keyword
MENU ▼
Read by QxMD icon Read
search

Speed

keyword
https://www.readbyqxmd.com/read/28109158/using-the-volta-phase-plate-with-defocus-for-cryo-em-single-particle-analysis
#1
Radostin Danev, Dimitry Tegunov, Wolfgang Baumeister
Previously, we reported an in-focus data acquisition method for cryo-EM single particle analysis with the Volta phase plate (VPP) (Danev and Baumeister, 2016). Here, we extend the technique to include a small amount of defocus which enables contrast transfer function measurement and correction. This hybrid approach simplifies the experiment and increases the data acquisition speed. It also removes the resolution limit inherent to the in-focus method thus allowing 3D reconstructions with resolutions better than 3 Å...
January 21, 2017: ELife
https://www.readbyqxmd.com/read/28108974/design-and-evaluation-of-topical-diclofenac-sodium-gel-using-hot-melt-extrusion-technology-as-a-continuous-manufacturing-process-with-kolliphor%C3%A2-p407
#2
Jaywant Pawar, Rajkiran Narkhede, Purnima Amin, Vaishali Tawde
The aim of the present context was to develop and evaluate a Kolliphor® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process. In this study, we have explored first time ever HME as an industrially feasible and continuous manufacturing technology for the manufacturing of gel formulation using Kolliphor® P407 and Kollisolv® PEG400 as a gel base. Diclofenac sodium was used as a model drug. The HME parameters such as feeding rate, screw speed, and barrel temperature were crucial for the semisolid product development, and were optimized after preliminary trials...
January 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28108637/tomm40-523-variant-and-cognitive-decline-in-older-persons-with-apoe-%C3%AE%C2%B53-3-genotype
#3
Lei Yu, Michael W Lutz, Robert S Wilson, Daniel K Burns, Allen D Roses, Ann M Saunders, Chris Gaiteri, Philip L De Jager, Lisa L Barnes, David A Bennett
OBJECTIVE: To interrogate a poly-T variant (rs10524523, '523) in TOMM40, a gene adjacent to the APOE gene on chromosome 19, in older persons with APOE ε3/3 homozygosity for association with cognitive decline, the clinical hallmark of Alzheimer disease (AD). METHODS: Data came from participants in 2 cohort studies of aging and dementia who underwent annual clinical evaluations for up to 21 years. APOE and TOMM40'523 genotypes were determined from DNA from blood or brain samples...
January 20, 2017: Neurology
https://www.readbyqxmd.com/read/28108362/an-in-vitro-study-on-the-burn-wound-healing-activity-of-cotton-fabrics-incorporated-with-phytosynthesized-silver-nanoparticles-in-male-wistar-albino-rats
#4
Pannerselvam Balashanmugam, Dharmalingam Jothinathan Mukesh Kumar, Rajenderan Murugan, Perumal Palani, Pudupalayam Thangavelu Kalaichelvan, Hyung Joo Kim, Vijay Singh, Rangarajulu Senthil Kumaran
In modern therapeutics, chemically synthesized drugs have been reported as causing adverse effects including allergies, rashes, itches, and swelling. For the past few decades, silver nanoparticles (AgNPs) have widely been applied in medical domains due to their antimicrobial and wound healing properties. In the present study, different concentrations of phytosynthesized AgNPs-saturated cotton dress fabrics - in comparison to cotton fabrics treated with commercial ointment - were tested for 18days to assess their ability to speed the healing of rats' burn wounds...
January 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28108267/fitness-and-fatness-in-relation-with-attention-capacity-in-european-adolescents-the-helena-study
#5
Cristina Cadenas-Sanchez, Jeremy Vanhelst, Jonatan R Ruiz, Ruth Castillo-Gualda, Lars Libuda, Idoia Labayen, Pilar De Miguel-Etayo, Ascensión Marcos, Eszter Molnár, Andrés Catena, Luis A Moreno, Michael Sjöström, Frederic Gottrand, Kurt Widhalm, Francisco B Ortega
OBJECTIVES: To examine the association of health-related physical fitness components and accurate measures of fatness with attention in European adolescents. DESIGN: Cross-sectional study. METHODS: A sub-sample of 444 adolescents from the HELENA study (14.5±1.2years) from 6 different countries participated in this study. Adolescents underwent evaluations of fitness (20m shuttle run, handgrip strength, standing long jump and 4×10m shuttle run tests), fatness (body mass index, skinfold thicknesses, bioelectrical impedance, Bod Pod and dual-energy X-ray absorptiometry) and attention (d2-test)...
August 9, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28108236/comparison-between-piezosurgery-and-conventional-osteotomy-in%C3%A2-cranioplasty-with-fronto-orbital-advancement
#6
Markus Martini, Andreas Röhrig, Rudolf Hermann Reich, Martina Messing-Jünger
BACKGROUND: Cranioplasty of patients with craniosynostosis requires rapid, precise and gentle osteotomy of the skull to avoid complications and benefit the healing process. The aim of this prospective clinical study was to compare two different methods of osteotomy. Piezosurgery and conventional osteotomy were compared using an oscillating saw and high speed drill while performing cranioplasties with fronto-orbital advancement. METHODS: Thirty-four children who required cranioplasty with fronto-orbital advancement were recruited consecutively...
December 21, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28108153/parameters-from-the-complete-phonatory-range-of-an-excised-rabbit-larynx
#7
Randal D Mills, Keith Dodd, Alex Ablavsky, Erin Devine, Jack J Jiang
OBJECTIVE: This study aims to collect data throughout the complete phonatory range using rabbit larynges. STUDY DESIGN: This is a methodological excised rabbit larynx study. METHODS: Seven rabbit larynges were dissected and mounted on a modified excised laryngeal apparatus. Phonation was initiated at phonation threshold pressure (PTP) and airflow was increased by consistent increments until phonation instability pressure (PIP) was reached...
January 17, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28108122/-fast-methods-of-fungal-and-bacterial-identification-maldi-tof-mass-spectrometry-chromogenic-media
#8
María Siller-Ruiz, Sara Hernández-Egido, Fernando Sánchez-Juanes, José Manuel González-Buitrago, Juan Luis Muñoz-Bellido
MALDI-TOF mass spectrometry is now a routine resource in Clinical Microbiology, because of its speed and reliability in the identification of microorganisms. Its performance in the identification of bacteria and yeasts is perfectly contrasted. The identification of mycobacteria and moulds is more complex, due to the heterogeneity of spectra within each species. The methodology is somewhat more complex, and expanding the size of species libraries, and the number of spectra of each species, will be crucial to achieve greater efficiency...
January 17, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28108083/impact-of-straight-unconnected-radially-oriented-and-tapered-mesopores-on-column-efficiency-a-theoretical-investigation
#9
Fabrice Gritti
Superficially porous particles (SPPs) can be prepared from a pseudomorphic transformation (PMT) which produces straight, unconnected, and radially-oriented mesopores (ROMs). ROMs can be either both ends open in fully porous particles (FPPs) or one-end-closed in SPPs. The impact of ROMs on the longitudinal diffusion (B/u), solid-liquid mass transfer resistance (Csu), and on the eddy dispersion (A(u)) height equivalent to a theoretical plate (HETP) of 3D randomly packed columns was investigated based on theoretical viewpoints...
January 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28108080/prediction-of-gradient-retention-data-for-hydrophilic-interaction-liquid-chromatographic-separation-of-native-and-fluorescently-labeled-oligosaccharides
#10
Nikola Vaňková, Petr Česla
In this work, we have investigated the predictive properties of mixed-mode retention model and oligomeric mixed-mode model, taking into account the contribution of monomeric units to the retention, in hydrophilic interaction liquid chromatography. The gradient retention times of native maltooligosaccharides and their fluorescent derivatives were predicted in the oligomeric series with number of monomeric glucose units in the range from two to seven. The maltooligosaccharides were separated on a packed column with carbamoyl-bonded silica stationary phase and 15 gradient profiles with different initial and final mobile phase composition were used with the gradient times 5; 7...
January 16, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28108004/nonlinear-svm-dtc-for-induction-motor-drive-using-input-output-feedback-linearization-and-high-order-sliding-mode-control
#11
Abdelkarim Ammar, Amor Bourek, Abdelhamid Benakcha
This paper presents a nonlinear Direct Torque Control (DTC) strategy with Space Vector Modulation (SVM) for an induction motor. A nonlinear input-output feedback linearization (IOFL) is implemented to achieve a decoupled torque and flux control and the SVM is employed to reduce high torque and flux ripples. Furthermore, the control scheme performance is improved by inserting a super twisting speed controller in the outer loop and a load torque observer to enhance the speed regulation. The combining of dual nonlinear strategies ensures a good dynamic and robustness against parameters variation and disturbance...
January 17, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28107998/multiplex-and-accurate-quantification-of-acute-kidney-injury-biomarker-candidates-in-urine-using-protein-standard-absolute-quantification-psaq-and-targeted-proteomics
#12
Benoît Gilquin, Mathilde Louwagie, Michel Jaquinod, Alexandre Cez, Guillaume Picard, Leila El Kholy, Brigitte Surin, Jérôme Garin, Myriam Ferro, Thomas Kofman, Caroline Barau, Emmanuelle Plaisier, Pierre Ronco, Virginie Brun
There is a need for multiplex, specific and quantitative methods to speed-up the development of acute kidney injury biomarkers and allow a more specific diagnosis. Targeted proteomic analysis combined with stable isotope dilution has recently emerged as a powerful option for the parallelized evaluation of candidate biomarkers. This article presents the development of a targeted proteomic assay to quantify 4 acute kidney injury biomarker candidates in urine samples. The proteins included in the assessed panel consisted of myo-inositol oxygenase (MIOX), phosphoenolpyruvate carboxykinase 1 (PCK1), neutrophil gelatinase-associated lipocalin (NGAL) and liver fatty acid-binding protein (L-FABP)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107675/a-novel-modal-independent-ultrasonic-motor-with-dual-stator
#13
Jian Liu, Jiamei Jin, Ruinan Ji, Di Chen
In this paper, a novel modal-independent ultrasonic motor with dual stator is proposed, in order to relieve the difficulty of adjustment for coincidence of modal frequencies of a stator for multi-modal coupling type ultrasonic motor (USM). It consists of two stators (an upper stator and a lower stator) and a rotor. The stators are excited the 3rd longitudinal vibration mode, by arranging the location of rotor and two stators, the rotor can realize rotary motion by friction effect with the stators. The rotor is mounted between the maximum deformation location of the upper stator and the nodal line of the lower stator...
January 10, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28107628/constructing-fast-carrier-tracks-into-flexible-perovskite-photodetectors-to-greatly-improve-responsivity
#14
Xiaoming Li, Dejian Yu, Jun Chen, Yue Wang, Fei Cao, Yi Wei, Ye Wu, Lin Wang, Ying Zhu, Zhiguo Sun, Jianping Ji, Yalong Shen, Handong Sun, Haibo Zeng
Intrinsically high mobility and large absorption coefficient endow inorganic halide perovskites (IHPs) with great promise for high-performance photodetectors (PDs), which, however, are being hindered by the low carrier extraction and transport efficiency of the solution assembled films. Here, we report on a general strategy to enhance the film conductivity of perovskites that conductive nanonets were constructed with carbon nanotubes (CNTs) to provide fast carriers tracks. As a result, the CsPbBr3 nanosheet/CNT composite films exhibit high conductivity and the advantages are demonstrated by the high performances of corresponding planar PDs...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28107368/multi-channel-optical-coherence-elastography-using-relative-and-absolute-shear-wave-time-of-flight
#15
Eli Elyas, Alex Grimwood, Janine T Erler, Simon P Robinson, Thomas R Cox, Daniel Woods, Peter Clowes, Ramona De Luca, Franco Marinozzi, Jérémie Fromageau, Jeffrey C Bamber
Elastography, the imaging of elastic properties of soft tissues, is well developed for macroscopic clinical imaging of soft tissues and can provide useful information about various pathological processes which is complementary to that provided by the original modality. Scaling down of this technique should ply the field of cellular biology with valuable information with regard to elastic properties of cells and their environment. This paper evaluates the potential to develop such a tool by modifying a commercial optical coherence tomography (OCT) device to measure the speed of shear waves propagating in a three-dimensional (3D) medium...
2017: PloS One
https://www.readbyqxmd.com/read/28107207/dynamic-mechanical-interactions-between-neighboring-airspaces-determine-cyclic-opening-and-closure-in-injured-lung
#16
Ludovic Broche, Gaetano Perchiazzi, Liisa Porra, Angela Tannoia, Mariangela Pellegrini, Savino Derosa, Alessandra Sindaco, João Batista Borges, Loïc Degrugilliers, Anders Larsson, Göran Hedenstierna, Anthony S Wexler, Alberto Bravin, Sylvia Verbanck, Bradford J Smith, Jason H T Bates, Sam Bayat
OBJECTIVES: Positive pressure ventilation exposes the lung to mechanical stresses that can exacerbate injury. The exact mechanism of this pathologic process remains elusive. The goal of this study was to describe recruitment/derecruitment at acinar length scales over short-time frames and test the hypothesis that mechanical interdependence between neighboring lung units determines the spatial and temporal distributions of recruitment/derecruitment, using a computational model. DESIGN: Experimental animal study...
January 19, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28107059/age-dependent-modulation-of-songbird-summer-feather-molt-by-temporal-and-functional-constraints
#17
Yosef Kiat, Nir Sapir
Time constraints influence various ecological, life-history, and demographic properties of individuals and populations of many species throughout the annual cycle. Feather molt is a timely undertaking that is considered among the three most energy-demanding processes in the life cycle of birds. To deal with time pressure, passerines may shorten their molt duration, using three non-mutually exclusive mechanisms: (1) replacing only part of the plumage, (2) increasing the speed of molt, and (3) postponing the renewal of some or all the plumage to a later season (i...
February 2017: American Naturalist
https://www.readbyqxmd.com/read/28106858/regulation-of-dna-replication-in-early-embryonic-cleavages
#18
REVIEW
Chames Kermi, Elena Lo Furno, Domenico Maiorano
Early embryonic cleavages are characterized by short and highly synchronous cell cycles made of alternating S- and M-phases with virtually absent gap phases. In this contracted cell cycle, the duration of DNA synthesis can be extraordinarily short. Depending on the organism, the whole genome of an embryo is replicated at a speed that is between 20 to 60 times faster than that of a somatic cell. Because transcription in the early embryo is repressed, DNA synthesis relies on a large stockpile of maternally supplied proteins stored in the egg representing most, if not all, cellular genes...
January 19, 2017: Genes
https://www.readbyqxmd.com/read/28106849/a-reinforcement-learning-model-equipped-with-sensors-for-generating-perception-patterns-implementation-of-a-simulated-air-navigation-system-using-ads-b-automatic-dependent-surveillance-broadcast-technology
#19
Santiago Álvarez de Toledo, Aurea Anguera, José M Barreiro, Juan A Lara, David Lizcano
Over the last few decades, a number of reinforcement learning techniques have emerged, and different reinforcement learning-based applications have proliferated. However, such techniques tend to specialize in a particular field. This is an obstacle to their generalization and extrapolation to other areas. Besides, neither the reward-punishment (r-p) learning process nor the convergence of results is fast and efficient enough. To address these obstacles, this research proposes a general reinforcement learning model...
January 19, 2017: Sensors
https://www.readbyqxmd.com/read/28106755/the-performance-of-several-docking-programs-at-reproducing-protein-macrolide-like-crystal-structures
#20
Alejandro Castro-Alvarez, Anna M Costa, Jaume Vilarrasa
The accuracy of five docking programs at reproducing crystallographic structures of complexes of 8 macrolides and 12 related macrocyclic structures, all with their corresponding receptors, was evaluated. Self-docking calculations indicated excellent performance in all cases (mean RMSD values ≤ 1.0) and confirmed the speed of AutoDock Vina. Afterwards, the lowest-energy conformer of each molecule and all the conformers lying 0-10 kcal/mol above it (as given by Macrocycle, from MacroModel 10.0) were subjected to standard docking calculations...
January 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
5911
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"