancy accounting for 1-2% of all pelvic neoplasms. Dissemination usually occurs through local invasion and rarely metastasises to distal locations. Metastasis of vaginal cancer to the breast is extremely infrequent and unique. A 66-year-old Asian woman presented with vaginal bleeding and was found to have a vaginal mass and a left breast mass. Pathological assessment of the biopsies revealed identical squamous cell characteristics of both masses. We describe a very rare and novel case of a distally located vaginal carcinoma with metastasis to the breast Federation of Gynecology and Obstetrics (FIGO) stage IV (FIGO IVB)...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27367953/osteopathic-approach-to-the-diagnosis-of-appendiceal-mucinous-cystadenocarcinoma-mimicking-primary-ovarian-malignant-neoplasm
#14
Daniel Martingano, Hashroop Gurm, Andrew Oliff, Francis X Martingano, George Aglialoro
The fifth leading cause of cancer-related deaths among women in the United States is ovarian cancer. An estimated 21,980 new cases and 14,270 estimated deaths occurred nationwide in 2014. More than two-thirds of cases of ovarian cancer are diagnosed at stage III or IV when the peritoneal cavity or other organs are affected. Primary appendiceal malignant neoplasms may mimic advanced-stage ovarian cancer and can be misdiagnosed because of its presentation as a palpable adnexal mass. The authors describe a 42-year-old woman who was admitted to the department of obstetrics and gynecology to receive treatment for presumed advanced-stage ovarian cancer...
July 1, 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/27354994/solitary-fibrous-tumor-of-the-greater-omentum-mimicking-an-ovarian-tumor-in-a-young-woman
#15
Elisabet Rodriguez Tarrega, Juan Jose Hidalgo Mora, Vicente Paya Amate, Olivia Vega Oomen
We report a case of solitary fibrous tumor (SFT) of greater omentum in a young woman. SFT arising from the greater omentum can mimic a gynecologic neoplasm. SFTs are generally benign but some of them are malignant and have uncertain prognosis. An adequate follow-up is essential in these patients.
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27338636/adenocarcinoma-ex-goblet-cell-carcinoid-appendiceal-type-crypt-cell-adenocarcinoma-is-a-morphologically-distinct-entity-with-highly-aggressive-behavior-and-frequent-association-with-peritoneal-intra-abdominal-dissemination-an-analysis-of-77-cases
#16
Michelle D Reid, Olca Basturk, Walid L Shaib, Yue Xue, Serdar Balci, Hye-Jeong Choi, Gizem Akkas, Bahar Memis, Brian S Robinson, Bassel F El-Rayes, Charles A Staley, Christopher A Staley, Joshua H Winer, Maria C Russell, Jessica H Knight, Michael Goodman, Alyssa M Krasinskas, Volkan Adsay
High-grade versions of appendiceal goblet cell carcinoids ('adenocarcinoma ex-goblet cell carcinoids') are poorly characterized. We herein document 77 examples. Tumors occurred predominantly in females (74%), mean age 55 years (29-84), most with disseminated abdominal (77% peritoneal, 58% gynecologic tract involvement) and stage IV (65%) disease. Many presented to gynecologic oncologists, and nine had a working diagnosis of ovarian carcinoma. Metastases to liver (n=3) and lung (n=1) were uncommon and none arose in adenomatous lesions...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27315240/-clinical-evaluation-of-female-pelvic-tumors-application-fields-of-integrated-pet-mri
#17
J Grueneisen, L Umutlu
Integrated positron emission tomography (PET) and magnetic resonance imaging (MRI) scanning has recently become established in clinical imaging. Various studies have demonstrated the great potential of this new hybrid imaging procedure for applications in the field of oncology and the diagnostics of inflammatory processes. With initial studies demonstrating the feasibility and high diagnostic potential of PET/MRI comparable to PET-computed tomography (CT), the focus of future studies should be on the identification of application fields with a potential diagnostic benefit of PET/MRI over other established diagnostic tools...
July 2016: Der Radiologe
https://www.readbyqxmd.com/read/27293931/neuroendocrine-cancer-of-rectum-metastasizing-to-ovary
#18
Sapna Vinit Amin, Aswathy Kumaran, Sunanda Bharatnur, Akhila Vasudeva, Kartik Udupa, Dinesh Bangalore Venkateshiah, Shaila T Bhat
Neuroendocrine carcinomas (NECs) are rare malignancies that originate from the hormone-producing cells of the body's neuroendocrine system. Rectal high grade NEC (HG-NEC) constituting less than 1% of colorectal cancers can cause large ovarian metastasis that may be the initial presenting complaint. Ovarian Krukenberg tumor from a primary rectal HG-NEC is a very unusual and exceedingly uncommon differential diagnosis for secondary ovarian malignancy. This case report describes one such extremely rare case of a woman who had presented to the gynecology department with features suggestive of ovarian malignancy and was ultimately diagnosed to have Krukenberg tumor originating from neuroendocrine cancer of rectum...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27275284/dna-cytometry-and-nuclear-morphometry-in-ovarian-benign-borderline-and-malignant-tumors
#19
Amina A Gamal El Din, Manal A Badawi, Shereen E Abdel Aal, Nihad A Ibrahim, Fatma A Morsy, Nermeen M Shaffie
BACKDROUND: Ovarian carcinoma is a leading cause of death in gynecological malignancy. Ovarian surface epithelial serous and mucinous tumours are classified as benign, borderline, and malignant. The identification of borderline tumours most likely to act aggressively remains an important clinical issue. AIM: This work aimed to study DNA ploidy and nuclear area in ovarian serous and mucinous; benign, borderline and malignant tumours. MATERIAL AND METHODS: This study included forty ovarian (23 serous and 17 mucinous) tumours...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27255164/genomewide-copy-number-analysis-of-m%C3%A3-llerian-adenosarcoma-identified-chromosomal-instability-in-the-aggressive-subgroup
#20
Jen-Chieh Lee, Tzu-Pin Lu, Chun A Changou, Cher-Wei Liang, Hsien-Neng Huang, Alexandra Lauria, Hsuan-Ying Huang, Chin-Yao Lin, Ying-Cheng Chiang, Ben Davidson, Ming-Chieh Lin, Kuan-Ting Kuo
Müllerian adenosarcomas are malignant gynecologic neoplasms. Advanced staging and sarcomatous overgrowth predict poor prognosis. Because the genomic landscape remains poorly understood, we conducted this study to characterize the genomewide copy number variations in adenosarcomas. Sixteen tumors, including eight with and eight without sarcomatous overgrowth, were subjected to a molecular inversion probe array analysis. Copy number variations, particularly losses, were significantly higher in cases with sarcomatous overgrowth...
September 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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