Maxim Karagyaur, Alexandra Primak, Kirill Bozov, Dmitriy Sheleg, Mikhail Arbatsky, Stalik Dzhauari, Maria Illarionova, Ekaterina Semina, Larisa Samokhodskaya, Polina Klimovich, Arkadiy Velichko, Mikhail Drach, Ekaterina Sotskaya, Vladimir Popov, Kseniya Rubina, Mariia Parfenenko, Julia Makus, Boris Tsygankov, Vsevolod Tkachuk, Elena Neyfeld
INTRODUCTION: Impaired function of brain morphogenic genes is considered one of the predisposing factors for the manifestation of psychiatric and cognitive disorders, such as paranoid schizophrenia (SCZ) and major depressive disorder (MDD). Identification of such genes (genes of neurotrophic factors and guidance molecules among them) and their deleterious genetic variants serves as a key to diagnosis, prevention, and possibly treatment of such disorders. In this study, we have examined the prevalence of genomic variants in brain morphogenic genes in individuals with SCZ and MDD within a Russian population...
2024: Frontiers in Psychiatry