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https://www.readbyqxmd.com/read/29165513/-a-five-year-experience-with-zoonotic-salmonella-at-a-pediatric-reference-centre
#1
Patricia Barrios, Federica Badía, Valentina Misa, M Inés Mota, Arací Martínez, Hebert Mariño, Gabriela Algorta, Javier Prego, M Catalina Pírez
BACKGROUND: Salmonella can cause asymptomatic infections, diarrhea, bacteremia and focal infections such as meningitis and osteomyelitis. AIM: To describe clinical and microbiological aspects of infections by Salmonella spp. in children in a pediatric referral hospital: Centro Hospitalario Pereira Rossell, in Montevideo, Uruguay. MATERIALS AND METHODS: Descriptive and retrospective study of 46 patients, from which Salmonella spp was isolated between January 1, 2005 and December 31, 2010...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29164043/antiviral-activity-of-itraconazole-against-echovirus-30-infection-in-vitro
#2
Jae-Sug Lee, Hwa-Jung Choi, Jae-Hyoung Song, Hyun-Jeong Ko, Kyungah Yoon, Jeong-Min Seong
Objectives: Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether the antifungal drug itraconazole could exhibit antiviral activity against echovirus 30. Methods: The cytopathic effect and viral RNA levels were assessed in RD cells as indicators of viral replication. The effects of itraconazole were compared to those of two known antiviral drugs, rupintrivir and pleconaril. The time course and time-of-addition assays were used to approximate the time at which itraconazole exerts its activity in the viral cycle...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29163992/cd56-negative-aggressive-nk-cell-leukemia-relapsing-as-multiple-cranial-nerve-palsies-case-report-and-literature-review
#3
M Guerreiro, F Príncipe, M J Teles, S Fonseca, A H Santos, E Fonseca, P Gomes, C Marques, M Lima
Background: Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε(+) and surface CD3(-), CD2(+), and CD56(+) immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29162645/the-amazing-brain-drain
#4
Marie Blanchette, Richard Daneman
In this issue of JEM, Antila et al. (https://doi.org/10.1084/jem.20170391) demonstrate that central nervous system lymphatics develop in the mouse meninges during early postnatal periods and display remarkable plasticity in adult periods through manipulation of VEGF-C-VEGFR3 signaling.
November 21, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29162413/-frontoethmoidal-encephalocele-detected-after-meningitis-caused-by-two-microorganisms
#5
Alicia Llombart Vidal, Raquel Revert Gil, Inmaculada Bonilla Díaz, Pedro Jesús Alcalá Minagorre
No abstract text is available yet for this article.
November 18, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29160642/neonatal-bacterial-meningitis-a-systematic-review-of-european-available-data
#6
Antonio DI Mauro, Francesca Cortese, Nicola Laforgia, Beatrice Pantaleo, Rachele Giuliani, Donato Bonifazi, Marco M Ciccone, Paola Giordano
BACKGROUND: Despite advances in neonatal intensive care and the improvements in surveillance, prevention and vaccination programs, neonatal meningitis still represents an important cause of morbidity and mortality in infants, with the highest mortality in the newborn population. AIM: To summarize current knowledge about this topic with particular attention to management of neonatal meningitis in order to provide a useful tool for clinicians. METHODS: We reviewed the existent literature from five European Countries (France, German, Italy, Spain and United Kingdom) on the effectiveness of treatments for bacterial meningitis in newborns taking into consideration the antibiotic resistance phenomenon...
November 21, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/29160524/a-fatal-case-of-tuberculous-meningitis-in-a-child-with-juvenile-idiopathic-arthritis-a-diagnostic-challenge
#7
Zumrut Sahbudak Bal, Pinar Yazici, Semra Sen, Cenk Eraslan, Cengiz Cavusoglu, Bulent Karapinar, Fadil Vardar
The prognosis of tuberculous meningitis, a rare form of extrapulmonary tuberculosis, depends on the stage of treatment initiation. We report a fatal case of tuberculous meningitis. The patient had received successive tumor necrosis factor (TNF) antagonists and abatacept to treat juvenile idiopathic arthritis, with negative results for polymerase chain reaction and acid-fast bacilli on smear, had normal cerebrospinal fluid (CSF) adenosine deaminase and glucose levels. Six weeks post-admission, the CSF culture demonstrated Mycobacterium tuberculosis...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160197/isolation-and-molecular-characterization-of-group-b-streptococcus-from-laboratory-long-evans-rats-rattus-norvegicus-with-and-without-invasive-group-b-streptococcal-disease
#8
Caroline Bodi Winn, Vasudevan Bakthavatchalu, Michael Y Esmail, Yan Feng, JoAnn Dzink-Fox, Lauren Richey, Scott E Perkins, Eric K Nordberg, James G Fox
PURPOSE: Group B Streptococcus (S. agalactiae, GBS) is a Gram-positive opportunistic pathogen that inhabits the respiratory, urogenital and gastrointestinal tracts of humans and animals. Maternal colonization of GBS is a risk factor for a spectrum of clinical diseases in humans and a principle cause of neonatal meningitis and septicaemia. METHODOLOGY: We describe polymicrobial sepsis including GBS in two gravid adult female Long-Evans rats experiencing acute mortality from a colony of long-term breeding pairs...
November 21, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29160002/a-randomized-double-blind-trial-of-needle-free-injected-lidocaine-versus-topical-anesthesia-for-infant-lumbar-puncture
#9
Ryan Caltagirone, Vidya R Raghavan, Kathleen Adelgais, Genie E Roosevelt
OBJECTIVES: Lumbar punctures (LPs) are commonly performed in febrile infants to evaluate for meningitis, and local anesthesia increases the likelihood of LP success. Traditional methods of local anesthesia require injection which may be painful or topical application which is not effective immediately. Recent advances in needle-free jet injection may offer a rapid alternative to these modalities. We compared a needle-free jet-injection system (J-Tip(™) ) with 1% buffered lidocaine to topical anesthetic (TA) cream for local anesthesia in infant LPs...
November 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29159765/characteristic-comparison-of-meningitis-and-non-meningitis-of-streptococcus-suis-in-an-experimentally-infected-porcine-model
#10
Yingying Sun, Hongtao Liu, Rui Du, Shuguang Li, Guanggang Qu, Rining Zhu, Shuang Zhao, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Liancheng Lei
This study tested the differences of meningitis and non-meningitis of Streptococcus suis (SS). In this study, an infected pig model of streptococcal meningitis was established. Compared with the non-meningitis Streptococcus suis group (JZLQ001 group), the meningitis Streptococcus suis group (JZLQ022) exhibited neurological symptoms, such as ataxia and foaming at the mouth, and the brain showed a large area of congestion at 5 days post-infection (p.i.). Moreover, bacterial counts, white blood cells (WBCs), neutrophils, and blood glucose in the blood reached a peak and were significantly higher than those of the JZLQ001 group at 3 days p...
November 20, 2017: Inflammation
https://www.readbyqxmd.com/read/29159001/a-unique-case-of-acute-cerebral-venous-sinus-thrombosis-secondary-to-primary-varicella-zoster-virus-infection
#11
Syed F Imam, Omair Ul Haq Lodhi, Zainab Fatima, Saneeya Nasim, Waseem T Malik, Muhammad Sabih Saleem
Primary varicella zoster virus (VZV) infection, predominantly in the pediatric population, presents with pyrexia and a classic pruritic vesicular rash. In adults, although less common, it is more severe and linked to more complications. Neurological complications, which account for less than 1% of all VZV complications, include meningitis, encephalitis, arterial vasculopathy, and venous thrombosis. We present a case of a 39-year-old male who developed extensive cerebral venous sinus thrombosis following primary VZV infection...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29158433/whole-genome-characterization-of-bacillus-cereus-associated-with-specific-disease-manifestations
#12
T Chang, J W Rosch, Z Gu, H Hakim, C Hewitt, A Gaur, G Wu, R T Hayden
Bacillus cereus remains an important cause of infections, particularly in immunocompromised hosts. While typically associated with enteric infections, disease manifestations can be quite diverse and include skin infections, bacteremia, pneumonia, and meningitis. Whether there are any genetic correlates of bacterial strains with particular clinical manifestations remains unknown. To address this gap in understanding we undertook whole genome analysis of B. cereus strains isolated from patients with a range of disease manifestations, including non-invasive colonizing disease, superficial skin infections, and invasive bacteremia...
November 20, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29158097/a-novel-minimally-invasive-treatment-strategy-for-acute-traumatic-epidural-hematoma-endovascular-embolization-combined-with-drainage-surgery-and-use-of-urokinase
#13
Yuhui Zhang, Qiang Li, Rui Zhao, Zhigang Yang, Yanan Li, Weijie Min, Zhijian Yue, Jianmin Liu
BACKGROUND: Hematoma evacuation is regular treatment for acute traumatic epidural hematoma (ATEDH) patients meeting with surgery indications. However, it is an invasive approach performed under general anesthesia. Here, a novel minimally invasive method of endovascular embolization with subsequent drainage surgery and use of urokinase was established to treat ATEDH under local anesthesia. METHODS: a novel minimally invasive method of endovascular embolization with subsequent drainage surgery and use of urokinase was established to treat ATEDH under local anesthesia...
November 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29157147/a-case-of-aseptic-meningitis-in-a-cetuximab-experienced-patient-with-metastatic-colon-cancer
#14
Chelsea L Rohrer, Zunilda Grullon, Sarah K George, Raul Castillo, Kelli Karasiewicz
Cetuximab is a monoclonal antibody against epidermal growth factor receptor and is used in the treatment of head and neck cancer, non-small cell lung cancer, and colorectal cancer. This case report describes a rare (<1% incidence) side effect of cetuximab administration: aseptic meningitis. We report a case which is, to our knowledge, the only case at the time of submission of this manuscript of aseptic meningitis in a patient being treated for metastatic colon cancer who was not cetuximab-naïve. This case report may help inform clinicians about the identification and outcome of this adverse event...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29156511/molecular-epidemiology-and-prevalence-of-echovirus-30-in-zhejiang-province-china-from-2002-to-2015
#15
Yin Chen, Yi Sun, Juying Yan, Ziping Miao, Changping Xu, Yanjun Zhang, Haiyan Mao, Liming Gong
Echovirus 30 serotype (ECHO30) has been responsible for several, recent, worldwide outbreaks of viral meningitis. In Zhejiang Province, China, ECHO30 has been one of the main causes of viral meningitis for years. This study, using phylogenetic analysis on VP1 gene, was performed to investigate the general molecular epidemiology and genetic patterns of ECHO30 circulating in Zhejiang Province between the years 2002 and 2015. The nucleotide sequences of ECHO30 VP1 showed that they were 64.8% identical with the prototype strain, Bastianni, while the amino acids were 84...
November 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29155782/partial-optic-nerve-transection-in-rats-a-model-established-with-a-new-operative-approach-to-assess-secondary-degeneration-of-retinal-ganglion-cells
#16
Fancheng Yan, Sailiang Guo, Yijie Chai, Lan Zhang, Kegao Liu, Qingjun Lu, Ningli Wang, Shuning Li
Previous studies have shown that the secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. Partial optic nerve transection is considered a useful and reproducible model. Compared with other optic nerve injury models used commonly for assessing secondary degeneration, e.g. complete optic nerve transection and optic nerve crush models, the partial optic nerve transection model is superior as it distinguishes primary from secondary degeneration in situ. Therefore, it serves as an excellent tool for evaluating secondary degeneration...
October 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155345/the-relationship-between-hematoma-and-pachymeninges-in-an-interdural-hematoma-diagnosis-and-surgical-strategy
#17
Ko-Ting Chen, Hsu-Chen Huang, Ya-Jui Lin, Ming-Houng Chen, Tsung-Che Hsieh
BACKGROUND: The exact location of a hematoma in relation to the pachymeninges contributes to typical radiographic presentations. However, because of the complexity of hematoma evolution and neomembrane formation, an unexpected intraoperative finding may lead to a change of surgical strategy. Besides, the concentration of hemoglobin and its degradation products, the integrity of red blood cells (RBCs), and the infiltration of fibroblasts, polymorphonuclear neutrophils, and macrophages are factors that affect the imaging characteristics on computed tomography (CT) and magnetic resonance imaging (MRI) as the hematoma ages...
November 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29154044/modulating-host-immune-responses-to-fight-invasive-fungal-infections
#18
REVIEW
James E Scriven, Mark W Tenforde, Stuart M Levitz, Joseph N Jarvis
Modulation of host immunity in invasive fungal infection is an appealing but as yet mostly elusive treatment strategy. Animal studies in invasive candidiasis and aspergillosis have demonstrated beneficial effects of colony stimulating factors, interferon-gamma and monoclonal antibodies. More recent studies transfusing leukocytes pre-loaded with lipophilic anti-fungal drugs, or modulated T-cells, along with novel vaccination strategies show great promise. The translation of immune therapies into clinical studies has been limited to date but this is changing and the results of new Candida vaccine trials are eagerly awaited...
November 15, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29153586/non-specific-effects-of-childhood-vaccinations-a-case-control-study-nested-into-a-health-and-demographic-surveillance-system-in-rural-burkina-faso
#19
G Pfeiffer, A B Fisker, E Nebié, J Hengelbrock, A Sié, H Becher, O Müller
INTRODUCTION: Previous studies in African countries have been suggestive of non-specific effects (NSE) of vaccination on child survival. Live vaccines (e.g. measles, MV) have been found to reduce child mortality while inactivated vaccines (e.g. diphtheria-tetanus-pertussis, DTP) have been associated with increased mortality; NSE were often found to be sex-specific. METHODS: A case-control study nested into the Health and Demographic Surveillance System (HDSS) cohort of the Centre de Recherche en Santé de Nouna (CRSN) was conducted in northwestern Burkina Faso...
November 15, 2017: Vaccine
https://www.readbyqxmd.com/read/29152704/west-nile-disease-in-tunisia-an-overview-of-60-years
#20
Salah Hammami, Thameur Ben Hassine, Annamaria Conte, Jihène Amdouni, Fabrizio De Massis, Soufiène Sghaier, Sonia Ben Hassen
West Nile virus (WNV) is an arthropod borne virus of public health importance. The virus is a member of the genus Flavivirus and belongs to the Japanese encephalitis virus (JEV) antigenic complex under the Flaviviridae family. The WNV is continuously spreading across Tunisia especially in the coastal and Southern area of the country. The first human West Nile disease (WND) epidemic in Tunisia occurred in 1997, since then, the quantity and the extension of spillover effects increased constantly. However, the existing knowledge of factors triggering such events continues to be rather poor...
September 30, 2017: Veterinaria Italiana
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