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Cancer biomaterials

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https://www.readbyqxmd.com/read/28205621/cryogel-supported-stem-cell-factory-for-customized-sustained-release-of-bispecific-antibodies-for-cancer-immunotherapy
#1
Roberta Aliperta, Petra B Welzel, Ralf Bergmann, Uwe Freudenberg, Nicole Berndt, Anja Feldmann, Claudia Arndt, Stefanie Koristka, Marcello Stanzione, Marc Cartellieri, Armin Ehninger, Gerhard Ehninger, Carsten Werner, Jens Pietzsch, Jörg Steinbach, Martin Bornhäuser, Michael P Bachmann
Combining stem cells with biomaterial scaffolds provides a promising strategy for the development of drug delivery systems. Here we propose an innovative immunotherapeutic organoid by housing human mesenchymal stromal cells (MSCs), gene-modified for the secretion of an anti-CD33-anti-CD3 bispecific antibody (bsAb), in a small biocompatible star-shaped poly(ethylene glycol)-heparin cryogel scaffold as a transplantable and low invasive therapeutic machinery for the treatment of acute myeloid leukemia (AML). The macroporous biohybrid cryogel platform displays effectiveness in supporting proliferation and survival of bsAb-releasing-MSCs overtime in vitro and in vivo, avoiding cell loss and ensuring a constant release of sustained and detectable levels of bsAb capable of triggering T-cell-mediated anti-tumor responses and a rapid regression of CD33(+) AML blasts...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192881/stem-cell-biomaterials-and-growth-factors-therapy-for-hepatocellular-carcinoma
#2
REVIEW
Soleiman Jaferian, Maryam Soleymaninejad, Babak Negahdari, Ali Eatemadi
Hepatocellular carcinoma is an antecedent of liver illnesses, including viral hepatitis, alcohol abuse, or metabolic disease. Transforming growth factor-Beta (TGF-b) plays an important role in creating a favorable microenvironment for tumor cell growth via two major mechanisms: an intrinsic activity as an autocrine growth factor and an extrinsic activity by inducing microenvironment changes. Recently stem cell therapy as also been a promising and potential treatment for liver cancer and in addition signaling pathways like GF/GFR systems, SDF-1α/CXC4 ligand receptor interaction and PI3K/Akt signaling, and cytokines has been identified to regulate cell fate decisions, and can be utilized to positively influence cell therapy outcomes...
February 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28183660/anticancer-activity-of-biologically-synthesized-silver-and-gold-nanoparticles-on-mouse-myoblast-cancer-cells-and-their-toxicity-against-embryonic-zebrafish
#3
Rajan Ramachandran, Chandran Krishnaraj, Allur Subramaniyan Sivakumar, Palaniappan Prasannakumar, V K Abhay Kumar, Kwan Seob Shim, Chul-Gyu Song, Soon-Il Yun
The aim of this study was to evaluate the anticancer activity of bioinspired silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) against mouse myoblast cancer cells (C2C12). Both AgNPs and AuNPs were biologically synthesized using Spinacia oleracea Linn., aqueous leaves extract. UV-Vis. spectrophotometer, high resolution-transmission electron microscopy (HR-TEM), field emission-scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD) studies supported the successful synthesis of AgNPs and AuNPs...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183652/betulin-loaded-pedot-films-for-regional-chemotherapy
#4
Katarzyna Krukiewicz, Magdalena Cichy, Piotr Ruszkowski, Roman Turczyn, Tomasz Jarosz, Jerzy K Zak, Mieczyslaw Lapkowski, Barbara Bednarczyk-Cwynar
Chemotherapy is one of the most commonly used cancer treatments. Even so, it has significant adverse effects on healthy tissues. These effects can be avoided through the use of regional chemotherapy, an approach based on delivering the anti-cancer agents locally, to the site of cancer tissue accumulation. Among the different classes of biomaterials that are used as drug carriers, conducting polymers allow reversible, electrostatic immobilization and controlled release of a variety of compounds. In this work, we describe a method for producing surfaces possessing anti-cancer activity, which are a potential tool for regional chemotherapy...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28178627/fundamentals-of-protein-and-cell-interactions-in-biomaterials
#5
REVIEW
Hammed Tanimowo Aiyelabegan, Esmaeil Sadroddiny
The extracellular matrix (ECM) is an active and complex microenvironment with outstanding biomechanical, biophysical, and biochemical characteristics, which can indirectly or directly controls cell adhesion, migration, proliferation, and differentiation, as well as partaking in regeneration and homeostasis of organs and tissues. The ECM has captivated a great deal of attention with the rapid progress of tissue engineering (TE) in the field of regenerative medicine (RM). Approaches to TE, RM and cancer therapy center on the necessity to deliver cell signals to direct cell proliferation and differentiation...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28177587/continuous-microfluidic-assembly-of-biodegradable-poly-beta-amino-ester-dna-nanoparticles-for-enhanced-gene-delivery
#6
David R Wilson, Arman Mosenia, Mark P Suprenant, Rahul Upadhya, Denis Routkevitch, Randall A Meyer, Alfredo Quinones-Hinojosa, Jordan J Green
Translation of biomaterial-based nanoparticle formulations to the clinic faces significant challenges including efficacy, safety, consistency and scale-up of manufacturing, and stability during long-term storage. Continuous microfluidic fabrication of polymeric nanoparticles has the potential to alleviate the challenges associated with manufacture, while offering a scalable solution for clinical level production. Poly(beta-amino esters) (PBAE)s are a class of biodegradable cationic polymers that self-assemble with anionic plasmid DNA to form polyplex nanoparticles that have been shown to be effective for transfecting cancer cells specifically in vitro and in vivo...
February 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28143506/utilization-of-ct-scanning-associated-with-complex-spine-surgery
#7
Vikas V Patel, Gunnar B J Andersson, Steven R Garfin, Donald L Resnick, Jon E Block
BACKGROUND: Due to the risk associated with exposure to ionizing radiation, there is an urgent need to identify areas of CT scanning overutilization. While increased use of diagnostic spinal imaging has been documented, no previous research has estimated the magnitude of follow-up imaging used to evaluate the postoperative spine. METHODS: This retrospective cohort study quantifies the association between spinal surgery and CT utilization. An insurance database (Humana, Inc...
January 31, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28129640/nuclear-transport-of-cancer-extracellular-vesicle-derived-biomaterials-through-nuclear-envelope-invagination-associated-late-endosomes
#8
Germana Rappa, Mark F Santos, Toni M Green, Jana Karbanová, Justin Hassler, Yongsheng Bai, Sanford H Barsky, Denis Corbeil, Aurelio Lorico
Extracellular membrane vesicles (EVs) function as vehicles of intercellular communication, but how the biomaterials they carry reach the target site in recipient cells is an open question. We report that subdomains of Rab7+ late endosomes and nuclear envelope invaginations come together to create a sub-nuclear compartment, where biomaterials associated with CD9+ EVs are delivered. EV-derived biomaterials were also found in the nuclei of host cells. The inhibition of nuclear import and export pathways abrogated the nuclear localization of EV-derived biomaterials or led to their accumulation therein, respectively, suggesting that their translocation is dependent on nuclear pores...
January 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28126309/smart-radiation-therapy-biomaterials
#9
REVIEW
Wilfred Ngwa, Francis Boateng, Rajiv Kumar, Darrell J Irvine, Silvia Formenti, Twalib Ngoma, Carsten Herskind, Marlon R Veldwijk, Georg Lars Hildenbrand, Michael Hausmann, Frederik Wenz, Juergen Hesser
Radiation therapy (RT) is a crucial component of cancer care, used in the treatment of over 50% of cancer patients. Patients undergoing image guided RT or brachytherapy routinely have inert RT biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to "smart" RT biomaterials, designed to do more than 1 function. Such smart biomaterials include next-generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimuli and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor subvolume while minimizing normal tissue toxicities...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28113138/characterization-catalyzed-water-oxidation-and-anticancer-activities-of-a-nir-bodipy-mn-polymer
#10
Ya-Quan Lan, Ke-Jing Xiao, Yun-Jie Wu, Qiu-Yun Chen
To obtain near-IR absorbing biomaterials as fluorescence cellular imaging and anticancer agents for hypoxic cancer cell, a nano NIR fluorescence Mn(III/IV) polymer (PMnD) was spectroscopically characterized. The PMnD shows strong emission at 661nm when excited with 643nm. Furthermore, PMnD can catalyze water oxidation to generate dioxygen when irradiated by red LED light (10W). In particular, the PMnD can enter into HepG-2 cells and mitochondria. Both anticancer activity and the inhibition of the expression of HIF-1α for PMnD were concentration dependent...
January 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28106714/a-promising-future-for-prostate-cancer-diagnostics
#11
EDITORIAL
Stephen J Assinder, Vanitha Bhoopalan
It has been estimated that globally there is a death attributable to prostate cancer every four minutes. As life expectancy in all world regions increases, so too incidence of this disease of the ageing male will increase. For many men diagnosis occurs after presentation with symptoms of altered urinary dynamics. Unfortunately, these changes, whilst also associated with benign disease, are evident quite late in the aetiology of prostate cancer. Early detection provides for better management and prognosis. This Special Issue provides an up to date view of the advances made towards early diagnosis and prognosis...
January 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/28089528/hydrogel-spacer-distribution-within-the-perirectal-space-in-patients-undergoing-radiotherapy-for-prostate-cancer-impact-of-spacer-symmetry-on-rectal-dose-reduction-and-the-clinical-consequences-of-hydrogel-infiltration-into-the-rectal-wall
#12
Benjamin W Fischer-Valuck, Anupama Chundury, Hiram Gay, Walter Bosch, Jeff Michalski
PURPOSE: Hydrogel prostate-rectum spacers, biomaterials placed between the prostate and rectum, continue to gain interest as a method to reduce or limit rectal dose during dose escalated prostate cancer radiation therapy. Because the spacer is initially injected into the perirectal space as a liquid, the final distribution can vary. The purpose of this study was to evaluate hydrogel spacer (SpaceOAR system) implantation and distribution from a recent prospective randomized control trial and correlate spacer symmetry with rectal dose reduction as well as rectal wall infiltration (RWI) to acute and late toxicity...
October 17, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28077049/evaluation-on-biological-compatibility-of-carboxymethyl-chitosan-as-biomaterials-for-antitumor-drug-delivery
#13
Zhiwen Jiang, Baoqin Han, Wanshun Liu, Yanfei Peng
Carboxymethyl-chitosan, a water-soluble derivative of chitosan, has emerged as a promising candidate for biomedical applications due to its excellent water solubility, biodegradation, biocompatibility, hydrating, antimicrobial, and nontoxicity. In this paper, the antitumor proliferation and metastasis was studied in vitro and in vivo to evaluate biocompatibility of carboxymethyl-chitosan as biomaterials for antitumor drug delivery. The results showed that carboxymethyl-chitosan could significantly reduce the clone formation and tumor migration of human cancer cells including kidney cancer cell line OS-RC-2, gastric cancer cell line SGC-7901, colon cancer cell line HT-29, and nonsmall cell lung cancer cell line NCI-H1650 in vitro...
February 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28074285/t-cell-receptor-repertoire-usage-in-cancer-as-a-surrogate-marker-for-immune-responses
#14
REVIEW
David Schrama, Cathrin Ritter, Jürgen C Becker
Characterizing the interaction of cancer cells with the host adaptive immune system is critical for understanding tumor immunology and the modus operandi of immunotherapeutic interventions to treat cancer. As the key cellular effectors of adaptive immunity, T cells are endowed with specialized receptors (the T cell receptor; TCR), to recognize and to eliminate cancer cells. The diversity of the TCR repertoire results from specialized genetic diversification mechanisms that generate an incredible variability allowing recognizing extensive collections of antigens...
January 10, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28067628/3d-bioprinting-improving-in-vitro-models-of-metastasis-with-heterogeneous-tumor-microenvironments
#15
REVIEW
Jacob L Albritton, Jordan S Miller
Even with many advances in treatment over the past decades, cancer still remains a leading cause of death worldwide. Despite the recognized relationship between metastasis and increased mortality rate, surprisingly little is known about the exact mechanism of metastatic progression. Currently available in vitro models cannot replicate the three-dimensionality and heterogeneity of the tumor microenvironment sufficiently to recapitulate many of the known characteristics of tumors in vivo Our understanding of metastatic progression would thus be boosted by the development of in vitro models that could more completely capture the salient features of cancer biology...
January 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28064504/development-of-l-tyrosine-based-enzyme-responsive-amphiphilic-poly-ester-urethane-nanocarriers-for-multiple-drug-delivery-to-cancer-cells
#16
Rajendra Aluri, Manickam Jayakannan
New classes of enzymatic-biodegradable amphiphilic poly(ester-urethane)s were designed and developed from l-tyrosine amino acid resources and their self-assembled nanoparticles were employed as multiple drug delivery vehicles in cancer therapy. The amine and carboxylic acid functional groups in l-tyrosine were converted into dual functional ester-urethane monomers and they were subjected to solvent free melt polycondensation with hydrophilic polyethylene glycols to produce comb-type poly(ester-urethane)s. The phenolic unit in the l-tyrosine was anchored with hydrophobic alkyl side chain to bring appropriate amphiphilicity in the polymer geometry to self-assemble them as stable nanoscaffolds in aqueous medium...
January 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28048421/su-g-tep3-06-nanoparticle-aided-external-beam-radiotherapy-leveraging-the-cerenkov-effect
#17
Z Ouyang, B Liu, S Yasmin-Karim, E Sajo, W Ngwa
PURPOSE: This study investigates the feasibility of exploiting the Cerenkov radiation (CR) present during external beam radiotherapy (EBRT) for significant therapeutic gain, using titanium dioxide nanoparticles (titania) delivered via a new design of radiotherapy biomaterials. METHODS: Recently published work has shown that CR generated by radionuclides during PET imaging could substantially enhance damage to cancer cells in the presence of 0.625 µg/g titania. We hypothesize that equal or greater damage can be achieved during EBRT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047773/we-fg-bra-09-using-graphene-oxide-nano-flakes-during-image-guided-radiotherapy-to-minimize-the-potential-of-cancer-recurrence-or-metastasis
#18
D Toomeh, W Ngwa, E Sajo, Y Hao, S Gadoue
PURPOSE: An increasing number of studies show that cancer stem cells (CSCs) become more invasive (metastatic) and may escape into the blood stream and lymph nodes during radiotherapy (RT), before they have received a lethal dose during RT. Other Studies have shown that Graphene oxide (GO) can selectively inhibit the proliferative expansion of CSCs across multiplicative tumor types. In this study we investigate the feasibility of using GO during radiotherapy (RT) to minimize the escape of CSCs towards preventing cancer metastasis or recurrence...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046538/tu-h-campus-tep2-05-selective-protection-of-normal-tissue-by-cerium-oxide-nanoparticles-during-radiation-therapy
#19
Z Ouyang, S Yasmin-Karim, G Strack, E Sajo, W Ngwa
PURPOSE: Cerium oxide nanoparticles (CONPs) have unique pH dependent properties such that they act as a radical modulator. These properties may be used in radiation therapy (RT) to protect normal tissue. This work investigates the selective radioprotection of CONPs in-vitro and potential for in-situ delivery of CONPs in prostate cancer RT. METHODS: i) Normal human umbilical vein endothelial cells (HUVEC) and human prostate cancer cells (PC-3) were treated with 0 or 2 ng/mL CONPs (NP size: 5 nm)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034673/high-content-image-informatics-of-the-structural-nuclear-protein-numa-parses-trajectories-for-stem-progenitor-cell-lineages-and-oncogenic-transformation
#20
Sebastián L Vega, Er Liu, Varun Arvind, Jared Bushman, Hak-Joon Sung, Matthew L Becker, Sophie Lelièvre, Joachim Kohn, Pierre-Alexandre Vidi, Prabhas V Moghe
Stem and progenitor cells that exhibit significant regenerative potential and critical roles in cancer initiation and progression remain difficult to characterize. Cell fates are determined by reciprocal signaling between the cell microenvironment and the nucleus; hence parameters derived from nuclear remodeling are ideal candidates for stem/progenitor cell characterization. Here we applied high-content, single cell analysis of nuclear shape and organization to examine stem and progenitor cells destined to distinct differentiation endpoints, yet undistinguishable by conventional methods...
February 1, 2017: Experimental Cell Research
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