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Max Wolff, Klaus-Martin Krönke, John Venz, Anja Kräplin, Gerhard Bühringer, Michael N Smolka, Thomas Goschke
Self-control is commonly assumed to depend on executive functions (EFs). However, it is unclear whether real-life self-control failures result from deficient EF competencies or rather reflect insufficient conflict-induced mobilization of executive control, and whether self-control depends more critically on function-specific EF competencies or general executive functioning (GEF), that is, common competencies that underlie all EFs. Here we investigated whether failure-related action versus state orientation, a personality trait related to the conflict-induced mobilization of cognitive control, moderates the effect of general and function-specific control competencies on self-control...
October 13, 2016: Journal of Experimental Psychology. General
Brandi Wynne, Trinity Kronk, Otor Al-Khalili, Benjamin Ko, Franziska Theilig, Douglas Eaton, Robert Hoover
OBJECTIVE: Hypertension is characterized by increased sodium reabsorption along the aldosterone-sensitive distal nephron (ASDN) and systemic inflammation. Interleukin-6 (IL-6) is a possible mediator, signaling via the transmembrane IL-6 receptor alpha (IL-6Rα); however, whether IL-6Rα is present in the distal convoluted tubule (DCT) is unknown. Increased sodium reabsorption is not always correlated with increased aldosterone (Aldo). Thus, understanding how Aldo-independent sodium reabsorption occurs is critical...
September 2016: Journal of Hypertension
Stefanie Lindner, Jan Krönke
Thalidomide was sold in the 1950s as a sedative and was also used by pregnant women to treat morning sickness. It became notorious for causing severe birth defects and was removed from the market. More than four decades later, thalidomide had a renaissance in the treatment of cancer. Thalidomide and its more potent analogs, lenalidomide and pomalidomide, are nowadays approved treatments for multiple myeloma and myelodysplastic syndrome with deletion of chromosome 5q. In addition, thalidomide and its analogs inhibit release of tumor necrosis factor-α and increase interleukin-2 (IL-2) and interferon-γ release from T cells...
August 5, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Jochen A Ackermann, Katharina Hofheinz, Mario M Zaiss, Gerhard Krönke
12/15-lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Although 12/15-LOX has been implicated in the pathogenesis of multiple chronic inflammatory diseases, its physiologic functions seem to include potent immune modulatory properties that physiologically contribute to the resolution of inflammation and the clearance of inflammation-associated tissue damage. This review aims to give a comprehensive overview about our current knowledge on the role of this enzyme during the regulation of inflammation and immunity...
July 29, 2016: Biochimica et Biophysica Acta
Velizar Shivarov, Anna Dolnik, Katharina M Lang, Jan Krönke, Florian Kuchenbauer, Peter Paschka, Verena I Gaidzik, Hartmut Döhner, Richard F Schlenk, Konstanze Döhner, Lars Bullinger
No abstract text is available yet for this article.
July 28, 2016: Haematologica
Daniel N Meijles, Lampson M Fan, Maziah M Ghazaly, Brendan Howlin, Martin Krönke, Gavin Brooks, Jian-Mei Li
BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the underlying mechanisms remain unknown. METHODS AND RESULTS: With the use of computer molecular modeling, we discovered that C242T single-nucleotide polymorphism causes significant structural changes in the extracellular loop of p22(phox) and reduces its interaction stability with Nox2 subunit...
June 14, 2016: Circulation
Marie-Luise Hütter-Krönke, Axel Benner, Konstanze Döhner, Jürgen Krauter, Daniela Weber, Margit Moessner, Claus-Henning Köhne, Heinz A Horst, Ingo G H Schmidt-Wolf, Mathias Rummel, Katharina Götze, Elisabeth Koller, Andreas L Petzer, Hans Salwender, Walter Fiedler, Heinz Kirchen, Detlef Haase, Stephan Kremers, Matthias Theobald, Axel C Matzdorff, Arnold Ganser, Hartmut Döhner, Richard F Schlenk
Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m(2) intravenously on day 1), all-trans retinoic acid (45 mg/m(2) orally on days 4-6 and 15 mg/m(2) orally on days 7-28), high-dose cytarabine (3 g/m(2)/12 h intravenously on days 1-3) and mitoxantrone (12 mg/m(2) intravenously on days 2-3) in 93 patients aged 18-60 years refractory to one cycle of induction therapy. Primary end point of the study was response to therapy; secondary end points included evaluation of toxicities, in particular, rate of sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation...
July 2016: Haematologica
P Luz-Crawford, N Ipseiz, G Espinosa-Carrasco, A Caicedo, G Tejedor, K Toupet, J Loriau, C Scholtysek, C Stoll, M Khoury, D Noël, C Jorgensen, G Krönke, F Djouad
OBJECTIVES: To define how peroxisome proliferator-activated receptor (PPAR) β/δ expression level in mesenchymal stem cells (MSCs) could predict and direct both their immunosuppressive and therapeutic properties. PPARβ/δ interacts with factors such as nuclear factor-kappa B (NF-κB) and regulates the expression of molecules including vascular cell adhesion molecule (VCAM)-1 and intercellular adhesion molecule (ICAM)-1. Since these molecules are critical for MSC function, we investigated the role of PPARβ/δ on MSC immunosuppressive properties...
March 8, 2016: Annals of the Rheumatic Diseases
S Bohl, S von Harsdorf, M Mulaw, S Hofmann, A Babiak, C P Maier, J Schnell, L-M Hütter-Krönke, K Scholl, V Wais, R F Schlenk, L Bullinger, M Ringhoffer, H Döhner, D Bunjes, M Bommer, F Kuchenbauer
No abstract text is available yet for this article.
July 2016: Bone Marrow Transplantation
Kristin Jakobshagen, Beate Ward, Nikola Baschuk, Sebastian Huss, Anna Brunn, Monika Malecki, Michael Fiolka, Gunther Rappl, Diana Corogeanu, Ulrike Karow, Petra Schiller, Hinrich Abken, Lukas C Heukamp, Martina Deckert, Martin Krönke, Olaf Utermöhlen
The immunoregulatory cytokine IL-10 suppresses T-cell immunity. The complementary question, whether IL-10 is also involved in limiting the collateral damage of vigorous T cell responses, has not been addressed in detail. Here, we report that the particularly strong virus-specific immune response during acute primary infection with the lymphocytic choriomeningitis virus (LCMV) in mice is significantly further increased in Il10-deficient mice, particularly regarding frequencies and cytotoxic activity of CD8(+) T cells...
November 2015: American Journal of Pathology
Max Wolff, Klaus-Martin Krönke, Thomas Goschke
Although cognitive control is commonly identified as the basis of self-controlled behavior, correlations found between trait self-control and laboratory measures of cognitive control such as Stroop interference are typically low. Based on the notion that self-control requires the ability to refrain from rewarded behaviors, and inspired by the recent finding that Stroop interference is modulated by reward associations, we propose the idea that the modulation of interference by reward associations (MIRA) is a cognitive marker of trait self-control...
September 24, 2015: Psychological Research
Yubin Luo, Guang-Liang Chen, Nicole Hannemann, Natacha Ipseiz, Gerhard Krönke, Tobias Bäuerle, Luis Munos, Stefan Wirtz, Georg Schett, Aline Bozec
The effect of metabolic stress on the bone marrow microenvironment is poorly defined. We show that high-fat diet (HFD) decreased long-term Lin(-)Sca-1(+)c-Kit(+) (LSK) stem cells and shifted lymphoid to myeloid cell differentiation. Bone marrow niche function was impaired after HFD as shown by poor reconstitution of hematopoietic stem cells. HFD led to robust activation of PPARγ2, which impaired osteoblastogenesis while enhancing bone marrow adipogenesis. At the same time, expression of genes such as Jag-1, SDF-1, and IL-7 forming the bone marrow niche was highly suppressed after HFD...
November 3, 2015: Cell Metabolism
Rebecca Kronk, Yvonne Weideman, Leah Cunningham, Lenore Resick
BACKGROUND: This article describes the use of photo-elicitation as a qualitative research method that captured transformational outcomes of baccalaureate nursing students who participated in a 10-day global service-learning experience in Nicaragua. METHOD: All participants (N = 8) took photographs as a natural way of capturing moments, scenes, and events that occurred during their immersion experience. Four weeks after the trip, each student selected photographs that were a meaningful visual representation of their experience and participated in a semistructured interview conducted by one of the three faculty investigators...
September 2015: Journal of Nursing Education
Klaus-Martin Krönke, Max Wolff, Annika Benz, Thomas Goschke
Although many smokers try to quit, relatively few are successful in their attempts. Here we investigated whether the ability to quit smoking is related to behavioral and neural measures of cognitive control. A functional magnetic resonance imaging study with a counting Stroop task was used to measure cognitive control in ex-smokers (N=10) who had successfully quit smoking and smokers (N=10) who continuously failed to quit smoking. Behavioral results showed a significant Stroop effect in ex-smokers and smokers...
October 30, 2015: Psychiatry Research
Debra Kramlich, Rebecca Kronk
OBJECTIVE: The purpose of this systematic review of the literature is to highlight published studies of perinatal substance use disorder that address relational aspects of various care delivery models to identify opportunities for future studies in this area. METHOD: Quantitative, qualitative, and mixed-methods studies that included relational variables, such as healthcare provider engagement with pregnant women and facilitation of maternal-infant bonding, were identified using PubMed, Scopus, and EBSCO databases...
September 2015: MCN. the American Journal of Maternal Child Nursing
Kathy Stein, Melissa Stoffels, Mariola Lysson, Bianca Schneiker, Oliver Dewald, Gerhard Krönke, Jörg C Kalff, Sven Wehner
Resolution of inflammation is an active counter-regulatory mechanism involving polyunsaturated fatty acid-derived proresolving lipid mediators. Postoperative intestinal motility disturbances, clinically known as postoperative ileus, occur frequently after abdominal surgery and are mediated by a complex inflammation of the intestinal muscularis externa. Herein, we tested the hypothesis that proresolving lipid mediators are involved in the resolution of postoperative ileus. In a standardized experimental model of postoperative ileus, we detected strong expression of 12/15-lipoxygenase within the postoperative muscularis externa of C57BL/6 mice, predominately located within CX3CR1(+)/Ly6C(+) infiltrating monocytes rather than Ly6G(+) neutrophils...
February 2016: Journal of Leukocyte Biology
Michelle A Floris-Moore, Katie Mollan, Aimee M Wilkin, Marc A Johnson, Angela Dm Kashuba, David A Wohl, Kristine B Patterson, Owen Francis, Catherine Kronk, Joseph J Eron
BACKGROUND: Etravirine (ETR), a non-nucleoside reverse transcriptase inhibitor approved for 200 mg twice-daily dosing in conjunction with other antiretrovirals (ARVs), has pharmacokinetic properties which support once-daily dosing. METHODS: In this single-arm, open-label study, 79 treatment-naive HIV-infected adults were assigned to receive ETR 400 mg plus tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) 300/200 mg once daily to assess antiviral activity, safety and tolerability...
2016: Antiviral Therapy
Emine Sahin, Julia S Brunner, Julia B Kral, Mario Kuttke, Leslie Hanzl, Hannes Datler, Hannah Paar, Nick Neuwinger, Victoria Saferding, Elisabeth Zinser, Angela Halfmann, Klara Soukup, Eva Hainzl, Tobias Lohmeyer, Birgit Niederreiter, Thomas Haider, Alexander M Dohnal, Gerhard Krönke, Stephan Blüml, Gernot Schabbauer
The PI3K signaling cascade in APCs has been recognized as an essential pathway to initiate, maintain, and resolve immune responses. In this study, we demonstrate that a cell type-specific loss of the PI3K antagonist phosphatase and tensin homolog (PTEN) in myeloid cells renders APCs toward a regulatory phenotype. APCs deficient for PTEN exhibit reduced activation of p38 MAPK and reduced expression of T cell-polarizing cytokines. Furthermore, PTEN deficiency leads to upregulation of markers for alternative activation, such as Arginase 1, with concomitant downregulation of inducible NO synthase in APCs in vitro and in vivo...
September 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Jan Krönke, Emma C Fink, Paul W Hollenbach, Kyle J MacBeth, Slater N Hurst, Namrata D Udeshi, Philip P Chamberlain, D R Mani, Hon Wah Man, Anita K Gandhi, Tanya Svinkina, Rebekka K Schneider, Marie McConkey, Marcus Järås, Elizabeth Griffiths, Meir Wetzler, Lars Bullinger, Brian E Cathers, Steven A Carr, Rajesh Chopra, Benjamin L Ebert
Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)), resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalidomide therapy, providing a mechanistic basis for the therapeutic window of lenalidomide in del(5q) MDS...
July 9, 2015: Nature
Julia L Bassell, Han Phan, Roberta Leu, Rebecca Kronk, Jeannie Visootsak
Down syndrome (DS) is the most common genetic cause of intellectual disability and results from an extra chromosome 21 (Trisomy 21). Sleep issues and/or obstructive sleep apnea (OSA) are assumed to be part of the DS phenotype with a high prevalence but are often under recognized. This cross-sectional study of children with DS examines the caregiver-reported sleep behaviors of 108 children with DS, ranging in age from 1.50 to 13.40 years (mean = 5.18 years) utilizing a standardized assessment tool, the Children's Sleep Habit Questionnaire (CSHQ)...
August 2015: American Journal of Medical Genetics. Part A
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