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Cancer biomaterials

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https://www.readbyqxmd.com/read/28522446/non-contact-electromagnetic-induction-heating-for-eradicating-bacteria-and-yeasts-on-biomaterials-and-possible-relevance-to-orthopaedic-implant-infections-in-vitro-findings
#1
B G Pijls, I M J G Sanders, E J Kuijper, R G H H Nelissen
OBJECTIVES: Infection of implants is a major problem in elective and trauma surgery. Heating is an effective way to reduce the bacterial load in food preparation, and studies on hyperthermia treatment for cancer have shown that it is possible to heat metal objects with pulsed electromagnetic fields selectively (PEMF), also known as induction heating. We therefore set out to answer the following research question: is non-contact induction heating of metallic implants effective in reducing bacterial load in vitro? METHODS: Titanium alloy cylinders (Ti6Al4V) were exposed to PEMF from an induction heater with maximum 2000 watts at 27 kHz after being contaminated with five different types of micro-organisms: Staphylococcus epidermidis; Staphylococcus aureus; Pseudomonas aeruginosa; spore-forming Bacillus cereus; and yeast Candida albicans...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28503951/gold-nanoparticles-applications-from-artificial-enzyme-till-drug-delivery
#2
Kazem Golchin, Jafar Golchin, Shahrooz Ghaderi, Neda Alidadiani, Sajjad Eslamkhah, Masoud Eslamkhah, Soodabeh Davaran, Abolfazl Akbarzadeh
Today, nano-medicine promotes new therapeutics and diagnostics tools, including sensing of biomolecules as a biosensor, cancer chemotherapy and drug or gene delivery. Because of small size and biocompatibility of gold nanoparticles (GNPs), they become a good candidate for biological application. Also, thanks to their biological and chemical properties, they can mimic function of some enzymes including super oxide dismutase (SOD), esterase, etc. Also, biomaterials and bioengineering have grown so fast since the last decade for many therapeutic applications such as tissue regeneration...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28485595/polymer-klak-peptide-conjugates-induce-cancer-cell-death-through-synergistic-effects-of-mitochondria-damage-and-autophagy-blockage
#3
Zeng-Ying Qiao, Wen-Jia Lai, Yao-Xin Lin, Dan Li, Xiaohui Nan, Yi Wang, Hao Wang, Qiaojun Fang
Nanoscaled polymer-peptide conjugates (PPCs) containing both functional peptides and synthetic polymer comprise a new family of biomaterials that can circumvent the limitation of peptides alone. Our previous work showed that PPCs with the therapeutic peptide KLAK, especially PPCs with shorter PEG spacers and a higher degree of polymerization, exhibit enhanced antitumor effects through disrupting mitochondrial membranes. However, as PPCs have a spherical nanostructure (45~60 nm), this may have other effects besides the conjugated therapeutic peptide KLAK itself when they enter cancer cells...
May 9, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28483696/spatial-distributions-of-pericellular-stiffness-in-natural-extracellular-matrices-are-dependent-on-cell-mediated-proteolysis-and-contractility
#4
M Keating, A Kurup, M Alvarez-Elizondo, A J Levine, E Botvinick
Bulk tissue stiffness has been correlated with regulation of cellular processes and conversely cells have been shown to remodel their pericellular tissue according to a complex feedback mechanism critical to development, homeostasis, and disease. However, bulk rheological methods mask the dynamics within a heterogeneous fibrous extracellular matrix (ECM) in the region proximal to a cell (pericellular region). Here, we use optical tweezers active microrheology (AMR) to probe the distribution of the complex material response function (α = α' + α'', in units of µm/nN) within a type I collagen ECM, a biomaterial commonly used in tissue engineering...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28455189/biomaterials-strategies-for-generating-therapeutic-immune-responses
#5
REVIEW
Sean H Kelly, Lucas S Shores, Nicole L Votaw, Joel H Collier
Biomaterials employed to raise therapeutic immune responses have become a complex and active field. Historically, vaccines have been developed primarily to fight infectious diseases, but recent years have seen the development of immunologically active biomaterials towards an expanding list of non-infectious diseases and conditions including inflammation, autoimmunity, wounds, cancer, and others. This review structures its discussion of these approaches around a progression from single-target strategies to those that engage increasingly complex and multifactorial immune responses...
April 25, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28450205/nucleic-acid-combinations-a-new-frontier-for-cancer-treatment
#6
REVIEW
Remant Bahadur K C, Bindu Thapa, Juliana Valencia-Serna, Hamidreza Montezari Aliabadi, Hasan Uludağ
The emerging molecular understanding of cancer cell behavior is leading to increasing possibilities to control unchecked cell growth and metastasis. On the other hand, development of multifunctional drug carriers at the 'nano'-scale is providing exciting new therapeutic strategies in clinical management of cancer beyond the conventional cytotoxic drugs. A new frontier in this regard is the combinational use of complementary agents based on nucleic acids to overcome the limitations of conventional therapy. The existence of tightly-integrated cross-talk through multiple signaling and effector pathways have been appreciated for some time, and the plasticity of such a network to overcome one-dimensional intervention is stimulating development of combinational therapy...
April 24, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28442269/enhanced-adhesion-and-in-situ-photothermal-ablation-of-cancer-cells-in-surface-functionalized-electrospun-microfiber-scaffold-with-graphene-oxide
#7
Nicolò Mauro, Cinzia Scialabba, Giovanna Pitarresi, Gaetano Giammona
The physicochemical characteristics of a biomaterial surface highly affect the interaction with living cells. Recently, much attention has been focused on the adhesion properties of functional biomaterials toward cancer cells, since is expected to control metastatic spread of a tumor, which is related to good probability containing the progression of disease burden. Here, we designed an implantable poly(caprolactone)-based electrospun microfiber scaffold, henceforth PCLMF-GO, to simultaneously capture and kill cancer cells by tuning physicochemical features of the hybrid surface through nitrogen plasma activation and hetero-phase graphene oxide (GO) covalent functionalization...
April 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28439901/biomimetic-strategies-to-recapitulate-organ-specific-microenvironments-for-studying-breast-cancer-metastasis
#8
REVIEW
Akshay A Narkhede, Lalita A Shevde, Shreyas S Rao
The progression of breast cancer from the primary tumor setting to the metastatic setting is the critical event defining stage IV disease, no longer considered curable. The microenvironment at specific organ sites is known to play a key role in influencing the ultimate fate of metastatic cells; yet microenvironmental mediated-molecular mechanisms underlying organ specific metastasis in breast cancer are not well understood. This review discusses biomimetic strategies employed to recapitulate metastatic organ microenvironments, particularly, bone, liver, lung and brain to elucidate the mechanisms dictating metastatic breast cancer cell homing and colonization...
April 25, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28437628/advanced-biomaterials-and-microengineering-technologies-to-recapitulate-the-stepwise-process-of-cancer-metastasis
#9
REVIEW
Nitish Peela, Danh Truong, Harpinder Saini, Hunghao Chu, Samaneh Mashaghi, Stephanie L Ham, Sunil Singh, Hossein Tavana, Bobak Mosadegh, Mehdi Nikkhah
Cancer is one of the leading causes of death globally according to the World Health Organization. Although improved treatments and early diagnoses have reduced cancer related mortalities, metastatic disease remains a major clinical challenge. The local tumor microenvironment plays a significant role in cancer metastasis, where tumor cells respond and adapt to a plethora of biochemical and biophysical signals from stromal cells and extracellular matrix (ECM) proteins. Due to these complexities, there is a critical need to understand molecular mechanisms underlying cancer metastasis to facilitate the discovery of more effective therapies...
April 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/28405506/oral-delivery-of-tumor-microparticle-vaccines-activates-nod2-signaling-pathway-in-ileac-epithelium-rendering-potent-antitumor-t-cell-immunity
#10
Wenqian Dong, Huafeng Zhang, Xiaonan Yin, Yuying Liu, Degao Chen, Xiaoyu Liang, Xun Jin, Jiadi Lv, Jingwei Ma, Ke Tang, Zhuowei Hu, Xiaofeng Qin, Bo Huang
Exploiting gut mucosal immunity to design new antitumor vaccination strategy remains unexplored. Tumor cell-derived microparticles (T-MP) are natural biomaterials that are capable of delivering tumor antigens and innate signals to dendritic cells (DC) for tumor-specific T cell immunity. Here, we show that T-MPs by oral vaccination route effectively access and activate mucosal epithelium, leading to subsequent antitumor T cell responses. Oral vaccination of T-MPs generated potent inhibitory effect against the growth of B16 melanoma and CT26 colon cancer in mice, which required both T cell and DC activation...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28402175/development-of-drug-loaded-chitosan-hollow-nanoparticles-for-delivery-of-paclitaxel-to-human-lung-cancer-a549-cells
#11
Jie Jiang, Ying Liu, Chao Wu, Yang Qiu, Xiaoyan Xu, Huiling Lv, Andi Bai, Xuan Liu
In this study, biodegradable chitosan hollow nanospheres (CHN) were fabricated using polystyrene nanospheres (PS) as templates. CHN were applied to increase the solubility of poorly water-soluble drugs. The lung cancer drug paclitaxel (PTX), which is used as a model drug, was loaded into CHN by the adsorption equilibrium method. The drug-loaded sample (PTX-CHN) offered sustained PTX release and good bioavailability. The state characterization of PTX by DSC, XRD and FTIR showed that the PTX absorbed into CHN existed in an amorphous state...
April 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28393688/nanoscale-functional-biomaterials-for-cancer-theranostics
#12
Linying Liu, Xiaoshuang Li, Lei Chen, Xin Zhang
Nanomedicine is widely developed in recent years. In nanomedicine system, nanoscale and nanostructured functional materials are used to manipulate the human biology systems at the molecular level for cancer imaging and therapy. New nanostructure based functional materials consist of nanoscale liposomes, spheres, micelles, capsules, emulsion, suspension and phamacosomes. Several functional nanoparticles such as lipid-based and polymer-based materials are demonstrated to be drug delivery vehicles and imaging agents...
April 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28385267/a-review-on-hyperthermia-via-nanoparticle-mediated-therapy
#13
REVIEW
Ayesha Sohail, Zaki Ahmad, O Anwar Bég, Sarmad Arshad, Lubna Sherin
Hyperthermia treatment, generated by magnetic nanoparticles (MNPs) is promising since it is tumour-focused, minimally invasive and uniform. The most unique feature of magnetic nanoparticles is its reaction and modulation by a magnetic force basically responsible for enabling its potential as heating mediators for cancer therapy. In magnetic nanoparticle hyperthermia, a tumour is preferentially loaded with systemically administered nanoparticles with high-absorption cross-section for transduction of an extrinsic energy source to heat...
April 3, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28371333/behavior-of-prostate-cancer-cells-in-a-nanohydroxyapatite-collagen-bone-scaffold
#14
Susana Cruz-Neves, Nilza Ribeiro, Inês Graça, Carmen Jerónimo, Susana R Sousa, Fernando J Monteiro
Prostate cancer (PCa) is the second leading cause of death among men in Europe and U.S. The metastatic dissemination pattern of PCa is unique, developing bone metastasis as the only site of progression, consequently with a prognosis very poor. The cancer cells interactions within the surrounding bone environment are critical for tumor growth and progression. Secreted protein, acidic and rich in cysteine (SPARC) is described to be involved in PCa cells migration and invasion into bone. Three-dimensional (3D) in vitro systems that are able to closely resemble the in vivo microenvironment are recently taking importance in cancer research...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28349127/polymeric-nanoparticle-based-delivery-of-trail-dna-for-cancer-specific-killing
#15
Stephany Y Tzeng, David R Wilson, Sarah K Hansen, Alfredo Quiñones-Hinojosa, Jordan J Green
Lack of specificity in cancer therapeutics severely limits the efficacy of many existing treatment modalities. The use of Tumor Necrosis Factor-related Apoptosis-Inducing Ligand (TRAIL) is of interest to the field due to this protein's ability to cause cell death specifically in cancer cells without harming the surrounding healthy tissue. Here, we report that polymeric nanoparticles, based on synthetic poly(beta-amino ester)s (PBAEs) and containing DNA, are able to selectively transfect cancer cells in vitro over healthy cells of the same tissue type...
June 2016: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28342377/live-cell-biosensing-platforms-using-graphene-based-hybrid-nanomaterials
#16
REVIEW
Tae-Hyung Kim, Donghyun Lee, Jeong-Woo Choi
A novel strategy to precisely detect or monitor various biomaterials in living cells poses paramount importance in understanding cellular processes. Graphene, a newly emerged two-dimensional carbon material, has been widely utilized for biosensors owing to its multifarious characteristics including mechanical, electrical, and optical properties (e.g. stability, conductivity, fluorescence quenching and photoluminescence). In addition, graphene derivatives and their innate characteristics, such as biocompatibility low cytotoxicity and water solubility have facilitated the use of graphene-based materials for live cell biosensing, wherein graphene is utilized as a core material by itself or in combination with other functional nanomaterials to load target-specific probes, fluorescent dyes, and other signaling molecules...
March 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28335259/lipid-nanovectors-to-deliver-rna-oligonucleotides-in-cancer
#17
REVIEW
Virginia Campani, Giuseppina Salzano, Sara Lusa, Giuseppe De Rosa
The growing knowledge on the mechanisms of gene silencing and gene regulation by non-coding RNAs (ncRNA), mainly small interfering RNA (siRNA) and microRNA (miRNA), is providing a significant boost to the development of new therapeutic strategies for the treatment of cancer. However, the design of RNA-based therapeutics is hampered by biopharmaceutical issues, thus requiring the use of suitable delivery strategies. In this regards, lipid nanovectors have been successfully investigated to deliver RNA in different forms of cancer...
July 9, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334523/transformable-nanomaterials-as-an-artificial-extracellular-matrix-for-inhibiting-tumor-invasion-and-metastasis
#18
Xiao-Xue Hu, Ping-Ping He, Guo-Bin Qi, Yu-Juan Gao, Yao-Xin Lin, Chao Yang, Pei-Pei Yang, Hongxun Hao, Lei Wang, Hao Wang
Tumor metastasis is one of the big challenges in cancer treatment and is often associated with high patient mortality. Until now, there is an agreement that tumor invasion and metastasis are related to degradation of extracellular matrix (ECM) by enzymes. Inspired by the formation of natural ECM and the in situ self-assembly strategy developed in our group, herein, we in situ constructed an artificial extracellular matrix (AECM) based on transformable Laminin (LN)-mimic peptide 1 (BP-KLVFFK-GGDGR-YIGSR) for inhibition of tumor invasion and metastasis...
April 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28319779/supramolecular-biofunctional-materials
#19
REVIEW
Jie Zhou, Jie Li, Xuewen Du, Bing Xu
This review discusses supramolecular biofunctional materials, a novel class of biomaterials formed by small molecules that are held together via noncovalent interactions. The complexity of biology and relevant biomedical problems not only inspire, but also demand effective molecular design for functional materials. Supramolecular biofunctional materials offer (almost) unlimited possibilities and opportunities to address challenging biomedical problems. Rational molecular design of supramolecular biofunctional materials exploit powerful and versatile noncovalent interactions, which offer many advantages, such as responsiveness, reversibility, tunability, biomimicry, modularity, predictability, and, most importantly, adaptiveness...
June 2017: Biomaterials
https://www.readbyqxmd.com/read/28304023/peptide-functionalized-gold-nanoparticles-versatile-biomaterials-for-diagnostic-and-therapeutic-applications
#20
REVIEW
Jingyi Zong, Steven L Cobb, Neil R Cameron
Colloidal gold solutions have been used for centuries in a wide variety of applications including staining glass and in the colouring of ceramics. More recently, gold nanoparticles (GNPs) have been studied extensively due to their interesting size-dependent electronic and optical properties. GNPs can be functionalized easily with biomolecules that contain thiols, amines, or even phosphine moieties. For example, the reaction of thiol-containing peptides with GNPs has been used extensively to prepare novel hybrid materials for biomedical applications...
May 2, 2017: Biomaterials Science
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