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https://www.readbyqxmd.com/read/28438282/in-vitro-susceptibility-of-methicillin-resistant-stayphylococcus-aureus-to-honey
#1
Muhammad Barkaat Hussain, Abdul Hannan, Muhammad Absar, NadeemShafique Butt
Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) is becoming much complicated and costly to treat as antimicrobial resistance is quite common. Twenty five MRSA strains isolated from infected wounds and three ATCC reference strains were evaluated for their susceptibility to locally produced black seed (Nigella sativa), beri (ZiziphusJujuba) and shain honey (Plectranthus rugosus wall) by agar incorporation assay. Medically graded manuka honey (UMF 21(+)) was included as control. Locally produced black seed honey inhibited all clinical isolates at mean MIC of 5...
May 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28421118/pattern-of-traditional-medicine-utilization-among-hiv-aids-patients-on-antiretroviral-therapy-at-a-university-hospital-in-northwestern-ethiopia-a-cross-sectional-study
#2
Abyot Endale Gurmu, Fitsum Sebsibe Teni, Wondmagegn Tamiru Tadesse
The objective of this study was to assess traditional, complementary, and alternative medicine (TCAM) utilization pattern among HIV/AIDS patients on antiretroviral therapy at University of Gondar Comprehensive Specialized Hospital. Materials and Methods. Data on sociodemographic profile and clinical and TCAM utilization were collected using a structured, pretested questionnaire from April 01 to May 28, 2014, through interviews with patients. Data on CD4 count, HIV stage, and ART regimen were collected from patient records...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28416010/the-effect-of-thymoquinone-coating-on-adhesive-properties-of-polypropylene-mesh
#3
Oktay Aydin, Kuzey Aydinuraz, Fatih Agalar, I Tayfun Sahiner, Canan Agalar, Cem Bayram, Emir Baki Denkbas, Pinar Atasoy
BACKGROUND: An incisional hernia is a common complication following abdominal surgery. Polypropylene mesh is frequently used in the repair of such defects and has nearly become the standard surgical treatment modality. Though they are very effective in reducing recurrence, mesh materials exhibit a strong stimulating effect for intraabdominal adhesion. The thymoquinone (TQ) extracted from Nigella sativa seeds has potential medical properties. TQ has anti-inflammatory, antioxidant and antibacterial properties...
April 17, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28415607/thymoquinone-exerts-potent-growth-suppressive-activity-on-leukemia-through-dna-hypermethylation-reversal-in-leukemia-cells
#4
Jiuxia Pang, Na Shen, Fei Yan, Na Zhao, Liping Dou, Lai-Chu Wu, Christopher L Seiler, Li Yu, Ke Yang, Veronika Bachanova, Eric Weaver, Natalia Y Tretyakova, Shujun Liu
Thymoquinone (TQ), a bioactive constituent of the volatile oil of Monarda fistulosa and Nigella sativa, possesses cancer-specific growth inhibitory effects, but the underlying molecular mechanisms remain largely elusive. We propose that TQ curbs cancer cell growth through dysfunction of DNA methyltransferase 1 (DNMT1). Molecular docking analysis revealed that TQ might interact with the catalytic pocket of DNMT1 and compete with co-factor SAM/SAH for DNMT1 inhibition. In vitro inhibitory assays showed that TQ decreases DNMT1 methylation activity in a dose-dependent manner with an apparent IC50 of 30 nM...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413647/nigella-sativa-seed-extract-attenuates-the-fatigue-induced-by-exhaustive-swimming-in-rats
#5
Mahbubur Rahman, Dong Kwon Yang, Gi-Beum Kim, Sei-Jin Lee, Shang-Jin Kim
In previous studies, Nigella sativa (NS) has been studied due to its various physiological and pharmacological activities. However, evidence on the effects of NS on physical fatigue following exhaustive swimming remains limited. In the present study, the authors evaluated the potential beneficial effects of NS against the fatigue activity following exhaustive swimming. Rats were orally administered with NS extract (2 g/kg/day) for 21 days, and the anti-fatigue effect was assessed by exhaustive swimming exercise...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28412654/nigella-sativa-a-traditional-tunisian-herbal-medicine-attenuates-bleomycin-induced-pulmonary-fibrosis-in-a-rat-model
#6
Anouar Abidi, Alexandre Robbe, Nadia Kourda, Saloua Ben Khamsa, Alexandre Legrand
The present study investigated the effects of Nigella sativa oil (NSO) on bleomycin (BLM)-induced lung fibrosis in rats. The rat model of pulmonary fibrosis (PF) was established by intratracheal instillation of BLM, and the effect of 1ml/kg oral NSO treatment once daily observed. The effect of NSO was studied over a period of 50daysusing (1)H RMN analysis on the urine and broncho alveolar lavage fluid (Balf) of the rats. Histopathological (inflammation and fibrosis) and immunohistochemical (TGF-β1 density) changes were evaluated...
April 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28400978/thymoquinone-attenuates-brain-injury-via-an-anti-oxidative-pathway-in-a-status-epilepticus-rat-model
#7
Yi-Ye Shao, Bing Li, Yong-Mei Huang, Qiong Luo, Yang-Mei Xie, Ying-Hui Chen
AIM: Status epilepticus (SE) results in the generation of reactive oxygen species (ROS), which contribute to seizure-induced brain injury. It is well known that oxidative stress plays a pivotal role in status epilepticus (SE). Thymoquinone (TQ) is a bioactive monomer extracted from black cumin (Nigella sativa) seed oil that has anti-inflammatory, anti-cancer, and antioxidant activity in various diseases. This study evaluated the protective effects of TQ on brain injury in a lithium-pilocarpine rat model of SE and investigated the underlying mechanism related to antioxidative pathway...
January 2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28396188/effects-of-nigella-sativa-extract-on-markers-of-cerebral-angiogenesis-after-global-ischemia-of-brain-in-rats
#8
Koroush Soleimannejad, Asghar Rahmani, Masoud Hatefi, Masoud Khataminia, Mohammad Reza Hafezi Ahmadi, Khairollah Asadollahi
BACKGROUND: Reduction of permanent or transient cerebral blood flow may lead to some structural and functional changes of the brain, causing high mortality and morbidity. The aim of this experimental study was to investigate the effects of hydroalcoholic extract of Nigella sativa (NS) on markers of cerebral angiogenesis in rats induced by global brain ischemia. METHODS: Thirty-two male Wistar rats (250 ± 20 g) were randomly divided into 4 groups: group 1, control group receiving only normal saline; group 2, sham group undergoing surgery and stroke induction without treatment; and groups 3 and 4 treated with 10 and 20 mg/kg NS, respectively, after induction of stroke...
April 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28392960/anti-aging-effect-of-nigella-sativa-fixed-oil-on-d-galactose-induced-aging-in-mice
#9
Mahdieh Jafari Shahroudi, Soghra Mehri, Hossein Hosseinzadeh
OBJECTIVES: Aging is an unconscious and gradual process that can lead to changes in biological systems. Induction of oxidative stress and apoptosis, hepatotoxicity and neurotoxicity are involved in the aging process. Regarding the antioxidant property of black seed oil, the aim of this study was to evaluate the anti-aging effect of Nigella sativa (N. sativa) oil on d-galactose-induced aging in mice. METHODS: For induction of aging, D-galactose (500 mg/kg, subcoutaneously SC) was administrated to male mice for 42 days...
March 2017: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28386474/finding-novel-antibiotic-substances-from-medicinal-plants-antimicrobial-properties-of-nigella-sativa-directed-against-multidrug-resistant-bacteria
#10
Seher Nancy Bakal, Stefan Bereswill, Markus M Heimesaat
The progressive rise in multidrug-resistant (MDR) bacterial strains poses serious problems in the treatment of infectious diseases. While the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. This rise in resistance illustrates the need for developing novel therapeutic and preventive antimicrobial options. The medicinal herb Nigella sativa and its derivatives constitute promising candidates. In a comprehensive literature survey (using the PubMed data base), we searched for publications on the antimicrobial effects of N...
March 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28378356/effect-of-an-orally-formulated-processed-black-cumin-from-iranian-traditional-medicine-pharmacopoeia-in-relieving-symptoms-of-knee-osteoarthritis-a-prospective-randomized-double-blind-and-placebo-controlled-clinical-trial
#11
Ahmad Salimzadeh, Anahita Ghourchian, Rasool Choopani, Homa Hajimehdipoor, Mohammad Kamalinejad, Maryam Abolhasani
AIM: Osteoarthritis is a global health problem, especially for the elderly. A good replacement for non-surgical treatments is the use of traditional medicines. We selected a revere plant (Nigella sativa L.), a widely utilized medicinal herb for the treatment of inflammatory conditions, from the Iranian traditional medicine (ITM) pharmacopoeia with proven anti-inflammatory and analgesic actions. METHODS: We performed a prospective, randomized, double-blind, and placebo-controlled clinical trial, in order to investigate whether the herb is useful in alleviating the symptoms of knee osteoarthritis...
April 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28374868/the-value-of-nigella-sativa-in-the-treatment-of-experimentally-induced-rhinosinusitis
#12
O Yoruk, A Tatar, O N Keles, A Cakir
The aim of this study was to investigate the effect of Nigella sativa and cephalexin in the therapy of experimental bacterial rhinosinusitis. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into five groups; control (n = 6), N. sativa 50 mg/ kg/d (n = 6), N. sativa 100 mg/kg/d (n = 6), N. sativa 200 mg/kg/d (n = 6), and cephalexin 20 mg/kg/d (n = 6) groups. N. sativa was given orally for 7 days. The same volume of normal saline (0.9% NaCl) was given as a vehicle to the control group for the same period...
February 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28361577/effects-of-nigella-sativa-seeds-and-certain-species-of-fungi-extracts-on-number-and-activation-of-dural-mast-cells-in-rats
#13
E Kilinc, Y Dagistan, B Kotan, A Cetinkaya
In this study, we aimed to investigate the effects of Nigella sativa seeds and certain species of fungi extracts on the number and degranulation states of dural mast cells in rats. Rats were fed ad libitum with normal tap water or tap water with extract of N. sativa seed, Ramaria condensata, Lactarius salmonicolor, Lactarius piperatus, and Tricholoma terreum for 3 days. Mast cells in dura mater were counted and evaluated in terms of granulation and degranulation states. Compound 48/80, a mast cell degranulating agent, and T...
March 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28349493/effect-of-nigella-sativa-seed-administration-on-prevention-of-febrile-neutropenia-during-chemotherapy-among-children-with-brain-tumors
#14
HebatAlla Fathi Mohamed Mousa, Nesrin Kamal Abd-El-Fatah, Olfat Abdel-Hamid Darwish, Shehata Farag Shehata, Shady Hassan Fadel
PURPOSE: Seeds of Nigella sativa (NS) are used to combat various disease conditions through their antibacterial effects. To evaluate the seeds' potential, we studied their effect on the prevention of febrile neutropenia (FN) in children with brain tumors. METHODS: A randomized pretest-post-test control group study including 80 children (2-18 years) with brain tumors undergoing chemotherapy were equally allocated into two groups. Intervention group received 5 g of NS seeds daily throughout treatment while controls received nothing...
March 27, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28344755/effect-of-topical-application-of-nigella-sativa-oil-and-oral-acetaminophen-on-pain-in-elderly-with-knee-osteoarthritis-a-crossover-clinical-trial
#15
Akram Kooshki, Reza Forouzan, Mohammad Hassan Rakhshani, Maryam Mohammadi
BACKGROUND: Limited evidence supports Nigella sativa's role as an effective complementary and alternative medicine and the anti-inflammatory effects of Nigella sativa on patients with allergic rhinitis. OBJECTIVE: The aim of this study was to investigate the effect of topical application of Nigella sativa oil and oral acetaminophen on pain in the elderly with knee osteoarthritis residing in a parents' home in Sabzevar. METHODS: This study is done as a crossover clinical trial...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28344496/the-impact-of-formulation-attributes-and-process-parameters-on-black-seed-oil-loaded-liposomes-and-their-performance-in-animal-models-of-analgesia
#16
Zerin T Rushmi, Nasrin Akter, Rabeya J Mow, Merina Afroz, Mohsin Kazi, Marcel de Matas, Mahbubur Rahman, Mohammad H Shariare
This study aimed to formulate black seed oil (Nigella sativa) loaded liposomes using the ethanol injection method to enhance oral bioavailability and improve therapeutic activity in small animal studies of analgesia. The impact of formulation attributes and process parameters on the liposomal system was evaluated with key quality attributes being particle size, morphology, and entrapment efficiency. The particle size and entrapment efficiency of the liposome preparation were found to be between the range of 50-900 nm and 34-87% respectively...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28324259/protective-effect-of-nigella-sativa-seeds-against-spermatocyte-chromosomal-aberrations-and-genotoxicity-induced-by-carbon-tetrachloride-in-mice
#17
Ashraf M Abdel-Moneim, Amina E Essawy, Sherifa S Hamed, Ashgan A Abou-Gabal, Aglal A Alzergy
Nigella sativa is a well-known dietary antioxidant and a valuable inhibitor of clastogenesis and carcinogenesis. The purpose of the present work was to investigate the effects of N. sativa seeds against chromosomal aberrations in primary spermatocytes and early embryonic lethality induced by CCl4 hepatotoxin in Swiss albino mice. One hundred male Swiss albino mice were randomly divided into five groups. Groups I, II, and III received only normal saline, olive oil, and aqueous suspension of N. sativa seeds (50 mg/kg b...
March 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28322956/polysaccharide-of-black-cumin-nigella-sativa-modulates-molecular-signaling-cascade-of-gastric-ulcer-pathogenesis
#18
Srikanta Belagihalli Manjegowda, Harsha Mysore Rajagopal, Shylaja Mallaiah Dharmesh
Gastric ulcer is a multi-step disease and healing requires a complex process including repair and re-architecture of gastric mucosa with the involvement of molecular events. Current study was designed to understand the gastric ulcer healing mechanism of rhamnogalacturonan-I type pectic polysaccharide of black cumin (BCPP) utilizing acetic acid induced gastric ulcers in rats. BCPP fed groups at 200mg/kg b.w. for 10days showed up to 85% healing of gastric ulcers with modulation of key molecular events involved in ulcer healing process such as increase in gastric mucin content, cyclooxygenase-2 (Cox-2) and prostaglandin E2 (PGE2)...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28320235/methanol-extract-of-nigella-sativa-seed-induces-changes-in-the-levels-of-neurotransmitter-amino-acids-in-male-rat-brain-regions
#19
Tarek El-Naggar, María Emilia Carretero, Carmen Arce, María Pilar Gómez-Serranillos
CONTEXT: Nigella sativa L. (Ranunculaceae) (NS) has been used for medicinal and culinary purposes. Different parts of the plant are used to treat many disorders. OBJECTIVE: This study investigates the effects of NS methanol extract on brain neurotransmitter amino acid levels. MATERIALS AND METHODS: We measured the changes in aspartate, glutamate, glycine and γ-aminobutyric acid in five brain regions of male Wistar rats after methanol extract treatment...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28302020/olfactory-loss-management-in-view-of-avicenna-focus-on-neuroprotective-plants
#20
Farnaz Sinaei, Seyed Ahmad Emami, Amirhossein Sahebkar, Behjat Javadi
BACKGROUND: Loss of olfaction can cause noticeable reduction in general quality of life. Only a small portion of patients with olfactory loss respond to current medications. Thus, development of novel therapeutic strategies seems to be necessary. Looking into traditional medical knowledge can be of great value in addressing useful remedies. Traditional Persian Medicine (TPM) has been practiced in Persia for more than 2000 years. Avicenna is the most eminent Persian physician. OBJECTIVE: To survey Avicenna's views on etiology and management of olfactory loss and to search for relevant modern pharmacological data...
March 16, 2017: Current Pharmaceutical Design
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