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Non vascularized bone grafts

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https://www.readbyqxmd.com/read/29781768/guided-bone-regeneration-and-implant-placement-in-association-with-a-coronally-positioned-palatal-sliding-flap-a-17-year-follow-up-case-report
#1
Carlo Maiorana, Pier Paolo Poli, Mario Beretta
The aim of the present case report was to show the 17-year hard and soft tissues stability of guided bone regeneration procedure associated with dental implants insertion. A 52-year-old male patient presented with a partial edentulism in the upper right maxilla. A graft consisting of deproteinized bovine bone mineral and autogenous bone stabilized by a non-resorbable expanded polytetrafluoroethylene membrane was used to reconstruct the missing bone applying the biological principles of guided bone regeneration...
May 21, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29721346/hsct-gave-as-a-manifestation-of-chronic-graft-versus-host-disease-a-case-report-and-review-of-the-existing-literature
#2
Michael J Grant, Mitchell E Horwitz
Gastric antral vascular ectasia or "watermelon stomach" is a significant cause of nonvariceal upper GI bleeding and is characterized by red, tortuous ectatic vessels along longitudinal folds in the gastric antrum. The existing literature links GAVE to patients with cirrhosis, scleroderma, bone marrow transplantation, and chronic renal failure among other associations, but its pathophysiology remains ill-defined. Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding...
2018: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29719912/vascularized-bone-grafting-for-reconstruction-of-oncologic-defects-in-the-spine-a-systematic-review-and-pooled-analysis-of-the-literature
#3
Rachel Pedreira, Charalampos Siotos, Brian H Cho, Stella M Seal, Deepa Bhat, Hannah M Carl, Michelle Seu, J P Wolinksy, Justin M Sacks
BACKGROUND:  Resection of primary spinal tumors requires reconstruction for restoration of spinal column stability. Traditionally, some combination of bone grafting and instrumentation is implemented. However, delayed healing environments are associated with pseudoarthrodesis and failure. Implementation of vascularized bone grafting (VBG) to complement hardware may present a solution. We evaluated the use of VBG in oncologic spinal reconstruction via systematic review and pooled analysis of literature...
May 2, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29699851/blockade-of-adhesion-molecule-lymphocyte-function-associated-antigen-1-improves-long-term-heart-allograft-survival-in-mixed-chimeras
#4
Nina Pilat, Philipp Sabler, Christoph Klaus, Benedikt Mahr, Lukas Unger, Karin Hock, Mario Wiletel, Christoph Schwarz, Ivan Kristo, Heinz Regele, Thomas Wekerle
BACKGROUND: The mixed chimerism approach for intentional induction of donor-specific tolerance was shown to be successful in various models from mice to humans. For transplant patients, the approach would obviate the need for long-term immunosuppression and associated side effects; moreover, it would preclude the risk of late graft loss due to chronic rejection. Widespread clinical application is hindered by toxicities related to recipient pre-conditioning. Herein we aimed to investigate a clinically relevant protocol for tolerance induction to cardiac allografts, sparing CD40 blockade or T-cell depletion...
March 30, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29673055/application-of-mesenchymal-stem-cells-to-enhance-non-union-bone-fracture-healing
#5
Mohammad Mousaei Ghasroldasht, Maryam M Matin, Hossein Kazemi Mehrjerdi, Hojjat Naderi-Meshkin, Ali Moradi, Masoud Rajabioun, Faeze Alipour, Samaneh Ghasemi, Mohammad Zare, Mahdi Mirahmadi, Hamid Reza Bidkhori, Ahmad Reza Bahrami
ECM components include a number of osteoinductive and osteoconductive factors, which are involved in bone fracture healing. In this study, a combination of adipose derived mesenchymal stem cells (Ad-MSCs), cancellous bone graft (CBG), and chitosan hydrogel (CHI) was applied to the in non-union bone fracture and healing effects were evaluated for the first time. After creation of animal models with non-union fracture in rats, they were randomly classified into seven groups. Radiography at 0, 2, 4 and 8 weeks after surgery, indicated the positive effects of Ad-MSCs+CBG+CHI and Ad-MSCs+CBG in treatment of bone fractures as early as 2 weeks after the surgery...
April 19, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29658528/gait-changes-in-patients-after-reconstruction-of-facial-bones-with-fibula-and-iliac-crest-free-vascularized-flaps
#6
Małgorzata Syczewska, Romuald Krajewski, Monika Kirwil, Ewa Szczerbik, Małgorzata Kalinowska
PURPOSE: Patients with malignant tumours of the oral cavity require its surgical removal and reconstruction of the bone and soft tissues. The grafts are obtained either from leg (fibula) or pelvis (iliac crest). The removal of grafts from the locomotor apparatus can impair the gait. The aim of this study was to find out how the localization of donor site influences the gait pattern. METHODS: Results obtained for 30 patients were analyzed (16 fibula graft, 14 iliac crest graft)...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29600207/treating-a-recalcitrant-non-union-of-the-radius-using-autogenous-bone-equine-bone-paste-equine-demineralized-bone-matrix-platelet-rich-plasma-and-bone-marrow-aspirate-a-case-report
#7
Ferdinando Da Rin De Lorenzo
Introduction: Non-unions at forearms are usually challenging and difficult to treat. If additionally, an infection is present, reconstructive surgery should be planned only after full debridement, antibiotic treatment, and confirmation, based on clinical observation and laboratory tests that the infection has subsided. Bone grafting may be required for reconstruction. The use of autogenous bone calls for a second surgical site with an increased risk of morbidity. Using bone substitutes may reduce the need for autogenous bone...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29551943/repair-of-bone-defect-of-the-lateral-forefoot-by-double-segment-triangular-fibula-flap-with-vascular-pedicle-a-case-report
#8
Ruifu Yang, Mingwu Zhou, Chaofeng Xing, Shimin Li, Li Song, Jia Chen, Yingjie Xiong, Kai Zhang
Objective: To expound the clinical effect of a new operation by transplanting double segment triangular fibula flap with vascular pedicle to repair the forefoot with lateral bone defect, and to study how to improve the operation method in the following stage. Methods: The inclusion criteria: More than 2 phalangeal and metatarsal bones defects of the lateral forefoot, widespread skin and soft tissue defects on pelma and dorsal foot, and destruction of the anterior aspect of foot arch, which seriously affects the foot function...
December 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29441709/multifunctional-cell-instructive-silk-bioactive-glass-composite-reinforced-scaffolds-toward-osteoinductive-proangiogenic-and-resorbable-bone-grafts
#9
Joseph Christakiran Moses, Samit Kumar Nandi, Biman B Mandal
The successful regeneration of large volume bone defects necessitates the use of proangiogenic and resorbable scaffolding matrix. Impaired and slow ingrowth of host vasculature within implanted grafts greatly compromises its effective osseointegration. By addressing this, it is demonstrated that the use of copper doped bioactive glass functionalizes silk microfiber reinforcements to improve the physicochemical and osteoinductive properties of two silk scaffolding matrices (mulberry Bombyx mori and non-mulberry Antheraea assama) employed in the study...
February 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29427540/novel-standardized-massive-bone-defect-model-in-rats-employing-an-internal-eight-hole-stainless-steel-plate-for-bone-tissue-engineering
#10
Huijie Jiang, Pengzhen Cheng, Donglin Li, Junqin Li, Jimeng Wang, Yi Gao, Shuaishuai Zhang, Tianqing Cao, Chunmei Wang, Liu Yang, Guoxian Pei
Massive bone defects are a challenge in orthopaedic research. Defective regeneration leads to bone atrophy, non-union of bone, and physical morbidity. Large animals are important models, however, production costs are high, nursing is complex, and evaluation methods are limited. A suitable laboratory animal model is required to explore the underlying molecular mechanism and cellular process of bone tissue engineering. We designed a stainless steel plate with 8 holes; the middle 2 holes were used as a guide to create a standardized critical size defect in the femur of anaesthetized rats...
April 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29290185/non-vascularized-autogenous-bone-grafts-for-reconstruction-of-maxillofacial-osseous-defects
#11
Waseem Ahmed, Muhammad Adil Asim, Afeefa Ehsan, Qalab Abbas
OBJECTIVE: To determine the outcomes of non-vascularized bone grafts for reconstruction of maxillofacial defects. STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Department of Oral and Maxillofacial Surgery, Armed Forces Institute of Dentistry, Rawalpindi, from January 2013 to December 2015. METHODOLOGY: Descriptive analyses of 30 patients, who underwent maxillofacial reconstruction with non-vascularized bone grafts, were conducted...
January 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29234656/amputation-risk-after-the-revascularization-procedures-in-sarcoma-resections
#12
Luiz Eduardo Moreira Teixeira, Thiago Marques Leão, Daniel Barbosa Regazzi, Cláudio Beling Gonçalves Soares
Objective: The objective of this study is to evaluate the efficacy of vascular reconstructive surgery after resection of bone and soft tissue tumors in extremities and the risk of progression to amputation. Methods: This is a retrospective, observational data collection from medical records of patients who underwent resection of bone and soft tissue tumors in the period of 2002-2015. Thirteen patients met the inclusion criteria, which evaluated the correlations between certain factors (gender, tumor type, location, reconstruction, revascularization and patency, infection) with amputation in the postoperative period...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234645/bone-graft-in-the-treatment-of-nonunion-of-the-scaphoid-with-necrosis-of-the-proximal-pole-a-literature-review
#13
Antônio Lourenço Severo, Marcelo Barreto Lemos, Osvandré Luiz Canfield Lech, Danilo Barreto Filho, Daniel Paulo Strack, Larissa Knapp Candido
Scaphoid fractures are the most common fractures of the carpal bones, corresponding to 60%. Of these, 10% progress to nonunion; moreover, 3% can present necrosis of the proximal pole. There are various methods of treatment using vascularized and non-vascularized bone grafts. To evaluate and compare the rate of scaphoid consolidation with necrosis of the proximal pole using different surgical techniques. The authors conducted a review of the literature using the following databases: PubMed and BIREME/LILACS, where 13 case series were selected (ten with use of vascularized bone grafts and three of non-vascularized bone grafts), according to inclusion and exclusion criteria...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29165014/fixation-of-proximal-pole-scaphoid-nonunion-with-non-vascularized-cancellous-autograft
#14
Timothy J Luchetti, Allison J Rao, John J Fernandez, Mark S Cohen, Robert W Wysocki
We present 20 patients with established proximal pole scaphoid nonunions treated with curettage and cancellous autograft from the distal radius and screw fixation. Fractures with significant proximal pole fragmentation were excluded. Patients were treated at a mean of 26 weeks after injury (range 12-72). Union occurred in 18 of 20 patients (90%) based on computed tomographic imaging. The two nonunions that did not heal were treated with repeat curettage and debridement and iliac crest bone grafting without revision of fixation...
January 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29114187/use-of-fibular-bone-graft-and-cancellous-screw-fixation-in-the-management-of-neglected-femur-neck-fractures-in-young-patients
#15
Ghulam Mustafa Kaim Khani, Kamran Hafeez, Muhammad Bux, Nusrat Rasheed, Naveed Ahmed, M Perwez Anjum
Objective: To present the clinical outcome of patients with neglected femur neck fracture treated with fibular bone graft. Methods: During May 2010-February 2013, 15 patients younger than 35 years of age with neglected fracture neck of femur were managed with non-vascularized fibular graft and cannulated screws. Fractures were classified according to Sandhu Classification. Hip function was assessed using Harris hip score. Results: Fifteen patients with mean age of 28...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29105591/treatment-of-the-scaphoid-humpback-deformity-is-correction-of-the-dorsal-intercalated-segment-instability-deformity-critical
#16
Christophe L Mathoulin, Margareta Arianni
Treatment of scaphoid fractures has been focused mainly on achieving union, with less attention to restoring normal scaphoid shape and orientation. Malalignment of one carpal bone will disrupt the kinetics of the entire wrist. The dorsal intercalated segment instability deformity associated with scaphoid waist nonunion is a nondissociative form of carpal instability. It has to be reduced in the treatment of scaphoid waist nonunions to avoid kinetic problems that will lead to arthritic changes. Computerized tomography scanning has become indispensable to visualize the humpback deformity clearly...
January 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29071736/histopathological-comparison-of-healing-after-maxillary-sinus-augmentation-using-xenograft-mixed-with-autogenous-bone-versus-allograft-mixed-with-autogenous-bone
#17
Pablo Galindo-Moreno, Juan G de Buitrago, Miguel Padial-Molina, Juan Emilio Fernández-Barbero, Javier Ata-Ali, Francisco O Valle
OBJECTIVE: To compare the clinical and histologic outcomes of two different grafting materials (allograft and xenograft) when combined with autogenous bone and covered with a collagen membrane for sinus augmentation. MATERIAL AND METHODS: A parallel case series of fourteen patients in need of a unilateral sinus augmentation was evaluated in this study. Seven patients received a graft composed by autologous cortical bone (ACB) and anorganic bovine bone in a ratio of 1:1; the other seven patients received ACB mixed with an allograft in the same ratio...
February 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28945157/success-of-scaphoid-nonunion-surgery-is-independent-of-proximal-pole-vascularity
#18
Schneider K Rancy, Morgan M Swanstrom, Edward F DiCarlo, Darryl B Sneag, Steve K Lee, Scott W Wolfe
We followed 35 consecutive patients with scaphoid nonunions in a prospective longitudinal registry. All nonunions were treated with curettage, non-vascularized autogenous grafting and headless screw fixation. Preoperative magnetic resonance imaging, intraoperative bleeding points and histopathological analysis of cancellous bone in the proximal pole were recorded as measures of viability. Healing was categorized as ≥50% bony bridging on computed tomographic images in the plane of the scaphoid. Nine of 23 proximal poles demonstrated ischaemia on magnetic resonance imaging but none were interpreted as infarcted...
January 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28893145/non-vascularized-iliac-bone-grafting-for-scaphoid-nonunion-with-avascular-necrosis
#19
Jihyeung Kim, Jin Woo Park, Jeehyeok Chung, Kee Jeong Bae, Hyun Sik Gong, Goo Hyun Baek
We present the surgical outcomes of non-vascularized bone grafting taken from the iliac crest in 24 patients with scaphoid nonunion and avascular necrosis. The Fisk-Fernandez technique was used in 11 patients, and cancellous bone grafting was used in 13 patients. Bony union was achieved in 22 of the 24 patients. Non-vascularized iliac bone grafting can be used for the surgical management of scaphoid nonunion with avascular necrosis. Although revascularization of the proximal fragment after surgery was not evaluated, bony union was confirmed in nearly all patients...
January 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28874877/bone-regeneration-in-minipigs-by-intrafibrillarly-mineralized-collagen-loaded-with-autologous-periodontal-ligament-stem-cells
#20
Ci Zhang, Boxi Yan, Zhen Cui, Shengjie Cui, Ting Zhang, Xuedong Wang, Dawei Liu, Ruli Yang, Nan Jiang, Yanheng Zhou, Yan Liu
Biomimetic intrafibrillarly-mineralized collagen (IMC) is a promising scaffold for bone regeneration because of its structural and functional similarity to natural bone. The objective of this study was to evaluate the bone regeneration potential of IMC loaded with autologous periodontal ligament stem cells (PDLSCs) in large bone defects in minipigs. A macroporous IMC with a bone-like subfibrillar nanostructure was fabricated using a biomimetic bottom-up approach. Non-healing full thickness defects were established on the cranial bone in minipigs, and IMC and hydroxyapatite (HA) scaffolds seeded with autologous PDLSCs were implanted into these defects...
September 5, 2017: Scientific Reports
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