keyword
https://read.qxmd.com/read/37803308/hemophagocytic-lymphohistiocytosis-and-histiocytic-necrotizing-lymphadenitis-secondary-to-hemodialysis-catheter-related-bloodstream-infection-caused-by-corynebacterium-striatum
#21
JOURNAL ARTICLE
ZhiPeng Zhao, Jing Li, Liu Yang, GuangWei Ren, LiHong Zhang, Tao Wang
BACKGROUND: We herein described the coexistence of hemophagocytic lymphohistiocytosis (HLH) and histiocytic necrotizing lymphadenitis, alternatively known as the Kikuchi disease (KD), secondary to hemodialysis catheter-related bloodstream infection (BSI) caused by Corynebacterium striatum. CASE PRESENTATION: A patient on maintenance hemodialysis had developed persistent fever and Corynebacterium striatum was subsequently identified from the culture of both catheter tip and peripheral blood...
October 6, 2023: BMC Nephrology
https://read.qxmd.com/read/37741062/who-really-hoards-hoarding-symptoms-in-adults-with-attention-deficit-hyperactivity-disorder-adhd-obsessive-compulsive-disorder-ocd-and-healthy-controls
#22
JOURNAL ARTICLE
Giacomo Grassi, Corinna Moradei, Chiara Cecchelli, Michael van Ameringen
UNLABELLED: Although hoarding disorder (HD) is included in the DSM-5 in the obsessive-compulsive and related disorders chapter, in the last few years, HD has been consistently associated with attention-deficit hyperactivity disorder (ADHD). Some studies on HD patients show higher comorbidity with ADHD than with OCD and some studies on ADHD patients found significant higher rates of HD symptoms compared to the general population. However, the aim of the present study was to be the first direct comparison of the prevalence of HD and HD symptoms across adults with a primary diagnosis of ADHD, OCD and a sample of matched healthy controls (HCs)...
September 17, 2023: Journal of Psychiatric Research
https://read.qxmd.com/read/37663953/%C3%AE-blocker-use-in-hemodialysis-the-japan-dialysis-outcomes-and-practice-patterns-study
#23
JOURNAL ARTICLE
Ken Iseri, Chisato Miyakoshi, Nobuhiko Joki, Yoshihiro Onishi, Shingo Fukuma, Hirokazu Honda, Kazuhiko Tsuruya
RATIONALE & OBJECTIVE: Despite α-blockers' use for hypertension as add-on therapy in patients treated with hemodialysis, scant information is available on their association, particularly with safety, in these patients. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: patients treated with hemodialysis and receiving antihypertensive agents in the Japan Dialysis Outcomes and Practice Patterns Study, phases 4-6, were analyzed...
September 2023: Kidney medicine
https://read.qxmd.com/read/37642165/the-micrornas-mirs-overexpressing-mesenchymal-stem-cells-mscs-therapy-in-neurological-disorders-hope-or-hype
#24
REVIEW
Sulieman Ibraheem Shelash Al-Hawary, Anas Yahya Ali, Yasser Fakri Mustafa, Ria Margiana, Shamsutdinova Maksuda Ilyasovna, Montather F Ramadan, Sami G Almalki, Marim Alwave, Safa Alkhayyat, Ali Alsalamy
Altered expression of multiple miRNAs was found to be extensively involved in the pathogenesis of different neurological disorders including Alzheimer's disease, Parkinson's disease, stroke, epilepsy, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. One of the biggest concerns within gene-based therapy is the delivery of the therapeutic microRNAs to the intended place, which is obligated to surpass the biological barriers without undergoing degradation in the bloodstream or renal excretion...
August 29, 2023: Biotechnology Progress
https://read.qxmd.com/read/37636644/laryngeal-anaplastic-lymphoma-kinase-positive-b-cell-lymphoma-case-report-and-review
#25
JOURNAL ARTICLE
Sunil Sam Varghese, Ashish Varghese, Preethi Anni Mercy Paul, Kaffy Dhawan, Pulkit Gupta
Larynx is an uncommon extranodal site for non-Hodgkin lymphoma (NHL). Anaplastic lymphoma kinase (ALK)-positive B-cell lymphoma is a rare and aggressive form of NHL. A 19-year-old male presented to the ENT department with globus sensation, hoarseness, cervical lymphadenopathy and weight loss. A 70-degree rigid endoscopic examination of the larynx showed a vascular, irregular, submucosal mass arising from the right aryepiglottic fold causing near complete obstruction of the laryngeal airway. PET-CT showed hypermetabolic lesions in the supraglottis, cervical lymph nodes, cervical spine, ribs and abdominal lymph nodes...
September 2023: Indian Journal of Otolaryngology and Head and Neck Surgery
https://read.qxmd.com/read/37608265/intradialytic-neuromuscular-electrical-stimulation-with-optional-virtual-reality-distraction-improves-not-only-muscle-strength-and-functional-capacity-but-also-serum-albumin-level-in-haemodialysis-patients-a-pilot-randomized-clinical-trial
#26
JOURNAL ARTICLE
Lena Schinner, Klaus Nagels, Julia Scherf, Christoph Schmaderer, Uwe Heemann, Claudius Küchle, Liya Hannemann
BACKGROUND: Sarcopenia is highly prevalent in haemodialysis (HD) patients and linked to a poor prognosis regarding comorbidities and premature mortality. Previous studies assessed the effects of neuromuscular electrical stimulation in haemodialysis patients. This study adds to the relevance of neuromuscular electrical stimulation (NMES) applications combined with a virtual reality (VR) distraction to increase intensity, dosage, and efficiency of NMES and slow sarcopenia progression in HD patients...
August 23, 2023: BMC Nephrology
https://read.qxmd.com/read/37600827/proinflammatory-role-of-monocytes-in-sars-cov-2-infection-in-chronic-hemodialysis-patients
#27
JOURNAL ARTICLE
Viorica Bumbea, Luminita Ardelean, Luminita Radulescu, Luminita Damian, Horia Bumbea, Ion Dumitru, Claude Lambert, Ana-Maria Vladareanu
BACKGROUND: Fully mature monocytes that express CD14, but not CD16, undergo phagocytosis within tissues, whereas non-classical monocytes, CD14-low CD16+, represent <11% of peripheral monocytes and have primary pro-inflammatory functions. Inflammation plays a major role in Covid-19 disease and adds to the inflammation caused by chronic hemodialysis. The aim of our study was to monitor monocyte subsets in five patients with end-stage kidney disease (ESKD) over a 1-year period after a mild Covid-19 infection...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37582307/mixed-longitudinal-and-cross-sectional-analyses-of-deep-gray-matter-and-white-matter-using-diffusion-weighted-images-in-premanifest-and-manifest-huntington-s-disease
#28
MULTICENTER STUDY
Beini Hu, Laurent Younes, Xuan Bu, Chin-Fu Liu, J Tilak Ratnanather, Jane Paulsen, Nellie Georgiou-Karistianis, Michael I Miller, Christopher Ross, Andreia V Faria
Changes in the brain of patients with Huntington's disease (HD) begin years before clinical onset, so it remains critical to identify biomarkers to track these early changes. Metrics derived from tensor modeling of diffusion-weighted MRIs (DTI), that indicate the microscopic brain structure, can add important information to regional volumetric measurements. This study uses two large-scale longitudinal, multicenter datasets, PREDICT-HD and IMAGE-HD, to trace changes in DTI of HD participants with a broad range of CAP scores (a product of CAG repeat expansion and age), including those with pre-manifest disease (i...
2023: NeuroImage: Clinical
https://read.qxmd.com/read/37453562/purinergic-receptors-in-cognitive-disturbances
#29
REVIEW
Peter Illes, Henning Ulrich, Jiang-Fan Chen, Yong Tang
Purinergic receptors (Rs) of the ATP/ADP, UTP/UDP (P2X, P2Y) and adenosine (A1, A2A)-sensitive classes broadly interfere with cognitive processes both under quasi normal and disease conditions. During neurodegenerative illnesses, high concentrations of ATP are released from the damaged neuronal and non-neuronal cells of the brain; then, this ATP is enzymatically degraded to adenosine. Thus, the primary injury in neurodegenerative diseases appears to be caused by various protein aggregates on which a superimposed damage mediated by especially P2X7 and A2AR activation develops; this can be efficiently prevented by small molecular antagonists in animal models of the above diseases, or are mitigated in the respective knockout mice...
July 13, 2023: Neurobiology of Disease
https://read.qxmd.com/read/37430148/short-term-effects-of-an-elimination-diet-and-healthy-diet-in-children-with-attention-deficit-hyperactivity-disorder-a-randomized-controlled-trial
#30
JOURNAL ARTICLE
Annick Huberts-Bosch, Margreet Bierens, Verena Ly, Jessica van der Velde, Heleen de Boer, Gerry van Beek, Danielle Appelman, Sacha Visser, Lisa H P Bos, Lisa Reijmers, Jolanda van der Meer, Niki Kamphuis, Jos M T Draaisma, Rogier Donders, Gigi H H van de Loo-Neus, Pieter J Hoekstra, Marco Bottelier, Alejandro Arias-Vasquez, Helen Klip, Jan K Buitelaar, Saskia W van den Berg, Nanda N Rommelse
An Elimination Diet (ED) may be effective in reducing symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), but has never been compared to an active control condition [i.e., Healthy Diet (HD)]. In a two-armed RCT, a total of N = 165 children (5-12 years) with ADHD were randomized by means of minimization (1:1) to either an ED (N = 84) or HD (N = 81) within two Dutch child and adolescent psychiatry centers. The design included a non-randomized comparator arm including N = 58 children being treated with Care as Usual (CAU)...
July 11, 2023: European Child & Adolescent Psychiatry
https://read.qxmd.com/read/37422169/opportunities-and-challenges-in-drug-discovery-targeting-the-orphan-receptor-gpr12
#31
REVIEW
Pingyuan Wang, Ling Lv, Haoran Li, Chang-Yun Wang, Jia Zhou
G-protein-coupled receptor 12 (GPR12) is a brain-specific expression orphan G-protein-coupled receptor (oGPCR) that regulates various physiological processes. It is an emerging therapeutic target for central nervous system (CNS) disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), attention deficit hyperactivity disorder (ADHD), and schizophrenia, as well as other human diseases, such as cancer, obesity, and metabolic disorders. GPR12 remains a less extensively investigated oGPCR, particularly in terms of its biological functions, signaling pathways, and ligand discovery...
July 6, 2023: Drug Discovery Today
https://read.qxmd.com/read/37396990/revealing-novel-cytb-and-nad-5-genes-based-population-diversity-and-benzimidazole-resistance-in-echinococcus-granulosus-of-bovine-origin
#32
JOURNAL ARTICLE
Mughees Aizaz Alvi, Ayed Alshammari, Rana Muhammad Athar Ali, Shahbaz Ul Haq, Rizwan Bashir, Li Li, Muhammad Saqib, Muhammad Sohail Sajid, Muzafar Ghafoor, Muhammad Imran, Muhammad Umar Ijaz, Bao-Quan Fu, Mohd Saeed, Irfan Ahmad, You-Yu Liu, Hong-Bin Yan, Wan-Zhong Jia
Cystic echinococcosis (CE) is a neglected zoonotic disease caused by Echinococcus granulosus ( sensu stricto ). The parasite affects a wide range of livestock and wild animals. In this study, the population diversity of the Echinococcus species was investigated based on mitochondrial cytochrome b ( cyt b) and NADH dehydrogenase subunit 5 ( nad 5) genes. In addition to this, β-tubulin gene isoforms of Echinococcus granulosus were amplified to determine the resistance against benzimidazoles. For this purpose, 40 cyst samples from cattle ( n  = 20) and buffaloes ( n  = 20) were collected from the main abattoir of Sialkot...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37333679/use-of-contezolid-for-the-treatment-of-refractory-infective-endocarditis-in-a-patient-with-chronic-renal-failure-case-report
#33
Sheng Zhao, Wei Zhang, Linfei Zhang, Jing Zhang, Jinghang Li, Linjie Si, Yi Ding, Mingke Li, Yuanyuan Song
Infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus (MRSA) is usually life threatening and difficult to treat. Contezolid is a newly approved oxazolidinone antimicrobial agent showing potent activity against MRSA. We successfully treated a case of refractory IE caused by MRSA with contezolid in a 41-year-old male patient. The patient was admitted due to recurrent fever and chills for more than 10 days. He had chronic renal failure for more than 10 years and under ongoing hemodialysis...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37329702/attention-deficit-hyperactivity-disorder-in-children-with-hearing-loss
#34
JOURNAL ARTICLE
Diya Ramanathan, Pavel Kipnis, Patricia Klaas, Ksenia A Aaron, Samantha Anne
OBJECTIVE: To evaluate rates of Attention-Deficit/Hyperactivity Disorder (AD/HD) diagnosis among pediatric patients with normal hearing (NH) and hearing loss (HL) with and without comorbidities. STUDY DESIGN: Retrospective cohort study of NH and HL patients following chart review of all pediatric patients with a history of tympanostomy tube placement treated at the Cleveland Clinic Foundation between 2019 and 2022. METHODS: Patient demographic information, hearing status (type of HL, laterality, severity), and comorbidities including prematurity, genetic syndromes, disorders with neurological impairment, and autism spectrum disorder (ASD) were collected...
August 2023: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/37257770/remote-neurocognitive-interventions-for-attention-deficit-hyperactivity-disorder-opportunities-and-challenges
#35
REVIEW
Da-Wei Zhang, Stuart J Johnstone, Bruno Sauce, Martijn Arns, Li Sun, Han Jiang
Improving neurocognitive functions through remote interventions has been a promising approach to developing new treatments for attention-deficit/hyperactivity disorder (AD/HD). Remote neurocognitive interventions may address the shortcomings of the current prevailing pharmacological therapies for AD/HD, e.g., side effects and access barriers. Here we review the current options for remote neurocognitive interventions to reduce AD/HD symptoms, including cognitive training, EEG neurofeedback training, transcranial electrical stimulation, and external cranial nerve stimulation...
May 29, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/37252016/prevalence-and-risk-factors-of-attention-deficit-hyperactivity-disorder-in-the-saudi-population-a-systematic-review-and-meta-analysis
#36
JOURNAL ARTICLE
Ahmed Hamed Aljadani, Tahani Salem Alshammari, Rawan Ibrahim Sadaqir, Naif Osaywid Eid Alrashede, Bushra Mubarak Aldajani, Samiah Ahmed Almehmadi, Abdullah Saleh Altuhayni, Mohamed Ahmed Abouzed
OBJECTIVES: To determine the prevalence and risk factors of attention deficit hyperactivity disorder (ADHD) in Saudi Arabia. METHODS: Observational studies (case-control, cohort, and cross-sectional) that reported the prevalence and risk factors of ADHD among Saudis and were published in English were included. In March 2022, a computerized search was conducted on Medline (via PubMed), Web of Science, and Scopus using keywords associated with ADHD and Saudi Arabia...
2023: Saudi Journal of Medicine & Medical Sciences
https://read.qxmd.com/read/37239203/resting-state-dynamic-reconfiguration-of-spatial-attention-cortical-networks-and-visuospatial-functioning-in-non-verbal-learning-disability-nvld-a-hd-eeg-investigation
#37
JOURNAL ARTICLE
Ambra Coccaro, Maria Grazia Di Bono, Antonio Maffei, Camilla Orefice, Rachele Lievore, Irene Mammarella, Mario Liotti
Nonverbal learning disability (NVLD) is a neurodevelopmental disorder characterized by deficits in visuospatial processing but spared verbal competencies. Neurocognitive markers may provide confirmatory evidence for characterizing NVLD as a separate neurodevelopmental disorder. Visuospatial performance and high-density electroencephalography (EEG) were measured in 16 NLVD and in 16 typically developing (TD) children. Cortical source modeling was applied to assess resting-state functional connectivity (rs-FC) in spatial attention networks (dorsal (DAN) and ventral attention networks (VAN)) implicated in visuospatial abilities...
April 27, 2023: Brain Sciences
https://read.qxmd.com/read/37237975/hemodialysis-serum-stimulates-the-txnip-enos-stat3-inflammatory-pathway-in-vitro
#38
JOURNAL ARTICLE
Keren Cohen-Hagai, Hadil Kashua, Sydney Benchetrit, Tali Zitman-Gal
BACKGROUND: Endothelial dysfunction, vascular inflammation and accelerated atherosclerosis have been investigated extensively in patients with chronic kidney disease (CKD). These conditions, as well as protein-energy malnutrition and oxidative stress, impair kidney function and contribute to increased morbidity and mortality among patients with end-stage kidney disease undergoing hemodialysis (HD). TXNIP, a key regulator of oxidative stress, has been linked to inflammation and suppresses eNOS activity...
May 17, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37187500/a-meningioma-mimic-and-distinct-subtype-of-primary-central-nervous-system-lymphoma-primary-dural-lymphoma
#39
Sushanth Sreenivasan, Risha Solanki, Pragnan Kancharla, Cyrus Khan, Yazan Samhouri
Primary central nervous system lymphoma (PCNSL) is an aggressive form of extranodal non-Hodgkin lymphoma that arises in the brain parenchyma, eyes, meninges, or spinal cord in the absence of systemic disease. Primary dural lymphoma (PDL), in contrast, arises from the dura mater of the brain. PDL is usually a low-grade B-cell marginal zone lymphoma (MZL), whereas other types of PCNSL are usually high-grade large B-cell lymphoma. This specific pathological subtype has important therapeutic and prognostic implications, making PDL a distinct subtype of PCNSL...
April 2023: Journal of Hematology (Brossard, Quebec)
https://read.qxmd.com/read/37167478/prognostic-potential-of-creatinine-and-cystatin-c-in-covid-19-a-retrospective-cohort-study-from-karolinska-university-hospital
#40
JOURNAL ARTICLE
Anna Sjöström, Per Olof Markgren, Magnus Hansson
Acute kidney injury (AKI) is common in COVID-19 and is diagnosed using relative serum creatinine increase. Estimated GFR (eGFR) is a more accurate measure of glomerular filtration due to compensation for age and sex. Serum Cystatin-C, less affected by non-renal factors than creatinine, may further improve renal function estimation and add prognostic information. Our aim is to investigate the importance of a calculated eGFR in relation to creatinine as well as the value of Cystatin-C in patients with severe COVID-19...
May 11, 2023: Scandinavian Journal of Clinical and Laboratory Investigation
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