Isabel Neale, Mohammad Ali, Barbara Kronsteiner, Stephanie Longet, Priyanka Abraham, Alexandra S Deeks, Anthony Brown, Shona C Moore, Lizzie Stafford, Susan L Dobson, Megan Plowright, Thomas A H Newman, Mary Y Wu, Edward J Carr, Rupert Beale, Ashley D Otter, Susan Hopkins, Victoria Hall, Adriana Tomic, Rebecca P Payne, Eleanor Barnes, Alex Richter, Christopher J A Duncan, Lance Turtle, Thushan I de Silva, Miles Carroll, Teresa Lambe, Paul Klenerman, Susanna Dunachie
Serological correlates of protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection after vaccination ("vaccine breakthrough") have been described. However, T cell correlates of protection against breakthrough are incompletely defined, especially the specific contributions of CD4+ and CD8+ T cells. Here, 279 volunteers in the Protective Immunity from T Cells in Healthcare Workers (PITCH) UK cohort study were enrolled in a nested case-control study. Cases were those who tested SARS-CoV-2 PCR or lateral flow device (LFD) positive after two vaccine doses during the Delta-predominant era ( n = 32), while controls were those who did not report a positive test or undergo anti-nucleocapsid immunoglobulin G (IgG) seroconversion during this period ( n = 247)...
September 1, 2023: MBio