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Cancer biomaterials

Francisco Pelaez, Navid Manuchehrabadi, Priyatanu Roy, Harishankar Natesan, Yiru Wang, Emilian Racila, Heather Fong, Kevin Zeng, Abby M Silbaugh, John C Bischof, Samira M Azarin
Currently, there are very few therapeutic options for treatment of metastatic disease, as it often remains undetected until the burden of disease is too high. Microporous poly(ε-caprolactone) biomaterials have been shown to attract metastasizing breast cancer cells in vivo early in tumor progression. In order to enhance the therapeutic potential of these scaffolds, they were modified such that infiltrating cells could be eliminated with non-invasive focal hyperthermia. Metal disks were incorporated into poly(ε-caprolactone) scaffolds to generate heat through electromagnetic induction by an oscillating magnetic field within a radiofrequency coil...
February 28, 2018: Biomaterials
B G De Geest
Biomaterials-based strategies to engineer the immune system have gathered considerable attention the past decade and have opened new avenues for vaccine delivery and for modulating the immune system to fight cancer. This review highlights some of these strategies that involve well-defined particle-based delivery systems that are constructed in a multistep fashion. Particular attention is devoted to the design of micro and nanoparticles to deliver antigen and molecular adjuvants to antigen presenting immune cell subsets in lymphatic tissue...
March 8, 2018: Molecular Immunology
Rongrong Huang, Nongyue He, Zhiyang Li
DNA has emerged as a promising biomaterial for assembling a variety of nanostructures based on its programmable base pairing. It also has other remarkable properties including stability, prominent biocompatibility, and can easily be modified with functional groups for further applications. In the past few decades, researchers have established various design rules and assembly technologies to improve the stability and complexity of DNA nanostructures. The detection of cancer-associated biomarkers has significant importance in identifying patients with different clinical stages and also in developing adaptive therapeutic strategies...
March 6, 2018: Biosensors & Bioelectronics
Marin Strijker, Arja Gerritsen, Jony van Hilst, Maarten F Bijlsma, Bert A Bonsing, Lodewijk A Brosens, Marco J Bruno, Ronald M van Dam, Frederike Dijk, Casper H van Eijck, Arantza Farina Sarasqueta, Paul Fockens, Michael F Gerhards, Bas Groot Koerkamp, Erwin van der Harst, Ignace H de Hingh, Jeanin E van Hooft, Clément J Huysentruyt, Geert Kazemier, Joost M Klaase, Cornelis J van Laarhoven, Hanneke W van Laarhoven, Mike S Liem, Vincent E de Meijer, L Bengt van Rijssen, Hjalmar C van Santvoort, Mustafa Suker, Judith H Verhagen, Joanne Verheij, Hein W Verspaget, Roos A Wennink, Johanna W Wilmink, I Quintus Molenaar, Marja A Boermeester, Olivier R Busch, Marc G Besselink
OBJECTIVES: Large biobanks with uniform collection of biomaterials and associated clinical data are essential for translational research. The Netherlands has traditionally been well organized in multicenter clinical research on pancreatic diseases, including the nationwide multidisciplinary Dutch Pancreatic Cancer Group and Dutch Pancreatitis Study Group. To enable high-quality translational research on pancreatic and periampullary diseases, these groups established the Dutch Pancreas Biobank...
April 2018: Pancreas
Joanna Mystkowska, Katarzyna Niemirowicz-Laskowska, Dawid Łysik, Grażyna Tokajuk, Jan R Dąbrowski, Robert Bucki
Metallic biomaterials in the oral cavity are exposed to many factors such as saliva, bacterial microflora, food, temperature fluctuations, and mechanical forces. Extreme conditions present in the oral cavity affect biomaterial exploitation and significantly reduce its biofunctionality, limiting the time of exploitation stability. We mainly refer to friction, corrosion, and biocorrosion processes. Saliva plays an important role and is responsible for lubrication and biofilm formation as a transporter of nutrients for microorganisms...
March 6, 2018: International Journal of Molecular Sciences
Udi Sarig, Hadar Sarig, Aleksander Gora, Muthu Kumar Krishnamoorthi, Gigi Chi Ting Au-Yeung, Elio de-Berardinis, Su Yin Chaw, Priyadarshini Mhaisalkar, Hanumakumar Bogireddi, Seeram Ramakrishna, Freddy Yin Chiang Boey, Subbu S Venkatraman, Marcelle Machluf
Tissue development, regeneration, or de-novo tissue engineering in-vitro, are based on reciprocal cell-niche interactions. Early tissue formation mechanisms, however, remain largely unknown given complex in-vivo multifactoriality, and limited tools to effectively characterize and correlate specific micro-scaled bio-mechanical interplay. We developed a unique model system, based on decellularized porcine cardiac extracellular matrices (pcECMs)-as representative natural soft-tissue biomaterial-to study a spectrum of common cell-niche interactions...
March 2, 2018: Scientific Reports
Tao Huang, Xinglong Luan, Qi Xia, Shaofeng Pan, Qi An, Yaling Wu, Yihe Zhang
The molecularly selective regulation of molecular fluxes in a biomaterial that delivers simultaneously multiple chemical species is still beyond the touch of materials scientists. We developed a delivery material using layer-by-layer (LbL) technique that discriminatively regulates the delivery flux of bioactive small molecules, represented by a peptide containing RGD fragment and the chemotherapy drug DOX. Molecularly selective flux regulations in layer-by-layer films are realized using fast reversible supramolecular bindings between cyclodextrin and its guests...
February 22, 2018: Chemistry, An Asian Journal
Ichiyo Shibahara, Mitsuto Hanihara, Takashi Watanabe, Mitsuru Dan, Sumito Sato, Hiroki Kuroda, Akinori Inamura, Madoka Inukai, Atsuko Hara, Yoshie Yasui, Toshihiro Kumabe
Biomaterials to treat cancers hold therapeutic potential; however, their translation to bedside treatment requires further study. The carmustine (1,3-bis (2-chloroethyl)-1-nitrosourea; BCNU) wafer, a biodegradable polymer, currently is the only drug that is able to be placed at the surgical site to treat malignant tumors. However, how this wafer affects the surrounding tumor microenvironment is not well understood to date. We retrospectively reviewed all patients with glioblastoma treated with and without BCNU wafers who underwent repeat resection at tumor recurrence...
February 21, 2018: Journal of Neuro-oncology
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
Yanke Wang, Dongdong Cai, Huixia Wu, Yu Fu, Yang Cao, Yingjian Zhang, Dongmei Wu, Qiwei Tian, Shiping Yang
Multifunctional nano-biomaterials with the integration of diagnostic and therapeutic functions have shown great promise in improving the efficacy of cancer therapy. Herein, a new nanoplatform based on functionalized Cu 3 BiS 3 nanoparticles (NPs) is fabricated for tumour-targeted combination phototherapy. The as-synthesized hydrophobic Cu 3 BiS 3 NPs are modified with DSPE-PEG/DSPE-PEG-NH 2 , followed by the conjugation of the photosensitizer chlorin e6 (Ce6) and the target ligand folic acid (FA). The introduced Ce6 can further form a chelate complex with Gd 3+ ...
February 16, 2018: Nanoscale
Zhiying Wang, He Shen, Saijie Song, Liming Zhang, Wei Chen, Jianwu Dai, Zhijun Zhang
Delivery of functional genes into stem cells shows great application prospect in DNA-based tissue engineering. However, comparing with epithelial cells and cancer cells, stem cells usually exhibit low gene transfection efficiency. To enhance the transfection efficiency, non-viral gene delivery in combination with biomaterial scaffolds, has raised increasing interests from researchers in tissue engineering. Nanofibers fabricated by electrospinning technique mimicking extracellular matrix (ECM) are widely used in tissue engineering applications...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Jian Li, Yuxiao Zhang, Liyi Chen, Xinhua Lu, Zhibin Li, Yongyong Xue, Yan-Qing Guan
Based on our earlier work with co-immobilized TNF-α plus IFN-γ induction of HeLa cell death, we used FRET and XRD techniques to examine the differences in the structure of co-immobilized TNF-α plus IFN-γ and free TNF-α plus IFN-γ. The expressions of both TNF-α and IFN-α increased significantly, as determined by gene microarray analysis, however, in the presence of TNF-α plus IFN-α inhibitors, TNF-α and IFN-α did not increase in HeLa cells induced by co-immobilized TNF-γ plus IFN-α. This suggests that the TNF-α and IFN-α are the results of autocrine signaling in HeLa cells, and that cell death is caused by these substances...
February 13, 2018: ACS Applied Materials & Interfaces
Samaneh Hosseini, Mohammad Amin Shamekhi, Shahrbanoo Jahangir, Fatemeh Bagheri, Mohamadreza Baghaban Eslaminejad
Malignant bone tumors, although quite rare, are one of the causes of death in children and adolescents. Surgery as a common and primary treatment for removal of virtually bone cancer cause large bone defects. Thus, restoration of hard tissues like bone and cartilage after surgical tumor resection needs efficient therapeutic approaches. Tissue engineering (TE) is a powerful approach which has provided hope for restoration, maintenance, or improvement of damaged tissues. This strategy generally supplies a three-dimensional scaffold as an active substrate to support cell recruitment, infiltration, and proliferation for neo-tissues...
February 9, 2018: Advances in Experimental Medicine and Biology
Shaohua Cui, Zhuoan Cheng, Wenxin Qin, Liyan Jiang
In lung cancer and other malignancies, the so-called "liquid biopsy" is quickly moving into clinical practice. Its full potential has not yet been fully identified, but the "liquid biopsy" is no longer a promise but has become a reality that allows for better treatment selection and monitoring of lung cancer. This emerging field has significant potential to make up for the limitations of the traditional tissue-derived biomaterials. Exosomes are spherical nano-sized vesicles with a diameter of 40-100 nm and a density of 1...
February 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Hong Li, Yi Jia, Haonan Peng, Junbai Li
Dopamine-based materials are emerging as novel biomaterials and have attracted considerable interests in the fields of biosensing, bioimaging and cancer therapy due to their unique physicochemical properties, such as versatile adhesion property, high chemical reactivity, excellent biocompatibility and biodegradability, strong photothermal conversion capacity, etc. In this review, we present an overview of recent research progress on dopamine-based materials for diagnosis and therapy of cancer. The review starts with a summary of the physicochemical properties of dopamine-based materials in general...
January 29, 2018: Advances in Colloid and Interface Science
Zhen-Wei Zhu, Lin Chen, Jing-Xian Liu, Jun-Wen Huang, Gang Wu, Yan-Fang Zheng, Kai-Tai Yao
Cancer stem cells (CSCs) are considered to serve a key role in tumor progression, recurrence and metastasis. Tumorsphere culture is the most important method for enriching CSCs and is widely used in basic research and drug screening. However, the traditional suspension cell culture system has several disadvantages, including low efficiency, high cost and difficult procedure, making it difficult to produce tumorspheres on a large scale. In the present study, two biomaterials, methylcellulose (MC) and gellan gum (GG), were used to construct a novel culture system based on the traditional system...
January 2018: Experimental and Therapeutic Medicine
Werner E G Müller, Meik Neufurth, Shunfeng Wang, Maximilian Ackermann, Rafael Muñoz-Espí, Qingling Feng, Qiang Lu, Heinz C Schröder, Xiaohong Wang
Using femur explants from mice as an in vitro model, we investigated the effect of the physiological polymer, inorganic polyphosphate (polyP), on differentiation of the cells of the bone marrow in their natural microenvironment into the osteogenic and chondrogenic lineages. In the form of amorphous Ca-polyP nano/microparticles, polyP retains its function to act as both an intra- and extracellular metabolic fuel and a stimulus eliciting morphogenetic signals. The method for synthesis of the nano/microparticles with the polyanionic polyP also allowed the fabrication of hybrid particles with the bisphosphonate zoledronic acid, a drug used in therapy of bone metastases in cancer patients...
January 31, 2018: International Journal of Molecular Sciences
Patrick Ming-Kuen Tang, Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Jessica Shuk Chun Hung, Qing-Ming Wang, Guang-Yu Lian, Jingyi Sheng, Xiao-Ru Huang, Ka-Fai To, Hui-Yao Lan
Natural killer (NK) cells belong to the innate immune system and are a first-line anti-cancer immune defense; however, they are suppressed in the tumor microenvironment and the underlying mechanism is still largely unknown. The lack of a consistent and reliable source of NK cells limits the research progress of NK cell immunity. Here, we report an in vitro system that can provide high quality and quantity of bone marrow-derived murine NK cells under a feeder-free condition. More importantly, we also demonstrate that siRNA-mediated gene silencing successfully inhibits the E4bp4-dependent NK cell maturation by using this system...
January 9, 2018: Journal of Visualized Experiments: JoVE
Yu-Qing Xie, Lixia Wei, Li Tang
Cancer immunotherapy has recently shown dramatic clinical success inducing durable response in patients of a wide variety of malignancies. Further improvement of the clinical outcome with immune related cancer treatment requests more exquisite manipulation of a patient's immune system with increased immunity against diseases while mitigating the toxicities. To meet this challenge, biomaterials applied to immunoengineering are being developed to achieve tissue- and/or cell-specific immunomodulation and thus could potentially enhance both the efficacy and safety of current cancer immunotherapies...
January 14, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Lindsay E Clegg, Feilim Mac Gabhann
Inducing therapeutic angiogenesis to effectively form hierarchical, non-leaky networks of perfused vessels in tissue engineering applications and ischemic disease remains an unmet challenge, despite extensive research and multiple clinical trials. Here, we use a previously-developed, multi-scale, computational systems pharmacology model of human peripheral artery disease to screen a diverse array of promising pro-angiogenic strategies, including gene therapy, biomaterials, and antibodies. Our previously-validated model explicitly accounts for VEGF immobilization, Neuropilin-1 binding, and weak activation of VEGF receptor 2 (VEGFR2) by the "VEGFxxxb" isoforms...
January 12, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
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