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Total laryngectomy

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https://www.readbyqxmd.com/read/28716144/macrophage-type-2-differentiation-in-a-patient-with-laryngeal-squamous-cell-carcinoma-and-metastatic-prostate-adenocarcinoma-to-the-cervical-lymph-nodes
#1
Michael C Topf, Madalina Tuluc, Larry A Harshyne, Adam Luginbuhl
BACKGROUND: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. The tumor microenvironment contains a milieu of secreted factors and vesicles, which in certain circumstances can gain access to lymphatic vessels that drain to local lymph nodes...
July 18, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28714539/safety-and-efficacy-of-functional-laryngectomy-for-end-stage-dysphagia
#2
Michael C Topf, Linda C Magaña, Kelly Salmon, James Hamilton, William M Keane, Adam Luginbuhl, Joseph M Curry, David M Cognetti, Maurits Boon, Joseph R Spiegel
OBJECTIVES/HYPOTHESIS: To evaluate functional outcomes and complication rate after total laryngectomy (TL) for dysfunctional larynx with end-stage dysphagia. STUDY DESIGN: Retrospective chart review. METHODS: Chart review was performed on all patients who underwent TL from January 2008 to July 2016 at a single tertiary academic medical center. Patients who underwent TL for dysfunctional larynx without preoperative evidence of malignancy were included...
July 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28711215/changes-occurring-in-mucosal-contractility-of-the-inferior-turbinate-and-mucociliary-clearance-following-total-laryngectomy-a-prospective-clinical-trial
#3
Ilker Kocak, Remzi Dogan, Sabri Baki Eren, Selahattin Tugrul, Orhan Ozturan, Aysenur Meric Hafiz
OBJECTIVE: In this study, changes occurring in the contractility capacity of the inferior turbinate and mucociliary clearance time due to the interruption of nasal air flow were examined. MATERIAL & METHODS: A total of 23 patients undergone total laryngectomy between June 2010 and June 2012 were included in the study. Acoustic rhinometry test was performed in the patients before and after 0.05% oxymetazoline nasal topical decongestant administration. In addition, saccharin test was applied in order to measure mucociliary clearance...
July 12, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28691045/pharyngocutaneous-fistula-as-an-alternative-access-route-for-inserting-a-percutaneous-endoscopic-gastrostomy-tube-in-head-and-neck-cancer-patients
#4
Louise Deluiz Verdolin Di Palma, Gustavo Francisco de Souza E Mello, Cindy Lis Granados, Ricardo Dardengo Glória, Caroline Sauter Dalbem, Rolantre Lopes da Cruz, Ana Carolina Maron Ayres, Renata Sofia Camara Lisboa, Alexandre Dias Pelosi, Maria Aparecida Ferreira, Gilberto Reynaldo Mansur, Simone Guaraldi da Silva, Theresa Christina Damian Ribeiro, Fernando Luiz Dias
BACKGROUND AND STUDY AIMS:  Performing a percutaneous endoscopic gastrostomy (PEG) in head and neck cancer (HNC) patients can be challenging because of the presence of trismus, pharyngeal obstruction by tumor, and pharyngoesophageal strictures or fistula. Pharyngocutaneous fistula (PCF) is a major postoperative concern in patients submitted to total laryngectomy (TL). In the medical literature to date, the cervical fistula has been used as an access to PEG in only four reports. The aim of this study was to evaluate the safety of cervical fistula for insertion of a PEG tube...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28684925/the-electrolarynx-voice-restoration-after-total-laryngectomy
#5
REVIEW
Rachel Kaye, Christopher G Tang, Catherine F Sinclair
The ability to speak and communicate with one's voice is a unique human characteristic and is fundamental to many activities of daily living, such as talking on the phone and speaking to loved ones. When the larynx is removed during a total laryngectomy (TL), loss of voice can lead to a devastating decrease in a patient's quality of life, and precipitate significant frustration over their inability to communicate with others effectively. Over the past 50 years there have been many advances in techniques of voice restoration after TL...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28680497/late-term-effects-of-surgery-on-nasal-functions-in-patients-who-underwent-total-laryngectomy-surgery
#6
Deniz Karaoglu, Murat Kocyigit, Safiye Giran Ortekin, Mustafa Kemal Adali
Introduction  There is a common opinion that losing airway functions in total laryngectomy patients cause changes in nasal physiological rates. Studies conducted to review the subject present gaps, especially in terms of objective measurements. Objective  We evaluated late-term effects of surgery on nasal functions in patients who underwent total laryngectomy surgery more than two years ago. Methods  We included in the study 22 patients who had undergone total laryngectomy, as well as 24 healthy subjects with similar demographic characteristics as the control group...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28671270/laryngectomy-and-smoking-an-analysis-of-postoperative-risk
#7
Jacob S Brady, Meghan M Crippen, Andrey Filimonov, Jean Anderson Eloy, Soly Baredes, Richard Chan Woo Park
OBJECTIVES: To investigate the impact of smoking on complication rates following total laryngectomy. STUDY DESIGN AND METHODS: The National Surgical Quality Improvement Program database was queried for all total laryngectomies between 2005 and 2014. Patients were identified as smokers (n = 561) or nonsmokers (n = 513) and compared via univariate and multivariate analyses. A nearest-neighbor propensity score-generating algorithm was used to build a subpopulation (n = 714) of matched cases and evaluated in a similar manner...
July 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28664029/endovascular-therapy-for-a-post-irradiated-cervical-pseudoaneurysm-at-the-carotid-stump-a-case-report
#8
Masayasu Arihara, Kei Miyata, Satoshi Iihoshi, Hiroyuki Yamaguchi, Kentaro Toyama, Katsuya Komatsu, Atsumu Hashimoto, Masahiko Wanibuchi, Nobuhiro Mikuni
A nearly 80-year-old man with a history of radiotherapy (RT) and total laryngectomy for laryngeal cancer 25 years previously presented with a rapidly growing mass on the right side of his neck. A huge pseudoaneurysm (pseudoAN) was detected at the right carotid bifurcation, though angiography performed four years previously had shown total occlusion of the internal carotid artery. Stent-assisted coil embolization enabled aneurysm sac shrinkage. Clinicians must be aware that the stump of an arterial occlusion associated with RT can change into a pseudoAN over the long term and must provide follow-up in such cases...
April 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/28635221/-treatment-of-intractable-aspiration-after-partial-laryngectomy-by-cuffed-tracheostomy-tube-with-inner-cannula
#9
P Wang, Y H Liu, Q S Xu, Z S Zheng
Objective: To evaluate the efficacy of cuffed tracheostomy tube with inner cannula for the treatment of intractable aspiration after partial laryngectomy. Methods: From May 2010 to June 2015, 15 patients with intractable aspiration after partial laryngectomy of laryngeal and hypopharyngeal carcinoma were enrolled. Cuffed tracheostomy tube with inner cannula was used in the 15 patients for treatment of intractable aspiration. The patients and their family were trained to manage the cuffed tracheostomy tube with inner cannula and to eat since the 14th day after surgery...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28635071/total-laryngectomy-a-new-lateral-cervical-approach
#10
Giuseppe Spriano, Giuseppe Mercante, Fabio Ferreli, Raul Pellini
Nowadays, total laryngectomy is primarily performed for advanced laryngeal cancers with involvement of the laryngeal skeleton and/or extending outside the larynx, hypo- or oropharynx. Another field of application is represented by salvage surgery following chemo-radiation therapy failure. In both these situations, laryngectomy is achieved by therapeutic or elective neck dissection(1-2) . This procedure is carried out by adopting an open trans cervical approach. This article is protected by copyright. All rights reserved...
June 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28609773/transoral-robotic-surgery-total-laryngectomy-evaluation-of-functional-and-survival-outcomes-in-a-retrospective-case-series-at-a-single-institution
#11
Giri Krishnan, Suren Krishnan
BACKGROUND: Transoral robotic surgery total laryngectomy (TORS-TL) is a minimally invasive endoscopic surgical approach which can theoretically minimise the morbidity of large external incisions and limit dissection of tissue planes so as to reduce the risk of pharyngocutaneous fistulae related to poor tissue healing secondary to radiation soft tissue injury or malnutrition. The purpose of this paper was to report our experience with this uncommon surgical approach. METHODS: A retrospective chart review was conducted at a single institution to evaluate the functional and survival outcomes of a series of patients who underwent TORS-TL...
June 14, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/28608731/survival-outcomes-in-patients-with-t2n0m0-stage-ii-squamous-cell-carcinoma-of-the-larynx
#12
Danielle L Gainor, Emily Marchiano, Emily Bellile, Matthew E Spector, Jeremy M G Taylor, Gregory T Wolf, Norman D Hogikyan, Mark E Prince, Carol R Bradford, Avraham Eisbruch, Francis Worden, Andrew G Shuman
Objective Emerging data have demonstrated suboptimal outcomes among patients with stage II larynx cancer. Our objective is to report survival outcomes for T2N0M0 larynx cancer and to determine the cause-specific survival. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Adults with T2N0M0 squamous cell carcinoma of the larynx treated with curative intent. Methods A head and neck cancer epidemiology database was queried for eligible subjects from 2003 to 2014...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607897/a-comparative-study-of-pharyngeal-repair-in-two-layers-versus-three-layers-following-total-laryngectomy-in-carcinoma-of-larynx
#13
Asok K Saha, Saikat Samaddar, Avijit Choudhury, Abir Chaudhury, Nirmalya Roy
Larynx is the second most common site for cancer in the upper aerodigestive tract. One of the dreaded complications following total laryngectomy has been pharyngo cutaneous fistula (PCF). PCF merits special attention due to its significant negative impact on the recovery process. Total laryngectomy profoundly alters speech. Effective voice restoration is essential for the rehabilitation of these patients. Inadequate consensus exists as to the best technique of pharyngeal repair to decrease incidence of PCF and ensure good quality voice following total laryngectomy...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28594992/association-of-modified-frailty-index-score-with-perioperative-risk-for-patients-undergoing-total-laryngectomy
#14
Brandon Wachal, Matthew Johnson, Alissa Burchell, Harlan Sayles, Katherine Rieke, Robert Lindau, William Lydiatt, Aru Panwar
Importance: Objective preoperative risk assessment tools, such as the Modified Frailty Index (mFI), may inform patient and physician decision making when considering total laryngectomy. Estimation of outcomes may help to set realistic expectations about recovery and outcomes and facilitate optimal resource management. Objective: To evaluate the association between the mFI score as a measure of frailty and outcomes following total laryngectomy. Design, Setting, and Participants: Retrospective evaluation using the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP), a risk- and case-mix-adjusted national quality assessment program...
June 8, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28592347/management-of-the-thyroid-gland-during-laryngectomy
#15
S X Li, M A Polacco, B J Gosselin, L X Harrington, A J Titus, J A Paydarfar
OBJECTIVES: This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement. METHODS: A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported...
June 8, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28580621/functional-outcomes-of-fasciocutaneous-free-flap-and-pectoralis-major-flap-for-salvage-total-laryngectomy
#16
Sally Nguyen, François Thuot
BACKGROUND: Pectoralis major muscle flaps (PMMFs) and fasciocutaneous free flaps (FFFs) are commonly used for reconstruction of the surgical defect after salvage total laryngectomy. This study compared swallowing function in patients who underwent reconstruction with either PMMF or FFF. METHODS: This study was based on a retrospective cohort of patients treated at the CHU de Québec between January 2000 and March 2015. Demographics, chemoradiation data, surgical protocol, pathologic results, complications, evolution, esophageal dilation, diet intake, and feeding tube dependence were documented...
June 5, 2017: Head & Neck
https://www.readbyqxmd.com/read/28573675/fasciocutaneous-free-flaps-for-reconstruction-of-hypopharyngeal-defects
#17
Cesare Piazza, Francesca Del Bon, Alberto Paderno, Alberto Grammatica, Nausica Montalto, Valentina Taglietti, Piero Nicolai
OBJECTIVES/HYPOTHESIS: Different reconstructive options are available for defects following total laryngectomy (TL) and circumferential (CH) or partial hypopharyngectomy (PH). We evaluated the flap success, pharyngocutaneous fistula, and pharyngoesophageal stenosis rates in two groups of patients treated by different policies. STUDY DESIGN: Comparison between two cohorts of patients treated by TL with PH/CH ± cervical esophagectomy and reconstructed according to different strategies...
June 2, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28572015/validation-of-the-lithuanian-version-of-the-speech-handicap-index
#18
Ruta Pribuisiene, Vykintas Liutkevicius, Kipras Pribuisis, Virgilijus Uloza
OBJECTIVE: The objective is to study the cultural adaptation and validation of the Speech Handicap Index (SHI) questionnaire to the Lithuanian language. METHODS: Cultural adaptation and validation of the translated Lithuanian version of the SHI (SHI-LT) was performed as described by the Scientific Advisory Committee of the Medical Outcomes Trust. The SHI-LT was completed by 46 patients after total laryngectomy and by 60 healthy subjects of the control group. Validity and reliability of the SHI-LT were evaluated...
May 29, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28558451/-treatment-of-glottic-cancer-involving-the-anterior-commissure-by-transoral-co-2-laser-surgery
#19
J J Li, J L Zhang, F Y He, S C Tang, Z F Zhu, W X Chen
Objective: To study the clinical outcome of transoral CO(2) laser surgery for glottic cancer involving the anterior commissure. Methods: Thirty-two cases of glottic cancer involving the anterior commissure treated by transoral CO(2) laser surgery between March 2009 and December 2013 were retrospectively reviewed. Among these cases, 27 were T1bM0M0, 5 were T2N0M0. All cases were followed-up for more than 3 years. Results: All the 32 cases were successfully treated. Perioperative complications included injuries in the soft palate mucosa(13/32, 40...
May 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28546727/huge-carcinosarcoma-of-the-endolarynx-a-rare-tumour-with-unusual-presentation
#20
Rakesh Kumar Singh, Richi Sinha, Anju Singh, Sanjay Suman, Madhu Priya
Carcinosarcoma or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma, which comprises 2 to 3 % of all laryngeal cancer. It is considered to be a biphasic tumour, composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. We present a case of huge carcinosarcoma of larynx in a 34 year-old male who developed severe stridor and dysphagia. The diagnosis was confirmed histopathologically, hence the disease was treated through total laryngectomy followed by adjuvant chemotherapy and radiotherapy...
June 2017: Indian Journal of Surgical Oncology
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