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open spina bifida

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https://www.readbyqxmd.com/read/28277363/fetoscopic-open-neural-tube-defect-repair-development-and-refinement-of-a-two-port-carbon-dioxide-insufflation-technique
#1
Michael A Belfort, William E Whitehead, Alireza A Shamshirsaz, Zhoobin H Bateni, Oluyinka O Olutoye, Olutoyin A Olutoye, David G Mann, Jimmy Espinoza, Erin Williams, Timothy C Lee, Sundeep G Keswani, Nancy Ayres, Christopher I Cassady, Amy R Mehollin-Ray, Magdalena Sanz Cortes, Elena Carreras, Jose L Peiro, Rodrigo Ruano, Darrell L Cass
OBJECTIVE: To describe development of a two-port fetoscopic technique for spina bifida repair in the exteriorized, carbon dioxide-filled uterus and report early results of two cohorts of patients: the first 15 treated with an iterative technique and the latter 13 with a standardized technique. METHODS: This was a retrospective cohort study (2014-2016). All patients met Management of Myelomeningocele Study selection criteria. The intraoperative approach was iterative in the first 15 patients and was then standardized...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28236314/non-visualization-of-choroid-plexus-of-the-fourth-ventricle-as-a-first-trimester-predictor-of-posterior-fossa-anomalies-and-chromosomal-defects-a-three-dimensional-ultrasound-study
#2
P Martinez-Ten, T Illescas, B Adiego, M Estevez, C Bermejo, A E Wong, W Sepulveda
OBJECTIVE: To assess non-visualization of the choroid plexus of the fourth ventricle (CP-IVV) as a simple, qualitative, and reproducible first-trimester ultrasound feature of the posterior fossa that predicts brain anomalies and chromosomal defects. METHODS: Three-dimensional (3D) ultrasound datasets of the fetal brain were prospectively obtained from 65 consecutive singleton, normal first-trimester fetuses and retrospectively from 27 fetuses identified as having an abnormal fetal posterior fossa on the first-trimester scan, which were randomly included in the final study group...
February 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28135033/reverse-thermal-gel-for-in-utero-coverage-of-spina-bifida-defects-an-innovative-bioengineering-alternative-to-open-fetal-repair
#3
Ahmed I Marwan, Sarah M Williams, James R Bardill, Jane Gralla, Noraishah M Abdul-Aziz, Daewon Park
Current state-of-the-art management of open spina bifida defects entails an open fetal surgery approach associated with significant morbidities. In an attempt to reduce these risks and provide for an earlier minimally invasive repair, it is aimed to develop and characterize an innovative alternative using a unique reverse thermal gel. This study focuses on characterization of the physical and biological properties of the polymer and its in vivo applicability. Based on the knowledge and benchmarking, the "ideal" biomaterial should have the following characteristics: stability in amniotic fluid, limited permeability, biocompatibility, biologically functional, nontoxic, ability to support cellular functions, and in vivo applicability...
January 30, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27979598/how-successful-is-the-transition-to-adult-urology-care-in-spina-bifida-a-single-center-7-year-experience
#4
Konrad M Szymanski, Mark P Cain, Thomas J Hardacker, Rosalia Misseri
INTRODUCTION: Rates of successful transition from adolescent to adult spina bifida (SB) care are unknown. OBJECTIVE: We aimed to assess rates and predictors of successful transition from a multidisciplinary SB clinic to a transitional urology clinic (TUC), or a pediatric or adult urologist. STUDY DESIGN: We retrospectively reviewed patients discharged from a multidisciplinary SB clinic (2006-2012), collecting demographic and clinical data...
February 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27780281/surgical-management-of-functional-constipation-preliminary-report-of-a-new-approach-using-a-laparoscopic-sigmoid-resection-combined-with-a-malone-appendicostomy
#5
Alessandra Gasior, Giulia Brisighelli, Karen Diefenbach, Victoria Alison Lane, Carlos Reck, Richard J Wood, Marc Levitt
Introduction Functional constipation is a common problem in children. It usually can be managed with laxatives but a small subset of patients develop intolerable cramps and need to be temporarily treated with enemas. The senior author has previously reported: 1) open sigmoid resection as a surgical option, but this did not sufficiently reduce the laxative need, then 2) a transanal approach (with resection of rectosigmoid), but this led to a high rate of soiling due to extensive stretching of the anal canal and loss of the rectal reservoir...
October 25, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27766742/intracranial-translucency-assessment-at-first-trimester-nuchal-translucency-ultrasound
#6
Annah Lane, Ling Lee, Donna Traves, Andreas Lee
INTRODUCTION: The antenatal diagnosis of open spina bifida (OSB), a neural tube defect, is predominantly made at the second trimester morphology scan by ultrasound detection of structural abnormalities resulting from the associated Chiari II malformation. Evidence has emerged suggesting that these structural abnormalities can be detected earlier, by examination of the posterior fossa as part of the first trimester nuchal translucency scan. In particular, absence of the intra-cranial translucency (IT) of the fourth ventricle has shown promise as a diagnostic marker of OSB, although the sensitivity and specificity of this finding varies widely in the literature...
October 21, 2016: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/27500985/diagnostic-accuracy-of-intracranial-translucency-in-detecting-spina-bifida-a-systematic-review-and-meta-analysis
#7
REVIEW
Giuseppe M Maruotti, Gabriele Saccone, Francesco D'Antonio, Vincenzo Berghella, Laura Sarno, Maddalena Morlando, Antonia Giudicepietro, Pasquale Martinelli
OBJECTIVE: To evaluate the diagnostic accuracy of intracranial translucency (IT) in the detection of spina bifida (SB) in the first trimester of pregnancy. METHODS: We included study assessing the accuracy of sonographic measurements of IT in a mid-sagittal view of the fetal face in prediction of SB in the first trimester of pregnancy. The primary outcome was the accuracy of IT in prediction of spina bifida. Summary estimates of sensitivity, specificity, positive and negative likelihood ratios (LR), and diagnostic odds ratio for the overall predictive accuracy of IT were computed...
November 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27305320/outcomes-of-infants-followed-up-at-least-12-months-after-fetal-open-and-endoscopic-surgery-for-meningomyelocele-a-systematic-review-and-meta-analysis
#8
Edward Araujo, Gabriele Tonni, Wellington P Martins
OBJECTIVE: To assess the outcomes of infants followed-up at least 12 months after open and endoscopic fetal surgery for the treatment of spina bifida. METHODS: A searching in The Cochrane Library, LILACS, PubMed and SCOPUS databases for fetal meningomyelocele (MMC) open or endoscopic surgery in humans from 2003 on-wards with follow-up at least 12 months. The rate of the estimated proportions was evaluated by the 95% confidence interval (CI). RESULTS: A total of 19 studies were finally included (17 open and 2 endoscopic surgery)...
June 15, 2016: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/27273605/survey-on-current-postnatal-surgical-management-of-myelomeningocele-in-germany
#9
Uwe Max Mauer, Arne Jahn, Luise Unterreithmeir, Wolfgang Wagner, Ulrich Kunz, Chris Schulz
Background and Study Aims Although postnatal surgery can be regarded as the standard of care for open myelomeningocele (MMC), there is no uniform treatment for this condition in Germany. This study assessed the current situation regarding the management of open MMC, a first and essential step toward the development of standards of practice. Patients and Methods In the second half of 2009, we had sent standardized questionnaires to 139 neurosurgery departments and 73 pediatric surgery departments (number of returned questionnaires: 98 and 62, respectively) to identify the principles of MMC management...
November 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27179533/factors-associated-with-the-timeliness-of-postnatal-surgical-repair-of-spina-bifida
#10
Elizabeth Radcliff, Cynthia H Cassell, Sarah B Laditka, Judy K Thibadeau, Jane Correia, Scott D Grosse, Russell S Kirby
PURPOSE: Clinical guidelines recommend repair of open spina bifida (SB) prenatally or within the first days of an infant's life. We examined maternal, infant, and health care system factors associated with time-to-repair among infants with postnatal repair. METHODS: This retrospective, statewide, population-based study examined infants with SB born in Florida 1998-2007, ascertained by the Florida Birth Defects Registry. We used procedure codes from hospital discharge records to identify the first recorded myelomeningocele repair (ICD-9 CM procedure code 03...
August 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27146872/-bilateral-hydronephrosis-as-a-result-of-opioid-induced-bowel-spasm-in-a-patient-with-an-ileal-conduit
#11
F Girtler, K Rödder, M Fisch
A 47-year-old woman with spina bifida and an ileal conduit since childhood presented with left-sided flank pain, bilateral hydronephrosis and oliguria suspicious for a recurrent stenosis at the ureteral implantation site. Her history revealed a recent increase in her pain medication with opioids for treatment of neuropathic pain. After insertion of percutaneous nephrostomy on the left side and confirmation of the stenosis, open reimplantation of the ureter was already discussed with the patient. However after dose reduction of the opioid therapy hydronephrosis resolved...
October 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27114066/regulation-of-cell-protrusions-by-small-gtpases-during-fusion-of-the-neural-folds
#12
Ana Rolo, Dawn Savery, Sarah Escuin, Sandra C de Castro, Hannah E J Armer, Peter M G Munro, Matteo A Molè, Nicholas D E Greene, Andrew J Copp
Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida. Using mouse embryos, we show that cell protrusions emanating from the apposed neural fold tips, at the interface between the neuroepithelium and the surface ectoderm, are required for completion of neural tube closure. By genetically ablating the cytoskeletal regulators Rac1 or Cdc42 in the dorsal neuroepithelium, or in the surface ectoderm, we show that these protrusions originate from surface ectodermal cells and that Rac1 is necessary for the formation of membrane ruffles which typify late closure stages, whereas Cdc42 is required for the predominance of filopodia in early neurulation...
April 26, 2016: ELife
https://www.readbyqxmd.com/read/27100442/a-large-bladder-tumor-covered-with-a-thick-shell-of-necrotic-material-misdiagnosis-of-a-patient-with-spina-bifida
#13
Lei Wang, Zhe Zhou, Miao-zi Gong, Dong-liang Pan, Xiang-hua Zhang, Ning-chen Li, Yan-qun Na
Bladder tumor arising in a spina bifida patient is rare and may be clinically latent. We report the case of a 61-year-old female patient with spina bifida, neurogenic bladder, and a history of recurrent urinary tract infections. A B-ultrasound and non-contrast computed tomography scan did not reveal any bladder mass, but an unexplained "well-filled" bladder was observed, which was confusing as the catheter was present and open. However, a subsequent cystoscopic evaluation revealed a large bladder mass measuring 9...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27022783/comparison-of-two-and-three-dimensional-ultrasonography-in-the-evaluation-of-lesion-level-in-fetuses-with-spina-bifida
#14
Márcio José Rosa Requeijo, Victor Bunduki, Rossana Pulcineli Vieira Francisco, Marco Antonio Borges Lopes, Rodrigo Ruano, Marcelo Zugaib
PURPOSE: To evaluate the precision of both two- and three-dimensional ultrasonography in determining vertebral lesion level (the first open vertebra) in patients with spina bifida. METHODS: This was a prospective longitudinal study comprising of fetuses with open spina bifida who were treated in the fetal medicine division of the department of obstetrics of Hospital das Clínicas of the Universidade de São Paulo between 2004 and 2013. Vertebral lesion level was established by using both two- and three-dimensional ultrasonography in 50 fetuses (two examiners in each method)...
March 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/26901156/fetoscopic-versus-open-repair-for-spina-bifida-aperta-a-systematic-review-of-outcomes
#15
REVIEW
Luc Joyeux, Alexander C Engels, Francesca M Russo, Julio Jimenez, Tim Van Mieghem, Paolo De Coppi, Frank Van Calenbergh, Jan Deprest
OBJECTIVE: To compare outcomes of fetoscopic spina bifida aperta repair (FSBAR) with the results of the open approach (OSBAR) as in the Management Of Myelomeningocele Study (MOMS). METHODS: This was a systematic comparison of reports on FSBAR with data from the MOMS (n = 78). Inclusion criteria were studies of spina bifida aperta patients who underwent FSBAR and were followed for ≥12 months. Primary outcome was perinatal mortality. Secondary outcomes included operative, maternal, fetal, neonatal and infant outcomes...
2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/26889207/profiling-placental-and-fetal-dna-methylation-in-human-neural-tube-defects
#16
E Magda Price, Maria S Peñaherrera, Elodie Portales-Casamar, Paul Pavlidis, Margot I Van Allen, Deborah E McFadden, Wendy P Robinson
BACKGROUND: The incidence of neural tube defects (NTDs) declined by about 40 % in Canada with the introduction of a national folic acid (FA) fortification program. Despite the fact that few Canadians currently exhibit folate deficiency, NTDs are still the second most common congenital abnormality. FA fortification may have aided in reducing the incidence of NTDs by overcoming abnormal one carbon metabolism cycling, the process which provides one carbon units for methylation of DNA. We considered that NTDs persisting in a folate-replete population may also occur in the context of FA-independent compromised one carbon metabolism, and that this might manifest as abnormal DNA methylation (DNAm)...
2016: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/26884351/termination-of-pregnancy-after-prenatal-diagnosis-of-spina-bifida-a-german-perspective
#17
Christian M Domröse, Sandra Bremer, Caroline Buczek, Annegret Geipel, Christoph Berg, Ulrich Gembruch, Arne Willruth
PURPOSE: To analyze fetal cases with spina bifida undergoing termination of pregnancy according to chromosomal analysis and further diagnosed sonographic findings. METHODS: Retrospective analysis of cases with spina bifida leading to termination of pregnancy in a tertiary referral center from 2002 to 2011. RESULTS: In the study period, 246 cases of spina bifida were diagnosed in our center and 157 parents chose termination of pregnancy. The time of diagnosis was on average 2 days before the first presentation at our department (22 + 3, range: 12 + 3 - 33 + 3 weeks of gestation)...
October 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/26655060/-analysis-of-fetal-posterior-fossa-during-the-first-trimester-ultrasound-scan
#18
P Mace, E Quarello
The diagnosis of an abnormal fetal posterior fossa is usually done during the second trimester scan. However, some forms of open spina bifida with Arnold-Chiari malformation can be detected from the first trimester ultrasound with a precise examination of the posterior fossa and intracranial translucency. Furthermore, other abnormalities of the posterior fossa such as cystic malformations also seem to be accessible to early detection. This work detailed the possible usual and unusual aspects of the posterior fossa individualized during the first trimester ultrasound scan...
January 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/26612040/procedure-related-complications-of-open-vs-endoscopic-fetal-surgery-for-treatment-of-spina-bifida-in-an-era-of-intrauterine-myelomeningocele-repair-systematic-review-and-meta-analysis
#19
REVIEW
E Araujo Júnior, A J Eggink, J van den Dobbelsteen, W P Martins, D Oepkes
OBJECTIVE: To assess and compare the rate of procedure-related complications after intrauterine treatment of spina bifida by endoscopic surgery and by open fetal surgery. METHODS: Systematic literature searches in PubMed and SCOPUS databases were performed on 20 September 2015 to identify randomized controlled trials and observational studies on treatment of human spina bifida by endoscopic or open fetal surgery techniques. Only studies with ≥ 10 cases that were published in or after 2000 were included in the meta-analysis in order to reduce the risk of bias...
August 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26531948/a-cost-analysis-of-open-spina-bifida-detection-in-the-first-trimester
#20
A Turcu-Stiolica
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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