Karel van Duijvenboden, Dennis E M de Bakker, Joyce C K Man, Rob Janssen, Marie Günthel, Matthew C Hill, Ingeborg B Hooijkaas, Ingeborg van der Made, Petra H van der Kraak, Aryan Vink, Esther E Creemers, James F Martin, Phil Barnett, Jeroen Bakkers, Vincent M Christoffels
BACKGROUND: Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively validated new molecular markers, including Nppb, encoding B-type natriuretic peptide, after infarction. METHODS: Transgenic reporter mice were used to identify the Nppb-positive border zone after myocardial infarction...
September 9, 2019: Circulation