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Cancer biomaterials

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https://www.readbyqxmd.com/read/29776024/simple-and-universal-model-for-electron-impact-ionization-of-complex-biomolecules
#1
Hong Qi Tan, Zhaohong Mi, Andrew A Bettiol
We present a simple and universal approach to calculate the total ionization cross section (TICS) for electron impact ionization in DNA bases and other biomaterials in the condensed phase. Evaluating the electron impact TICS plays a vital role in ion-beam radiobiology simulation at the cellular level, as secondary electrons are the main cause of DNA damage in particle cancer therapy. Our method is based on extending the dielectric formalism. The calculated results agree well with experimental data and show a good comparison with other theoretical calculations...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756237/biopolymers-for-antitumor-implantable-drug-delivery-systems-recent-advances-and-future-outlook
#2
REVIEW
Sepehr Talebian, Javad Foroughi, Samantha J Wade, Kara L Vine, Alireza Dolatshahi-Pirouz, Mehdi Mehrali, João Conde, Gordon G Wallace
In spite of remarkable improvements in cancer treatments and survivorship, cancer still remains as one of the major causes of death worldwide. Although current standards of care provide encouraging results, they still cause severe systemic toxicity and also fail in preventing recurrence of the disease. In order to address these issues, biomaterial-based implantable drug delivery systems (DDSs) have emerged as promising therapeutic platforms, which allow local administration of drugs directly to the tumor site...
May 13, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29756030/3d-tissue-engineered-in-vitro-models-of-cancer-in-bone
#3
Anna M Sitarski, Heather Fairfield, Carolyne Falank, Michaela R Reagan
Biological models are necessary tools for gaining insight into underlying mechanisms governing complex pathologies such as cancer in the bone. Models range from in vitro tissue culture systems to in vivo models and can be used with corresponding epidemiological and clinical data to understand disease etiology, progression, driver mutations, and signaling pathways. In bone cancer, as with many other cancers, in vivo models are often too complex to study specific cell-cell interactions or protein roles, and 2D models are often too simple to accurately represent disease processes...
February 12, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29746930/biomimetic-models-to-examine-microenvironmental-regulation-of-glioblastoma-stem-cells
#4
Pinaki S Nakod, Yonghyun Kim, Shreyas S Rao
Glioblastoma multiforme (GBM), a malignant brain tumor, is the deadliest form of human cancer with low survival rates because of its highly invasive nature. In recent years, there has been a growing appreciation for the role that glioblastoma stem cells (GSCs) play during tumorigenesis and tumor recurrence of GBM. GSCs are a specialized subset of GBM cells with stem cell-like features that contribute to tumor initiation and therapeutic resistance. Thus, to enhance therapeutic efficiency and improve survival, targeting GSCs and their microenvironmental niche appears to be a promising approach...
May 7, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29740535/enhancing-the-therapeutic-efficacy-of-cancer-treatment-with-cannabinoids
#5
Sayeda Yasmin-Karim, Michele Moreau, Romy Mueller, Neeharika Sinha, Raymond Dabney, Allen Herman, Wilfred Ngwa
Over the years, many in vitro and in vivo studies have shown the antineoplastic effects of cannabinoids (CBDs), with reports advocating for investigations of combination therapy approaches that could better leverage these effects in clinical translation. This study explores the potential of combination approaches employing CBDs with radiotherapy (RT) or smart biomaterials toward enhancing therapeutic efficacy during treatment of pancreatic and lung cancers. In in vitro studies, clonogenic assay results showed greater effective tumor cell killing, when combining CBDs and RT...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29736981/advances-in-biomaterials-for-drug-delivery
#6
REVIEW
Owen S Fenton, Katy N Olafson, Padmini S Pillai, Michael J Mitchell, Robert Langer
Advances in biomaterials for drug delivery are enabling significant progress in biology and medicine. Multidisciplinary collaborations between physical scientists, engineers, biologists, and clinicians generate innovative strategies and materials to treat a range of diseases. Specifically, recent advances include major breakthroughs in materials for cancer immunotherapy, autoimmune diseases, and genome editing. Here, strategies for the design and implementation of biomaterials for drug delivery are reviewed...
May 7, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29736367/tissue-engineering-for-urinary-tract-reconstruction-and-repair-progress-and-prospect-in-china
#7
REVIEW
Qingsong Zou, Qiang Fu
Several urinary tract pathologic conditions, such as strictures, cancer, and obliterations, require reconstructive plastic surgery. Reconstruction of the urinary tract is an intractable task for urologists due to insufficient autologous tissue. Limitations of autologous tissue application prompted urologists to investigate ideal substitutes. Tissue engineering is a new direction in these cases. Advances in tissue engineering over the last 2 decades may offer alternative approaches for the urinary tract reconstruction...
April 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29726837/fracture-resistant-antibiofilm-adherent-self-assembled-pmma-zno-nanoformulations-for-biomedical-applications-physico-chemical-and-biological-perspectives-of-nano-reinforcement
#8
Indu Raj, Miran Mozetic, Jayachandran V Prabhu, Jiya Jose, Sabu Thomas, Nandakumar Kalarikkal
Antimicrobial, antibiofilm adherent, fracture resistant nano Zinc Oxide (ZnO NP) formulations based on poly methyl methacrylate (PMMA) matrix were developed by ex situ compression moulding technique in a facile manner. These formulations demonstrated potent, long-term biofilm-resisting effects against Candida Albicans (9000 CFU to 1000CFU) and Streptococcal Mutans. Proposed mechanism of biofilm resistance was the release of metallic ions/metal oxide by 'particle-corrosion'. MTT and cellular proliferation assays confirmed both qualitatively and quantitatively equal human skin fibroblast cell line proliferations (approximately 75%) on both PMMA/ZnO formulation and on neat PMMA...
May 4, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29726120/nanoscale-platforms-for-messenger-rna-delivery
#9
REVIEW
Bin Li, Xinfu Zhang, Yizhou Dong
Messenger RNA (mRNA) has become a promising class of drugs for diverse therapeutic applications in the past few years. A series of clinical trials are ongoing or will be initiated in the near future for the treatment of a variety of diseases. Currently, mRNA-based therapeutics mainly focuses on ex vivo transfection and local administration in clinical studies. Efficient and safe delivery of therapeutically relevant mRNAs remains one of the major challenges for their broad applications in humans. Thus, effective delivery systems are urgently needed to overcome this limitation...
May 4, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29722119/development-of-mesoporous-bioactive-glass-nanoparticles-and-its-use-in-bone-tissue-engineering
#10
REVIEW
Chee Hoe Kong, Chris Steffi, Zhilong Shi, Wilson Wang
The incidence of bone disorders, from trauma, tissue degeneration due to ageing, pathological conditions to cancer, has been increasing. The pursuit for bone graft substitutes to assist in regenerating large bone defects is ever growing as a result of the shortage in conventional autografts and allografts, in addition to the associated risks of disease transmission. However, the use of alloplastic biomaterials is limited in clinical settings, as further investigations are required to address the properties of synthetic grafts to mimic the native bone tissue and deliver desirable biomolecules to facilitate bone regeneration...
May 2, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29713164/global-trends-in-nanomedicine-research-on-triple-negative-breast-cancer-a-bibliometric-analysis
#11
REVIEW
Ramon Handerson Gomes Teles, Herick Fernando Moralles, Márcia Regina Cominetti
Nanotechnology has emerged as a promising tool in the clinic to combat several difficult-to-manage diseases, such as cancer, which is the second leading cause of death worldwide. Chemotherapeutic drugs present several limitations such as undesired side effects, low specificity, resistance, and high relapse rates. Triple negative breast cancer (TNBC) is caused by cells that lack specific receptors in their membrane, such as estrogen (ER+) and progesterone (PR+) receptors, or by cells that do not express the amplification of human epidermal growth factor receptor-2 (HER-2+)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29691818/nanomaterials-nanocomposites-for-osteochondral-tissue
#12
Ohan S Manoukian, Connor Dieck, Taylor Milne, Caroline N Dealy, Swetha Rudraiah, Sangamesh G Kumbar
For many years, the avascular nature of cartilage tissue has posed a clinical challenge for replacement, repair, and reconstruction of damaged cartilage within the human body. Injuries to cartilage and osteochondral tissues can be due to osteoarthritis, sports, aggressive cancers, and repetitive stresses and inflammation on wearing tissue. Due to its limited capacity for regeneration or repair, there is a need for suitable material systems which can recapitulate the function of the native osteochondral tissue physically, mechanically, histologically, and biologically...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29684688/layer-by-layer-hollow-photosensitizer-microcapsule-design-via-a-manganese-carbonate-hard-template-for-photodynamic-therapy-in-cells
#13
Andreza Ribeiro Simioni, Priscila Costa Carvalho de Jesus, Antonio Claudio Tedesco
BACKGROUND: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. In this paper, we describe a novel drug delivery system for loading photosensitizer drugs into hollow multilayered microcapsules for photoprocess applications...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29670009/pursuing-intracellular-pathogens-with-hyaluronan-from-a-pro-infection-polymer-to-a-biomaterial-for-trojan-horse-systems
#14
REVIEW
Elita Montanari, Chiara Di Meo, Angela Oates, Tommasina Coviello, Pietro Matricardi
Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a biomaterial for drug delivery systems, thanks to its physico-chemical features and ability to target and enter certain cells. The most important receptor of HA is ‘Cluster of Differentiation 44’ (CD44), a cell surface glycoprotein over-expressed by a number of cancers and heavily involved in HA endocytosis...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29652594/tissue-engineering-and-regenerative-medicine-2017-a-year-in-review
#15
Kyung Min Park, Young Min Shin, Kyobum Kim, Heungsoo Shin
In 2017, a new paradigm change caused by artificial intelligence and big data analysis resulted in innovation in each field of science and technology, and also significantly influenced progress in tissue engineering and regenerative medicine (TERM). TERM has continued to make technological advances based on interdisciplinary approaches and has contributed to the overall field of biomedical technology including cancer biology, personalized medicine, development biology, and cell-based therapeutics. While researchers are aware that there is still a long way to go until TERM reaches the ultimate goal of patient treatment through clinical translation, the rapid progress in convergence studies led by technological improvements in TERM has been encouraging...
March 13, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29644518/mathematical-modelling-of-the-interaction-between-cancer-cells-and-an-oncolytic-virus-insights-into-the-effects-of-treatment-protocols
#16
Adrianne L Jenner, Chae-Ok Yun, Peter S Kim, Adelle C F Coster
Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered viruses to target and kill cancer cells. One major limitation of this treatment is that virus particles are rapidly cleared by the immune system, preventing them from arriving at the tumour site. To improve virus survival and infectivity Kim et al. (Biomaterials 32(9):2314-2326, 2011) modified virus particles with the polymer polyethylene glycol (PEG) and the monoclonal antibody herceptin. Whilst PEG modification appeared to improve plasma retention and initial infectivity, it also increased the virus particle arrival time...
April 11, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29606313/beyond-tissue-stiffness-and-bioadhesivity-advanced-biomaterials-to-model-tumor-microenvironments-and-drug-resistance
#17
REVIEW
Ankur Singh, Ilana Brito, Jan Lammerding
Resistance to chemotherapy and pathway-targeted therapies poses a major problem in cancer research. While the fields of tumor biology and experimental therapeutics have already benefited from ex vivo preclinical tissue models, these models have yet to address the reasons for malignant transformations and the emergence of chemoresistance. With the increasing number of ex vivo models poised to incorporate physiological biophysical properties, along with the advent of genomic sequencing information, there are now unprecedented opportunities to better understand tumorigenesis and to design therapeutic approaches to overcome resistance...
April 2018: Trends in Cancer
https://www.readbyqxmd.com/read/29577878/establishment-of-a-tumor-neovascularization-animal-model-with-biomaterials-in-rabbit-corneal-pouch
#18
Yu-Ping Chu, Hong-Chuan Li, Ling Ma, Yang Xia
AIMS: The present animal model of tumor neovascularization most often used by researchers is zebrafish. For studies on human breast cancer cell neovascularization, a new animal model was established to enable a more convenient study of tumor neovascularization. MAIN METHODS: A sodium alginate-gelatin blend gel system was used to design the new animal model. The model was established using rabbit corneal pouch implantation. Then, the animal model was validated by human breast cancer cell lines MCF-7-Kindlin-2 and MCF-7-CMV...
March 22, 2018: Life Sciences
https://www.readbyqxmd.com/read/29577649/exopolysaccharides-from-a-codonopsis-pilosula-endophyte-activate-macrophages-and-inhibit-cancer-cell-proliferation-and-migration
#19
Min Chen, Yuanyuan Li, Zhu Liu, Yajun Qu, Huajie Zhang, Dengwen Li, Jun Zhou, Songbo Xie, Min Liu
BACKGROUND: Exopolysaccharides with structural diversity have shown wide applications in biomaterial, food, and pharmaceutical industries. Herein, we isolated an endophytic strain, 14-DS-1, from the traditional medicinal plant Codonopsis pilosula to elucidate the characteristics and anti-cancer activities of purified exopolysaccharides. METHODS: HPLC and GC-MS were conducted to purify and characterize the exopolysaccharides isolated from 14-DS-1. Quantitative RT-PCR, cell migration assays, immunofluorescence staining, and flow cytometry analysis were conducted to investighate the biological activity of DSPS...
March 25, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29576601/genome-database-of-the-latvian-population-lgdb-design-goals-and-primary-results
#20
Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
BACKGROUND: The Genome Database of the Latvian Population (LGDB) is a national biobank that collects, maintains, and processes health information, data, and biospecimens collected from representatives of the Latvian population. These specimens serve as a foundation for epidemiological research and prophylactic and therapeutic purposes. METHODS: Participant recruitment and biomaterial and data processing were performed according to specifically designed standard protocols, taking into consideration international quality requirements...
March 24, 2018: Journal of Epidemiology
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