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https://www.readbyqxmd.com/read/28635542/gene-expression-study-of-mitochondrial-complex-i-in-schizophrenia-and-paranoid-personality-disorder
#1
Arvin Haghighatfard, Sarah Andalib, Mozhdeh Amini Faskhodi, Soha Sadeghi, Amir Hossein Ghaderi, Shadi Moradkhani, Jalal Rostampour, Zeinab Tabrizi, Ali Mahmoodi, Talie Karimi, Zakieh Ghadimi
OBJECTIVES: The aetiology and molecular mechanisms of schizophrenia (SCZ) and paranoid personality disorder (PPD) are not yet clarified. The present study aimed to assess the role of mitochondrial complex I and cell bioenergetic pathways in the aetiology and characteristics of SCZ and PPD. METHODS: mRNA levels of all genomic and mitochondrial genes which encode mitochondrial complex I subunits (44 genes) were assessed in blood in 634 SCZ, 340 PPD patients and 528 non-psychiatric subjects using quantitative real-time PCR, and associated comprehensive psychiatric, neurological and biochemical assessments...
February 20, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28631974/personality-disorders-are-not-as-we-thought-hierarchical-factor-structure-at-the-criterion-level
#2
Ana Muñoz-Champel, Fernando Gutiérrez, Josep M Peri, Rafael Torrubia
The use of personality disorder (PD) categories persists, despite the evidence against them. An often overlooked reason for this is the fact that the true structure underlying the Diagnostic and Statistical Manual of Mental Disorders (DSM) taxonomy is still unknown: We cannot be certain which disorders are valid, and which ones are arbitrary mixtures of heterogeneous traits. To address this gap, we factor analyzed the Personality Diagnostic Questionnaire (PDQ-4+; Hyler, 1994 ) at the criterion level in a mixed clinical and nonclinical sample of 2,519 individuals...
February 22, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28628826/different-yet-similar-prisoners-versus-psychiatric-patients%C3%A2-%C3%A2-a-comparison-of-their-mental-health
#3
S Otte, N Vasic, S Nigel, J Streb, T Ross, C Spitzer, H J Grabe, M Dudeck
BACKGROUND: Previous research indicates that prisoners have severe psychological distress. To assess their distress level and potential need for treatment, the present study compared the subjective psychological distress of long- and short-term prisoners with that of psychiatric and forensic patients. METHODS: Long- (n=98) and short-term prisoners (n=94) and forensic (n=102) and psychiatric (n=199) patients completed the German versions of the Symptom Checklist Revised (SCL-90-R) and Brief Symptom Inventory (BSI)...
April 26, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28617374/-positive-changes-in-the-severity-of-residual-psychotic-symptoms-in-schizophrenic-patients-switched-to-treatment-with-risperidone
#4
D S Burminskiy, M A Morozova
AIM: To evaluate the effect of changing therapy from typical antipsychotics to the atypical antipsychotic risperidone in the treatment of difficult-to-treat residual psychotic symptoms. MATERIAL AND METHODS: The study included 15 patients, 8 men and 7 women, mean age 49.1±10.25 years, diagnosed with paranoid schizophrenia, partial remission (ICD-10 F20.04). At the beginning all participants received regular maintenance antipsychotic therapy with typical antipsychotics...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28594264/treatment-response-and-tolerability-with-once-monthly-paliperidone-palmitate-initiated-shortly-after-hospital-admission-in-patients-with-schizophrenia
#5
Ludger Hargarter, Marjolein Lahaye, Pierre Cherubin, Martin Lambert, Marnina Swarz, Gali Joldygulov, Flavio Vischia, Veronica Chomskaya, Vasilis P Bozikas, Eva-Maria Tsapakis, Andreas Schreiner
OBJECTIVES: Partial or non-adherence in patients with schizophrenia is common and increases the risk of relapse. This study explored safety, tolerability and treatment outcomes in patients hospitalised for an exacerbation of schizophrenia initiated on maintenance treatment of once-monthly paliperidone palmitate (PP1M). METHODS: A 6-week, observational cohort study of patients initiated on PP1M within 3 weeks after hospital admission. RESULTS: Overall, 367 patients were documented, 85...
June 8, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28578719/stress-sensitivity-in-paranoia-poor-me-paranoia-protects-against-the-unpleasant-effects-of-social-stress
#6
A Udachina, R P Bentall, F Varese, G Rowse
BACKGROUND: The attributional theory of paranoia suggests that paranoid beliefs may protect individuals from low self-esteem and distress (Bentall et al. 2001). The current study tested this theory by investigating a hypothesis that paranoid beliefs in combination with low perceived deservedness of persecution (poor-me beliefs) confer protection against the distress caused by social but not activity related stress. METHODS: Paranoid symptoms, perceived deservedness of persecution, self-esteem, mood, and stress levels of individuals diagnosed with schizophrenia spectrum disorders (N = 91) and healthy controls (N = 52) were assessed in the context of daily life using the experience sampling method...
June 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28577859/fenethylline-induced-psychosis-fenethylline-themed-paranoid-delusions-or-both
#7
Claire Twark, Joji Suzuki
No abstract text is available yet for this article.
March 28, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28560857/interpersonal-sensitivity-bullying-victimization-and-paranoid-ideation-among-help-seeking-adolescents-and-young-adults
#8
Alice Masillo, Lucia R Valmaggia, Riccardo Saba, Martina Brandizzi, Nella Lo Cascio, Ludovica Telesforo, Paola Venturini, Aniello Izzo, M Teresa Mattioli, Marco D'Alema, Paolo Girardi, Paolo Fiori Nastro
AIM: The effects of a negative interpersonal experience, such as bullying victimization in childhood and adolescence, can be strong and long lasting. Bullying victimization is associated with paranoid ideation and suspiciousness. Few studies have focused on personality traits of victims of bullying. The aim of this study is to investigate whether a particular personality trait called interpersonal sensitivity may be related to suspiciousness in those who experienced bullying victimization...
May 30, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28548578/emotional-cognitive-and-behavioral-reactions-to-paranoid-symptoms-in-clinical-and-nonclinical-populations
#9
Célia Barreto Carvalho, Carolina da Motta, José Pinto-Gouveia, Ermelindo Manuel Bernardo Peixoto
BACKGROUND: Paranoia is a disruptive belief that can vary across a continuum, ranging from persecutory delusions presented in clinical settings to paranoid cognitions that are highly prevalent in the general population. The literature suggests that paranoid thoughts derive from the activation of a paranoid schema or information processing biases that can be sensitive to socially ambiguous stimuli and influence the processing of threatening situations. METHODS: Four groups (schizophrenic participants in active psychotic phases, n=61; stable participants in remission, n=30; participants' relatives, n=32; and, healthy controls, n=64) were assessed with self-report questionnaires to determine how the reactions to paranoia of clinical patients differ from healthy individuals...
2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28533580/olanzapine-induced-neuroleptic-malignant-syndrome
#10
Seyedhamze Hosseini, Forouzan Elyasi
Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drugs. We present the case of a 27-year-old man with a history of paranoid schizophrenia that showed signs consistent with NMS that occurred after treatment with olanzapine...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28527059/personality-disorders-in-cluster-headache-a-study-using-the-millon-clinical-multiaxial-inventory-iii
#11
Sylvie Hélène Marie Jeanne Piacentini, Lara Draghi, Alberto Proietti Cecchini, Massimo Leone
A great deal of studies suggests that cluster headache (CH) patients are usually comorbid to anxiety-mood spectrum disorders and psychopathological symptoms; however, the personality profiles reported in the literature strictly depend on type of assessment used. Psychiatric comorbidities have been extensively studied in migraine and they are recognized to represent a major risk factor associated with poorer outcome, playing a role in the headache chronification process at once as cause and consequence of it...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28524542/negative-schemata-about-the-self-and-others-and-paranoid-ideation-in-at-risk-states-and-those-with-persisting-positive-symptoms
#12
Hendrik Müller, Walter de Millas, Wolfgang Gaebel, Jutta Herrlich, Alkomiet Hasan, Birgit Janssen, Georg Juckel, Anne Karow, Tilo Kircher, Stefanie Kiszkenow-Bäker, Stefan Klingberg, Joachim Klosterkötter, Seza Krüger-Özgürdal, Martin Lambert, Marion Lautenschlager, Wolfgang Maier, Tanja Maria Michel, Stefanie Mehl, Bernhard W Müller, Verena Pützfeld, Franziska Rausch, Michael Riedel, Gudrun Sartory, Frank Schneider, Michael Wagner, Georg Wiedemann, Andreas Wittorf, Thomas Wobrock, Wolfgang Wölwer, Mathias Zink, Andreas Bechdolf
BACKGROUND: The objective of this study is to test the conflicting theories concerning the association of negative self and other schemata and paranoid ideation. METHODS: A risk-based approach, including risk stratification, is used to gain insight into the association of the negative self and other schemata that may be shared by individuals or differentiate between individuals at clinical high risk (CHR) for a first-episode psychosis and those with full-blown psychosis...
May 19, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28513366/nurses-wearing-body-cams
#13
J Kissoon
This is inconceivable in mental health settings. Can you imagine an acutely unwell individual with paranoid and psychotic symptoms being seen by a nurse wearing a body cam? Not to mention issues around confidentiality.
May 17, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28509902/a-latent-genetic-subtype-of-major-depression-identified-by-whole-exome-genotyping-data-in-a-mexican-american-cohort
#14
C Yu, M Arcos-Burgos, J Licinio, M-L Wong
Identifying data-driven subtypes of major depressive disorder (MDD) is an important topic of psychiatric research. Currently, MDD subtypes are based on clinically defined depression symptom patterns. Although a few data-driven attempts have been made to identify more homogenous subgroups within MDD, other studies have not focused on using human genetic data for MDD subtyping. Here we used a computational strategy to identify MDD subtypes based on single-nucleotide polymorphism genotyping data from MDD cases and controls using Hamming distance and cluster analysis...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28500827/psychological-vulnerability-to-stress-in-carriers-of-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
#15
Eleni-Magdalini Kyritsi, Georgia Koltsida, Ioanna Farakla, Aikaterini Papanikolaou, Elena Critselis, Emilia Mantzou, Emmanouil Zoumakis, Gerasimos Kolaitis, George P Chrousos, Evangelia Charmandari
OBJECTIVE: Carriers of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) demonstrate increased secretion of cortisol precursors following ACTH stimulation, suggestive of impaired cortisol production and compensatory increases in hypothalamic corticotropin-releasing hormone (CRH) secretion. Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression. We performed an endocrinologic and psychological evaluation in carriers of 21-OHD and matched control subjects...
January 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28482196/auditory-and-non-auditory-hallucinations-in-first-episode-psychosis-differential-associations-with-diverse-clinical-features
#16
Chiara Galletti, Enrico Paolini, Alfonso Tortorella, Michael T Compton
Data from 247 first-episode psychosis patients were used to explore associations between types of hallucinations and nine diverse clinical characteristics. Psychopathology was rated using the Scale for the Assessment of Positive Symptoms and Scale for the Assessment of Negative Symptoms (SANS). Childhood adversity was assessed with seven instruments; family history with an adapted version of the Family Interview for Genetic Studies; age at onset of psychosis and duration of untreated psychosis (DUP) with the Symptom Onset in Schizophrenia inventory; and insight with the Birchwood Insight Scale...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28470477/association-of-serum-trace-elements-with-schizophrenia-and-effects-of-antipsychotic-treatment
#17
Xuefei Chen, Yinghui Li, Ting Zhang, Yingshui Yao, Chong Shen, Yong Xue
Variation of serum trace elements was previously reported in schizophrenia (SZ) patients; however, whether such variation is resulted from the antipsychotic treatment remains obscure. A case control study consist of 165 SZ inpatients and 614 healthy controls measured serum magnesium (Mg), Copper (Cu), calcium (Ca), phosphorus (Phos), iron (Fe), and zinc (Zn) to investigate the relationship of trace elements and SZ. The SZ patients were further followed up (average 3.8 weeks) to evaluate the effects of antipsychotic treatment on the trace element concentrations using repeated measures ANOVA analysis...
May 3, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28454921/interpersonal-sensitivity-in-those-at-clinical-high-risk-for-psychosis-mediates-the-association-between-childhood-bullying-victimisation-and-paranoid-ideation-a-virtual-reality-study
#18
J McDonnell, D Stahl, F Day, P McGuire, L R Valmaggia
BACKGROUND: Experience of bullying victimisation in childhood and heightened interpersonal sensitivity have been independently linked to the clinical high risk for psychosis. AIM: To examine the potential mediating effect of interpersonal sensitivity in explaining the link between childhood bullying victimisation and real-time paranoid ideation in adult participants at clinical high risk for psychosis. METHOD: In a cross-sectional study data were collected for 64 individuals at clinical high risk for psychosis...
April 26, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28451897/sleeping-paranoia-away-an-actigraphy-and-experience-sampling-study-with-adolescents
#19
Timo Hennig, Tania M Lincoln
Paranoid symptoms co-occur with distress and poor functioning and constitute a risk for psychosis and other mental disorders. Poor sleep is known to be associated with paranoid symptoms, but the direction of the effect and the mediating factors have not been studied thoroughly. In an experience-sampling study, 61 adolescents wore an actigraph over eight nights and also rated their sleep, symptoms of paranoia, and potentially mediating factors. Shorter sleep time and more dreaming predicted paranoid symptoms in multilevel regression models...
April 27, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28449568/bilateral-pretibial-edema-associated-with-paliperidone-palmitate-long-acting-injectable-a-case-report
#20
Erdinc Cicek, Ismet Esra Cicek, Faruk Uguz
Peripheral edema is observed as an adverse effect of the usage of antipsychotics in the literature. This case report describes a 36-year-old female patient with the diagnosis of paranoid schizophrenia who presented with pretibial edema following initiation of long-acting injectable paliperidone palmitate. Pretibial edema developed within the second week of treatment and completely disappeared after its discontinuation.
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
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