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https://www.readbyqxmd.com/read/29891368/protective-role-of-thymoquinone-against-paraquat-induced-hepatotoxicity-in-mice
#1
Hamed Zeinvand-Lorestani, Amir Nili-Ahmadabadi, Fatemeh Balak, Gholamreza Hasanzadeh, Omid Sabzevari
Paraquat is a common and effective herbicide; although its poisoning could lead to severe oxidative organ damages and its main target organs are the lungs, kidneys, heart, and liver. Thymoquinone is the active ingredient of Nigella sativa which is traditionally used in herbal medicine; recent studies have shown that thymoquinone could inhibit oxidative stress. This study explores protective effects of thymoquinone on paraquat-induced hepatotoxicity in mice. Accordingly, adult male mice were randomly divided into nine groups for three continuous days intraperitoneal injection treatment: (1) control; (2) solvent; (3) 20 mg/kg vitamin E; (4) 20 mg/kg thymoquinone; (5) 20 mg/kg paraquat and Groups 6, 7, 8, and 9 received 20 mg/kg of vitamin E and 5, 10, and 20 mg/kg of thymoquinone, respectively...
June 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29881712/early-and-late-preventive-effect-of-nigella-sativa-on-the-bleomycin-induced-pulmonary-fibrosis-in-rats-an-experimental-study
#2
Hamid Reza Poursalehi, Mitra Samareh Fekri, Fariba Sharifi Far, Ali Mandegari, Atefe Izadi, Rahil Mahmoodi, Hadi Nematollahi, Fateme Porgholamhosein, Vahideh Ghorani, Masome Samareh Fekri
Objective: Pulmonary fibhrosis is a disease of the connective tissues in the respiratory system. Nigella sativa has been used for the treatment of pulmonary diseases like asthma. This study investigated the early and late preventive effect of methanolic extract of N. sativa on a bleomycin- induced pulmonary fibrosis model. Materials and Methods: This study was carried out using 52 rats. Pulmonary fibrosis was induced by a single endotracheal injection of bleomycin (5 mg/kg)...
May 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29881705/thymoquinone-recovers-learning-function-in-a-rat-model-of-alzheimer-s-disease
#3
Parvin Poorgholam, Parichehreh Yaghmaei, Zahra Hajebrahimi
Objective: Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of amyloid beta in the hippocampus. In recent decades, herbal medicine has been widely used to treat many neurodegenerative disorders,as in comparison to conventional drugs, herbal remedies exert minimal side effects. Here, the effects of thymoquinone, as the main active component of Nigella sativa , on passive avoidance memory in rat model of Alzheimer's disease, were evaluated. Materials and Methods: Hippocampal injection of amyloid beta (Aβ) was used to induce Alzheimer's disease in male Wistar rats, followed by intra peritoneal administrations of 5 and 10 mg/kg thymoquinone on a daily basis for 4 weeks...
May 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29857879/effect-of-nigella-sativa-supplementation-on-obesity-indices-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
REVIEW
Seyed Mohammad Mousavi, Ali Sheikhi, Hamed Kord Varkaneh, Meysam Zarezadeh, Jamal Rahmani, Alireza Milajerdi
BACKGROUND & OBJECTIVE(S): No meta-analysis is available on the effect of Nigella sativa (NS) on obesity indices. This systematic review and meta-analysis was conducted to systematically review the available Randomized Clinical Trials (RCTs) that examined the effects of NS on Body Weight (BW), Body Mass index (BMI), and Waist Circumference (WC) in adults. METHODS: Relevant articles published up to January 2018 were searched through PubMed/Medline, SCOPUS, Cochrane Library, and Google Scholar databases, using relevant keywords...
June 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29805796/thymoquinone-ameliorates-doxorubicin-induced-cardiotoxicity-in-swiss-albino-mice-by-modulating-oxidative-damage-and-cellular-inflammation
#5
Mohammad Firoz Alam, Gyas Khan, Mohammed M Safhi, Saeed Alshahrani, Rahimullah Siddiqui, Sivakumar Sivagurunathan Moni, Tarique Anwer
Thymoquinone is the active constituent of Nigella sativa , having antioxidant and anti-inflammatory actions. In present study, we have analyzed the effects of thymoquinone on doxorubicin (DOX) induced cardiotoxicity in mice. In this experiment, thirty mice (25-35 gm) were divided into five groups (Groups A, B, C, D, and E) each containing six animals. Normal saline was given to a control group (Group A) for 14 days. Cardiotoxicity was induced by DOX (15 mg/kg, i.p.) in Group B, once on the 13th day of the study, and Groups C and D also received DOX (15 mg/kg, i...
2018: Cardiology Research and Practice
https://www.readbyqxmd.com/read/29799656/modulatory-effects-of-some-natural-products-on-hepatotoxicity-induced-by-combination-of-sodium-valproate-and-paracetamol-in-rats
#6
Hanan S Zaky, Amany M Gad, Ekram Nemr, Wedad Hassan, Ola M Abd El-Raouf, Aza A Ali
Possible hepatoprotective effect of Curcuma longa and/or Nigella sativa against hepatotoxicity induced by coadministration of sodium valproate (SV) and paracetamol was studied. Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (250 mg/kg, p.o.), or both herbs for 21 days, respectively. Toxicity groups 5, 6, and 7 received SV (300 mg/kg, i.p.), paracetamol (1000 mg/kg, p.o.) for the last 4 days or both for 21 days, respectively. Protection groups 8, 9, and 10 received C...
May 25, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29796216/medicinal-herbs-in-the-treatment-of-neuropathic-pain-a-review
#7
REVIEW
Fatemeh Forouzanfar, Hossein Hosseinzadeh
Chronic neuropathic pain is a common significant and debilitating problem that presents a major challenge to health-care. Despite the large number of available drugs, there are no curative conventional treatments for neuropathic pain. Nowadays, more attention has been focused on the herbal formulation in the field of drug discovery. Therefore, we performed an extensive review about herbal drugs and plants that exhibited protective effects on neuropathic pain. In this review, the beneficial effects of each plant in different neuropathic pain model, either in animals or in patients are reported...
April 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29765815/in-vitro-investigation-of-antimicrobial-activities-of-ethnomedicinal-plants-against-dental-caries-pathogens
#8
Mamta Besra, Vipin Kumar
The study aimed to evaluate the antimicrobial activity of medicinal plant extracts against the bacterial pathogens prominent in dental caries. A total of 20 plant species (herbs, shrubs and trees) belonging to 18 genera and 15 families were documented for dental caries. Antimicrobial activity of solvent extracts and essential oil from plants were determined by zone of inhibition on the growth of Streptococcus mutans (MTCC 497) and Lactobacillus acidophilus (MTCC 10307) using the agar well diffusion method. The results of in vitro antimicrobial assay prove that methanol is more successful in the extraction of phytochemicals from plant samples than aqueous solvent, as methanol extracts show higher antimicrobial activity than aqueous extracts against both the test pathogens...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29759145/thymoquinone-increases-the-expression-of-neuroprotective-proteins-while-decreasing-the-expression-of-pro-inflammatory-cytokines-and-the-gene-expression-nf%C3%AE%C2%BAb-pathway-signaling-targets-in-lps-ifn%C3%AE-activated-bv-2-microglia-cells
#9
Makini K Cobourne-Duval, Equar Taka, Patricia Mendonca, Karam F A Soliman
Neuroinflammation and microglial activation are pathological markers of a number of central nervous system (CNS) diseases. Chronic activation of microglia induces the release of excessive amounts of reactive oxygen species (ROS) and pro-inflammatory cytokines. Additionally, chronic microglial activation has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Thymoquinone (TQ) has been identified as one of the major active components of the natural product Nigella sativa seed oil...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29751576/thymoquinone-suppresses-irf-3-mediated-expression-of-type-i-interferons-via-suppression-of-tbk1
#10
Nur Aziz, Young-Jin Son, Jae Youl Cho
Interferon regulatory factor (IRF)-3 is known to have a critical role in viral and bacterial innate immune responses by regulating the production of type I interferon (IFN). Thymoquinone (TQ) is a compound derived from black cumin ( Nigella sativa L.) and is known to regulate immune responses by affecting transcription factors associated with inflammation, including nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). However, the role of TQ in the IRF-3 signaling pathway has not been elucidated...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29749248/antiproliferative-and-antiapoptotic-effect-of-thymoquinone-on-cancer-cells-in-vitro
#11
G Kus, M Ozkurt, S Kabadere, N Erkasap, G Goger, F Demirci
OBJECTIVES: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma,T98; prostate, LnCaP) as well as mouse embryonic fibroblast cell lines (3T3), and for the induction of apoptosis. METHODS: Individual cell lines were treated with thymoquinone and N. sativa oil for 24 and 48 hr. Survival rate with MTT, apoptosis with flow cytometry and caspase-9 mRNA enzyme levels with RT-PCR were determined in vitro...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29743967/neuropharmacological-potential-and-delivery-prospects-of-thymoquinone-for-neurological-disorders
#12
REVIEW
Md Jakaria, Duk-Yeon Cho, Md Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Dong-Kug Choi
Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections. In addition, it might be a potential neuropharmacological agent because it exhibits versatile potential for attenuating neurological impairments. It features greater beneficial effects in toxin-induced neuroinflammation and neurotoxicity. In various models of neurological disorders, it demonstrates emergent functions, including safeguarding various neurodegenerative diseases and other neurological diseases, such as stroke, schizophrenia, and epilepsy...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29739684/ameliorating-effects-of-nigella-sativa-oil-on-aggravation-of-inflammation-oxidative-stress-and-cytotoxicity-induced-by-smokeless-tobacco-extract-in-an-allergic-asthma-model-in-wistar-rats
#13
T Khaldi, N Chekchaki, M Boumendjel, F Taibi, M Abdellaoui, M Messarah, A Boumendjel
BACKGROUND: The comparison of smokeless tobacco (ST) exposure versus Ovalbumin (Ova) sensitized rats or asthmatic patients has hardly been studied in the literature. Thus, the present study aims to investigate the aggravation of inflammation, exacerbation of asthma, oxidative stress and cytotoxicity induced by ST. METHODS: ST was given at the dose of 40mg/kg in an allergic asthma model in Wistar rats. Furthermore, the effects of oral administration of Nigella sativa oil (NSO), at a dose of 4mL/kg/day, were investigated...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29733120/thymoquinone-protects-rat-liver-after-partial-hepatectomy-under-ischemia-reperfusion-through-oxidative-stress-and-endoplasmic-reticulum-stress-prevention
#14
Ahlem Bouhlel, Mohamed Bejaoui, Ismail Ben Mosbah, Najet Hadj Abdallah, Catherine Ribault, Roselyne Viel, Hassen Hentati, Anne Corlu, Hassen Ben Abdennebi
Ischemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were equally divided into four groups (n=6) receiving an oral administration of either vehicle solution (Sham and PH groups) or TQ at 30 mg/kg (TQ and TQ+PH groups) for ten consecutive days. Then, rats underwent PH (70%) with 60 min of ischemia followed by 24h of reperfusion (PH and TQ+PH groups)...
May 7, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29730530/fingerprint-profile-and-efficacy-associated-markers-of-nigella-sativa-oil-for-geographical-origin-determination-using-targeted-and-untargeted-hptlc-multivariate-analysis
#15
Eman Shawky, Nihal M El Newehy, Amira M Beltagy, Mohammad M Abd-Alhaseeb, Gamal A Omran, Fathallah M Harraz
Efficacy directed-fingerprint analysis of high-performance thin layer chromatography is proposed to set up fingerprint activity relationship modeling for precise discrimination of chemical and effective consistency of Nigella sativa oils from different geographical origins. A whole of 27 samples of N. sativa oils from three geographical area (Egypt, Ethiopia and Syria) were collected and their antimicrobial, cytotoxic, anti-inflammatory and analgesic activities were measured. The results revealed that there was significant difference in the biological activities of the oils collected...
April 30, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29719661/protective-effects-of-nigella-sativa-on-synaptic-plasticity-impairment-induced-by-lipopolysaccharide
#16
Akbar Anaeigoudari, Fatemeh Norouzi, Azam Abareshi, Farimah Beheshti, Azita Aaghaei, Mohammad Naser Shafei, Zahra Gholamnezhad, Mahmoud Hosseini
In the present study the protective effect of Nigella sativa ( N. sativa ) on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: 1) control (saline), 2) LPS, 3) LPS -N. sativa , and 4) N. sativa. In a Morris water maze test, the escape latency and traveled path to find the platform as well as time spent and the traveled distance in target quadrant (Q1 ) were measured. Long term potentiation (LTP) from CA1 area of hippocampus followed by high frequency stimulation to Schafer collateral was studied and slope, slope 10-90% and amplitude of field excitatory field potential (fEPSP) were calculated...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29717629/a-comparative-study-of-the-effects-of-nigella-sativa-oil-gel-and-aloe-vera-gel-on-wound-healing-in-diabetic-rats
#17
Yunita Sari, Iwan Purnawan, Dhadhang Wahyu Kurniawan, Eman Sutrisna
Clinicians and wound care nurses in Indonesia usually use Nigella sativa oil (NSO) gel and aloe vera (AV) gel to treat diabetic ulcers. However, there are no studies directly comparing the effects of NSO and AV gels on wound healing, so it is unknown which of these 2 plants is better at promoting wound healing in diabetic ulcers. If the comparative efficacy between these 2 gels was known, it would be important evidence favoring the clinical use of one or the other product in Indonesia. The aim of this study was to investigate and compare the effectiveness of NSO and AV gels on wound healing in a rat model of diabetic ulcers...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29710533/thymoquinone-alleviates-arsenic-induced-hippocampal-toxicity-and-mitochondrial-dysfunction-by-modulating-mptp-in-wistar-rats
#18
Fakiha Firdaus, Mohd Faraz Zafeer, Mohammad Waseem, Rizwan Ullah, Masood Ahmad, Mohammad Afzal
Arsenic is a pervasive environmental pollutant that is found in ground waters globally and is related to numerous morbidities in the high-risk population areas in countries including Bangladesh, India, and the USA. Arsenic exposure has been ubiquitously reported for exacerbating free radical generation, mitochondrial dysfunction, and apoptosis by interfering with the mPTP functioning. Over the past decades, nutraceuticals with antioxidant properties have shown promising efficacy in arsenic poisoning. In the present study, we have examined, the protective efficacy of thymoquinone (TQ), an active component of seed oil of Nigella sativa with antioxidant and anti-inflammatory activity on arsenic-induced toxicity in hippocampi of Wistar rats...
April 4, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29706929/neuromodulatory-effect-of-thymoquinone-in-attenuating-glutamate-mediated-neurotoxicity-targeting-the-amyloidogenic-and-apoptotic-pathways
#19
Ibram Amin Fouad, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed
Overexposure of the glutamatergic N-methyl-d-aspartate (NMDA) receptor to the excitatory neurotransmitter l-glutamic acid leads to neuronal cell death by excitotoxicity as a result of increased intracellular Ca2+ , mitochondrial dysfunction, and apoptosis. Moreover, it was previously reported that prolonged activation of the NMDA receptor increased beta-amyloid (Aβ) levels in the brain. Thymoquinone (TQ), the active constituent of Nigella sativa seeds, has been shown to have potent antioxidant and antiapoptotic effects...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29701149/nigella-sativa-l-and-its-bioactive-constituents-as-hepatoprotectant-a-review
#20
Heena Tabassum, Asad Ahmad, Iffat Zareen Ahmad
BACKGROUND: The pharmacological properties of Nigella sativa L. are well attributed to the presence of bioactive compounds, mainly, thymoquinone (TQ), thymol (THY) and α hederin and their antioxidant effects. TQ,THY and alpha-hederin (α-hederin) provide protection to liver from injury via different mechanisms including inhibition of iron-dependent lipid peroxidation, elevation in total thiol content and (GSH) level, radical scavenging, increasing the activity of quinone reductase, catalase, superoxide dismutase(SOD) and glutathione transferase (GST), inhibition of NF-κB activity and inhibition of both (COX) and (LOX) protects liver from injuries...
April 26, 2018: Current Pharmaceutical Biotechnology
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