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https://www.readbyqxmd.com/read/29161807/intravenous-dextran-70-infusion-has-protective-effects-on-ischemia-reperfusion-injury-of-kidney-an-experimental-study
#1
Atilla Semercioz, Mustafa Z Temiz, Ipek Erbarut, Ugur Izol, Serdar Aykan, Murat Tuken, Engin Kandirali
BACKGROUND: Renal ischemia-reperfusion (IR) leads to alterations of tubular epithelial cells, interstitial microvasculopathy and endothelial cell dysfunction in peritubular capillaries. Although dextrans have deteriorative effects on healthy kidney, their favorable effects on post-ischemic microvascular disturbances have been demonstrated. Therefore, we aimed to investigate in vivo effects of systemic Dextran 70 administration in kidney tissue with ischemia-reperfusion injury. METHODS: Twenty-one rats were allocated as sham, IR and IR+ Dextran 70 treatment groups...
November 21, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29156155/leukotriene-b4-indicates-lung-injury-and-on-going-inflammatory-changes-after-severe-trauma-in-a-porcine-long-term-model
#2
Philipp Störmann, Birgit Auner, Lukas Schimunek, Rafael Serve, Klemens Horst, Tim-P Simon, Roman Pfeifer, Kernt Köhler, Frank Hildebrand, Sebastian Wutzler, Hans-Christoph Pape, Ingo Marzi, Borna Relja
BACKGROUND: Recognizing patients at risk for pulmonary complications (PC) is of high clinical relevance. Migration of polymorphonuclear leukocytes (PMN) to inflammatory sites plays an important role in PC, and is tightly regulated by specific chemokines including interleukin (IL)-8 and other mediators such as leukotriene (LT)B4. Previously, we have reported that LTB4 indicated early patients at risk for PC after trauma. Here, the relevance of LTB4 to indicating lung integrity in a newly established long-term porcine severe trauma model (polytrauma, PT) was explored...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29154845/effects-of-trans-stilbene-and-terphenyl-compounds-on-different-strains-of-leishmania-and-on-cytokines-production-from-infected-macrophages
#3
Federica Bruno, Germano Castelli, Fabrizio Vitale, Elisa Giacomini, Marinella Roberti, Claudia Colomba, Antonio Cascio, Manlio Tolomeo
Most of the antileishmanial modern therapies are not satisfactory due to high toxicity or emergence of resistance and high cost of treatment. Previously, we observed that two compounds of a small library of trans-stilbene and terphenyl derivatives, ST18 and TR4, presented the best activity and safety profiles against Leishmania infantum promastigotes and amastigotes. In the present study we evaluated the effects of ST18 and the TR4 in 6 different species of Leishmania and the modifications induced by these two compounds in the production of 8 different cytokines from infected macrophages...
November 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29154202/polymorphisms-in-inflammasome-genes-and-risk-of-asthma-in-brazilian-children
#4
Vinicius Nunes Cordeiro Leal, Isabel Rugue Genov, Márcia C Mallozi, Dirceu Solé, Alessandra Pontillo
Considering its role in inflammation and recently described "alternative" roles in epithelial homeostasis and Th1/Th2 balance, we hypothesize that inflammasome genetics could contribute to the development of asthma. Selected functional polymorphisms in inflammasome genes are evaluated in a cohort of asthmatic children and their families. Gain-of-function NLRP1 variants rs11651270, rs12150220 and rs2670660 resulted significantly associated to asthma in trios (TDT) analysis; and rs11651270 and rs2670660 also with asthma severity and total IgE level in asthmatic children...
November 15, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29151018/study-of-the-nlrp3-inflammasome-component-genes-and-downstream-cytokines-in-patients-with-type-2-diabetes-mellitus-with-carotid-atherosclerosis
#5
Junli Lee, Jing Wan, Linyun Lee, Changhua Peng, Hailong Xie, Chengbin Lee
BACKGROUND: A role for the NLRP3 inflammasome has been reported in various diseases, such as diabetes mellitus, atherosclerosis (AS), nephropathy, rheumatism, and others, although limited information is available concerning the role of the NLRP3 inflammasome, interleukin-1β (IL-1β) and interleukin-18 (IL-18) in patients with type 2 diabetes mellitus (T2DM) and carotid atherosclerosis (CAS). Therefore, this cross-sectional study investigated these inflammatory components in patients with T2DM complicated with carotid atherosclerosis (T2DM + CAS)...
November 18, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29150951/inflammasome-its-role-in-traumatic-brain-and-spinal-cord-injury
#6
REVIEW
Keywan Mortezaee, Neda Khanlarkhani, Cordian Beyer, Adib Zendedel
Traumatic brain injury (TBI) and spinal cord injury (SCI) are pathological events that lead to neuropathological conditions which have in consequence the initiation of pro-inflammatory cytokine production. Neuroinflammation plays a key role in the secondary phase of both TBI and SCI after initial cell death. Activation of cytoplasmic inflammasome complexes is regarded as the essential step of neuroinflammation and a key trigger for neuronal death called pyroptosis. Inflammasome complexes are involved in activation of caspase-1 which catalyzes the cleavage of pro-interleukins into their active forms (including interleukin-18 (IL-18) and IL-1β)...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29146643/are-il18rap-gene-polymorphisms-associated-with-body-mass-regulation-a-cross-sectional-study
#7
Vanesa Martínez-Barquero, Griselda de Marco, Sergio Martínez-Hervas, Victoria Adam-Felici, Cristina Pérez-Soriano, Verónica Gonzalez-Albert, Gemma Rojo, Juan Francisco Ascaso, José Tomás Real, Ana Barbara Garcia-Garcia, Juan Carlos Martín-Escudero, Raquel Cortes, Felipe Javier Chaves
OBJECTIVES: To investigate the association between IL18RAP and body mass index (BMI) and obesity and to verify the effect of a polymorphism in the microRNA136 (MIR136) IL18RAP binding region. DESIGN: We analysed samples from two Spanish cross-sectional studies, VALCAR (Spanish Mediterranean coast) and Hortega (Spanish centre). These studies aimed at analysing cardiovascular risk and development of cardiovascular disease in the general population. Both populations correspond to regions with different characteristics...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145789/helicobacter-pylori-controls-nlrp3-expression-by-regulating-hsa-mir-223-3p-and-il-10-in-cultured-and-primary-human-immune-cells
#8
Suneesh Kumar Pachathundikandi, Steffen Backert
Inflammasome-mediated production of mature IL-1β and IL-18 cytokines represents an important innate immune response against infecting pathogens. Helicobacter pylori, one of the most successful and persistent human pathogens, induces severe inflammation leading to gastritis and more serious gastric diseases. H. pylori modulates different immune responses for its survival and inflammasome signaling is manipulated by the cag pathogenicity island ( cagPAI), urease and VacA cytotoxin. Here we report that H. pylori regulates NLRP3 expression, an inflammasome forming regulator, in infected THP-1 monocytes...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/29143812/the-nlrp3-inflammasome-in-acute-myocardial-infarction
#9
REVIEW
Stefano Toldo, Antonio Abbate
The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction (AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is then further exacerbated by an intense and highly specific inflammatory response that occurs during reperfusion. Numerous studies have highlighted the central role of the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in this process. The inflammasome, an integral part of the innate immune system, is a macromolecular protein complex that finely regulates the activation of caspase 1 and the production and secretion of powerful pro-inflammatory cytokines such as IL-1β and IL-18...
November 16, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29142469/hypothermic-machine-perfusion-with-metformin-university-of-wisconsin-solution-for-ex-vivo-preservation-of-standard-and-marginal-liver-grafts-in-a-rat-model
#10
Yi-Chao Chai, Guo-Xin Dang, Hai-Qi He, Jian-Hua Shi, Hong-Ke Zhang, Rui-Tao Zhang, Bo Wang, Liang-Shuo Hu, Yi Lv
AIM: To compare the effect of University of Wisconsin (UW) solution with or without metformin, an AMP-activated protein kinase (AMPK) activator, for preserving standard and marginal liver grafts of young and aged rats ex vivo by hypothermic machine perfusion (HMP). METHODS: Eighteen young (4 mo old) and 18 aged (17 mo old) healthy male SD rats were selected and randomly divided into three groups: control group, UW solution perfusion group (UWP), and UW solution with metformin perfusion group (MUWP)...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29142190/detection-of-atherosclerotic-plaques-in-the-rabbit-aorta-using-ultrasound-microbubbles-conjugated-to-interleukin-18-antibodies
#11
Zhen-Zhen Jiang, Xia-Tian Liu, Cai-Ye Ma, Cong He, Xing-Yun Li, Chuan-Lin Hou, Zu-Sheng Cheng, Guo-Yuan Xia
BACKGROUND The purpose of the study was to investigate the ability of microbubbles (MBs) targeting interleukin-18 (IL-18) to detect plaques in a rabbit atherosclerotic plaque model. MATERIAL AND METHODS A rabbit atherosclerotic plaque model was established. The locations of the atherosclerotic plaques were verified by two-dimensional scanning and color Doppler flow imaging. An IL-18 antibody was conjugated to naked MBs (MBc) using the biotin-streptavidin conjugation method, resulting in the formation of MBIL-18...
November 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29138829/resveratrol-ameliorates-inflammatory-damage-and-protects-against-osteoarthritis-in-a-rat-model-of-osteoarthritis
#12
Yulong Wei, Jie Jia, Xin Jin, Wei Tong, Hongtao Tian
Resveratrol is a non‑flavonoid polyphenol compound with a stilbene structure. As a type of phytoalexin produced under stress in plants, it improves the plant's resistance against pathogens and environment deterioration, and performs important functions beneficial to human health, such as anti‑cancer, anti‑oxidation, regulating blood lipid levels and prolonging life span. The effects of resveratrol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA...
November 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136779/juglanin-ameliorates-lps-induced-neuroinflammation-in-animal-models-of-parkinson-s-disease-and-cell-culture-via-inactivating-tlr4-nf-%C3%AE%C2%BAb-pathway
#13
Fang-Xue Zhang, Ren-Shi Xu
Parkinson's disease (PD) is a common neuro-degenerative disorder, and novel therapeutic targets are required for the treatment of PD. Juglanin is a natural compound extracted from the crude Polygonum aviculare, exhibiting anti-inflammatory, anti-oxidant and anti-cancer activities. In our study, PD in mice was induced by systemic LPS treatment as evidenced by enhanced α-synuclein and reduced tyrosine hydroxylase (TH), which were reversed by juglanin treatment. Moreover, juglanin administration attenuated LPS-caused behavioral and memory impairments and reduced LPS-induced enhancement of neuro-degenerative markers, including amyloid β (Aβ) and p-Tau...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29130931/confounding-role-of-tumor-necrosis-factor-in-cryopyrin-associated-periodic-syndromes
#14
Balaji Banoth, Fayyaz S Sutterwala
The NLRP3 inflammasome is a critical component of the innate immune system and can be activated in response to microbial and endogenous danger signals. Activation of the NLRP3 inflammasome results in caspase-1-dependent secretion of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function missense mutations in NLRP3 result in a group of autoinflammatory diseases collectively known as the cryopyrin-associated periodic syndromes (CAPS). CAPS patients have traditionally been successfully treated with therapeutics targeting the IL-1 pathway; however, there are a number of identified CAPS patients who show only a partial response to IL-1 blockade...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29130929/tnf-regulates-transcription-of-nlrp3-inflammasome-components-and-inflammatory-molecules-in-cryopyrinopathies
#15
Matthew D McGeough, Alexander Wree, Maria E Inzaugarat, Ariela Haimovich, Casey D Johnson, Carla A Peña, Raphaela Goldbach-Mansky, Lori Broderick, Ariel E Feldstein, Hal M Hoffman
The NLRP3 inflammasome is a protein complex responsible for caspase-1-dependent maturation of the proinflammatory cytokines IL-1β and IL-18. Gain-of-function missense mutations in NLRP3 cause the disease spectrum known as the cryopyrin-associated periodic syndromes (CAPS). In this study, we generated Nlrp3-knockin mice on various KO backgrounds including Il1b/Il18-, caspase-1-, caspase-11- (Casp1/11-), and Tnf-deficient strains. The Nlrp3L351P Il1b-/- Il18-/- mutant mice survived and grew normally until adulthood and, at 6 months of age, exhibited marked splenomegaly and leukophilia...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29129846/the-il18-promoter-polymorphism-rs1946518-is-associated-with-the-risk-of-periodontitis-in-japanese-women-the-kyushu-okinawa-maternal-and-child-health-study
#16
Keiko Tanaka, Yoshihiro Miyake, Takashi Hanioka, Shinya Furukawa, Nobuyuki Miyatake, Masashi Arakawa
Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in periodontitis and its polymorphisms might modulate the individual susceptibility to periodontitis. Only a limited number of studies on the association between IL18 single-nucleotide polymorphisms (SNPs) and the risk of periodontitis have been realized, however. The aim of this case-control study among young post-partum Japanese women (18 to 45 years) was to determine the impact of SNPs, rs1946518 (-607 C/A) and rs187238 (-137G/C), on periodontitis...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29129476/pyroptosis-and-its-relationship-to-atherosclerosis
#17
REVIEW
Yuan-Jun Xu, Lei Zheng, Yan-Wei Hu, Qian Wang
Pyroptosis is a pro-inflammatory form of regulated cell death and is dependent on the enzymatic activity of inflammatory proteases that belong to the family of cysteine-dependent aspartate-specific proteases (caspases). Pyroptosis is morphologically, mechanistically, and pathophysiologically distinct from other forms of cell death, including apoptosis and necrosis. Pyroptosis is characterized by rapid plasma membrane rupture, with the consequent release of intracellular contents and pro-inflammatory mediators, including interleukin (IL)-1β, IL-18, and the alarmin HMGB-1...
November 10, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29128729/recent-advances-in-inflammasome-biology
#18
REVIEW
David E Place, Thirumala-Devi Kanneganti
The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1β, and IL-18 execute an inflammatory form of cell death termed pyroptosis. Activation of this complex often involves the adaptor protein ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis. Here we discuss new regulatory mechanisms that have been identified for the canonical inflammasomes, the most recently identified NLRP9b inflammasome, and the new gasdermin family of proteins that mediate pyroptosis and other forms of regulated cell death...
November 9, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29123531/chronic-obstructive-pulmonary-disease-derived-circulating-cells-release-il-18-and-il-33-under-ultrafine-particulate-matter-exposure-in-a-caspase-1-8-independent-manner
#19
Gianluigi De Falco, Chiara Colarusso, Michela Terlizzi, Ada Popolo, Michela Pecoraro, Mario Commodo, Patrizia Minutolo, Mariano Sirignano, Andrea D'Anna, Rita P Aquino, Aldo Pinto, Antonio Molino, Rosalinda Sorrentino
Chronic obstructive pulmonary disease (COPD) is considered the fourth-leading causes of death worldwide; COPD is caused by inhalation of noxious indoor and outdoor particles, especially cigarette smoke that represents the first risk factor for this respiratory disorder. To mimic the effects of particulate matter on COPD, we isolated peripheral blood mononuclear cells (PBMCs) and treated them with combustion-generated ultrafine particles (UFPs) obtained from two different fuel mixtures, namely, pure ethylene and a mixture of ethylene and dimethylfuran (the latter mimicking the combustion of biofuels)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29120743/staphylococcus-aureus-epicutaneous-exposure-drives-skin-inflammation-via-il-36-mediated-t-cell-responses
#20
Haiyun Liu, Nathan K Archer, Carly A Dillen, Yu Wang, Alyssa G Ashbaugh, Roger V Ortines, Tracy Kao, Steven K Lee, Shuting S Cai, Robert J Miller, Mark C Marchitto, Emily Zhang, Daniel P Riggins, Roger D Plaut, Scott Stibitz, Raif S Geha, Lloyd S Miller
Staphylococcus aureus colonization contributes to skin inflammation in diseases such as atopic dermatitis, but the signaling pathways involved are unclear. Herein, epicutaneous S. aureus exposure to mouse skin promoted MyD88-dependent skin inflammation initiated by IL-36, but not IL-1α/β, IL-18, or IL-33. By contrast, an intradermal S. aureus challenge promoted MyD88-dependent host defense initiated by IL-1β rather than IL-36, suggesting that different IL-1 cytokines trigger MyD88 signaling depending on the anatomical depth of S...
November 8, 2017: Cell Host & Microbe
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