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open spina bifida

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https://www.readbyqxmd.com/read/29924078/use-of-an-in-home-body-weight-support-system-by-a-child-with-spina-bifida
#1
Elena Kokkoni, Samuel W Logan, Tracy Stoner, Terri Peffley, James C Galloway
PURPOSE: To examine the feasibility of a new open-area body weight support system (BWSS) to act as both an "assistive" and a "rehabilitative" device within the home. INTERVENTION: A 5-year-old boy with spina bifida used the BWSS during self-selected activities for 10 weeks. Feasibility, behavioral, and clinical assessments provided a quantification of his activity in and out of the BWSS. OUTCOMES: On average, the child used the device on 2...
July 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29878486/in-utero-open-surgery-progress-or-stagnation-in-the-prenatal-management-of-spina-bifida
#2
Y Ville
No abstract text is available yet for this article.
June 7, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29858946/homologous-cryopreserved-amniotic-membrane-in-the-repair-of-myelomeningocele-preliminary-experience
#3
Elisabetta Marton, Enrico Giordan, Giorgio Gioffrè, Giuseppe Canova, Adolfo Paolin, Marina Grazia Mazzucco, Pierluigi Longatti
OBJECTIVE: Surgical management of spinal dysraphism often requires the use of dural substitutes. Amniotic membrane (AM) has drawn the interest of clinicians for its valuable concentration of cytokines and factors capable of promoting wound healing, re-epithelialization, inhibiting fibrosis and regulating angiogenesis. These beneficial qualities could make AM an interesting dural substitute for spina bifida repair. In this study, we describe the use of banked homologous AM as a dural substitute for the repair of spinal dysraphism in newborns...
June 1, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29797041/-spina-bifida
#4
REVIEW
R Mühl-Benninghaus
Spina bifida is a congenital disorder with incomplete closure of the spinal column due to a bony vertebral defect. The term spina bifida literally means cleft spine and is used as a generic term of spinal dysraphism (Greek: Raphe = seam). It is a midline defect that occurs during the embryonic period. The insufficient closure of one or more vertebral arches is the result of an incomplete junction of the neural tube. Depending on the extent of the neural tube defect, various types of spina bifida can be differentiated...
May 24, 2018: Der Radiologe
https://www.readbyqxmd.com/read/29793368/maxillo-occipital-line-a-sonographic-marker-for-screening-of-open-spina-bifida-in-the-first-trimester-of-pregnancy
#5
Jayshree Ramkrishna, Edward Araujo Júnior, Alberto Borges Peixoto, Fabricio Da Silva Costa, Simon Meagher
OBJECTIVE: To describe a new first-trimester sonographic landmark the maxillo-occipital line which may be useful for early screening of open spina bifida. METHODS: Maxillo-occipital line was prospectively evaluated in 100 low-risk pregnancies at the time of first-trimester sonographic screening examination between 11 and 13 + 6 weeks' gestation. All the pregnant women subsequently had a normal second-trimester scan and normal outcomes. Midsagittal brain images of 14 fetuses with known diagnosis of open spina bifida were evaluated retrospectively to review the maxillo-occipital line...
June 13, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29774817/bladder-reconstruction-with-bowel-robot-assisted-laparoscopic-ileocystoplasty-with-mitrofanoff-appendicovesicostomy-in-pediatric-patients
#6
Nimrod S Barashi, Maria Veronica Rodriguez, Vignesh T Packiam, Mohan S Gundeti
Neurogenic bladder occur as a consequence of several conditions, most commonly posterior urethral valves syndrome, spina bifida, tethered cord, sacral agenesis, and Arnold-Chiari malformation. It is characterized by diminished bladder capacity and/or reduced compliance, associated with high-pressure voiding that can lead to deterioration of renal function if left untreated. When medical management fails, bladder reconstruction with bowel (aumentation ileocystoplasty) becomes the treatment of choice for these patients...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29730690/ultrasound-and-magnetic-resonance-imaging-in-the-prenatal-diagnosis-of-open-spina-bifida
#7
REVIEW
Romeo Micu, Anca Lucia Chicea, Dan Georgian Bratu, Paula Nita, Georgiana Nemeti, Radu Chicea
Open spina bifida, also known as spina bifida aperta is a neural tube defect involving the lack of closure of vertebral arches and associated meninges and/or spinal cord abnormalities.Ultrasound examination is the gold standard for the diagnosis of spina bifida aperta. It represents the main imaging tool used to ascertain this diagnosis early in gestation. Three-dimensional ultrasound is necessary to detect the level and the size of the defect. Magnetic resonance imaging (MRI) represents a more sensitive tool, giving specific information of the defect and associated anomalies, playing an important role in ruling out differential diagnosis...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29489502/updates-in-fetal-spina-bifida-repair
#8
Yair J Blumenfeld, Michael A Belfort
PURPOSE OF REVIEW: To examine updates in fetal spina bifida surgical repair, as well as promising results emerging from translational medicine. RECENT FINDINGS: Although the Management of Myelomeningocele Study sponsored by the National Institutes of Health helped establish the neonatal benefits of prenatal spina bifida repair via uterine hysterotomy, also known as 'open' fetal surgery, fetoscopic approaches may yield better maternal and obstetric outcomes. SUMMARY: Spina bifida is a severe congenital malformation associated with significant neonatal and childhood morbidity and mortality...
April 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29388237/safety-and-efficacy-of-fetal-surgery-techniques-to-close-a-spina-bifida-defect-in-the-fetal-lamb-model-a-systematic-review
#9
REVIEW
Luc Joyeux, Felix De Bie, Enrico Danzer, Tim Van Mieghem, Alan W Flake, Jan Deprest
OBJECTIVE: To determine the safety and efficacy of different neurosurgical techniques for closure of spina bifida (SB) in the fetal lamb model. METHOD: Systematic review of studies reporting on fetal lambs undergoing induction and closure of SB compared with non-operated normal lambs (negative controls) and/or lambs not undergoing closure of the defect (positive controls). Primary outcomes were (1) survival at birth (safety) and/or (2) presence of Somatosensory Evoked Potentials on hind limbs and/or improvement in quantitative histological spinal cord findings and/or reversal of hindbrain herniation (efficacy)...
March 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29379237/intracranial-translucency-as-a-sonographic-marker-for-detecting-open-spina-bifida-at-11-13-6-weeks-scan-our-experience
#10
Madhavi L Teegala, Dhamangaonkar G Vinayak
Aims and Objectives: The fourth ventricle, seen as intracranial translucency (IT) at 11-13+6 weeks, has been reported to be obliterated in cases of open spina bifida (OSB). Our aim was to assess its role in detecting OSB at 11-13+6 weeks. Materials and Methods: This prospective study was conducted at foetal medicine unit from January 2014 to June 2015. All women who underwent both first and mid-trimester scan in our unit were included in the study. IT was categorized as normal, obliterated or not clear...
October 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29314321/percutaneous-fetoscopic-closure-of-large-open-spina-bifida-using-a-bilaminar-skin-substitute
#11
Denise A Lapa Pedreira, Gregório L Acacio, Rodrigo T Gonçalves, Renato Augusto M Sá, Reynaldo A Brandt, Ramen Chmait, Eftichia Kontopoulos, Ruben A Quintero
OBJECTIVE: We have previously described our percutaneous fetoscopic technique for the treatment of open spina bifida (OSB). However, approximately 20-30% of OSB defects are too large to allow primary skin closure. We hereby describe a modification of our standard technique using a bilaminar skin substitute to allow closure of such large spinal defects. The aim of this study was to report our clinical experience with the use of a bilaminar skin substitute and a percutaneous fetoscopic technique for the prenatal closure of large spina bifida defects...
January 4, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29258087/in-utero-plastic-surgery-in-zurich-successful-use-of-distally-pedicled-random-pattern-transposition-flaps-for-definitive-skin-closure-during-open-fetal-spina-bifida-repair
#12
Martin Meuli, Claudia Meuli-Simmen, Luca Mazzone, Sasha J Tharakan, Roland Zimmermann, Nicole Ochsenbein, Ueli Moehrlen
BACKGROUND: One of the intraoperative challenges of fetal spina bifida repair is skin closure when there is an extended skin defect. Thus, we examined whether distally pedicled random pattern transposition flaps (TFs) are a valid option to overcome this problem. SUBJECTS AND METHODS: All patients undergoing in utero repair of spina bifida with application of a TF for back skin closure were analyzed focusing on intraoperative flap characteristics and postoperative flap performance...
December 20, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29125525/early-postnatal-bladder-function-in-fetoscopic-myelomeningocele-repair-patients
#13
Gene O Huang, Michael A Belfort, William E Whitehead, Oluyinka O Olutoye, Jonathan Castillo, Heidi Castillo, Kathryn K Ostermaier, Chester J Koh, Duong D Tu
PURPOSE: Prenatal repair of myelomeningocele (MMC) via hysterotomy has demonstrated neurosurgical and motor benefits, when compared to postnatal repairs. Urologic benefits, however, remain to be seen. The purpose of this study was to review early postnatal bladder function in patients undergoing a novel endoscopic approach for MMC repair using an exteriorized uterus. METHODS: A prospective urologic assessment of patients undergoing fetoscopic MMC repair and receiving subsequent care at our facility, was performed...
December 11, 2017: Journal of Pediatric Rehabilitation Medicine
https://www.readbyqxmd.com/read/29101642/prenatal-surgery-for-spina-bifida-a-therapeutic-dilemma-proceedings-of-the-shine-conference-belfast
#14
Mano Shanmuganathan, Deborah A Sival, Kelly-Ann Eastwood, Katie Morris, Jacqueline Cartmill, Axel Heep, Janusz Bohosiewicz, Agnieszka Pastuszka, Alyson Hunter, Amanda Ali, Roy McConnell, Darach Crimmins, Fergal Malone, Carolyn Bailie, Jan Deprest, Cathy McKillop, Zarko Alfirevic, Fionnuala McAuliffe, Stephen Ong
This is a transcript of a scientific conference on the subject of prenatal surgery for spina bifida. It represents the views of three patients, an obstetrician, a postnatal neurosurgeon, a neonatologist, a paediatric neurologist, two surgeons who practice open spina bifida foetal surgery, a fetoscopic surgeon and an obstetrician experienced in randomised trials and systematic reviews. Implications for current practice and recommendations for future research are also discussed in detail.
November 3, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28904629/reliability-of-patellar-height-indices-in-children-with-cerebral-palsy-and-spina-bifida
#15
S A Rethlefsen, K K Barrett, T A L Wren, G Blumstein, D Gargiulo, D D Ryan, R M Kay
BACKGROUND: The Koshino (KI) and Caton-Deschamps (CDI) indices are used to measure patellar height in children, with the CDI showing excellent reliability in typically developing (TD) children. Reliability of such measures in children with cerebral palsy (CP) and spina bifida (SB) is unknown. METHODS: Lateral knee radiographs were reviewed retrospectively for children with TD (n = 49), CP (n = 48) and SB (n = 42). Five raters took measurements from radiographs twice, at least two weeks apart...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28832491/committee-opinion-no-720-maternal-fetal-surgery-for-myelomeningocele
#16
(no author information available yet)
Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28832482/committee-opinion-no-720-summary-maternal-fetal-surgery-for-myelomeningocele
#17
(no author information available yet)
Myelomeningocele, a severe form of spina bifida, occurs in approximately 1 in 3,000 live births in the United States. The extent of disability is generally related to the level of the myelomeningocele defect, with a higher upper level of lesion generally corresponding to greater deficits. Open maternal-fetal surgery for myelomeningocele repair is a major procedure for the woman and her affected fetus. Although there is demonstrated potential for fetal and pediatric benefit, there are significant maternal implications and complications that may occur acutely, postoperatively, for the duration of the pregnancy, and in subsequent pregnancies...
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28659205/-the-standard-mid-pregnancy-anomaly-scan-in-the-netherlands-what-is-its-effect
#18
M Gijtenbeek, M C Haak
- The mid-pregnancy anomaly scan was introduced into the Netherlands in 2007. The scan is performed at 18- 21 weeks of pregnancy.- The detection rate of open spina bifida is 94%.- In the Netherlands, 60% of all congenital heart defects are diagnosed prenatally compared with 35-40% in other countries. There is a strong relationship between the severity of the heart defect and the detection rate, as more than 95% of all univentricular heart defects are detected.- The detection rate of isolated cleft lip and cleft palate has increased from 32% to 87%...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28607062/biomechanical-coupling-facilitates-spinal-neural-tube-closure-in-mouse-embryos
#19
Gabriel L Galea, Young-June Cho, Gauden Galea, Matteo A Molè, Ana Rolo, Dawn Savery, Dale Moulding, Lucy H Culshaw, Evanthia Nikolopoulou, Nicholas D E Greene, Andrew J Copp
Neural tube (NT) formation in the spinal region of the mammalian embryo involves a wave of "zippering" that passes down the elongating spinal axis, uniting the neural fold tips in the dorsal midline. Failure of this closure process leads to open spina bifida, a common cause of severe neurologic disability in humans. Here, we combined a tissue-level strain-mapping workflow with laser ablation of live-imaged mouse embryos to investigate the biomechanics of mammalian spinal closure. Ablation of the zippering point at the embryonic dorsal midline causes far-reaching, rapid separation of the elevating neural folds...
June 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28593553/prenatal-diagnosis-of-spina-bifida-from-intracranial-translucency-to-intrauterine-surgery
#20
REVIEW
Waldo Sepulveda, Amy E Wong, Francisco Sepulveda, Juan L Alcalde, Juan C Devoto, Felipe Otayza
Accurate and timely prenatal diagnosis of spina bifida (SB) is a major goal of modern antenatal care. Prenatal screening for open SB should be first performed at the time of routine first-trimester ultrasound by examining the posterior fossa for obliteration or non-visualization of the fourth ventricle ("intracranial translucency") and cisterna magna. The second step of screening is the second-trimester anatomy scan, at which time the features of the Chiari type II malformation should be looked for, including ventriculomegaly, scalloping of the frontal bones ("lemon" sign), and backward and caudal displacement of the cerebellar vermis with obliteration of the cisterna magna ("banana" sign)...
July 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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