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Cancer survivors needs

Richard A Anderson, David H Brewster, Rachael Wood, Sian Nowell, Colin Fischbacher, Tom W Kelsey, W Hamish B Wallace
STUDY QUESTION: What is the impact of cancer in females aged ≤39 years on subsequent chance of pregnancy? SUMMARY ANSWER: Cancer survivors achieved fewer pregnancies across all cancer types, and the chance of achieving a first pregnancy was also lower. WHAT IS KNOWN ALREADY: The diagnosis and treatment of cancer in young females may be associated with reduced fertility but the true pregnancy deficit in a population is unknown. STUDY DESIGN, SIZE, DURATION: We performed a retrospective cohort study relating first incident cancer diagnosed between 1981 and 2012 to subsequent pregnancy in all female patients in Scotland aged 39 years or less at cancer diagnosis (n = 23 201)...
June 15, 2018: Human Reproduction
Ashley B Sanders, David E Conroy, Kathryn H Schmitz, Niraj Gusani
PURPOSE: This study aimed to characterize physical activity (PA) and sedentary behavior (SB) profiles in older gastrointestinal (GI) cancer survivors, assess their interest in interventions to modify these behaviors, and evaluate the acceptability of digital tools for delivering interventions to modify these behaviors. METHODS: Survivors (M = 65 years) from an outpatient survivorship clinic at the Penn State Cancer Institute completed a questionnaire during a clinic appointment...
June 18, 2018: Journal of Gastrointestinal Cancer
Ciarán Haberlin, Tom O'Dwyer, David Mockler, Jonathan Moran, Dearbhaile M O'Donnell, Julie Broderick
PURPOSE: Achieving adequate levels of physical activity (PA) and avoiding sedentary behaviour are particularly important in cancer survivors. eHealth, which includes, but is not limited to, the delivery of health information through Internet and mobile technologies, is an emerging concept in healthcare which may present opportunities to improve PA in cancer survivors. The aim of this systematic review was to explore the effects of eHealth in the promotion of PA among cancer survivors...
June 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Gordon Winocur, Ian Johnston, Hélène Castel
Cancer survivors who undergo chemotherapy for non-CNS tumours often report substantial cognitive disturbances that adversely affect quality of life, during and after treatment. The neurotoxic effects of anti-cancer drugs have been confirmed in clinical and pre-clinical research. Work with animals has also identified a range of factors and underlying mechanisms that contribute to chemotherapy-induced cognitive impairment. However, there is a continuing need to develop standard cognitive testing procedures for validation and comparison purposes, broaden the search for biological and neurochemical mechanisms, and develop improved animal models for investigating the combined effects of treatment, the disease, and other potential factors (e...
June 1, 2018: Cancer Treatment Reviews
Li-Wei Jing, Chao Zhang, Feng Jin, Ai-Ping Wang
BACKGROUND There is a great need for a quality of sexual life questionnaire (QVS) in breast cancer survivors (BCSs) based on the Chinese social culture since the imported tools lack localization verification. To develop a QVS in BCSs and determine its validity and reliability. MATERIAL AND METHODS In the qualitative study, a total of 21 BCSs were interviewed by purposive sampling and snowball sampling; and in the quantitative study, a total of 249 BCSs, who were admitted and received outpatient follow-up, were investigated...
June 16, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Rahel Kasteler, Linda M H Kam, Annette Weiss, Nicolas Waespe, Grit Sommer, Florian Singer, Nicolas X von der Weid, Marc Ansari, Claudia E Kuehni
BACKGROUND: Childhood cancer survivors are at increased risk for pulmonary morbidity and mortality. International guidelines recommend pulmonary function tests (PFT) during follow-up care. This nationwide study assessed how many children received PFT within 5 years after pulmotoxic treatment in Switzerland, types of tests, and predictors for testing. METHODS: We included all children from the Swiss Childhood Cancer Registry who were diagnosed with cancer from 1990 to 2013 at age 0-16 years, survived for ≥2 years from diagnosis, and had pulmotoxic chemotherapy with bleomycin, busulfan, nitrosoureas, and/or chest radiotherapy...
June 15, 2018: Pediatric Blood & Cancer
Christina Wei, Elizabeth Crowne
Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of the hypothalamic-pituitary-adrenal axis (HPAA) are the least common, but the consequences are severe if missed. Patients with tumours located and /or had surgery performed near the hypothalamic-pituitary region and those treated with an accumulative cranial radiotherapy dose of over 30 Gy are most at risk of adrenocorticotrophic hormone (ACTH) deficiency. Primary adrenal insufficiency may occur in patients with tumours located in or involving one or both adrenals...
June 12, 2018: Endocrine-related Cancer
Shaqul Qamar Wani, Talib Khan, Saiful Yamin Wani, Mohammad Ashraf Teli, Nazir Ahmad Khan, Liza Rafiq Mir, Mohammad Maqbool Lone, Fir Afroz
Context: The disease and surgery of the breast not only evoke a fear of mutilation and loss of feminity but is also responsible for psychosocial, behavioral, and sexual problems. Aim: To analyze prospectively the time trends in "breast specific functional and symptom scale scores in female breast cancer survivors." Settings and Design: The prospective study was conducted in the Department of Radiation Oncology at Tertiary Referral Hospital...
April 2018: Journal of Cancer Research and Therapeutics
Maximiliane Burgmann, Kerstin Hermelink, Alex Farr, Friederike van Meegen, Annika Heiduschk, Jutta Engel, Thomas Kolben, Tom Degenhardt, Nina Ditsch, Sven Mahner, Nadia Harbeck, Rachel Würstlein
Background: This study evaluates interventions offered to young breast cancer (BC) patients, including fertility preservation, genetic testing, and counseling for parenthood concerns, and analyzes the effect of BC on biographical issues. Methods: Women who were diagnosed with BC at the age of 18-40 years and who underwent treatment at the Breast Center, Ludwig-Maximilian University (LMU) in Munich between 2006 and 2013, were eligible for this study. Patients received a self-developed questionnaire which covered the following topics: fertility preservation, family planning, genetic testing, parenthood concerns and children's needs, partnership status, and employment situation...
April 2018: Breast Care
Linda Trinh, Kelly P Arbour-Nicitopoulos, Catherine M Sabiston, Scott R Berry, Andrew Loblaw, Shabbir M H Alibhai, Jennifer M Jones, Guy E Faulkner
BACKGROUND: Given the high levels of sedentary time and treatment-related side effects in prostate cancer survivors (PCS), interventions targeting sedentary behavior (SED) may be more sustainable compared to physical activity (PA). PURPOSE: To examine the feasibility of a web-based intervention (RiseTx) for reducing SED and increasing moderate-to-vigorous physical activity (MVPA) among PCS undergoing ADT. Secondary outcomes include changes in SED, MVPA, light intensity PA, and quality of life...
June 7, 2018: International Journal of Behavioral Nutrition and Physical Activity
Gemma Dyer, Lisa Brice, Mark Schifter, Nicole Gilroy, Masura Kabir, Mark Hertzberg, Matt Greenwood, Stephen R Larsen, John Moore, David Gottlieb, Gillian Huang, Megan Hogg, Louisa Brown, Jeff Tan, Christopher Ward, Ian Kerridge
BACKGROUND: Oral and dental disease is a major cause of long-term morbidity following allogeneic blood and marrow transplantation (Allo-BMT). This study aimed to describe the extent and range of oral and dental complications in BMT recipients, and to identify gaps in service provision provided to this high-risk group. METHODS: Participants were Allo-BMT recipients, aged >18years, and received transplants between 2000-2012 in NSW. They completed seven surveys, the purpose-designed Sydney Post-BMT Study survey and six other validated instruments...
June 7, 2018: Australian Dental Journal
Michelle A Mollica, Kathryn E Weaver, Timothy S McNeel, Erin E Kent
BACKGROUND: Rural cancer patients often have challenges in accessing quality care. This study examined associations between the place of residence at cancer diagnosis (urban vs rural) and patient ratings of access to care among older cancer survivors participating in Medicare-managed care. METHODS: Using Surveillance, Epidemiology, and End Results -Consumer Assessment of Healthcare Providers and Systems (SEER-CAHPS) linked data, which included SEER data and Medicare CAHPS patient experience surveys, this study identified urban (n = 6140) and rural Medicare beneficiaries (n = 686) aged ≥ 65 years with a breast, lung, colorectal, or prostate cancer diagnosis who had completed a Medicare CAHPS survey between 1998 and 2013...
June 7, 2018: Cancer
Saro H Armenian, Gregory T Armstrong, Gregory Aune, Eric J Chow, Matthew J Ehrhardt, Bonnie Ky, Javid Moslehi, Daniel A Mulrooney, Paul C Nathan, Thomas D Ryan, Helena J van der Pal, Elvira C van Dalen, Leontien C M Kremer
Cardiovascular disease (CVD), which includes cardiomyopathy/heart failure, coronary artery disease, stroke, pericardial disease, arrhythmias, and valvular and vascular dysfunction, is a major concern for long-term survivors of childhood cancer. There is clear evidence of increased risk of CVD largely attributable to treatment exposures at a young age, most notably anthracycline chemotherapy and chest-directed radiation therapy, and compounded by traditional cardiovascular risk factors accrued during decades after treatment exposure...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Lisa B Kenney, Zoltan Antal, Jill P Ginsberg, Bradford S Hoppe, Sharon L Bober, Richard N Yu, Louis S Constine, Hanneke M van Santen, Roderick Skinner, Daniel M Green
Reproductive health is a common concern and often a source of distress for male childhood, adolescent, and young adult cancer survivors. Clinical and epidemiologic research in survivor populations has identified alkylating agent chemotherapy, testicular radiation, and surgery or radiation to the genitourinary organs, lower spine, or the hypothalamic-pituitary region as risk factors for adverse reproductive outcomes, including impaired spermatogenesis, testosterone insufficiency, and sexual dysfunction. Much of the research on male survivors has focused on the outcome of fertility, using spermatogenesis, serum gonadotropins, and paternity as the measures...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Emily S Tonorezos, Dana Barnea, Richard J Cohn, Monica S Cypriano, Brice C Fresneau, Riccardo Haupt, Lars Hjorth, Yasushi Ishida, Jarmila Kruseova, Claudia E Kuehni, Purna A Kurkure, Thorsten Langer, Paul C Nathan, Jane E Skeen, Roderick Skinner, Nurdan Tacyildiz, Marry M van den Heuvel-Eibrink, Jeanette F Winther, Melissa M Hudson, Kevin C Oeffinger
With improvements in cancer treatment and supportive care, a growing population of survivors of childhood cancer at risk for significant and potentially life-threatening late effects has been identified. To provide a current snapshot of the models of care from countries with varying levels of resources and health care systems, stakeholders in childhood cancer survivorship clinical care and research were identified from 18 countries across five continents. Stakeholders responded to a survey and provided a brief narrative regarding the current state of survivorship care...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Paul C Nathan, Tara O Henderson, Anne C Kirchhoff, Elyse R Park, K Robin Yabroff
In addition to the long-term physical and psychological sequelae of cancer therapy, adult survivors of childhood cancer are at an elevated risk for financial hardship. Financial hardship can have material, psychological, and behavioral effects, including high out-of-pocket medical costs, asset depletion and debt, limitations in or inability to work, job lock, elevated stress and worry, and a delaying or forgoing of medical care because of cost. Most financial hardship research has been conducted in survivors of adult cancers...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Tara M Brinkman, Christopher J Recklitis, Gisela Michel, Martha A Grootenhuis, James L Klosky
The diagnosis, treatment, and medical late effects of childhood cancer may alter the psychosocial trajectory of survivors across their life course. This review of the literature focuses on mental health symptoms, achievement of social milestones, socioeconomic attainment, and risky health behaviors in survivors of childhood cancer. Results suggest that although most survivors are psychologically well adjusted, survivors are at risk for anxiety and depression compared with siblings. Although the absolute risk of suicide ideation and post-traumatic stress symptoms is low, adult survivors are at increased risk compared with controls...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Kirsten K Ness, James L Kirkland, Maria Monica Gramatges, Zhaoming Wang, Mondira Kundu, Kelly McCastlain, Xiujie Li-Harms, Jinghui Zhang, Tamar Tchkonia, Saskia Martine Francesca Pluijm, Gregory T Armstrong
The improvement in survival of childhood cancer observed across the past 50 years has resulted in a growing acknowledgment that simply extending the lifespan of survivors is not enough. It is incumbent on both the cancer research and the clinical care communities to also improve the health span of survivors. It is well established that aging adult survivors of childhood cancer are at increased risk of chronic health conditions, relative to the general population. However, as the first generation of survivors age into their 50s and 60s, it has become increasingly evident that this population is also at risk of early onset of physiologic aging...
June 6, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Lin Yang, Ai Koyanagi, Lee Smith, Liang Hu, Graham A Colditz, Adetunji T Toriola, Guillermo Felipe López Sánchez, Davy Vancampfort, Mark Hamer, Brendon Stubbs, Thomas Waldhör
BACKGROUND: We evaluated the associations of handgrip strength and cognitive function in cancer survivors ≥ 60 years old using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: Data in two waves of NHANES (2011-2014) were aggregated. Handgrip strength in kilogram (kg) was defined as the maximum value achieved using either hand. Two cognitive function tests were conducted among adults 60 years and older. The Animal Fluency Test (AFT) examines categorical verbal fluency (a component of executive function), and the Digital Symbol Substitution test (DSST) assesses processing speed, sustained attention, and working memory...
2018: PloS One
May Aasebø Hauken, Bibbi Hølge-Hazelton, Torill M B Larsen
BACKGROUND: Cancer in young adults is rare but young adult cancer patients (YACPs) are at an increased risk of severe physical and psychosocial impairments during cancer treatment and survivorship. However, little is known about the onset of this process. OBJECTIVE: The aim of this study was to explore how young cancer survivors experience the process of being diagnosed with cancer. METHODS: A qualitative method founded on a phenomenological-hermeneutical approach was used and included in-depth interviews with 20 young adult survivors (aged 24-35 years) with different cancer diagnoses, analyzed by Systematic Text Condensation...
June 1, 2018: Cancer Nursing
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