keyword
https://read.qxmd.com/read/38513455/network-evolution-of-core-symptoms-after-lung-cancer-thoracoscopic-surgery-a-dynamic-network-analysis
#21
JOURNAL ARTICLE
Xiaobo Wang, Danfeng Gu, Jinrong Wei, Haoran Pan, Lijia Hou, Mingqi Zhang, Xinyan Wu, Huihong Wang
OBJECTIVES: To investigate relationships between various symptoms occurring 1-2 and 5-6 days following days after thoracoscopic surgery, to identify core symptoms, and to monitor changes in core symptoms over time following lung cancer thoracoscopic surgery. METHODS: We evaluated symptoms using the Anderson Symptom Scale (Chinese version) and the Lung Cancer-Specific Symptoms Template in 214 lung cancer patients hospitalized in the Department of Thoracic Surgery of a provincial hospital in Jiangsu Province from March 2023 to September 2023...
March 20, 2024: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://read.qxmd.com/read/38511482/rational-evolution-for-altering-the-ligand-preference-of-estrogen-receptor-alpha
#22
JOURNAL ARTICLE
Roy Eerlings, Purvi Gupta, Xiao Yin Lee, Tien Nguyen, Sarah El Kharraz, Florian Handle, Elien Smeets, Lisa Moris, Wout Devlies, Bram Vandewinkel, Irina Thiry, Duy Tien Ta, Anton Gorkovskiy, Karin Voordeckers, Els Henckaerts, Vitor B Pinheiro, Frank Claessens, Kevin J Verstrepen, Arnout Voet, Christine Helsen
Estrogen receptor α is commonly used in synthetic biology to control the activity of genome editing tools. The activating ligands, estrogens, however, interfere with various cellular processes, thereby limiting the applicability of this receptor. Altering its ligand preference to chemicals of choice solves this hurdle but requires adaptation of unspecified ligand-interacting residues. Here, we provide a solution by combining rational protein design with multi-site-directed mutagenesis and directed evolution of stably integrated variants in Saccharomyces cerevisiae...
April 2024: Protein Science
https://read.qxmd.com/read/38509417/potential-protein-kinase-inhibitors-that-target-g-quadruplex-dna-structures-in-the-human-telomeric-regions
#23
JOURNAL ARTICLE
Bhavya Banjan, Abel John Koshy, Haritha Kalath, Levin John, Sowmya Soman, Rajesh Raju, Amjesh Revikumar
Telomeric regions contain Guanine-rich sequences arranged in a planar manner and connected by Hoogsteen hydrogen bonds that can fold into G-quadruplex (G4) DNA structures, and can be stabilized by monovalent metal cations. The presence of G4 DNA holds significance in cancer-related processes, especially due to their regulatory potential at transcriptional and translational levels of oncogene and tumor suppressor genes. The objective of this current research is to explore the evolving realm of FDA-approved protein kinase inhibitors, with a specific emphasis on their capacity to stabilize the G4 DNA structures formed at the human telomeric regions...
March 21, 2024: Molecular Diversity
https://read.qxmd.com/read/38508089/b-cell-clonality-in-cancer
#24
REVIEW
E A Bryushkova, N V Mushenkova, M A Turchaninova, D K Lukyanov, D M Chudakov, E O Serebrovskaya
Carcinogenesis in the process of long-term co-evolution of tumor cells and immune environment essentially becomes possible due to incorrect decisions made, remembered, and reproduced by the immune system at the level of clonal populations of antigen-specific T- and B-lymphocytes. Tumor-immunity interaction determines the nature of such errors and, consequently, delineates the possible ways of successful immunotherapeutic intervention. It is generally recognized that tumor-infiltrating B cells (TIL-B) can play both pro-tumor and anti-tumor roles...
March 18, 2024: Seminars in Immunology
https://read.qxmd.com/read/38508032/determination-of-the-optimal-ph-for-doxorubicin-encapsulation-in-polymeric-micelles
#25
JOURNAL ARTICLE
Lucrezia Desiderio, Natalie Solfried Gjerde, Elisamaria Tasca, Luciano Galantini, Irantzu Llarena, Paolo Di Gianvincenzo, Sunisa Thongsom, Sergio E Moya, Mauro Giustini
HYPOTHESIS: The anticancer drug doxorubicin hydrochloride (DX) shows a high solubility in aqueous media thanks to the positive charge in the ammonium group. This feature, however, affects the drug encapsulation in the hydrophobic domains of polymeric micelles (PMs) used for the targeted delivery of the drug. At basic pH, DX deprotonates but also acquires a negative charge in the phenolic groups of the anthracycline structure. Both the efficiency and the rate of encapsulation will be increased by choosing an appropriate pH such that the drug molecule is in neutral form...
March 15, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38506499/exocyclic-dna-adducts-and-oxidative-stress-parameters-useful-tools-for-biomonitoring-exposure-to-aldehydes-in-smokers
#26
JOURNAL ARTICLE
Héléna Alamil, Marie-Lise Colsoul, Natacha Heutte, Marie Van Der Schueren, Laurence Galanti, Mathilde Lechevrel
Exocyclic DNA adducts have been shown to be potential biomarkers of cancer risk related to oxidative stress and exposure to aldehydes in smokers. In fact, aldehydes potentially arise from tobacco combustion directly and endogenously through lipid peroxidation. This study aims to investigate the relationship between a profile of nine aldehydes-induced DNA adducts and antioxidant activities, in order to evaluate new biomarkers of systemic exposure to aldehydes. Using our previously published UPLC-MS/MS method, adducts levels were quantified in the blood DNA of 34 active smokers...
March 20, 2024: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://read.qxmd.com/read/38504228/ischemic-heart-disease-related-mortality-in-brazil-2006-to-2020-a-study-of-multiple-causes-of-death
#27
JOURNAL ARTICLE
Luiz A V M Bastos, Paolo B Villela, Jose L P Bichara, Emilia M do Nascimento, Eduardo L V M Bastos, Basilio de B Pereira, Glaucia M M Oliveira
CONTEXT: Both the aging of the population and the increase in noncommunicable diseases may influence the progression and outcomes culminating in death, changing the evolution of ischemic heart diseases (IHDs) and their associated causes. Using the multiple causes of death method could help understand the magnitude of these relationships and enable better targeting of investments in health. OBJECTIVES: To evaluate the mortality from IHD in Brazil between 2006 and 2020 using the method of multiple causes and identify differences in the distribution pattern of IHD mortality by sex and geographic region...
March 19, 2024: BMC Public Health
https://read.qxmd.com/read/38504075/network-pharmacology-molecular-docking-and-molecular-dynamics-simulation-analysis-reveal-the-molecular-mechanism-of-halociline-against-gastric-cancer
#28
JOURNAL ARTICLE
Xiangru Zha, Rong Ji, Yang Li, Rong Cao, Songlin Zhou
Halociline, a derivative of alkaloids, was isolated from the marine fungus Penicillium griseofulvum by our group. This remarkable compound exhibits promising antineoplastic activity, yet the precise molecular mechanisms underlying its anticancer properties remain enigmatic. To unravel these mechanisms, we employed an integrated approach of network pharmacology analysis, molecular docking simulations, and molecular dynamics simulations to explore halociline therapeutic targets for gastric cancer. The data from network pharmacology indicate that halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance...
March 19, 2024: Molecular Diversity
https://read.qxmd.com/read/38503755/exemestane-plus-everolimus-and-palbociclib-in-metastatic-breast-cancer-clinical-response-and-genomic-transcriptomic-determinants-of-resistance-in-a-phase-i-ii-trial
#29
JOURNAL ARTICLE
Jorge Gómez Tejeda Zañudo, Romualdo Barroso-Sousa, Esha Jain, Qingchun Jin, Tianyu Li, Jorge E Buendia-Buendia, Alyssa Pereslete, Daniel L Abravanel, Arlindo R Ferreira, Eileen Wrabel, Karla Helvie, Melissa E Hughes, Ann H Partridge, Beth Overmoyer, Nancy U Lin, Nabihah Tayob, Sara M Tolaney, Nikhil Wagle
The landscape of cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) resistance is still being elucidated and the optimal subsequent therapy to overcome resistance remains uncertain. Here we present the final results of a phase Ib/IIa, open-label trial (NCT02871791) of exemestane plus everolimus and palbociclib for CDK4/6i-resistant metastatic breast cancer. The primary objective of phase Ib was to evaluate safety and tolerability and determine the maximum tolerated dose/recommended phase II dose (100 mg palbociclib, 5 mg everolimus, 25 mg exemestane)...
March 19, 2024: Nature Communications
https://read.qxmd.com/read/38503713/aspergillus-nodules-natural-history-and-the-effect-of-antifungals
#30
JOURNAL ARTICLE
Chris Kosmidis, Mahmoud Achira, Jeremy Yong, Chris Harris, Rohit Bazaz
BACKGROUND: Aspergillus nodules are classified as a subset of chronic pulmonary aspergillosis. The optimal management approach is not known as their natural evolution following biopsy, the rate of progression to chronic cavitary pulmonary aspergillosis (CCPA) and the effect of antifungal treatment have not been described. OBJECTIVES: To describe the clinical course of patients diagnosed with Aspergillus nodules and the effect of antifungal treatment. PATIENTS/METHODS: We present a series of 23 patients with histologically confirmed Aspergillus nodules and describe serial imaging, antifungal treatment and progression to other diagnoses...
March 2024: Mycoses
https://read.qxmd.com/read/38503461/knowledge-perceptions-attitudes-and-barriers-pertaining-to-genetic-literacy-among-surgeons-a-scoping-review
#31
REVIEW
Zuhaib M Mir, Linda Y N Fei, Sandra McKeown, Rachelle Dinchong, Nicholas Cofie, Nancy Dalgarno, Alison Rusnak, Rona E Cheifetz, Shaila J Merchant
BACKGROUND: The rapid evolution of genetic technologies and utilization of genetic information for clinical decision-making has necessitated increased surgeon participation in genetic counselling, testing, and appropriate referral of patients for genetic services, without formal training in genetics. We performed a scoping review to describe surgeons' knowledge, perceptions, attitudes, and barriers pertaining to genetic literacy in the management of patients who had confirmed cancer or who were potentially genetically at risk...
2024: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://read.qxmd.com/read/38502829/azacitidine-combined-with-venetoclax-alleviates-aml-mr-with-tp53-mutation-in-sds-a-case-report-and-literature-review
#32
JOURNAL ARTICLE
Cuiping Ma, Haiyan Lang, Yuhan Chen, Lu Yang, Chong Wang, Lizhen Han, Xinyi Chen, Wei Ma
Shwachman-Diamond syndrome (SDS) is an autosomal recessive genetic disease, which is prone to transform into myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). TP53 mutation is a driving factor involved in the transformation of SDS into MDS/AML, and in the evolution of MDS to AML. Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curable approach, however, challenge remains regarding the balance between efficacy and the high risk from treatment-related toxicity and mortality to achieve temporary disease control before transplantation to gain time and opportunities for transplantation...
March 15, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38502171/machine-learning-approaches-to-predict-symptoms-in-people-with-cancer-systematic-review
#33
REVIEW
Nahid Zeinali, Nayung Youn, Alaa Albashayreh, Weiguo Fan, Stéphanie Gilbertson White
BACKGROUND: People with cancer frequently experience severe and distressing symptoms associated with cancer and its treatments. Predicting symptoms in patients with cancer continues to be a significant challenge for both clinicians and researchers. The rapid evolution of machine learning (ML) highlights the need for a current systematic review to improve cancer symptom prediction. OBJECTIVE: This systematic review aims to synthesize the literature that has used ML algorithms to predict the development of cancer symptoms and to identify the predictors of these symptoms...
March 19, 2024: JMIR Cancer
https://read.qxmd.com/read/38502057/distinct-molecular-profiles-drive-multifaceted-characteristics-of-colorectal-cancer-metastatic-seeds
#34
JOURNAL ARTICLE
Yuanyuan Zhao, Bing Zhang, Yiming Ma, Mengmeng Guo, Fuqiang Zhao, Jianan Chen, Bingzhi Wang, Hua Jin, Fulai Zhou, Jiawei Guan, Qian Zhao, Qian Liu, Hongying Wang, Fangqing Zhao, Xia Wang
Metastasis of primary tumors remains a challenge for early diagnosis and prevention. The cellular properties and molecular drivers of metastatically competent clones within primary tumors remain unclear. Here, we generated 10-16 single cell-derived lines from each of three colorectal cancer (CRC) tumors to identify and characterize metastatic seeds. We found that intrinsic factors conferred clones with distinct metastatic potential and cellular communication capabilities, determining organ-specific metastasis...
May 6, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38499531/the-evolution-of-metastatic-upper-tract-urothelial-carcinoma-through-genomic-transcriptomic-and-single-cell-protein-markers-analysis
#35
JOURNAL ARTICLE
Kentaro Ohara, André Figueiredo Rendeiro, Bhavneet Bhinder, Kenneth Wha Eng, Hiranmayi Ravichandran, Duy Nguyen, David Pisapia, Aram Vosoughi, Evan Fernandez, Kyrillus S Shohdy, Jyothi Manohar, Shaham Beg, David Wilkes, Brian D Robinson, Francesca Khani, Rohan Bareja, Scott T Tagawa, Madhu M Ouseph, Andrea Sboner, Olivier Elemento, Bishoy M Faltas, Juan Miguel Mosquera
The molecular characteristics of metastatic upper tract urothelial carcinoma (UTUC) are not well understood, and there is a lack of knowledge regarding the genomic and transcriptomic differences between primary and metastatic UTUC. To address these gaps, we integrate whole-exome sequencing, RNA sequencing, and Imaging Mass Cytometry using lanthanide metal-conjugated antibodies of 44 tumor samples from 28 patients with high-grade primary and metastatic UTUC. We perform a spatially-resolved single-cell analysis of cancer, immune, and stromal cells to understand the evolution of primary to metastatic UTUC...
March 18, 2024: Nature Communications
https://read.qxmd.com/read/38498748/deep-drug-synergy-prediction-network-using-modified-triangular-mutation-based-differential-evolution
#36
JOURNAL ARTICLE
Dilbag Singh, Ahmad Ali Alzubi, Manjit Kaur, Vijay Kumar, Heung-No Lee
Drug combination therapy is crucial in cancer treatment, but accurately predicting drug synergy remains a challenge due to the complexity of drug combinations. Machine learning and deep learning models have shown promise in drug combination prediction, but they suffer from issues such as gradient vanishing, overfitting, and parameter tuning. To address these problems, the deep drug synergy prediction network, named as EDNet is proposed that leverages a modified triangular mutation-based differential evolution algorithm...
March 18, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38496877/genetic-mutation-profiling-reveals-biomarkers-for-targeted-therapy-efficacy-and-prognosis-in-non-small-cell-lung-cancer
#37
JOURNAL ARTICLE
Hao Bai, Yan Zhou, Wanting Liu, Wang-Yang Xu, Lei Cheng, Yingying Huo, Hao Ji, Liwen Xiong
INTRODUCTION: The genetic heterogeneity of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor ( EGFR ) mutations may affect clinical responses and outcomes to EGFR tyrosine kinase inhibitors (EGFR-TKIs). This study aims to investigate the genomic factors that influence the efficacy and clinical outcomes of first-line, second-line and third-line treatments in NSCLC and explore the heterogeneity of resistance mechanisms. MATERIALS AND METHODS: This real-world study comprised 65 patients with EGFR mutant NSCLC...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38496753/renal-cell-oncocytoma-tumor-evolutions-a-case-report
#38
Alaa Khalid Alduraibi, Noora Bin Essa, Jamshed Bomanji
This report delineates the clinical progression of a renal oncocytoma in a 38-year-old female, initially asymptomatic, over a three-year follow-up period following her treatment for papillary thyroid cancer. The timeline of this case is as follows: In 2016, the patient was treated with total thyroidectomy and I131 for thyroid cancer. During an annual follow-up, an incidental renal mass was detected via FDG PET/CT, initially characterized as a benign, non-FDG-avid renal oncocytoma. Over two years, this lesion demonstrated a remarkable increase in FDG uptake and a slight growth in size, coupled with new I131 uptake in subsequent scans...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38496580/a-longitudinal-single-cell-and-spatial-multiomic-atlas-of-pediatric-high-grade-glioma
#39
Jonathan H Sussman, Derek A Oldridge, Wenbao Yu, Chia-Hui Chen, Abigail M Zellmer, Jiazhen Rong, Arianne Parvaresh-Rizi, Anusha Thadi, Jason Xu, Shovik Bandyopadhyay, Yusha Sun, David Wu, C Emerson Hunter, Stephanie Brosius, Kyung Jin Ahn, Amy E Baxter, Mateusz P Koptyra, Rami S Vanguri, Stephanie McGrory, Adam C Resnick, Phillip B Storm, Nduka M Amankulor, Mariarita Santi, Angela N Viaene, Nancy Zhang, Thomas De Raedt, Kristina Cole, Kai Tan
Pediatric high-grade glioma (pHGG) is an incurable central nervous system malignancy that is a leading cause of pediatric cancer death. While pHGG shares many similarities to adult glioma, it is increasingly recognized as a molecularly distinct, yet highly heterogeneous disease. In this study, we longitudinally profiled a molecularly diverse cohort of 16 pHGG patients before and after standard therapy through single-nucleus RNA and ATAC sequencing, whole-genome sequencing, and CODEX spatial proteomics to capture the evolution of the tumor microenvironment during progression following treatment...
March 8, 2024: bioRxiv
https://read.qxmd.com/read/38496472/visualizing-the-spatio-temporal-dynamics-of-clonal-evolution-with-ling3d-software
#40
Anjun Hu, Awino Maureiq E Ojwang', Kayode D Olumoyin, Katarzyna A Rejniak
Cancer clonal evolution, especially following anti-cancer treatments, depends on the locations of the mutated cells within the tumor tissue. Cells near the vessels, exposed to higher concentrations of drugs, will undergo a different evolutionary path than cells residing far from the vasculature in the areas of lower drug levels. However, classical representations of cell lineage trees do not account for this spatial component of emerging cancer clones. Here, we propose the LinG3D (Lineage Graphs in 3D) algorithms to trace clonal evolution in space and time...
March 7, 2024: bioRxiv
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