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Ards influenza

Hui Wang, XinCai Xiao, Jianyun Lu, Zongqiu Chen, Kuibiao Li, Hui Liu, Lei Luo, Ming Wang, ZhiCong Yang
BACKGROUND: Guangzhou reported its first laboratory-confirmed case of influenza A (H7N9) on January 10, 2014. A total of 25 cases were reported from the first wave of the epidemic until April 8, 2014. The fatality rate was much higher than in previous reports. The objective of the current work was to describe the clinical and epidemiological characteristics of A (H7N9) patients in Guangzhou and explore possible reasons for the high fatality rate. METHODS: Clinical and epidemiological information regarding A (H7N9) cases in Guangzhou was collected through review of medical records and field research...
October 3, 2016: BMC Infectious Diseases
Xiangjie Sun, Hui Zeng, Amrita Kumar, Jessica A Belser, Taronna R Maines, Terrence M Tumpey
: A role for pulmonary endothelial cells in the orchestration of cytokine production and leukocyte recruitment during influenza virus infection, leading to severe lung damage, has been recently identified. As the mechanistic pathway for this ability is not fully known, we extended previous studies on influenza virus tropism in cultured human pulmonary endothelial cells. Here, we found that a subset of avian influenza viruses, including potentially pandemic H5N1, H7N9, and H9N2 viruses, could infect human pulmonary endothelial cells (HULEC) with high efficiency compared to human H1N1 or H3N2 viruses...
October 5, 2016: Journal of Virology
Nina Buchtele, Peter Schellongowski, Andja Bojic, Alexander Hermann, Oliver Robak, Wolfgang Lamm, Thomas Staudinger
INTRODUCTION: Data on prolonged extracorporeal membrane oxygenation (ECMO) usage in influenza associated acute respiratory distress syndrome (ARDS) are lacking. Furthermore, no consensus exists on when to terminate ECMO treatment in refractory cases. This report highlights additional treatment measures and complications in prolonged ECMO therapy and discusses associated ethical burdens. CASE REPORT: We report on a 64-year-old man with confirmed H1N1 influenza virus infection who was successfully weaned from 65-day ECMO treatment with an excellent outcome...
July 4, 2016: International Journal of Artificial Organs
Urs Pietsch, Christina Müller-Höcker, Annette Enzler-Tschudy, Miodrag Filipovic
No abstract text is available yet for this article.
October 2016: Intensive Care Medicine
Manuela Bonizzoli, Rosaria Arvia, Simona di Valvasone, Francesco Liotta, Krystyna Zakrzewska, Alberta Azzi, Adriano Peris
Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). ARDS and pneumonia are closely related to critically ill patients; however, the etiologic agent is not always identified. The presence of human herpes simplex virus 1, human cytomegalovirus and Epstein-Barr virus in respiratory samples of critically ill patients is increasingly reported even without canonical immunosuppression. The main aim of this study was to better understand the significance of herpesviruses finding in lower respiratory tract of ARDS patients hospitalized in ICU...
August 2016: Medical Microbiology and Immunology
Christin Peteranderl, Luisa Morales-Nebreda, Balachandar Selvakumar, Emilia Lecuona, István Vadász, Rory E Morty, Carole Schmoldt, Julia Bespalowa, Thorsten Wolff, Stephan Pleschka, Konstantin Mayer, Stefan Gattenloehner, Ludger Fink, Juergen Lohmeyer, Werner Seeger, Jacob I Sznajder, Gökhan M Mutlu, G R Scott Budinger, Susanne Herold
Influenza A viruses (IAV) can cause lung injury and acute respiratory distress syndrome (ARDS), which is characterized by accumulation of excessive fluid (edema) in the alveolar airspaces and leads to hypoxemia and death if not corrected. Clearance of excess edema fluid is driven mostly by the alveolar epithelial Na,K-ATPase and is crucial for survival of patients with ARDS. We therefore investigated whether IAV infection alters Na,K-ATPase expression and function in alveolar epithelial cells (AECs) and the ability of the lung to clear edema...
April 1, 2016: Journal of Clinical Investigation
Rena Brauer, Peter Chen
Influenza infection can cause acute respiratory distress syndrome (ARDS), leading to poor disease outcome with high mortality. One of the driving features in the pathogenesis of ARDS is the accumulation of fluid in the alveoli, which causes severe pulmonary edema and impaired oxygen uptake. In this issue of the JCI, Peteranderl and colleagues define a paracrine communication between macrophages and type II alveolar epithelial cells during influenza infection where IFNα induces macrophage secretion of TRAIL that causes endocytosis of Na,K-ATPase by the alveolar epithelium...
April 1, 2016: Journal of Clinical Investigation
Chandra C Ghosh, Sascha David, Ruyang Zhang, Anthony Berghelli, Katelyn Milam, Sarah J Higgins, Jon Hunter, Aditi Mukherjee, Yongyue Wei, Mei Tran, Freeman Suber, Lester Kobzik, Kevin C Kain, Shulin Lu, Ansgar Santel, Kiichiro Yano, Prajna Guha, Daniel J Dumont, David C Christiani, Samir M Parikh
Ligands of the endothelial-enriched tunica interna endothelial cell kinase 2 (Tie2) are markedly imbalanced in severe infections associated with vascular leakage, yet regulation of the receptor itself has been understudied in this context. Here, we show that TIE2 gene expression may constitute a novel vascular barrier control mechanism in diverse infections. Tie2 expression declined rapidly in wide-ranging models of leak-associated infections, including anthrax, influenza, malaria, and sepsis. Forced Tie2 suppression sufficed to attenuate barrier function and sensitize endothelium to permeability mediators...
March 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
S B Yatsyshina, M R Ageeva, N S Vorobieva, A V Valdokhina, M A Elkina, A V Gorelov, V V Maleev, V I Pokrovsky
AIM: Study prevalence of adenovirus species and serotypes that had caused acute respiratory viral infection (ARVI) in Moscow in 2004 - 2014. MATERIALS AND METHODS: Material from respiratory tract of 4731 patients with ARVI and 663 conditionally healthy children and adults was used. ARVI causative agents were detected by PCR with real-time detection using AmpliSens reagent kits (CRIE, Moscow). Membership of adenoviruses to a certain serotype was determined by sequencing of hexon gene segment...
September 2015: Zhurnal Mikrobiologii, Epidemiologii, i Immunobiologii
Wenrui Wu, Ding Shi, Daiqiong Fang, Feifei Guo, Jing Guo, Fengming Huang, Yanfei Chen, Longxian Lv, Lanjuan Li
OBJECTIVES: The avian influenza H7N9 virus can cause cytokine overproduction and result in severe pneumonia and acute respiratory distress syndrome. Many studies have focused on hypercytokinemia during avian influenza infection. This study examined the association between C-reactive protein (CRP) and cytokines. METHODS: The plasma cytokine and chemokine profiles of 57 H7N9 patients were investigated using a multiplex immunoassay. The CRP levels of patients with H7N9 and patients with H1N1 were also compared...
March 2016: International Journal of Infectious Diseases: IJID
Tatiana Baranovich, Jeremy C Jones, Marion Russier, Peter Vogel, Kristy J Szretter, Susan E Sloan, Patrick Seiler, Jose M Trevejo, Richard J Webby, Elena A Govorkova
Most cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal antibodies targeting the stem of the influenza virus surface hemagglutinin (HA) is a rapidly developing strategy for the control of viruses of multiple HA subtypes. However, the mechanisms of action of these antibodies are not fully understood, and their ability to mitigate severe complications of influenza has been poorly studied...
April 2016: Antimicrobial Agents and Chemotherapy
Andrea Streng, Christiane Prifert, Benedikt Weissbrich, Johannes G Liese
BACKGROUND: Previous influenza surveillance at paediatric intensive care units (PICUs) in Germany indicated increased incidence of PICU admissions for the pandemic influenza subtype A(H1N1)pdm09. We investigated incidence and clinical characteristics of influenza in children admitted to PICUs during the first three post-pandemic influenza seasons, using active screening. METHODS: We conducted a prospective surveillance study in 24 PICUs in Bavaria (Germany) from October 2010 to September 2013...
2015: BMC Infectious Diseases
Takayuki Uematsu, Ei'ichi Iizasa, Noritada Kobayashi, Hiroki Yoshida, Hiromitsu Hara
Influenza virus (IFV) infection is a common cause of severe viral pneumonia associated with acute respiratory distress syndrome (ARDS), which is difficult to control with general immunosuppressive therapy including corticosteroids due to the unfavorable effect on viral replication. Studies have suggested that the excessive activation of the innate immunity by IFV is responsible for severe pathologies. In this study, we focused on CARD9, a signaling adaptor known to regulate innate immune activation through multiple innate sensor proteins, and investigated its role in anti-IFV defense and lung pathogenesis in a mouse model recapitulating severe influenza pneumonia with ARDS...
2015: Scientific Reports
Isabelle Bonmarin, Emmanuel Belchior, Jean Bergounioux, Christian Brun-Buisson, Bruno Mégarbane, Jean Loup Chappert, Bruno Hubert, Yann Le Strat, Daniel Lévy-Bruhl
During the 2009/10 pandemic, a national surveillance system for severe influenza cases was set up in France. We present results from the system's first four years. All severe influenza cases admitted to intensive care units (ICU) were reported to the Institut de Veille Sanitaire using a standardised form: data on demographics, immunisation and virological status, risk factors, severity (e.g. acute respiratory distress syndrome (ARDS) onset, mechanical ventilation, extracorporeal life support) and outcome. Multivariate analysis was performed to identify factors associated with ARDS and death...
2015: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Miguel Franquiz, Jeffrey Gonzales, Paul Saleeb, Carl Shanholtz
No abstract text is available yet for this article.
December 2015: Critical Care Medicine
Todd C Crawford, Joshua C Grimm, J Trent Magruder, R Scott Stephens, Christopher M Sciortino, A Jason Vaught, Janyne Althaus, Ashish S Shah, Bo S Kim
Gestational acute respiratory distress syndrome (ARDS) is a complicated problem with the potential to gravely harm both mother and fetus. This case report describes a young woman in her second trimester of pregnancy who developed progressive respiratory failure in the setting of newly diagnosed influenza, diffuse alveolar hemorrhage and lymphangioleiomyomatosis. The patient's condition was refractory to conventional interventions and required extracorporeal membrane oxygenation (ECMO) support. Her course was further complicated by preeclampsia requiring preterm delivery with cesarean section while on ECMO...
2015: Journal of Surgical Case Reports
Mayuri Nakano, Seiji Yoshida, Tadashi Nakayama, Fumitaka Ogushi, Masaki Hanibuchi, Yasuhiko Nishioka
A 51-year-old man was admitted to our hospital because of fever and diarrhea. Chest X-ray revealed consolidation in the left lower lung field. Ceftriaxone and minocycline were given empirically, under the suspicion of bacterial or atypical pneumonia. In spite of treatment with antibiotics, the disease rapidly progressed to systemic inflammatory response syndrome. The diagnosis of acute respiratory distress syndrome (ARDS) accompanied with influenza (H1N1) 2009 was made because of positive findings of real-time polymerase chain reaction...
May 2015: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
Guyi Wang, Yanyan Zhou, Subo Gong, Haiyun Dong, Guobao Wu, Xudong Xiang, Jianjun Tang
We report a case of H7N9 avian influenza pneumonia in a pregnant woman who developed acute respiratory distress syndrome (ARDS) managed with extracorporeal membrane oxygenation (ECMO). A 29-year-old, 27 week pregnant woman developed rapidly progressive pneumonia with bilateral infiltrates on chest x-ray and was confirmed to have influenza A (H7N9) infection. Her condition deteriorated and she developed ARDS which was managed with veno-venous extracorporeal membrane oxygenation (V-V ECMO) and treated with antimicrobials...
May 2015: Southeast Asian Journal of Tropical Medicine and Public Health
George V Patrut, Claudiu Neamtu, Mihai Ionac
INTRODUCTION: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO(1)) systems are a life-saving option in the treatment of acute respiratory distress syndrome (ARDS(2)), but may be encumbered by severe vascular complications in the groin. PRESENTATION OF CASE: A pregnant woman was admitted with respiratory failure due to H1N1 influenza. VA-ECMO was inserted percutaneously by the intensivists and then accidentally removed by the patient after 8 days. 24h later VA-ECMO was reinstalled with surgical denudation of femoral vessels in another department...
2015: International Journal of Surgery Case Reports
Philippe François Simon, Stuart McCorrister, Pingzhao Hu, Patrick Chong, Alex Silaghi, Garrett Westmacott, Kevin M Coombs, Darwyn Kobasa
Influenza A viruses (IAV) are important human and animal pathogens with potential for causing pandemics. IAVs exhibit a wide spectrum of clinical illness in humans, from relatively mild infections by seasonal strains to acute respiratory distress syndrome during infections with some highly pathogenic avian influenza (HPAI) viruses. In the present study, we infected A549 human cells with seasonal H1N1 (sH1N1), 2009 pandemic H1N1 (pdmH1N1), or novel H7N9 and HPAI H5N1 strains. We used multiplexed isobaric tags for relative and absolute quantification to measure proteomic host responses to these different strains at 1, 3, and 6 h post-infection...
November 6, 2015: Journal of Proteome Research
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