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https://www.readbyqxmd.com/read/27923666/lifetime-report-of-perceived-stress-at-work-and-cancer-among-men-a-case-control-study-in-montreal-canada
#1
Audrey Blanc-Lapierre, Marie-Claude Rousseau, Deborah Weiss, Mariam El-Zein, Jack Siemiatycki, Marie-Élise Parent
BACKGROUND: The association between perceived workplace psychological stress, over the entire work career, and cancer among men has never been assessed. This was explored in the context of a population-based case-control study conducted in Montreal, Canada. METHODS: 3103 incident cancer cases (11 types) diagnosed in 1979-1985 and 512 population controls were interviewed. Subjects described in detail each job held during their lifetime, including the occurrence of stress, and its reason...
December 3, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27922517/a-5-year-follow-up-of-study-patients-with-asymptomatic-iron-deficiency-anemia-using-a-nurse-led-pathway
#2
Sarah Ann Townsend, Danny Cheung, Elaine Horne, Rupert Ransford
A protocol-driven, systematic pathway was developed to allow rapid and coordinated investigation of patients with iron-deficiency anemia (IDA) in a nurse-delivered outpatient setting. The study objective was to assess the safety and efficacy of the pathway by 5-year outcome data for the exclusion of gastrointestinal (GI) malignancy. This is a 5-year follow-up study of 122 patients entered onto the pathway with negative initial upper and lower GI investigations. The study was conducted at Hereford County Hospital NHS Trust (a district general hospital serving 220,00 people)...
November 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/27896506/inflammation-based-prognostic-scores-utility-in-prognostication-and-patient-selection-for-cytoreduction-and-perioperative-intraperitoneal-chemotherapy-in-patients-with-peritoneal-metastasis-of-colonic-origin
#3
Chukwuemeka Ihemelandu
BACKGROUND: Tumor-associated systemic inflammatory response has been correlated with prognosis. Our aim was to analyze the utility of inflammation-based prognostic scores for prognostication and patient selection for cytoreduction and perioperative intraperitoneal chemotherapy (POIC) in patients diagnosed with peritoneal metastasis of colonic origin. METHODS: A retrospective analysis of a prospectively maintained database for all patients treated for peritoneal metastasis of colonic origin from February 2001 to April 2015...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27889548/impact-of-physician-adherence-to-colonoscopy-surveillance-guidelines-on-interval-colon-cancer
#4
Jennifer Nayor, John R Saltzman, Emily J Campbell, Molly L Perencevich, Kunal Jajoo, James M Richter
BACKGROUND AND AIMS: Interval colorectal cancer (iCRC) incidence is the criterion standard benchmark for measuring the effectiveness of colonoscopy. Colonoscopy surveillance guidelines are designed to minimize iCRC cases. Our aims were to (1) describe characteristics of iCRC patients; and (2) assess if development of iCRC is related to colonoscopy surveillance guideline intervals. METHODS: We performed a retrospective cohort study of post-colonoscopy iCRC cases in a large healthcare system...
November 23, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27881709/relationship-between-metformin-use-and-recurrence-and-survival-in-patients-with-resected-stage-iii-colon-cancer-receiving-adjuvant-chemotherapy-results-from-north-central-cancer-treatment-group-n0147-alliance
#5
Preet Paul Singh, Qian Shi, Nathan R Foster, Axel Grothey, Suresh G Nair, Emily Chan, Anthony F Shields, Richard M Goldberg, Sharlene Gill, Morton S Kahlenberg, Frank A Sinicrope, Daniel J Sargent, Steven R Alberts
BACKGROUND: Preclinical and epidemiological data suggest that metformin might have antineoplastic properties against colon cancer (CC). However, the effect of metformin use on patient survival in stage III CC after curative resection is unknown. The survival outcomes were comparable regardless of the duration of metformin use. PATIENTS AND METHODS: Before randomization to FOLFOX (folinic acid, 5-fluorouracil, oxaliplatin) with or without cetuximab, 1,958 patients with stage III CC enrolled in the N0147 study completed a questionnaire with information on diabetes mellitus (DM) and metformin use...
November 23, 2016: Oncologist
https://www.readbyqxmd.com/read/27872975/identification-of-recurrence-predictive-indicators-in-stage-i-colorectal-cancer
#6
Jun Ho Lee, Jong Lyul Lee, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
BACKGROUND: Patients with stage I colorectal cancer (CRC) rarely experience recurrences; therefore, few risk factors for recurrence are known. This study was designed to evaluate oncologic outcomes of patients with stage I CRC and to identify risk factors for recurrence after curative surgery. METHODS: A retrospective cohort of 860 patients from a single institution who underwent curative surgery for stage I CRC between July 1995 and June 2010 was enrolled. Patients who were diagnosed with hereditary, synchronous, or metachronous cancer and those who received preoperative chemoradiotherapy were excluded...
November 21, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27864808/latina-and-black-african-american-women-s-perspectives-on-cancer-screening-and-cancer-screening-reminders
#7
Susan Brandzel, Eva Chang, Leah Tuzzio, Camille Campbell, Nora Coronado, Erin J Aiello Bowles, Susan Carol Bradford, Diana S M Buist
INTRODUCTION: Racial and ethnic disparities continue to exist in cancer screening rates, especially among US Latina and Black/African American populations. We conducted six focus groups among 41 women from these communities in order to better understand their preferences about cancer screening reminders and the motivators and deterrents they face in obtaining recommended breast, cervical, and colon cancer screening. METHODS: Using self-reported patient race/ethnicity from electronic medical records of a large, integrated health care system in Seattle, we recruited women ages 30-60 to participate in one of five 2-hour focus groups...
November 18, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27861761/prediagnostic-alcohol-consumption-and-colorectal-cancer-survival-the-colon-cancer-family-registry
#8
Amanda I Phipps, Jamaica R Robinson, Peter T Campbell, Aung Ko Win, Jane C Figueiredo, Noralane M Lindor, Polly A Newcomb
BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline...
November 8, 2016: Cancer
https://www.readbyqxmd.com/read/27859394/systematic-review-with-meta-analysis-the-comparative-effectiveness-of-aspirin-vs-screening-for-colorectal-cancer-prevention
#9
REVIEW
L Emilsson, Ø Holme, M Bretthauer, N R Cook, J E Buring, M Løberg, H-O Adami, H D Sesso, M J Gaziano, M Kalager
BACKGROUND: Both aspirin use and screening with flexible sigmoidoscopy or guaiac faecal occult blood testing (FOBT) may reduce mortality from colorectal cancer, but comparative effectiveness of these interventions is unknown. AIM: To compare aspirin to guaiac FOBT screening with regard to incidence and mortality of colorectal cancer in a network meta-analysis. METHODS: We searched Medline, EMBASE and the COCHRANE central register (CENTRAL) for relevant randomised trials identified until 31 October 2015...
November 17, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27846172/colon-cancer-surgery-a-retrospective-study-based-on-a-large-administrative-database
#10
Mario Saia, Alessandra Buja, Domenico Mantoan, Ferdinando Agresta, Vincenzo Baldo
INTRODUCTION: Laparoscopic colectomy (LC) for colon cancer is considered as safe and effective as open colectomy. It has many benefits in terms of postoperative pain, length of hospital stay, and esthetic results. There is evidence in the United States of a positive trend in the proportion of oncologic patients undergoing LC. Our aim is to confirm this trend in Europe and identify factors associated with a greater use of LC. MATERIALS AND METHODS: A retrospective cohort study based on hospital discharge records (HDR) collected from 2008 to 2013 in a north-eastern Italian region (Veneto)...
December 2016: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/27845862/bamboo-salt-suppresses-colon-carcinogenesis-in-c57bl-6-mice-with-chemically-induced-colitis
#11
Jaehyun Ju, Ga-Young Lee, Yoon-Se Kim, Hee Kyung Chang, Myoung-Sool Do, Kun-Young Park
The aim of our experiment was to evaluate the anticancer effect of bamboo salt (BS) on C57BL/6 mice in an azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer model. BS, solar salt, and purified salt were evaluated for their protective effects during AOM/DSS-induced colon carcinogenesis in C57BL/6 mice. BS, especially after baking for nine separate intervals (BS9x), suppressed colon carcinogenesis in the mice. BS9x decreased colon length shortening, weight-to-length ratios, and tumor counts...
November 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27822767/colorectal-cancer-prognosis-following-obesity-surgery-in-a-population-based-cohort-study
#12
Wenjing Tao, Peter Konings, Mark A Hull, Hans-Olov Adami, Fredrik Mattsson, Jesper Lagergren
BACKGROUND: Obesity surgery involves mechanical and physiological changes of the gastrointestinal tract that might promote colorectal cancer progression. Thus, we hypothesised that obesity surgery is associated with poorer prognosis in patients with colorectal cancer. METHODS: This nationwide population-based cohort study included all patients with an obesity diagnosis who subsequently developed colorectal cancer in Sweden from 1980 to 2012. The exposure was obesity surgery, and the main and secondary outcomes were disease-specific mortality and all-cause mortality, respectively...
November 7, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27821793/a-study-of-thymidylate-synthase-expression-as-a-biomarker-for-resectable-colon-cancer-alliance-cancer-and-leukemia-group-b-9581-and-89803
#13
Donna Niedzwiecki, Rian M Hasson, Heinz-Josef Lenz, Cynthia Ye, Mark Redston, Shuji Ogino, Charles S Fuchs, Carolyn C Compton, Robert J Mayer, Richard M Goldberg, Thomas A Colacchio, Leonard B Saltz, Robert S Warren, Monica M Bertagnolli
PURPOSE: Tumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemotherapy for colorectal cancer, have been studied as a predictive or prognostic biomarker with mixed results. PATIENTS AND METHODS: Tumor TS levels were prospectively evaluated in two adjuvant therapy trials for patients with resected stage II or III colon cancer. TS expression was determined by standard immunohistochemistry and by automated quantitative analysis. Tumor mismatch repair deficiency (MMR-D) and BRAF c...
November 7, 2016: Oncologist
https://www.readbyqxmd.com/read/27812826/incidence-patterns-and-predictors-of-locoregional-recurrence-in-colon-cancer
#14
David Liska, Luca Stocchi, Georgios Karagkounis, Faisal Elagili, David W Dietz, Matthew F Kalady, Hermann Kessler, Feza H Remzi, James Church
BACKGROUND: Locoregional recurrence (LR) in colon cancer is uncommon but often incurable, while the factors associated with it are unclear. The purpose of this study was to identify patterns and predictors of LR after curative resection for colon cancer. METHODS: All patients who underwent colon cancer resection with curative intent between 1994 and 2008 at a tertiary referral center were identified from a prospectively maintained institutional database. The association of LR with clinicopathologic and treatment characteristics was determined using univariable and multivariable analyses...
November 3, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27811854/no-association-of-cpg-island-methylator-phenotype-and-colorectal-cancer-survival-population-based-study
#15
Min Jia, Lina Jansen, Viola Walter, Katrin Tagscherer, Wilfried Roth, Esther Herpel, Matthias Kloor, Hendrik Bläker, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
BACKGROUND: Previous studies have shown adverse effects of CpG island methylator phenotype (CIMP) on colorectal cancer (CRC) prognosis. However, sample sizes were often limited and only few studies were able to adjust for relevant molecular features associated with CIMP. The aim of this study was to investigate the impact of CIMP on CRC survival in a large population-based study with comprehensive adjustment. METHODS: The CIMP status and other molecular tumour features were analysed in 1385 CRC patients diagnosed between 2003 and 2010...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27811119/alcohol-consumption-and-the-risk-of-colorectal-cancer-in-mismatch-repair-gene-mutation-carriers
#16
S Ghazaleh Dashti, Daniel D Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Susan Parry, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Stephen N Thibodeau, Noralane M Lindor, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, Mark A Jenkins, Aung Ko Win
Background People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between alcohol consumption and colorectal cancer...
November 3, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27793399/does-repeated-lung-resection-provide-long-term-survival-for-recurrent-pulmonary-metastases-of-colorectal-cancer-%C3%A2-results-of-a-retrospective-japanese%C3%A2-multicenter-study
#17
Tomoyuki Hishida, Masahiro Tsuboi, Takehiro Okumura, Narikazu Boku, Yasuhisa Ohde, Yukinori Sakao, Katsuo Yoshiya, Ichinosuke Hyodo, Keita Mori, Haruhiko Kondo
BACKGROUND: The purpose of this study was to clarify the long-term survival outcomes after repeated lung resection (RLR) of pulmonary metastases from colorectal cancer (PM-CRC) using data from a Japanese nationwide investigation. METHODS: Among 898 patients who underwent R0 resection of PM-CRC at 46 Japanese institutions between 2004 and 2008, we analyzed the data of 216 patients who experienced recurrence limited to the lung after initial resection of PM-CRC. Overall survival (OS) after RLR was analyzed, and prognostic factors were explored using a multivariate Cox analysis...
October 25, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27778343/periodontal-disease-tooth-loss-and-colorectal-cancer-risk-results-from-the-nurses-health-study
#18
Fatemeh Momen-Heravi, Ana Babic, Shelley S Tworoger, Libin Zhang, Kana Wu, Stephanie A Smith-Warner, Shuji Ogino, Andrew T Chan, Jeffrey Meyerhardt, Edward Giovannucci, Charles Fuchs, Eunyoung Cho, Dominique S Michaud, Meir J Stampfer, Yau-Hua Yu, David Kim, Xuehong Zhang
Periodontal diseases including tooth loss might increase systemic inflammation, lead to immune dysregulation, and alter gut microbiota, thereby possibly influencing colorectal carcinogenesis. Few epidemiological studies have examined the association between periodontal diseases and colorectal cancer (CRC) risk. We collected information on the periodontal disease (defined as history of periodontal bone loss) and number of natural teeth in the Nurses' Health Study. A total of 77,443 women were followed since 1992...
October 25, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27766252/type-2-diabetes-antidiabetic-medications-and-colorectal-cancer-risk-two-case-control-studies-from-italy-and-spain
#19
Valentina Rosato, Alessandra Tavani, Esther Gracia-Lavedan, Elisabet Guinó, Gemma Castaño-Vinyals, Cristina M Villanueva, Manolis Kogevinas, Jerry Polesel, Diego Serraino, Federica E Pisa, Fabio Barbone, Victor Moreno, Carlo La Vecchia, Cristina Bosetti
BACKGROUND: Type 2 diabetes mellitus has been associated with an excess risk of colorectal cancer, although the time-risk relationship is unclear, and there is limited information on the role of antidiabetic medications. AIM: We examined the association between type 2 diabetes, antidiabetic medications, and the risk of colorectal cancer, considering also duration of exposures. METHODS: We analyzed data derived from two companion case-control studies conducted in Italy and Spain between 2007 and 2013 on 1,147 histologically confirmed colorectal cancer cases and 1,594 corresponding controls...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27756883/bevacizumab-and-wound-healing-complications-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Hongliang Zhang, Zhenguang Huang, Xiaoqin Zou, Taotao Liu
A meta-analysis was conducted to estimate the risk of wound-healing complications in patients who treated with neoadjuvant-adjuvant bevacizumab in various oncological indications. We searched PUBMED, EMBASE and the Cochrane Library through June 2016 to identify randomized controlled trials of bevacizumab and wound-healing complications. Seven RCTs studies involving 5,147 participants were included in the analysis. Compared with routine therapy, bevacizumab increased the incidence of wound-healing complications for various cancers...
October 14, 2016: Oncotarget
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