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https://www.readbyqxmd.com/read/29352519/nafamostat-mesilate-attenuates-inflammation-and-apoptosis-and-promotes-locomotor-recovery-after-spinal-cord-injury
#1
Hui-Quan Duan, Qiu-Li Wu, Xue Yao, Bao-You Fan, Hong-Yu Shi, Chen-Xi Zhao, Yan Zhang, Bo Li, Chao Sun, Xiao-Hong Kong, Xin-Fu Zhou, Shi-Qing Feng
AIM: Spinal cord injury (SCI) leads to severe neural damage for which there is currently no effective treatment. Exploration of the neuroprotective effect among clinically approved drugs will speed up clinical translation of SCI. Nafamostat mesilate (NM) as a synthetic serine protease inhibitor has been used clinically in pancreatitis treatments. However, its effectiveness in SCI is unknown. The aim of this study was to confirm the efficacy of NM in ameliorating SCI. METHODS: Intraperitoneal administration of NM was performed on a contusion SCI model in Wistar rat...
January 19, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29352361/the-modified-ravitch-approach-for-the-management-of-severe-anterior-flail-chest-with-bilateral-sternochondral-dislocations-a-case-report
#2
Gabriel Estremera, Ellen Chieko Omi, Eduardo Smith-Singares
The management of flail chest continues to evolve as scientific evidence and surgical experience accumulates. Flail chest injuries that span the sternum present a rare and complicated injury pattern that can be challenging to manage both medically and surgically. Our patient is a 69-year-old involved in a high-speed motor vehicle crash with respiratory failure secondary to an anterior flail chest. Tomographic examination confirmed a sternal fracture with bilateral sternochondral dislocations and multiple rib fractures...
January 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29352282/an-energy-efficient-failure-detector-for-vehicular-cloud-computing
#3
Jiaxi Liu, Zhibo Wu, Jian Dong, Jin Wu, Dongxin Wen
Failure detectors are one of the fundamental components for maintaining the high availability of vehicular cloud computing. In vehicular cloud computing, lots of RSUs are deployed along the road to improve the connectivity. Many of them are equipped with solar battery due to the unavailability or excess expense of wired electrical power. So it is important to reduce the battery consumption of RSU. However, the existing failure detection algorithms are not designed to save battery consumption RSU. To solve this problem, a new energy-efficient failure detector 2E-FD has been proposed specifically for vehicular cloud computing...
2018: PloS One
https://www.readbyqxmd.com/read/29352237/wearable-sweat-rate-sensors-for-human-thermal-comfort-monitoring
#4
Jai Kyoung Sim, Sunghyun Yoon, Young-Ho Cho
We propose watch-type sweat rate sensors capable of automatic natural ventilation by integrating miniaturized thermo-pneumatic actuators, and experimentally verify their performances and applicability. Previous sensors using natural ventilation require manual ventilation process or high-power bulky thermo-pneumatic actuators to lift sweat rate detection chambers above skin for continuous measurement. The proposed watch-type sweat rate sensors reduce operation power by minimizing expansion fluid volume to 0...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352163/word-mode-a-crowding-free-reading-protocol-for-individuals-with-macular-disease
#5
Stuart Wallis, Yit Yang, Stephen J Anderson
Central retinal loss through macular disease markedly reduces the ability to read largely because identification of a word using peripheral vision is negatively influenced by nearby text, a phenomenon termed visual crowding. Here, we present a novel peripheral reading protocol, termed Word Mode, that eliminates crowding by presenting each word in isolation but in a position that mimics its natural position in the line of text being read, with each new word elicited using a self-paced button press. We used a gaze-contingent paradigm to simulate a central scotoma in four normally-sighted observers, and measured oral reading speed for text positioned 7...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352153/biology-culture-co-evolution-in-finite-populations
#6
Bart de Boer, Bill Thompson
Language is the result of two concurrent evolutionary processes: biological and cultural inheritance. An influential evolutionary hypothesis known as the moving target problem implies inherent limitations on the interactions between our two inheritance streams that result from a difference in pace: the speed of cultural evolution is thought to rule out cognitive adaptation to culturally evolving aspects of language. We examine this hypothesis formally by casting it as as a problem of adaptation in time-varying environments...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352150/identification-and-quantification-of-plasma-calciprotein-particles-with-distinct-physical-properties-in-patients-with-chronic-kidney-disease
#7
Yutaka Miura, Yoshitaka Iwazu, Kazuhiro Shiizaki, Tetsu Akimoto, Kazuhiko Kotani, Masahiko Kurabayashi, Hiroshi Kurosu, Makoto Kuro-O
Calciprotein particles (CPP) are solid-phase calcium-phosphate bound to serum protein fetuin-A and dispersed as colloids in the blood. Recent clinical studies indicated that serum CPP levels were increased with decline of renal function and associated with inflammation and vascular calcification. However, CPP assays used in these studies measured only a part of CPP over a certain particle size and density. Here we show that such CPP are mostly artifacts generated during processing of serum samples in vitro...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352145/integrating-modality-specific-expectancies-for-the-deployment-of-spatial-attention
#8
Paola Mengotti, Frank Boers, Pascasie L Dombert, Gereon R Fink, Simone Vossel
The deployment of spatial attention is highly sensitive to stimulus predictability. Despite evidence for strong crossmodal links in spatial attentional systems, it remains to be elucidated how concurrent but divergent predictions for targets in different sensory modalities are integrated. In a series of behavioral studies, we investigated the processing of modality-specific expectancies using a multimodal cueing paradigm in which auditory cues predicted the location of visual or tactile targets with modality-specific cue predictability...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352088/an-archaeal-fluoride-responsive-riboswitch-provides-an-inducible-expression-system-for-hyperthermophiles
#9
Michael Clayton Speed, Brett W Burkhart, Jonathan W Picking, Thomas J Santangelo
Robust genetic systems for the hyperthermophilic Thermococcales have facilitated overexpression of native genes, allowed for the addition of sequences encoding secretion signals, epitope, and affinity tags to coding regions, and permitted the introduction of sequences encoding new proteins in these fast growing fermentative heterotrophs. Tightly controlled and easily manipulated systems permitting regulated gene expression are however limited for these hosts. Here we describe an alternative method for regulatory control reliant on a cis-encoded functional riboswitch in the model archaeon Thermococcus kodakarensis Despite the hyperthermophilic growth temperatures, the proposed structure of the riboswitch conforms to a fluoride-responsive riboswitch encoded in many bacteria, and similarly functions to regulate a component conserved fluoride export pathway...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29351988/confirmation-of-intersubunit-connectivity-and-topology-of-designed-protein-complexes-by-native-ms
#10
Aniruddha Sahasrabuddhe, Yang Hsia, Florian Busch, William Sheffler, Neil P King, David Baker, Vicki H Wysocki
Computational protein design provides the tools to expand the diversity of protein complexes beyond those found in nature. Understanding the rules that drive proteins to interact with each other enables the design of protein-protein interactions to generate specific protein assemblies. In this work, we designed protein-protein interfaces between dimers and trimers to generate dodecameric protein assemblies with dihedral point group symmetry. We subsequently analyzed the designed protein complexes by native MS...
January 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29351640/emergency-fast-bentall-operation
#11
Eugenio Neri, Enrico Tucci, Giulio Tommasino, Luigi Muzzi
We herein report an emergency technique of composite Bentall operation using a fast release valve. The technique was successfully performed in 2 emergency cases after failed supracoronary ascending aortic replacement in acute Type A aortic dissection. The speed and ease of execution are the main advantages of the procedure.
January 16, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29351494/factors-associated-with-sarcopenia-in-patients-with-colorectal-cancer
#12
Bianca Umbelino de Souza, Nilian Carla Silva Souza, Renata Brum Martucci, Viviane Dias Rodrigues, Nivaldo Barroso de Pinho, Maria Cristina Gonzalez, Carla Maria Avesani
Introduction; Sarcopenia are frequently observed in cancer patients and was associated with poor prognosis. Objectives; to determine the association of nutritional status, body composition, and clinic parameters with sarcopenia in patients with colorectal cancer (CRC). Methods; We conducted a cross-sectional study of 197 patients with CRC. The sarcopenia elements, including lumbar skeletal muscle index (SMI), handgrip strength, and gait speed were measured. The SMI was assessed by computed tomography at third lumbar vertebra...
January 19, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29351432/diurnal-pattern-in-skin-na-and-water-content-is-associated-with-salt-sensitive-hypertension-in-etb-receptor-deficient-rats
#13
Joshua S Speed, Kelly A Hyndman, Malgorzata Kasztan, Jermaine G Johnston, Kaehler J Roth, Jens M Titze, David M Pollock
Impairment in the ability of the skin to properly store Na+ non-osmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our lab has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na+ handling. Further, it is well established that loss of ETB receptor function impairs Na+ excretion by the kidney. Thus we hypothesized that rats lacking functional ETB receptors (ETB def) will have a reduced capacity of the skin to store Na+ during chronic high salt (HS) intake...
December 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351351/comparing-performance-on-the-mnread-ipad-application-with-the-mnread-acuity-chart
#14
Aurélie Calabrèse, Long To, Yingchen He, Elizabeth Berkholtz, Paymon Rafian, Gordon E Legge
Our purpose was to compare reading performance measured with the MNREAD Acuity Chart and an iPad application (app) version of the same test for both normally sighted and low-vision participants. Our methods included 165 participants with normal vision and 43 participants with low vision tested on the standard printed MNREAD and on the iPad app version of the test. Maximum Reading Speed, Critical Print Size, Reading Acuity, and Reading Accessibility Index were compared using linear mixed-effects models to identify any potential differences in test performance between the printed chart and the iPad app...
January 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29351336/chemotactic-drift-speed-for-bacterial-motility-pattern-with-two-alternating-turning-events
#15
Evgeniya V Pankratova, Alena I Kalyakulina, Mikhail I Krivonosov, Sergei V Denisov, Katja M Taute, Vasily Yu Zaburdaev
Bacterial chemotaxis is one of the most extensively studied adaptive responses in cells. Many bacteria are able to bias their apparently random motion to produce a drift in the direction of the increasing chemoattractant concentration. It has been recognized that the particular motility pattern employed by moving bacteria has a direct impact on the efficiency of chemotaxis. The linear theory of chemotaxis pioneered by de Gennes allows for calculation of the drift velocity in small gradients for bacteria with basic motility patterns...
2018: PloS One
https://www.readbyqxmd.com/read/29351248/a-comprehensive-study-of-a-micro-channel-heat-sink-using-integrated-thin-film-temperature-sensors
#16
Tao Wang, Jiejun Wang, Jian He, Chuangui Wu, Wenbo Luo, Yao Shuai, Wanli Zhang, Xiancai Chen, Jian Zhang, Jia Lin
A micro-channel heat sink is a promising cooling method for high power integrated circuits (IC). However, the understanding of such a micro-channel device is not sufficient, because the tools for studying it are very limited. The details inside the micro-channels are not readily available. In this letter, a micro-channel heat sink is comprehensively studied using the integrated temperature sensors. The highly sensitive thin film temperature sensors can accurately monitor the temperature change in the micro-channel in real time...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351240/machine-learning-and-infrared-thermography-for-fiber-orientation-assessment-on-randomly-oriented-strands-parts
#17
Henrique Fernandes, Hai Zhang, Alisson Figueiredo, Fernando Malheiros, Luis Henrique Ignacio, Stefano Sfarra, Clemente Ibarra-Castanedo, Gilmar Guimaraes, Xavier Maldague
The use of fiber reinforced materials such as randomly-oriented strands has grown in recent years, especially for manufacturing of aerospace composite structures. This growth is mainly due to their advantageous properties: they are lighter and more resistant to corrosion when compared to metals and are more easily shaped than continuous fiber composites. The resistance and stiffness of these materials are directly related to their fiber orientation. Thus, efficient approaches to assess their fiber orientation are in demand...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351127/four-months-of-wearing-a-balance-orthotic-improves-measures-of-balance-and-mobility-among-a-cohort-of-community-living-older-adults
#18
Sean Noah, Cynthia Gibson-Horn, Jennifer L Vincenzo
BACKGROUND AND PURPOSE: The Centers for Disease Control and Prevention estimated that there were 29 million falls and 7 million injuries in 2014 in the United States. Falls, decreased balance, and mobility disability are common in older adults and often result in loss of independence. Finding interventions to address these issues is important, as this age group is growing exponentially. Prior studies indicate balance and mobility can be improved by the balance-based torso-weighting (BBTW) assessment implemented through wear of a balance orthotic (BO)...
January 18, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29351023/does-talking-on-a-cell-phone-with-a-passenger-or-dialing-affect-driving-performance-an-updated-systematic-review-and-meta-analysis-of-experimental-studies
#19
Jeff K Caird, Sarah M Simmons, Katelyn Wiley, Kate A Johnston, William J Horrey
Objective An up-to-date meta-analysis of experimental research on talking and driving is needed to provide a comprehensive, empirical, and credible basis for policy, legislation, countermeasures, and future research. Background The effects of cell, mobile, and smart phone use on driving safety continues to be a contentious societal issue. Method All available studies that measured the effects of cell phone use on driving were identified through a variety of search methods and databases. A total of 93 studies containing 106 experiments met the inclusion criteria...
February 2018: Human Factors
https://www.readbyqxmd.com/read/29350962/high-speed-device-independent-quantum-random-number-generation-without-a-detection-loophole
#20
Yang Liu, Xiao Yuan, Ming-Han Li, Weijun Zhang, Qi Zhao, Jiaqiang Zhong, Yuan Cao, Yu-Huai Li, Luo-Kan Chen, Hao Li, Tianyi Peng, Yu-Ao Chen, Cheng-Zhi Peng, Sheng-Cai Shi, Zhen Wang, Lixing You, Xiongfeng Ma, Jingyun Fan, Qiang Zhang, Jian-Wei Pan
Quantum mechanics provides the means of generating genuine randomness that is impossible with deterministic classical processes. Remarkably, the unpredictability of randomness can be certified in a manner that is independent of implementation devices. Here, we present an experimental study of device-independent quantum random number generation based on a detection-loophole-free Bell test with entangled photons. In the randomness analysis, without the independent identical distribution assumption, we consider the worst case scenario that the adversary launches the most powerful attacks against the quantum adversary...
January 5, 2018: Physical Review Letters
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