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Non vascularized bone grafts

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https://www.readbyqxmd.com/read/28040089/success-rate-and-risk-factors-of-failure-of-the-induced-membrane-technique-in-children-a-systematic-review
#1
Jean-Charles Aurégan, Thierry Bégué, Guillaume Rigoulot, Christophe Glorion, Stéphanie Pannier
The induced membrane technique was designed by Masquelet et al. to address segmental bone defects of critical size in adults. It has been used after bone defects of traumatic, infectious and tumoral origin with satisfactory results. Recently, it has been used in children but, after an initial enthusiasm, several cases of failure have been reported. The purpose of this study was to assess the success rate and the risk factors of failure of the induced membrane for children. We conducted a systematic review of all the studies reporting the results of the induced membrane technique to address bone defects of critical size in children...
December 2016: Injury
https://www.readbyqxmd.com/read/28040088/restoration-of-long-bone-defects-treated-with-the-induced-membrane-technique-protocol-and-outcomes
#2
Peter V Giannoudis, Paul J Harwood, Theodoros Tosounidis, Nikolaos K Kanakaris
This prospective study was undertaken at a regional tertiary referral centre to evaluate the results of treatment of bone defects managed with the induced membrane (IM) technique. Inclusion criteria were patients with bone defects secondary to septic non-union, chronic osteomyelitis and acute fracture with bone loss. Pathological fractures with bone loss were excluded. Data collection included patient demographics, pathology, previous surgical intervention, size of bone defect, type of graft implanted, time-to-union and complications/reinterventions...
December 2016: Injury
https://www.readbyqxmd.com/read/28004288/in-vivo-quantification-of-the-revascularization-of-a-human-acellular-dermis-seeded-with-epcs-and-mscs-in-co-culture-with-fibroblasts-and-pericytes-in-the-dorsal-chamber-model-in-pre-irradiated-tissue
#3
M Vitacolonna, D Belharazem, P Hohenberger, E D Roessner
INTRODUCTION: Transplantation of a cell-seeded graft may improve wound healing after radiotherapy. However, the survival of the seeded cells depends on a rapid vascularization of the graft. Co-culturing of adult stem cells may be a promising strategy to accelerate the vessel formation inside the graft. Thus, we compared the in vivo angiogenic potency of mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) using dorsal skinfold chambers and intravital microscopy. MATERIALS AND METHODS: Cells were isolated from rat bone marrow and adipose tissue and characterized by immunostaining and flow cytometry...
December 21, 2016: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27900098/clinical-effects-of-three-surgical-approaches-for-a-giant-cell-tumor-of-the-distal-radius-and-ulna
#4
Jing Zhang, Yi Li, Dongqi Li, Junfeng Xia, Su Li, Shunling Yu, Yedan Liao, Xiaojuan Li, Huilin Li, Zuozhang Yang
The aim of the present study was to assess the curative effects of three surgical approaches for a giant cell tumor (GCT) of the distal radius and ulna. A total of 27 patients with GCT on distal radius and ulnas (7 and 20, respectively), confirmed by biopsy, were treated with individualized treatment regimens, according to the Campanacci's grade system: i) Curettage plus inactivated tumor bed and allogeneic bone graft/bone cement augmentation for Campanacci's grade I GCT of the distal radius and ulna (Group A); ii) simple en bloc resection for Campanacci's grade II and III GCT of the distal ulna (Group B); iii) en bloc resection and reconstruction with non-vascularized fibular autograft/allogeneic bone graft for Campanacci's II and III GCT of the distal radius (Group C)...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896458/prognostic-factors-in-the-treatment-of-carpal-scaphoid-non-unions
#5
F Schuind, F Moungondo, W El Kazzi
In this literature review, the authors analyse the prognostic factors in the curative treatment of scaphoid non-unions. The main negative prognostic factors are smoking, the time elapsed since the fracture, and avascular necrosis of the proximal fragment. If the latter is present, the revascularization by a pedicle or microsurgical bone autograft is probably the treatment of choice. In non-unions without evidence of osteonecrosis, vascularized bone grafts are probably not superior to conventional bone grafts, which can presently be performed under arthroscopic control, with minimal morbidity...
January 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27889329/perivascular-cells-and-tissue-engineering-current-applications-and-untapped-potential
#6
REVIEW
Elisa Avolio, Valeria V Alvino, Mohamed T Ghorbel, Paola Campagnolo
The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare...
November 24, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27829447/autologous-bone-graft-in-the-treatment-of-post-traumatic-bone-defects-a-systematic-review-and-meta-analysis
#7
Matheus Lemos Azi, Alessandro Aprato, Irene Santi, Mauricio Kfuri, Alessandro Masse, Alexander Joeris
BACKGROUND: This meta-analysis aimed to determine the bone union rate of bone defects treated with the different autologous bone graft techniques. METHODS: The PubMed and the Cochrane Library databases were searched using the terms: 'fracture' AND ('bone loss' OR 'defect' OR 'defects') AND 'bone graft', restricted to English language, to human species, and to a publication period from January 1999 to November 2014. Data were extracted by one of the reviewers and then checked by the second...
9, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27790578/clinical-evaluation-of-insulin-like-growth-factor-i-and-vascular-endothelial-growth-factor-with-alloplastic-bone-graft-material-in-the-management-of-human-two-wall-intra-osseous-defects
#8
Renu Devi, Jaya Dixit
INTRODUCTION: In recent years, emphasis on the use of growth factors for periodontal healing is gaining great momentum. Several growth factors showed promising results in periodontal regeneration. AIM: This study was designed to compare the clinical outcomes of 0.8μg recombinant human Vascular Endothelial Growth Factor (rh-VEGF) and 10μg recombinant human Insulin Like Growth Factor-I (rh-IGF-I) with β-Tricalcium Phosphate (β-TCP) and Polylactide-Polyglycolide Acid (PLGA) membrane in two wall intra-osseous defects...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27785580/management-of-scaphoid-nonunions-with-vascularized-bone-grafts-from-the-distal-radius-mid-to-long-term-follow-up
#9
Konstantinos N Malizos, Zoe Dailiana, Sokratis Varitimidis, Antonios Koutalos
Scaphoid nonunion represents a challenging problem that leads to disability if neglected. Vascularized bone grafts are proposed to augment the local biology and increase the likelihood of union but long-term outcomes are sparse. In this work, we present the mid- to long-term outcome of 140 scaphoid nonunions managed with vascularized bone grafts from the distal radius. Sixteen patients underwent concomitant closed wedge osteotomy of the distal radius because of arthritic changes. There were 130 males and ten females, with mean time from injury to surgery 3...
October 26, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27761662/non-vascularized-bone-grafting-in-scaphoid-nonunion-principles-and-type-of-fixation
#10
Ryoko Uesato, Satoshi Toh, Yoshimitsu Hayashi, Keiichiro Maniwa, Yasuyuki Ishibashi
In scaphoid fractures, delayed diagnosis and nonunion are fairly common as a result of several factors, including the difficulty of radiographic diagnosis of non-displaced fractures and underestimation of the injury by the patient. Main factors to consider when deciding treatment are the type of fracture and fracture stability. In the stable nonunion (Type D1 according to the Filan and Herbert classification, or linear type of Ikeda's classification), percutaneous screw fixation without bone graft is recommended...
October 19, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27704164/human-multipotent-adult-progenitor-cells-enhance-islet-function-and-revascularisation-when-co-transplanted-as-a-composite-pellet-in-a-mouse-model-of-diabetes
#11
João Paulo M C M Cunha, Gunter Leuckx, Peter Sterkendries, Hannelie Korf, Gabriela Bomfim-Ferreira, Lutgart Overbergh, Bart Vaes, Harry Heimberg, Conny Gysemans, Chantal Mathieu
AIMS/HYPOTHESIS: Hypoxia in the initial days after islet transplantation leads to considerable loss of islet mass and contributes to disappointing outcomes in the clinical setting. The aim of the present study was to investigate whether co-transplantation of human non-endothelial bone marrow-derived multipotent adult progenitor cells (MAPCs), which are non-immunogenic and can secrete angiogenic growth factors during the initial days after implantation, could improve islet engraftment and survival...
January 2017: Diabetologia
https://www.readbyqxmd.com/read/27628593/-pedicled-vascularized-bone-graft-for-scaphoid-reconstruction-after-zaidemberg
#12
B Schacher, R Böttcher, A Vogel, A Asmus, S Kim, A Eisenschenk, F Eichenauer
BACKGROUND: Nonunion of the scaphoid as a result of proximal fractures, failed surgical reconstruction, and especially avascular fragment necrosis are possible indications of vascularized bone grafts. Various techniques of vascularized (pedicled and free) grafts have been described. Pedicled grafts from the direct vicinity of the wrist provide several benefits. Harvest-site morbidity is reduced and preserved graft perfusion, without the need for blood vessel anastomosis, may lead to an improved consolidation...
September 15, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27580650/the-use-of-a-collagenated-porcine-cortical-lamina-in-the-reconstruction-of-alveolar-ridge-defects-a-clinical-and-histological-study
#13
Roberto Rossi, Davide Rancitelli, Pier P Poli, Marco Rasia Dal Polo, Ulf Nannmark, Carlo Maiorana
BACKGROUND: Alveolar ridge reconstruction by means of resorbable and non-resorbable membranes has been proposed to increase the hard tissue volume in deficient sites. The purpose of this study was therefore to clinically and histologically evaluate the use of collagenated porcine bone lamina in case of horizontal and vertical bone augmentation procedures in conjunction with particulate porcine xenograft. METHODS: Overall, 8 partially edentulous patients (6 females and 2 males) with a mean age of 45 years requiring bone regeneration procedures to achieve a prosthetically driven implant placement were enrolled...
October 2016: Minerva Stomatologica
https://www.readbyqxmd.com/read/27516833/reconstruction-of-continuity-defects-of-the-mandible-with-non-vascularized-bone-grafts-systematic-literature-review
#14
REVIEW
Babatunde Olayemi Akinbami
BACKGROUND: The use of NVBG for mandibular defects seems to be gradually giving way for more advanced reconstructive techniques but it has the advantages of shorter operating time and lesser amount of blood loss. The aim of this study was to review the available data on the success and failure rates of use of NVBG and factors associated with failure. METHOD: Studies published from 1978 to 2014 regarding the use of NVBG were searched. Most important information was graft success and failure outcomes...
September 2016: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/27511468/persistent-non-union-of-the-humeral-shaft-treated-by-plating-and-autologous-bone-grafting
#15
Tristan Pollon, Nicolas Reina, Stéphanie Delclaux, Paul Bonnevialle, Pierre Mansat, Nicolas Bonnevialle
INTRODUCTION: Surgical treatment of persistent non-union of the humeral shaft is a complex situation because of the risk of failure and surgery-related complications. The primary objective of this study was to evaluate clinical and radiological results of a continuous series of persistent non-union treated with plating and bone grafting. The secondary objective was to expose factors contributing to the failure of prior bone union attempts. MATERIAL AND METHODS: Sixteen patients (average age of 52 years) were treated for persistent non-union of the humeral shaft in our department; six of these patients had predisposing comorbidities or addictions...
August 10, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27477992/surgical-treatment-options-for-septic-non-union-of-the-tibia-two-staged-operation-flow-through-anastomosis-of-fvfg-and-continuous-local-intraarterial-infusion-of-heparin
#16
Ryoichi Kawakami, Soichi Ejiri, Michiyuki Hakozaki, Satoshi Hatashita, Nobuyuki Sasaki, Yoshitaka Kobayashi, Yoko Takahashi, Shin-Ichi Konno
BACKGROUND: The treatment of septic non-union of the tibia is a challenging area. The objective of this clinical study was to improve the treatment outcomes in patients with a highly active infection by the three strategies consisting of a two-staged operation, a flow-through technique for vascular anastomosis of a free vascularized fibular graft (FVFG), and continuous local intra-arterial infusion of heparin. PATIENTS & METHOD: Five patients with septic non-union of the tibia who were treated with an FVFG (mean age: 52...
December 16, 2016: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/27362810/the-use-of-a-collagenated-porcine-cortical-lamina-in-the-reconstruction-of-alveolar-ridge-defects-a-clinical-and-histological-study
#17
Roberto Rossi, Davide Rancitelli, Pier P Poli, Marco Rasia Dal Polo, Ulf Nannmark, Carlo Maiorana
BACKGROUND: Alveolar ridge reconstruction by means of resorbable and non-resorbable membranes has been proposed to increase the hard tissue volume in deficient sites. The purpose of this study was therefore to clinically and histologically evaluate the use of collagenated porcine bone lamina in case of horizontal and vertical bone augmentation procedures in conjunction with particulated porcine xenograft. METHODS: Overall, 8 partially edentulous patients (6 females and 2 males) with a mean age of 45 years requiring bone regeneration procedures to achieve a prosthetically driven implant placement were enrolled...
June 30, 2016: Minerva Stomatologica
https://www.readbyqxmd.com/read/27316391/bone-regeneration-strategies-with-bone-marrow-stromal-cells-in-orthopaedic-surgery
#18
REVIEW
J Stanovici, L-R Le Nail, M A Brennan, L Vidal, V Trichet, P Rosset, P Layrolle
Bone is the most transplanted tissue human with 1 million procedures every year in Europe. Surgical interventions for bone repair are required for varied reasons such as trauma resulting non-union fractures, or diseases including osteoporosis or osteonecrosis. Autologous bone grafting is the gold standard in bone regeneration but it requires a second surgery with associated pain and complications, and is also limited by harvested bone quantity. Synthetic bone substitutes lack the osteoinductive properties to heal large bone defects...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27293290/management-of-traumatic-tibial-diaphyseal-bone-defect-by-induced-membrane-technique
#19
Gaurav Gupta, Sohail Ahmad, Mohd Zahid, A H Khan, M K A Sherwani, Abdul Qayyum Khan
BACKGROUND: Gap nonunion of long bones is a challenging problem, due to the limitation of conventional reconstructive techniques more so if associated with infection and soft tissue defect. Treatment options such as autograft with non-vascularized fibula and cancellous bone graft, vascularized bone graft, and bone transportation are highly demanding on the part of surgeons and hospital setups and have many drawbacks. This study aims to analyze the outcome of patients with wide diaphyseal bone gap treated with induced-membrane technique (Masquelet technique)...
May 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27277947/fibula-regeneration-following-non-vascularized-graft-harvest-in-children
#20
Anil Agarwal, Anubrat Kumar
BACKGROUND: A peculiarity of non-vascularized fibular harvest is that the donor site regenerates new bone provided periosteum is preserved. We prospectively investigated the regenerated fibula quantitatively and studied clinical implications of non-regeneration. MATERIAL AND METHODS: The fibula was harvested using a periosteum preserving technique. Only fibulae from healthy legs were harvested. X-rays were done pre- and post-operatively at three and six months...
June 8, 2016: International Orthopaedics
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