Jonathan H Sussman, Derek A Oldridge, Wenbao Yu, Chia-Hui Chen, Abigail M Zellmer, Jiazhen Rong, Arianne Parvaresh-Rizi, Anusha Thadi, Jason Xu, Shovik Bandyopadhyay, Yusha Sun, David Wu, C Emerson Hunter, Stephanie Brosius, Kyung Jin Ahn, Amy E Baxter, Mateusz P Koptyra, Rami S Vanguri, Stephanie McGrory, Adam C Resnick, Phillip B Storm, Nduka M Amankulor, Mariarita Santi, Angela N Viaene, Nancy Zhang, Thomas De Raedt, Kristina Cole, Kai Tan
Pediatric high-grade glioma (pHGG) is an incurable central nervous system malignancy that is a leading cause of pediatric cancer death. While pHGG shares many similarities to adult glioma, it is increasingly recognized as a molecularly distinct, yet highly heterogeneous disease. In this study, we longitudinally profiled a molecularly diverse cohort of 16 pHGG patients before and after standard therapy through single-nucleus RNA and ATAC sequencing, whole-genome sequencing, and CODEX spatial proteomics to capture the evolution of the tumor microenvironment during progression following treatment...
March 8, 2024: bioRxiv