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Allotransplantation

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https://www.readbyqxmd.com/read/29775981/from-auto-to-allotransplantation-immunomodulatory-protocol-for-hand-and-arm-transplantation
#1
W P Andrew Lee, Jaimie T Shores, Gerald Brandacher
AIM:  To achieve a favorable risk-benefit balance for hand transplantation, an immunomodulatory protocol was developed in the laboratory and translated to clinical application. METHODS:  Following donor bone marrow infusion into transplant recipients, hand and arm allografts have been maintained on low-dose tacrolimus monotherapy. RESULTS:  Good-to-excellent functional recovery has been achieved in patients compliant with medication and therapy, thus restoring autonomous and productive lives...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29771837/face-of-the-future-lessons-learned-and-opportunities-in-composite-allotransplantation
#2
Rami S Kantar, J Rodrigo Diaz-Siso, Eduardo D Rodriguez
No abstract text is available yet for this article.
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29760704/exploring-the-immunomodulatory-moonlighting-activities-of-acute-phase-proteins-for-tolerogenic-dendritic-cell-generation
#3
REVIEW
Inmaculada Serrano, Ana Luque, Josep M Aran
The acute phase response is generated by an overwhelming immune-inflammatory process against infection or tissue damage, and represents the initial response of the organism in an attempt to return to homeostasis. It is mediated by acute phase proteins (APPs), an assortment of highly conserved plasma reactants of seemingly different functions that, however, share a common protective role from injury. Recent studies have suggested a crosstalk between several APPs and the mononuclear phagocyte system (MPS) in the resolution of inflammation, to restore tissue integrity and function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29755481/-phage-transplantation-in-allotransplantation-possible-treatment-in-graft-versus-host-disease
#4
Andrzej Górski, Ewa Jończyk-Matysiak, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Jan Borysowski
Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29752586/comparison-of-tracheal-reconstruction-with-allograft-fresh-xenograft-and-artificial-trachea-scaffold-in-a-rabbit-model
#5
Jae Yeon Lee, Jeong Hun Park, Dong-Woo Cho
This study evaluated the possibility of tracheal reconstruction with allograft, pig-to-rabbit fresh xenograft or use of a tissue-engineered trachea, and compared acute rejection of three different transplanted tracheal segments in rabbits. Eighteen healthy New Zealand White rabbits weighing 2.5-3.1 kg were transplanted with three different types of trachea substitutes. Two rabbits and two alpha 1, 3-galactosyltransferase gene-knockout pigs weighing 5 kg were used as donors. The rabbits were divided into three groups: an allograft control group consisting of rabbit-to-rabbit allotransplantation animals (n = 6), a fresh xenograft group consisting of pig-to-rabbit xenotransplantation animals (n = 6), and an artificial trachea scaffold group (n = 6)...
May 12, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29746324/extracorporeal-perfusion-in-vascularized-composite-allotransplantation-current-concepts-and-future-prospects
#6
Maximilian Kueckelhaus, Flemming Puscz, Alexander Dermietzel, Mehran Dadras, Sebastian Fischer, Nicco Krezdorn, Bohdan Pomahac, Tobias Hirsch
Severe injuries of the face and limbs remain a major challenge in today's reconstructive surgery. Vascularized composite allotransplantation (VCA) has emerged as a promising approach to restore these defects. Yet, there are major obstacles preventing VCA from broad clinical application. Two key restrictions are (1) the graft's limited possible ischemia time, keeping the potential donor radius extremely small, and (2) the graft's immunogenicity, making extensive lifelong monitoring and immunosuppressive treatment mandatory...
June 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29723921/de-novo-belatacept-in-clinical-vascularized-composite-allotransplantation
#7
Linda C Cendales, David S Ruch, Adela R Cardones, Guy Potter, Joshua Dooley J, Daniel Dore, Jonah Orr, Gregory Ruskin, Minqing Song, Dong-Feng Chen, Maria A Selim, Allan D Kirk
Most immunosuppressive regimens used in clinical vascularized composite allotransplantation (VCA) have been calcineurin inhibitor (CNI)-based. As such, most recipients have experienced CNI-related side effects. Costimulation blockade, specifically CD28/B7 inhibition with belatacept, has emerged as a clinical replacement for CNI-based immunosuppression in kidney transplantation. We have previously shown that belatacept can be used as a centerpiece immunosuppressant for VCA in non-human primates, and subsequently reported successful conversion from a CNI-based regimen to a belatacept-based regimen after clinical hand transplantation...
May 3, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29722767/amniotic-epithelial-stem-cells-salient-features-and-possible-therapeutic-role
#8
Aurelio Muttini, Barbara Barboni, Luca Valbonetti, Valentina Russo, Nicola Maffulli
This is a study of amniotic epithelial cells, which form the innermost layer of the amniotic membrane. These cells can be easily isolated and display peculiar and unique properties, such as plasticity and differentiation potential toward the 3 germinal layers, that may aid regeneration and/or repair of damaged or diseased tissues and organs. A robust literature based on in vitro, experimental, and clinical studies in large animals demonstrates that these cells can enhance the regeneration of tendons, bone, and articular cartilage...
June 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29716634/successful-fertility-following-optimized-perfusion-and-cryopreservation-of-whole-ovary-and-allotransplantation-in-a-premature-ovarian-insufficiency-rat-model
#9
Yan Ding, Jia-Liang Shao, Jun-Wei Li, Ying Zhang, Kai-Hua Hong, Ke-Qin Hua, Xiang Wang
BACKGROUND: Fertility preservation by whole ovary cryopreservation and transplantation (WOCP&TP) with vascular anastomosis requires successful cryopreservation. In this study, we investigated the possibility of restoring ovarian function and natural fertility after WOCP&TP in a premature ovarian insufficiency (POI) rat model. The influence of cryopreservation on the offspring of rats following WOCP&TP was also explored. METHOD: Rats aged 8-10 weeks were used as donors and recipients for allotransplantation...
May 2, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29707495/a-reassessment-of-tracheal-substitutes-a-systematic-review
#10
REVIEW
Brooks Udelsman, Douglas J Mathisen, Harald C Ott
Background: Tracheal substitutes remain an active area of research. For rare patients with large or complex defects that cannot be repaired primarily, replacement of the airway may represent the only treatment option. The present systematic review aims to assess the clinical successes and setbacks of current methods of airway replacement. Methods: Systematic review using Medline and PubMed from 01 January 2000 to 01 October 2017 focusing on clinical translation of circumferential or near circumferential (>270°) tracheal substitutes...
March 2018: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29704864/from-autotransplantation-to-allotransplantation-a-perspective-on-the-future-of-reconstructive-microsurgery
#11
L Scott Levin
It has been half a century since Susumu Tamai reported on the first thumb replantation. The evolution of reconstructive microsurgery has continually added new applications of the operating microscope for reconstructive surgery and has had profound impact on countless patients. From the time of Harold Gillies until today, the reconstructive ladder has evolved to a reconstructive elevator with the "penthouse" floor being represented by vascularized composite allotransplantation.
April 28, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29698991/the-battle-ground-between-two-giants-toe-transfer-and-hand-allotransplantation
#12
Fu-Chan Wei, Nidal F Al Deek
A few severe hand injuries represent a gray zone for the reconstructive surgeon, for which autologous tissue transfer and allotransplantation can yield satisfactory results, but not without downsides or morbidity.This article is written to address the dilemma of application of both techniques in those selected cases.
April 26, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29679150/ten-year-comparative-analysis-of-incidence-prognosis-and-associated-factors-for-dialysis-and-renal-transplantation-in-type-1-and-type-2-diabetes-versus-non-diabetes
#13
Carlo Bruno Giorda, Paolo Carnà, Mario Salomone, Roberta Picariello, Giuseppe Costa, Barbara Tartaglino, Roberto Gnavi
AIMS: To study the incidence of and the factors associated with renal dialysis and transplantation in type 1 (T1DM) and type 2 diabetes (T2DM). METHODS: Data on individuals who had received dialysis treatment or renal transplant between 1 January 2004 and 31 December 2013 were extracted from the regional administrative database (Piedmont, Italy), and the crude (cumulative) incidence of dialysis was calculated. Overall cumulative survival was estimated using the Kaplan-Meier method and compared using the log-rank test...
April 20, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29630119/intramuscular-islet-allotransplantation-in-type-1-diabetes-mellitus
#14
F Bertuzzi, G Colussi, A Lauterio, L De Carlis
OBJECTIVE: Alternative sites to the liver for islet transplantation have been studied for a long time. Intramuscular islet transplantation appears to be an alternative site to the liver because of the ease of access. First islet autotransplantations were reported in patients after total pancreatectomies. The transplanted islets showed a proper revascularization and their function was observed for up to 2 years after the implant. However, only a few cases of autotransplantation and no allotransplantation have been performed...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29620616/meeting-report-of-the-13th-congress-of-the-international-society-of-vascularized-composite-allotransplantation
#15
Annemarie Weissenbacher, Linda Cendales, Emmanuel Morelon, Palmina Petruzzo, Gerald Brandacher, Peter J Friend, Vijay Gorantla, Christina Kaufman, Johanna Krapf, Lawrence Scott Levin, Georgios Vrakas, Stefan Schneeberger
The International Society of Vascularized Composite Allotransplantation (ISVCA) held its 13th congress "Defining Success" in October 2017 in Salzburg, Austria. A total of 122 delegates from 22 countries representing 5 continents attended the conference. The theme strived to provide pathways to accomplish best possible outcomes in this unique and multifaceted field of transplantation. 'Ignite talks', a new feature introduced for the first time at the Salzburg meeting served as key elements for productive discussions on both congress days...
April 3, 2018: Transplantation
https://www.readbyqxmd.com/read/29597032/current-advanced-therapy-cell-based-medicinal-products-for-type-1-diabetes-treatment
#16
REVIEW
Alberto Cañibano-Hernández, Laura Sáenz Del Burgo, Albert Espona-Noguera, Jesús Ciriza, Jose Luis Pedraz
In the XXI century diabetes mellitus has become one of the main threats to human health with higher incidence in regions such as Europe and North America. Type 1 diabetes mellitus (T1DM) occurs as a consequence of the immune-mediated destruction of insulin producing β-cells located in the endocrine part of the pancreas, the islets of Langerhans. The administration of exogenous insulin through daily injections is the most prominent treatment for T1DM but its administration is frequently associated to failure in glucose metabolism control, finally leading to hyperglycemia episodes...
March 27, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29595735/a-new-composite-eyeball-periorbital-transplantation-model-in-humans-an-anatomical-study-in-preparation-for-eyeball-transplantation
#17
Maria Siemionow, Mehmet Bozkurt, Fatih Zor, Yalcin Kulahci, Safak Uygur, Can Ozturk, Risal Djohan, Frank Papay
BACKGROUND: Vascularized composite allotransplantation offers a new hope for restoration of orbital content and perhaps vision. The aim of this study was to introduce a new composite eyeball-periorbital transplantation model in fresh cadavers in preparation for composite eyeball allotransplantation in humans. METHODS: The composite eyeball-periorbital transplantation flap borders included the inferior border, outlined by the infraorbital rim; the medial border, created by the nasal dorsum; the lateral border, created by the lateral orbital rim; and the superior border, created by the superior part of the eyebrow...
April 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29570522/allotransplantation-from-dream-to-reality
#18
Denys Montandon
No abstract text is available yet for this article.
March 22, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29570162/il-34-inhibits-acute-rejection-of-rat-liver-transplantation-by-inducing-kupffer-cell-m2-polarization
#19
Zhengfei Zhao, Guangrui Pan, Chengyong Tang, Zhongtang Li, Daofeng Zheng, Xufu Wei, Zhongjun Wu
BACKGROUND: Recent studies have demonstrated that IL-34 is implicated in the regulation of macrophage functions. However, the effect of IL-34 on Kupffer cells (KCs) in acute rejection (AR) of liver transplantation remains unclear. METHODS: IL-34 expression was detected in graft and serum from allotransplantation and syngeneic transplantation groups. The adeno-associated virus expressing IL-34 (AAV-IL-34) was used to assess the effect of IL-34 on AR of rat liver transplantation...
March 22, 2018: Transplantation
https://www.readbyqxmd.com/read/29565508/islet-transplantation-30-years-after-the-first-transplants
#20
B Antonioli, M Galuzzi
First clinical islet allotransplantation in patients affected by type 1 diabetes mellitus was performed about 30 years ago. Despite the progressive improvement of the success rate, the clinical indication to the islet allotransplantation remains limited to selected patients affected by brittle type 1 diabetes mellitus. The burden of the immunosuppression therapy still represents the main critical issue but other areas might be subject to further improvements, such as the islet production, islet engraftment and long-term function...
March 2018: European Review for Medical and Pharmacological Sciences
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