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https://www.readbyqxmd.com/read/29453230/role-of-biomarkers-in-predicting-the-occurrence-of-thyroid-neoplasms-in-radiation-exposed-children
#1
Joseph Shulan, Leonid Vydro, Arthur B Schneider, Dan Mihailescu
With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation exposed children. 806 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. All subjects underwent a clinical examination, measurements of thyrotropin, thyroglobulin levels and thyroid imaging...
February 16, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29451059/-oncokompas-a-web-based-self-management-application-to-support-patient-activation-and-optimal-supportive-care-a-feasibility-study-among-breast-cancer-survivors
#2
Heleen C Melissant, Irma M Verdonck-de Leeuw, Birgit I Lissenberg-Witte, Inge R Konings, Pim Cuijpers, Cornelia F Van Uden-Kraan
BACKGROUND: Cancer survivors have to deal with symptoms related to cancer and its treatment. In Oncokompas, cancer survivors monitor their quality of life by completing patient reported outcome measures (PROMs), followed by personalized feedback, self-care advice, and supportive care options to stimulate patient activation. The aim of this study was to investigate feasibility and pretest-posttest differences of Oncokompas including a newly developed breast cancer (BC) module among BC survivors...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29446014/breast-cancer-survivors-report-similar-concerns-related-to-return-to-work-in-developed-and-developing-nations
#3
Shi-Xiang Luo, Jun-E Liu, Andy S K Cheng, Shu-Qin Xiao, Ya-Li Su, Michael Feuerstein
Aim To determine whether breast cancer survivors (BCS) at work following the diagnosis and/or treatment of breast cancer, in a rapidly developing country such as China experience similar to return to work challenges as reported in nations with established return to work (RTW) policy and procedures for employees with cancer. Methods Semi-structured interviews were conducted with 16 BCS who returned to work following diagnosis and/or primary cancer treatment. An Interpretative Phenomenological Analysis was used to investigate responses...
February 14, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29438192/changes-in-health-insurance-coverage-associated-with-the-affordable-care-act-among-adults-with-and-without-a-cancer-history-population-based-national-estimates
#4
Amy J Davidoff, Gery P Guy, Xin Hu, Felisa Gonzales, Xuesong Han, Zhiyuan Zheng, Helen Parsons, Donatus U Ekwueme, Ahmedin Jemal
BACKGROUND: The Affordable Care Act (ACA) improved health care coverage accessibility by expanding Medicaid eligibility, creating insurance Marketplaces, and subsidizing premiums. We examine coverage changes associated with ACA implementation, comparing adults with and without a cancer history. METHODS: We included nonelderly adults from the 2012 to 2015 National Health Interview Survey. Using information on state Medicaid policies (2013), expansion decisions (2015), family structure, income, insurance offers, and current coverage, we assigned adults in all 4 years to mutually exclusive eligibility categories including: Medicaid-eligible pre-ACA; expansion eligible for Medicaid; and Marketplace premium subsidy eligible...
March 2018: Medical Care
https://www.readbyqxmd.com/read/29437202/lymphedema-in-ovarian-cancer-survivors-assessing-diagnostic-methods-and-the-effects-of-physical-activity
#5
Neel S Iyer, Brenda Cartmel, Louis Friedman, Fangyong Li, Yang Zhou, Elizabeth Ercolano, Maura Harrigan, Linda Gottlieb, Ruth McCorkle, Peter E Schwartz, Melinda L Irwin
BACKGROUND: Lymphedema is a poorly understood side effect of gynecologic cancer treatment. This study was designed to determine the prevalence of lower limb lymphedema (LLL) in a sample of ovarian cancer survivors via 3 different diagnostic methods and to assess the effect of a randomized exercise intervention. METHODS: Physically inactive ovarian cancer survivors (n = 95) were enrolled in a 6-month randomized trial of exercise (primarily brisk walking) versus attention control...
February 13, 2018: Cancer
https://www.readbyqxmd.com/read/29436970/why-did-i-get-cancer-perceptions-of-childhood-cancer-survivors-in-korea
#6
Jaehee Yi, Min Ah Kim, Bridget G Parsons, Yelena P Wu
This study explored whether and how childhood cancer survivors in Korea ask and resolve the question of what may have caused their cancer. Thirty-one childhood cancer survivors participated in in-depth interviews about their self-questioning process in this regard. The findings indicate that Korean childhood cancer survivors pondered this question alone due to the stigma attached to cancer in the family and society. Their answers included internal factors (doing "bad things," having unhealthy eating habits, engaging in magical thinking, having a stress-prone personality, or having a biological susceptibility) or external factors (stressors, random events, the environment, or medical conditions)...
February 13, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29435844/physical-therapy-challenges-in-head-and-neck-cancer
#7
Dwight Baldoman, Ron Vandenbrink
Treatment sequelae such as trismus, shoulder dysfunction syndrome resulting from spinal accessory nerve palsy, and radiotherapy-induced neck fibrosis are often overlooked when in the management of head and neck cancer patients. This chapter examines these underappreciated issues and their corresponding physical therapy intervention based on current evidence. Head and neck cancer survivors must contend with these disabilities for years after treatment has been concluded. A few quit their jobs which puts a tremendous burden on them and their families with a diminished quality of life...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29435294/therapy-associated-myelodysplastic-syndrome-with-monosomy-7-arising-in-a-muir-torre-syndrome-patient-carrying-setbp1-mutation
#8
David Ullman, Erin Baumgartner, Nicholas Wnukowski, Gabe Koenig, Fady M Mikhail, Peter Pavlidakey, Deniz Peker
Muir-Torre Syndrome (MTS) is a rare hereditary autosomal dominant cancer syndrome and is linked to hereditary non-polyposis colorectal carcinoma (Lynch Syndrome). Individuals develop various skin neoplasms in addition to colorectal, endometrial and upper gastrointestinal malignancies. Therapy-associated myelodysplastic syndrome (T-MDS) is an aggressive hematologic malignancy and is considered a pre-leukemic phase. T-MDS is associated with prior exposure to chemo- and radiotherapy that potentially results in DNA damage...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29431889/coagulation-and-inflammation-in-long-term-cancer-survivors-results-from-the-adult-population
#9
Marina Panova-Noeva, Andreas Schulz, Natalie Arnold, Iris M Hermanns, Jürgen H Prochaska, Dagmar Laubert-Reh, Henri M Spronk, Maria Blettner, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J Lackner, Hugo Ten Cate, Philipp S Wild
BACKGROUND: The advancements in cancer treatment and detection of early cancer have resulted in steady increase of cancer survivors over the years. However, due to long term toxic effects of chemotherapy and radiotherapy, the incidence of cardiovascular disease (CVD) is increasing in survivors. OBJECTIVES: This study investigates traditional cardiovascular risk factors (CVRFs), inflammation and coagulation profile in long-term cancer survivors (cancer diagnosis ≥ five years) from a large adult population-based study sample...
February 12, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29429145/impact-of-an-interprofessional-primary-care-training-on-fear-of-cancer-recurrence-on-clinicians-knowledge-self-efficacy-anticipated-practice-behaviors-and-attitudes-toward-survivorship-care
#10
Julie Berrett-Abebe, Tamara Cadet, Larissa Nekhlyudov, Joan Vitello, Peter Maramaldi
There are an estimated 15.5 million cancer survivors in the United States, with numbers projected to increase. Many cancer survivors are receiving survivorship care in primary care settings, yet primary care providers report a need for additional training on addressing medical and psychosocial concerns of cancer survivors. This paper presents findings from a pilot study on the effectiveness of a novel training for interprofessional primary care providers on the clinically significant issue of fear of cancer recurrence...
February 10, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29426306/characteristics-of-people-living-in-italy-after-a-cancer-diagnosis-in-2010-and-projections-to-2020
#11
Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Stracci, Bianca Caruso, Maria Michiara, Anna Luisa Caiazzo, Marine Castaing, Stefano Ferretti, Lucia Mangone, Giuseppa Rudisi, Flavio Sensi, Guido Mazzoleni, Fabio Pannozzo, Rosario Tumino, Mario Fusco, Paolo Ricci, Gemma Gola, Adriano Giacomin, Francesco Tisano, Giuseppa Candela, Anna Clara Fanetti, Filomena Pala, Antonella Sutera Sardo, Massimo Rugge, Laura Botta, Luigino Dal Maso
BACKGROUND: Estimates of cancer prevalence are widely based on limited duration, often including patients living after a cancer diagnosis made in the previous 5 years and less frequently on complete prevalence (i.e., including all patients regardless of the time elapsed since diagnosis). This study aims to provide estimates of complete cancer prevalence in Italy by sex, age, and time since diagnosis for all cancers combined, and for selected cancer types. Projections were made up to 2020, overall and by time since diagnosis...
February 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29425060/measuring-development-of-adolescent-and-young-adult-cancer-patients-an-integrative-review-of-available-instruments
#12
Cynthia J Bell, Ryan A Bell, Brad Zebrack, Ikuko Kato, Alyssa Morse, Scott C Borinstein
Adolescents and young adults (AYAs) 15-39 years old face unique challenges during cancer treatment as developmental and social needs are often disrupted to achieve cure. Developmentally appropriate supportive care for AYAs across the cancer trajectory is needed. The purpose of this review is to identify and describe instruments that measure AYA development across physical, psychological, and social domains, commenting on the instruments' psychometric properties and usefulness in clinical practice and research...
February 9, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29424000/a-threshold-free-summary-index-of-prediction-accuracy-for-censored-time-to-event-data
#13
Yan Yuan, Qian M Zhou, Bingying Li, Hengrui Cai, Eric J Chow, Gregory T Armstrong
Prediction performance of a risk scoring system needs to be carefully assessed before its adoption in clinical practice. Clinical preventive care often uses risk scores to screen asymptomatic population. The primary clinical interest is to predict the risk of having an event by a prespecified future time t 0 . Accuracy measures such as positive predictive values have been recommended for evaluating the predictive performance. However, for commonly used continuous or ordinal risk score systems, these measures require a subjective cutoff threshold value that dichotomizes the risk scores...
February 8, 2018: Statistics in Medicine
https://www.readbyqxmd.com/read/29423356/stem-cell-therapies-for-the-resolution-of-radiation-injury-to-the-brain
#14
Sarah M Smith, Charles L Limoli
Purpose of review: To encapsulate past and current research efforts focused on stem cell transplantation strategies to resolve radiation-induced cognitive dysfunction. Recent Findings: Transplantation of human stem cells in the irradiated brain was first shown to resolve radiation-induced cognitive dysfunction in a landmark paper by Acharya et al., appearing in PNAS in 2009. Since that time, work from the same laboratory as well as other groups have reported on the beneficial (as well as detrimental) effects of stem cell grafting after cranial radiation exposure...
December 2017: Current Stem Cell Reports
https://www.readbyqxmd.com/read/29419945/shared-mental-models-of-cancer-survivorship-care
#15
M C Hebdon, K Abrahamson, R R Griggs, S A McComb
Quality cancer survivorship care relies on care continuity within the healthcare team. The purpose of this study was to explore the perspectives of healthcare team members regarding cancer survivorship care using the framework of shared mental models. Semi-structured interviews of cancer survivors, primary support individuals, oncology providers, primary care providers and registered nurses were completed. Data were extrapolated to seven primary themes with associated secondary themes. Primary themes included survivor definition and identity, care setting, team member roles, care gaps, survivor needs, barriers to care and facilitators of care...
February 8, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29419940/development-and-evaluation-of-a-holistic-surgical-head-and-neck-cancer-post-treatment-follow-up-clinic-using-touchscreen-technology-feasibility-study
#16
C J Semple, D Lannon, E Qudairat, E McCaughan, R McCormac
The efficacy of traditional follow-up care is being challenged, as cancer survivors' supportive and psychological needs are often neither identified, nor addressed. This study's aim was to develop a holistic surgical follow-up clinic for oral and oropharyngeal cancer patients were participants completed a disease-specific health-related quality of life tool (UWQOLv4) and item prompt list (Patient Concern Inventory) on a touchscreen computer. Information generated was used to focus the consultation on patient's identified needs and concerns...
February 8, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29411314/feasibility-and-preliminary-efficacy-of-an-exercise-telephone-counseling-intervention-for-hematologic-cancer-survivors-a-phase-ii-randomized-controlled-trial
#17
James R Vallerand, Ryan E Rhodes, Gordon J Walker, Kerry S Courneya
BACKGROUND: Supervised exercise interventions produce the largest improvements in patient-reported outcomes in cancer survivors but their scalability has been questioned. Telephone counseling has been proposed as a more feasible alternative but its impact on exercise behavior and health outcomes have been modest. Basing telephone counseling exercise (TCE) interventions on the theoretical advances described in the multi-process action control framework (M-PAC) may improve these outcomes...
February 6, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29409399/the-implications-of-women-s-activity-limitations-and-role-disruptions-during-breast-cancer-survivorship
#18
Sharon Keesing, Lorna Rosenwax, Beverley McNamara
Early survivorship is a time of critical transition for women survivors of breast cancer as they attempt to resume functional activities and important life roles. This study aimed to explore the challenges of women and their partners as they attempted to resume activities and roles, identify unmet needs and make recommendations regarding a suitable framework to support women and partners to recommence valued activities and important roles during early survivorship. Qualitative methods utilising in-depth interviews of women (n = 18) and their partners (n = 8), and two focus groups (n = 10) were completed in Perth, Western Australia, between June 2014 and April 2015...
January 2018: Women's Health
https://www.readbyqxmd.com/read/29404842/cardiorespiratory-fitness-and-adiposity-in-breast-cancer-survivors-is-meeting-current-physical-activity-recommendations-really-enough
#19
Alejandro Santos-Lozano, Javier Ramos, Alejandro Alvarez-Bustos, Blanca Cantos, Lidia B Alejo, Itziar Pagola, Ana Soria, Constanza Maximiano, Carmen Fiuza-Luces, Luisa Soares-Miranda, Alejandro Lucia, Ana Ruiz-Casado
PURPOSE: Breast cancer (BC) survivors are becoming increasingly predisposed to cardiovascular disease (CVD) mortality. Low cardiorespiratory fitness and physical activity (PA) levels, as well as high values of adiposity indices, contribute to CVD risk. We evaluated adiposity, cardiorespiratory profile, and PA levels in two independent cohorts of BC survivors. METHODS: Data were collected from two groups (99% women) from different areas of Madrid (Spain): group 1, n = 110, age 51...
February 5, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29404299/long-term-follow-up-of-retinoblastoma-survivors-experience-from-india
#20
Rachna Seth, Amitabh Singh, Vijay Guru, Bhavna Chawla, Sushmita Pathy, Savita Sapra
Background: Retinoblastoma (Rb) is the most common primary intraocular tumor of infancy and childhood. Survivors' ocular and visual problems and increased risk for subsequent malignancy are well documented, but data on long-term health status of Rb survivors are limited, this being particularly true for India. Methodology: Children who had completed treatment for Rb at least 2 years ago before and were under follow-up at the after cancer treatment clinic were evaluated...
October 2017: South Asian Journal of Cancer
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