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Cancer biomaterials

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https://www.readbyqxmd.com/read/29333729/immunoengineering-with-biomaterials-for-enhanced-cancer-immunotherapy
#1
REVIEW
Yu-Qing Xie, Lixia Wei, Li Tang
Cancer immunotherapy has recently shown dramatic clinical success inducing durable response in patients of a wide variety of malignancies. Further improvement of the clinical outcome with immune related cancer treatment requests more exquisite manipulation of a patient's immune system with increased immunity against diseases while mitigating the toxicities. To meet this challenge, biomaterials applied to immunoengineering are being developed to achieve tissue- and/or cell-specific immunomodulation and thus could potentially enhance both the efficacy and safety of current cancer immunotherapies...
January 14, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29327758/a-computational-analysis-of-pro-angiogenic-therapies-for-peripheral-artery-disease
#2
Lindsay E Clegg, Feilim Mac Gabhann
Inducing therapeutic angiogenesis to effectively form hierarchical, non-leaky networks of perfused vessels in tissue engineering applications and ischemic disease remains an unmet challenge, despite extensive research and multiple clinical trials. Here, we use a previously-developed, multi-scale, computational systems pharmacology model of human peripheral artery disease to screen a diverse array of promising pro-angiogenic strategies, including gene therapy, biomaterials, and antibodies. Our previously-validated model explicitly accounts for VEGF immobilization, Neuropilin-1 binding, and weak activation of VEGF receptor 2 (VEGFR2) by the "VEGFxxxb" isoforms...
January 12, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29304240/adipose-tissue-derived-stem-cells-in-a-fibrin-implant-enhance-neovascularization-in-a-peritoneal-grafting-site-a-potential-way-to-improve-ovarian-tissue-transplantation
#3
D D Manavella, L Cacciottola, C M Desmet, B F Jordan, J Donnez, C A Amorim, M M Dolmans
STUDY QUESTION: Do two different concentrations of human adipose tissue-derived stem cells (ASCs) embedded inside a fibrin scaffold have the potential to differentiate into vessels and aid vascularization in a peritoneal grafting site intended for ovarian tissue transplantation? SUMMARY ANSWER: Human ASCs in low and high concentrations differentiated into vessels when transplanted to mouse peritoneum inside a fibrin matrix, but only high ASC concentrations significantly increased human vessel area 14 days after transplantation...
January 3, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29303407/vaginoplasty-with-acellular-dermal-matrix-after-radical-resection-for-carcinoma-of-the-uterine-cervix
#4
Zhi Wang, Jiuzuo Huang, Ang Zeng, Ming Wu, Xiaojun Wang
Various methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer patients who received curative surgery in combination with radiotherapy. They underwent vaginoplasty with tissue-engineered biological material, acellular dermal matrix (ADM). After treatment, a vaginal dilator was advised to be used for 6 months to prevent contraction of vagina...
January 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29283071/silk-fibroin-based-drug-delivery-applications-promises-and-challenges
#5
Shahid Ud Din Wani, Gangadharappa Hosahalli Veerabhadrappa
BACKGROUND: Silk Fibroin (SF), a natural source material obtained from Bombyx mori, has been widely enlisted as biomaterial having outstanding mechanical properties. SF has been reported one of the propitious bio-polymer for various drug delivery systems, as well as drug delivery vehicle. OBJECTIVE: This review is summarised to provide in comprehensive applications of silk fibroin in various drug delivery systems, and also to present the current opportunities and requirements by furnishing a definitive assessment on silk fibroin as a polymer...
December 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29282221/brain-mimetic-3d-culture-platforms-allow-investigation-of-cooperative-effects-of-extracellular-matrix-features-on-therapeutic-resistance-in-glioblastoma
#6
Weikun Xiao, Rongyu Zhang, Alireza Sohrabi, Arshia Ehsanipour, Songping Sun, Jesse Liang, Christopher Walthers, Lisa Ta, David A Nathanson, Stephanie K Seidlits
Glioblastoma (GBM) tumors exhibit potentially actionable genetic alterations against which targeted therapies have been effective in treatment of other cancers. However, these therapies have largely failed in GBM patients. A notable example is EGFR kinase inhibitors, which display poor clinical efficacy despite overexpression and/or mutation of EGFR in >50% of GBM. In addressing this issue, preclinical models may be limited by the inability to accurately replicate pathophysiological interactions of GBM cells with unique aspects of the brain extracellular matrix (ECM), which is relatively enriched in hyaluronic acid (HA) and flexible...
December 27, 2017: Cancer Research
https://www.readbyqxmd.com/read/29258803/antioxidant-functionalized-polymer-capsules-to-prevent-oxidative-stress
#7
Aitor Larrañaga, Isma Liza Mohd Isa, Vaibhav Patil, Sagana Thamboo, Mihai Lomora, Marc A Fernández-Yague, Jose-Ramon Sarasua, Cornelia G Palivan, Abhay Pandit
Polymeric capsules exhibit significant potential for therapeutic applications as microreactors, where the bio-chemical reactions of interest are efficiently performed in a spatial and time defined manner due to the encapsulation of an active biomolecule (e.g., enzyme) and control over the transfer of reagents and products through the capsular membrane. In this work, catalase loaded polymer capsules functionalized with an external layer of tannic acid (TA) are fabricated via a layer-by-layer approach using calcium carbonate as a sacrificial template...
December 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29249461/improving-vaccine-and-immunotherapy-design-using-biomaterials
#8
REVIEW
Michelle L Bookstaver, Shannon J Tsai, Jonathan S Bromberg, Christopher M Jewell
Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as technologies to improve the efficacy of vaccines against infectious disease and immunotherapies for cancer, autoimmunity, and transplantation. New studies are also providing insight into the interactions between these materials and the immune system. This insight can be exploited for more efficient design of vaccines and immunotherapies. Here, we describe recent advances made possible through the unique features of biomaterials, as well as the important questions for further study...
November 15, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/29248638/peptide-and-peptide-carbon-nanotube-hydrogels-as-scaffolds-for-tissue-3d-tumor-engineering
#9
Mohammadali Sheikholeslam, Scott D Wheeler, Keely G Duke, Mungo Marsden, Mark Pritzker, P Chen
The use of hybrid self-assembling peptide (EFK8)-carbon nanotube (SWNT) hydrogels for tissue engineering and in vitro 3D cancer spheroid formation is reported. These hybrid hydrogels are shown to enhance the attachment, spreading, proliferation and movement of NIH-3T3 cells relative to that observed using EFK8-only hydrogels. After five days, ∼30% more cells are counted when the hydrogel contains SWNTs. Also, 3D encapsulation of these cells when injected in hydrogels does not adversely affect their behavior...
December 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29230350/spatially-graded-hydrogels-for-preclinical-testing-of-glioblastoma-anticancer-therapeutics
#10
S Pedron, H Polishetty, A M Pritchard, B P Mahadik, J N Sarkaria, B A C Harley
While preclinical models such as orthotopic tumors generated in mice from patient-derived specimens are widely used to predict sensitivity or therapeutic interventions for cancer, such xenografts can be slow, require extensive infrastructure, and can make in situ assessment difficult. Such concerns are heightened in highly aggressive cancers, such as glioblastoma (GBM), that display genetic diversity and short mean survival. Biomimetic biomaterial technologies offer an approach to create ex vivo models that reflect biophysical features of the tumor microenvironment (TME)...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29226386/theranostic-2d-tantalum-carbide-mxene
#11
Han Lin, Youwei Wang, Shanshan Gao, Yu Chen, Jianlin Shi
The large-dimensional and rigid ceramic bulks fabricated by high-temperature solid-phase reaction and sintering have never been considered for possibly entering and circulating within the blood vessels for biomedical applications, especially on combating cancer. Here, it is reported for the first time that MAX ceramic biomaterials exhibit unique functionalities for dual-mode photoacoustic/computed tomography imaging and are highly effective for in vivo photothermal ablation of tumors upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene)...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29207552/hydroxyapatite-coated-iron-oxide-nanoparticles-a-promising-nanomaterial-for-magnetic-hyperthermia-cancer-treatment
#12
Sudip Mondal, Panchanathan Manivasagan, Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Van Tu Nguyen, Hye Hyun Kim, Seung Yun Nam, Kang Dae Lee, Junghwan Oh
Targeting cancer cells without injuring normal cells is the prime objective in treatment of cancer. In this present study, solvothermal and wet chemical precipitation techniques were employed to synthesize iron oxide (IO), hydroxyapatite (HAp), and hydroxyapatite coated iron oxide (IO-HAp) nanoparticles for magnetic hyperthermia mediated cancer therapy. The synthesized well dispersed spherical IO-HAp nanoparticles, magnetite, and apatite phases were confirmed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and Field emission transmission electron microscopy (FETEM) with Energy Dispersive X-ray spectroscopy (EDS)...
December 4, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29205942/biomaterials-based-approaches-to-tumor-spheroid-and-organoid-modeling
#13
REVIEW
Pradip Shahi Thakuri, Chun Liu, Gary D Luker, Hossein Tavana
Evolving understanding of structural and biological complexity of tumors has stimulated development of physiologically relevant tumor models for cancer research and drug discovery. A major motivation for developing new tumor models is to recreate the 3D environment of tumors and context-mediated functional regulation of cancer cells. Such models overcome many limitations of standard monolayer cancer cell cultures. Under defined culture conditions, cancer cells self-assemble into 3D constructs known as spheroids...
December 4, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29202515/recent-progresses-in-breast-reconstruction-stem-cells-biomaterials-and-growth-factors
#14
Farshad Zarei, Hadis Daraee
Breast cancer is one of the most deadly tumors in women, and new procedures for post- surgical breast reconstruction have been developed which includes autologous stromal vascular fraction (SVF), platelet-derived growth factors, biomaterials and various stem cells. Adipose derived-stem cells (ASCs) has been reported to be one of the most widely used stem cell for breast reconstruction because of their ability to form new functional adipose tissue and vessels and in combination with stromal vascular fraction has been also reported efficient for breast reconstruction...
December 4, 2017: Drug Research
https://www.readbyqxmd.com/read/29186353/prevalence-and-clinical-association-of-gene-mutations-through-multiplex-mutation-testing-in-patients-with-nsclc-results-from-the-etop-lungscape-project
#15
K M Kerr, U Dafni, K Schulze, E Thunnissen, L Bubendorf, H Hager, S Finn, W Biernat, L Vliegen, J H Losa, A Marchetti, R Cheney, A Warth, E-J Speel, F Blackhall, K Monkhorst, E Jantus Lewintre, V Tischler, C Clark, J Bertran-Alamillo, P Meldgaard, K Gately, A Wrona, P Vandenberghe, E Felip, G De Luca, S Savic, T Muley, E F Smit, A-M C Dingemans, L Priest, P Baas, C Camps, W Weder, V Polydoropoulou, T R Geiger, R Kammler, T Sumiyoshi, M A Molina, D S Shames, R A Stahel, S Peters
Background: Reported prevalence of driver gene mutations in non-small cell lung cancer (NSCLC) is highly variable and clinical correlations are emerging. Using NSCLC biomaterial and clinical data from the ETOP Lungscape iBiobank, we explore the epidemiology of mutations and association to clinicopathological features and patient outcome (relapse-free survival, time-to-relapse, overall survival). Methods: Clinically-annotated, resected stage I-III NSCLC FFPE tissue was assessed for gene mutation using a microfluidics-based multiplex PCR platform...
November 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29177268/advanced-manufacturing-of-microdisk-vaccines-for-uniform-control-of-material-properties-and-immune-cell-function
#16
Qin Zeng, Peipei Zhang, Xiangbin Zeng, Lisa H Tostanoski, Christopher M Jewell
The continued challenges facing vaccines in infectious disease and cancer highlight a need for better control over the features of vaccines and the responses they generate. Biomaterials offer unique advantages to achieve this goal through features such as controlled release and co-delivery of antigens and adjuvants. However, many synthesis strategies lead to particles with heterogeneity in diameter, shape, loading level, or other properties. In contrast, advanced manufacturing techniques allow precision control of material properties at the micro- and nano-scale...
November 27, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29155557/wearable-nanoplasmonic-patch-detecting-sun-uv-exposure
#17
Jessica G Barajas-Carmona, Leydi Francisco-Aldana, Eden Morales-Narváez
Sun exposure is known to yield beneficial health outcomes, including synthesis of adequate levels of vitamin D, beneficial modulation of blood pressure and is a valuable factor in mental health care. However, the increasing incidence of sun/UV exposure-related illness, such as skin cancer, is seriously concerning public health authorities as well as the scientific community. Consequently, moderate sun/UV exposure is strongly recommended. A wearable nanoplasmonic patch whose original color changes upon sun exposure due to its UV-responsive capabilities that are visually detectable has been engineered...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29155396/biomimetic-synthesis-of-silver-nanoparticles-from-streptomyces-atrovirens-and-their-potential-anticancer-activity-against-human-breast-cancer-cells
#18
Ramasamy Subbaiya, Muthupandian Saravanan, Andavar Raja Priya, Konathala Ravi Shankar, Masilamani Selvam, Muhammad Ovais, Ramachandran Balajee, Hamed Barabadi
Silver nanoparticles (AgNPs) have been undeniable for its antimicrobial activity while its antitumour potential is still limited. Therefore, the present study focused on determining cytotoxic effects of AgNPs on Michigan cancer foundation-7 (MCF-7) breast cancer cells and its corresponding mechanism of cell death. Herein, the authors developed a bio-reduction method for AgNPs synthesis using actinomycetes isolated from marine soil sample. The isolated strain was identified by 16s ribotyping method and it was found to be Streptomyces atrovirens...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29155160/%C3%AE-v%C3%AE-3-and-%C3%AE-5%C3%AE-1-integrin-specific-ligands-from-tumor-angiogenesis-inhibitors-to-vascularization-promoters-in-regenerative-medicine
#19
REVIEW
Luís A Rocha, David A Learmonth, Rui A Sousa, António J Salgado
Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integrins involved in tumor angiogenesis and brake disease progression has resulted in new investigational drug entities reaching the clinical trial phase in humans. The use of integrin-specific ligands can be useful for the vascularization of regenerative medicine constructs, which remains a major limitation for translation into clinical practice...
November 15, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29154535/novel-gd-loaded-silicon-nanohybrid-a-potential-egfr-expressing-cancer-cell-targeting-mri-contrast-agent
#20
Sougata Sinha, Wing Yin Tong, Nathan H Williamson, Steven James Peter McInnes, Simon Puttick, Anna Cifuentes-Rius, Richa Bhardwaj, Sally E Plush, Nicolas H Voelcker
Continuing our research efforts in developing mesoporous silicon nanoparticle based biomaterials for cancer therapy, here we employed porous silicon nanoparticles as a nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule Gd-chelates (L1-Gd) enhanced the T1 contrast dramatically compared to distinct Gd-chelate (L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules and their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage...
November 20, 2017: ACS Applied Materials & Interfaces
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