keyword
MENU ▼
Read by QxMD icon Read
search

Oxycontin

keyword
https://www.readbyqxmd.com/read/29613851/an-innovative-solution-to-detect-classify-and-report-illicit-online-marketing-and-sales-of-controlled-substances-via-twitter-project-finalist-at-hhs-opioid-code-a-thon
#1
Tim Mackey, Janani Kalyanam, Josh Klugman, Ella Kuzmenko, Rashmi Gupta
BACKGROUND: On December 6-7, 2017, the U.S. Department of Health and Human Services hosted its first Code-a-Thon event aimed at leveraging technology and data-driven solutions to help combat the opioid epidemic. Authors, comprised of an interdisciplinary team from academia, the private sector, and the U.S. Centers for Disease Control and Prevention, participated in the Code-a-Thon as part of the "Prevention" track. OBJECTIVE: To develop and deploy a methodology using machine learning to accurately detect the marketing and sale of opioids by illicit online sellers via Twitter as part of participation at the HHS Opioid Code-a-Thon event...
March 27, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29582347/in-vitro-assessment-of-nasal-insufflation-of-comminuted-drug-products-designed-as-abuse-deterrent-using-the-vertical-diffusion-cell
#2
Heather Boyce, Dan Smith, Steve Byrn, Bhawana Saluja, Wen Qu, Vadim J Gurvich, Stephen W Hoag
In vitro evaluation of abuse deterrent formulations (ADFs) is a challenge since real abuse situations are variable and ADF technology is evolving. Specifically, an assessment of an ADF to deter nasal insufflation would be valuable. In this study, a vertical diffusion cell (VDC) was used to evaluate polyethylene oxide (PEO)-based tablets manipulated by three different forces. The commercially available products Oxycontin®, an ADF, Opana®, and metoprolol tartrate tablet formulations made in our laboratory were studied...
March 26, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29557812/new-opioid-analgesic-approvals-and-outpatient-utilization-of-opioid-analgesics-in-the-united-states-1997-through-2015
#3
Grace Chai, Jing Xu, James Osterhout, Mark A Liberatore, Kathleen L Miller, Carolyn Wolff, Marisa Cruz, Peter Lurie, Gerald Dal Pan
BACKGROUND: The opioid epidemic, driven in part by increased prescribing, is a public health emergency. This study examines dispensed prescription patterns and approvals of new opioid analgesic products to investigate whether the introduction of these new drugs increases prescribing. METHODS: Prescribing patterns based on dispensed prescription claims from the U.S. retail setting were assessed with new brand and generic opioid analgesic products approved in the United States from 1997 through 2015...
March 20, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29502154/the-impact-of-ugt2b7-c802t-and-cyp3a4-1g-polymorphisms-on-pain-relief-in-cancer-patients-receiving-oxycontin
#4
Jingwen Li, Peng Peng, Qi Mei, Shu Xia, Yijun Tian, Liya Hu, Yuan Chen
BACKGROUND: Single nucleotide polymorphisms (SNPs) in UGT2B7 C802T and CYP3A4*1G impact drug metabolism. This study aimed to investigate the impact of these SNPs on the efficacy of oxycontin for pain relief in cancer patients. METHODS: A total of 57 Han Chinese cancer patients (age range 20-70 years) who received oxycontin to ease pain for the first time were enrolled and divided into two groups (refractory group and remission group) according to pain relief. Peripheral blood samples were collected from each patient for sequencing analysis...
March 3, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29487064/sixty-seconds-on-oxycontin
#5
Anne Gulland
No abstract text is available yet for this article.
February 27, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29459379/oxycontin-maker-stops-marketing-opioids-as-report-details-payments-to-advocacy-groups
#6
Owen Dyer
No abstract text is available yet for this article.
February 19, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29371273/management-and-point-of-care-for-tobacco-dependence-prompt-a-feasibility-mixed-methods-community-based-participatory-action-research-project-in-ottawa-canada
#7
Smita Pakhale, Tina Kaur, Catherine Charron, Kelly Florence, Tiffany Rose, Sadia Jama, Robert Boyd, Joanne Haddad, Gonzalo Alvarez, Mark Tyndall
OBJECTIVE: To determine the feasibility of a Community-Based Participatory Tobacco Dependence Strategy (PROMPT) in the inner city population of Ottawa (Canada). DESIGN: A feasibility mixed methods prospective cohort study following principles of community-based participatory action research. INTERVENTION: Recruited 80 people whouse drugs, followed them for 6 months while providing access to counselling, nicotine replacement therapy and peer-support in a community setting...
January 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29308589/abuse-of-reformulated-oxycontin-updated-findings-from-a-sentinel-surveillance-sample-of-individuals-assessed-for-substance-use-disorder
#8
COMPARATIVE STUDY
Theresa A Cassidy, Eileen Thorley, Ryan A Black, Angela DeVeaugh-Geiss, Stephen F Butler, Paul Coplan
OBJECTIVE: To examine abuse prevalence for OxyContin and comparator opioids over a 6-year period prior to and following market entry of reformulated OxyContin and assess consistency in abuse across treatment settings and geographic regions. DESIGN: An observational study examining longitudinal changes using cross-sectional data from treatment centers for substance use disorder. SETTING: A total of 874 facilities in 39 states in the United States within the National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO®) surveillance system...
November 2017: Journal of Opioid Management
https://www.readbyqxmd.com/read/29246268/sleep-related-orgasms-in-a-57-year-old-woman-a-case-report
#9
Muna Irfan, Carlos H Schenck
We report a case of problematic spontaneous orgasms during sleep in a 57-year-old woman who also complained of hypnic jerks and symptoms of exploding head syndrome. To our knowledge, this is the first case report in the English language literature of problematic spontaneous orgasms during sleep. She had a complex medical and psychiatric history, and was taking oxycontin, venlafaxine, amitriptyline, and lurasidone. Prolonged video electroencephalogram monitoring did not record any ictal or interictal electroencephalogram discharges, and nocturnal video polysomnography monitoring did not record any behavioral or orgasmic event...
January 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29176089/the-body-politic-in-pain
#10
Beth Linker
In his 2015 book Pain: A Political History, Keith Wailoo demonstrates how a medicalized condition became central to defining party politics in the United States from World War II down to the present. Drawing on sources ranging from postwar Congressional hearings concerning the veteran welfare state to debates surrounding Rush Limbaugh's OxyContin addiction, Wailoo offers a fresh analysis of both U.S. political history and medical history, showing how today's highly polarized party system emerged in part from debates surrounding the existence and worth of pain, as well as its management...
2017: Perspectives in Biology and Medicine
https://www.readbyqxmd.com/read/29171358/the-comparative-pharmacokinetics-of-physical-manipulation-by-crushing-of-xtampza-%C3%A2-er-compared-with-oxycontin-%C3%A2
#11
Michael J Brennan, Ernest A Kopecky, Ann Marseilles, Melinda O'Connor, Alison B Fleming
AIM: To further characterize the pharmacokinetics of Xtampza® ER. SUBJECTS & METHODS: This was an open-label, randomized, active-controlled, five-treatment, five-period, naltrexone-blocked, cross-over study. Healthy subjects received five equivalent oxycodone doses: Xtampza ER (intact or crushed), OxyContin® (intact or crushed) or immediate-release (IR) oxycodone (crushed). Blood samples were collected to assess oxycodone concentrations. RESULTS: Crushed and intact Xtampza ER resulted in lower peak plasma concentrations compared with crushed oxycodone IR; crushed and intact Xtampza ER were bioequivalent...
November 2017: Pain Management
https://www.readbyqxmd.com/read/29048960/twitter-based-detection-of-illegal-online-sale-of-prescription-opioid
#12
Tim K Mackey, Janani Kalyanam, Takeo Katsuki, Gert Lanckriet
OBJECTIVES: To deploy a methodology accurately identifying tweets marketing the illegal online sale of controlled substances. METHODS: We first collected tweets from the Twitter public application program interface stream filtered for prescription opioid keywords. We then used unsupervised machine learning (specifically, topic modeling) to identify topics associated with illegal online marketing and sales. Finally, we conducted Web forensic analyses to characterize different types of online vendors...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29048952/increasing-availability-of-illicit-and-prescription-opioids-among-people-who-inject-drugs-in-a-canadian-setting-2010-2014
#13
Joel Ho, Kora DeBeck, M-J Milloy, Huiru Dong, Evan Wood, Thomas Kerr, Kanna Hayashi
BACKGROUND: Nonmedical use of prescription opioid and illicit opioid has been increasing at an alarming rate in North America over the past decade. OBJECTIVE: We sought to examine the temporal trends and correlates of the availability of illicit and prescription opioids among people who inject drugs (PWID) in Vancouver, Canada. METHODS: Data were derived from three prospective cohort studies of PWID in Vancouver between 2010 and 2014. In semiannual interviews, participants reported the availability of five sets of illicit and prescription opioids: (1) heroin; (2) Percocet (oxycodone/acetaminophen), Vicodin (hydrocodone/acetaminophen), or Demerol (meperidine); (3) Dilaudid (hydromorphone); (4) Morphine; (5) oxycontin/OxyNEO (controlled-release oxycodone)...
2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28716778/thrombotic-microangiopathy-associated-with-intravenous-injection-of-extended-release-oxycodone
#14
Kate J Robson, Danielle Clucas, Robin Filshie, Harshal Nandurkar
We describe the case of a 35-year-old man presenting with thrombotic microangiopathy (TMA) and renal impairment following, as he later disclosed, intravenous injection of oral formulation tamper-resistant extended-release oxycodone hydrochloride (Oxycontin). Recurrent misuse of this agent was associated with relapsing TMA despite treatment with terminal complement inhibitor eculizumab. Cases of TMA have been reported in the USA in association with intravenous misuse of extended-release oxymorphone (Opana ER) after the introduction of a new non-crushable formulation in 2012...
July 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28691404/-delisting-oxycontin%C3%A2-to-reduce-prescription-opioid-related-harms-in-ontario-canada-gauging-effects-5%C3%A2-years-later
#15
Benedikt Fischer, Lenka Vojtila, Paul Kurdyak
No abstract text is available yet for this article.
September 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28690668/white-opioids-pharmaceutical-race-and-the-war-on-drugs-that-wasn-t
#16
Julie Netherland, Helena Hansen
The US 'War on Drugs' has had a profound role in reinforcing racial hierarchies. Although Black Americans are no more likely than Whites to use illicit drugs, they are 6-10 times more likely to be incarcerated for drug offenses. Meanwhile, a very different system for responding to the drug use of Whites has emerged. This article uses the recent history of White opioids - the synthetic opiates such as OxyContin(®) that gained notoriety starting in the 1990s in connection with epidemic prescription medication abuse among White, suburban and rural Americans and Suboxone(®) that came on the market as an addiction treatment in the 2000s - to show how American drug policy is racialized, using the lesser known lens of decriminalized White drugs...
June 2017: BioSocieties
https://www.readbyqxmd.com/read/28653782/changes-in-drug-use-patterns-reported-on-the-web-after-the-introduction-of-adf-oxycontin-findings-from-the-researched-abuse-diversion-and-addiction-related-surveillance-radars-system-web-monitoring-program
#17
Suzanne K Vosburg, Colleen Haynes, Andrea Besharat, Jody L Green
This qualitative study summarizes information that individuals shared online about use of OxyContin following the August 2010 introduction of the abuse deterrent formulation (ADF). PURPOSE: The primary objective was to study online posts that endorsed continued use of OxyContin or a switch from OxyContin to another formulation of oxycodone or another substance altogether following the introduction of the ADF. A secondary objective was to determine whether posts revealed that the ADF led to cessation of OxyContin use...
September 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28318019/corrigendum-the-effect-of-an-abuse-deterrent-opioid-formulation-oxycontin-on-opioid-abuse-related-outcomes-in-the-postmarketing-setting
#18
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28292999/-outcomes-of-an-independent-clinical-study-to-compare-branded-and-generic-formulations-of-sustained-release-oxycodone
#19
COMPARATIVE STUDY
Mai Yamamoto, Yoshiko Saito, Yurika Onodera, Masayo Okawa, Kei Shimizu, Yusuke Yamamoto, Takeshi Nawa, Yoshifumi Aoyama
To evaluate the potential for the adoption of a generic formulation of sustained-release oxycodone(Oxycodone SR Capsules), an independent clinical study was planned to accurately evaluate the efficacy and safety during a 9-day period. After a 3-day pretreatment period, the generic formulation was administered to patients with progressive cancer, who had been treated with a branded formulation(OxyContin®Tablets)of the drug for 5 days at the same dose. This was followed by a 1- day observation period. Drug administration to 3 patients with pulmonary cancer achieved the primary(dose, pain level, and adverse drug reactions)and secondary(rescue dose frequency and quality of life)endpoints, as well as safety goals...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28267061/polysubstance-use-and-misuse-or-abuse-of-prescription-opioid-analgesics-a-multi-level-analysis-of-international-data
#20
Katherine I Morley, Jason A Ferris, Adam R Winstock, Michael T Lynskey
Increasing mortality and morbidity associated with opioid analgesics has led to concerns about their misuse and abuse, even when obtained through a prescription. These concerns have been most pronounced in the United States, but limited data make it difficult to determine whether it is a problem in other countries. We investigated opioid analgesic misuse and abuse in participants from the Global Drug Survey 2015 resident in the United States (N = 1334), United Kingdom (N = 1199), France (N = 1258), Germany (N = 866), and Australia (N = 1013) who had used at least 1 prescription opioid analgesic medication in the past year...
June 2017: Pain
keyword
keyword
5905
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"