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https://www.readbyqxmd.com/read/29656755/the-burden-of-lung-cancer-in-latin-america-and-challenges-in-the-access-to-genomic-profiling-immunotherapy-and-targeted-treatments
#1
REVIEW
Luis E Raez, Andrés F Cardona, Edgardo S Santos, Heath Catoe, Christian Rolfo, Gilberto Lopes, Carlos Barrios, Luis A Mas, Carlos Vallejos, Zyanya Lucia Zatarain-Barrón, Christian Caglevic, Oscar Arrieta
Lung cancer is a public health problem worldwide and Latin America (LATAM) cannot escape this reality. This malignant disease has not only a high prevalence in the region, but is also the main cause of cancer related deaths, and in other emerging countries, the incidence rates are still on the rise. Interestingly in most LATAM countries, lung cancer mortality has been decreasing in men but not in women, reflecting smoking patterns in countries such as Chile, Bolivia, and Brazil. Despite the fact that these issues are well known to government agencies, physicians and patients in the region, current efforts still fall behind those needed in order to face this problem of epidemic proportions...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29656176/underreporting-of-fatal-poisonings-in-brazil-a-descriptive-study-using-data-from-four-information-systems
#2
Andrea Franco Amoras Magalhães, Eloisa Dutra Caldas
Poisoning is a worldwide problem that involves individuals of all ages and a range of chemicals. In this study, fatal poisoning cases that occurred in the Federal District of Brazil (DF) from 2009 to 2013 were described using information from four systems, and the reasons for underreporting of each system were discussed. Data were obtained from the mortality information system (SIM), the notifiable disease information system (SINAN), the poison information center (CIT), and the forensic medicine institute (IML) of the DF...
April 4, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29652944/epidemiology-of-sepsis-in-brazil-incidence-lethality-costs-and-other-indicators-for-brazilian-unified-health-system-hospitalizations-from-2006-to-2015
#3
Ricardo Alfredo Quintano Neira, Silvio Hamacher, André Miguel Japiassú
BACKGROUND: Sepsis is considered a major worldwide health burden, with high mortality and associated costs. Health indicators are essential to define strategies to improve the treatment of diseases, and the epidemiology information of sepsis in developing countries is scarce. Thus, the aim of this work is to assess trends in the incidence, lethality, costs, and other indicators of sepsis for Brazilian Unified Health System (SUS-Sistema Único de Saúde) hospitalizations for the period from January 2006 to December 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29642907/equity-of-access-to-maternal-health-interventions-in-brazil-and-colombia-a-retrospective-study
#4
Amaila De La Torre, Zlatko Nikoloski, Elias Mossialos
BACKGROUND: Reducing maternal mortality is a top priority in Latin American countries. Despite the progress in maternal mortality reduction, Brazil and Colombia still lag behind countries at similar levels of development. METHODS: Using data from the Demographic Health Survey, this study quantified and compared, by means of concentration indices, the socioeconomic-related inequity in access to four key maternal health interventions in Brazil and Colombia. Decomposition analysis of the concentration index was used for two indicators - skilled attendance at birth and postnatal care in Brazil...
April 11, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29627806/long-term-benzodiazepine-use-in-patients-taking-antidepressants-in-a-public-health-setting-in-brazil-a-cross-sectional-study
#5
Izabela Fulone, Marcus Tolentino Silva, Luciane Cruz Lopes
OBJECTIVE: The aims of the study were to investigate the prevalence of long-term use of benzodiazepines in patients taking antidepressants and to identify the risk factors associated with the prolonged use of benzodiazepines. DESIGN: Cross-sectional study. SETTING: Public health system in Brazil. PARTICIPANTS: Outpatients using antidepressants from January 2008 to December 2009 were included. The data were obtained from pharmacy databases and medical records...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29626365/tongue-cancer-epidemiology-in-brazil-incidence-morbidity-and-mortality
#6
Daniel Cohen Goldemberg, Luiz Henrique Lima de Araújo, Héliton Spindola Antunes, Andreia Cristina de Melo, Luiz Claudio Santos Thuler
BACKGROUND: The purpose of this current research was to clarify for the scientific community the trends of tongue cancer epidemiology in Brazil. METHODS: The data came from Population Based Cancer Registries, Hospital Cancer Registries, and Mortality Information System from 2000 to 2014. RESULTS: The age-adjusted incidence rate are increasing in both men and women for base of tongue cancer and for other and unspecified parts of the tongue in women, and decreasing in men for other and unspecified parts of the tongue...
April 6, 2018: Head & Neck
https://www.readbyqxmd.com/read/29624595/social-determinants-their-relationship-with-leprosy-risk-and-temporal-trends-in-a-tri-border-region-in-latin-america
#7
Ivaneliza Simionato de Assis, Marcos Augusto Moraes Arcoverde, Antônio Carlos Viera Ramos, Luana Seles Alves, Thais Zamboni Berra, Luiz Henrique Arroyo, Ana Angélica Rêgo de Queiroz, Danielle Talita Dos Santos, Aylana de Souza Belchior, Josilene Dália Alves, Flávia Meneguetti Pieri, Reinaldo Antônio Silva-Sobrinho, Ione Carvalho Pinto, Clodis Maria Tavares, Mellina Yamamura, Marco Andrey Cipriani Frade, Pedro Fredemir Palha, Francisco Chiaravalloti-Neto, Ricardo Alexandre Arcêncio
BACKGROUND: Brazil is the only country in Latin America that has adopted a national health system. This causes differences in access to health among Latin American countries and induces noticeable migration to Brazilian regions to seek healthcare. This phenomenon has led to difficulties in the control and elimination of diseases related to poverty, such as leprosy. The aim of this study was to evaluate social determinants and their relationship with the risk of leprosy, as well as to examine the temporal trend of its occurrence in a Brazilian municipality located on the tri-border area between Brazil, Paraguay and Argentina...
April 6, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29623240/rio-s-mountainous-region-regi%C3%A3-o-serrana-2011-landslides-impact-on-public-mental-health-system
#8
Marcelo Dell'Aringa, Otavio Ranzani, Joost Bierens, Virginia Murray
INTRODUCTION In January 2011 landslides and floods followed heavy rain in the Mountainous Region of Rio de Janeiro State ("Região Serrana"), in southeastern Brazil. These events led to the largest disaster registered in Brazilian recent history. Few studies addressed the impacts of this disaster on public health, and we found none addressing the impact on mental health. This study reviewed the consequences of the 2011 disaster in the "Região Serrana", by comparing the demand for public mental health assistance data from time periods before and after the even  METHODS  We performed an ecologic study, analysing the aggregate data from "Região Serrana" during the period two years before and after the disaster, exporting data from the Brazilian open access public health database...
January 25, 2018: PLoS Currents
https://www.readbyqxmd.com/read/29617480/-trends-in-the-use-of-medical-and-dental-services-and-associations-with-educational-level-and-private-health-plan-coverage-in-brazil-1998-2013
#9
Luciane Maria Pilotto, Roger Keller Celeste
The public-private mix in the Brazilian health system favors double coverage of health services for individuals with private health plans and may aggravate inequities in the use of services. The aim of this study was to describe trends in the use of medical and dental services and associations with schooling and private health coverage. Data were obtained from a national household survey with representative samples in the years 1998, 2003, 2008, and 2013. The study described trends in the use of health services by adults, adjusted by private health coverage, years of schooling, sex, and age...
March 29, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29611503/accuracy-of-the-lee-white-clotting-time-performed-in-the-hospital-routine-to-detect-coagulopathy-in-bothrops-atrox-envenomation
#10
Jose Diego de Brito Sousa, Jacqueline Almeida Gonçalves Sachett, Sâmella Santos Oliveira, Iran Mendonça-da-Silva, Hedylamar Oliveira Marques, Marcus Vinicius Guimarães de Lacerda, Hui Wen Fan, Wuelton Marcelo Monteiro
Snake envenomation is a major public health problem in Brazil. Systemic complications that may arise from snakebites are mainly related to coagulopathy. The Lee-White clotting time (LWCT) is a simple and inexpensive test and available even in remote health facilities. However, the diagnostic value of such test needs to be evaluated to accurately diagnose coagulopathy in the clinical practice. This study aimed to assess the reliability of the LWCT performed in hospital routine to diagnose venom-induced coagulopathy...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29610711/determining-the-numbers-of-a-landscape-architect-species-tapirus-terrestris-using-footprints
#11
Danielle O Moreira, Sky K Alibhai, Zoe C Jewell, Cristina J da Cunha, Jardel B Seibert, Andressa Gatti
Background: As a landscape architect and a major seed disperser, the lowland tapir ( Tapirus terrestris ) is an important indicator of the ecological health of certain habitats. Therefore, reliable data regarding tapir populations are fundamental in understanding ecosystem dynamics, including those associated with the Atlantic Forest in Brazil. Currently, many population monitoring studies use invasive tagging with radio or satellite/Global Positioning System (GPS) collars. These techniques can be costly and unreliable, and the immobilization required carries physiological risks that are undesirable particularly for threatened and elusive species such as the lowland tapir...
2018: PeerJ
https://www.readbyqxmd.com/read/29609192/the-burden-of-indirect-causes-of-maternal-morbidity-and-mortality-in-the-process-of-obstetric-transition-a-cross-sectional-multicenter-study
#12
Jessica Fernandes Cirelli, Fernanda Garanhani Surita, Maria Laura Costa, Mary Angela Parpinelli, Samira Maerrawi Haddad, José Guilherme Cecatti
OBJECTIVE:  The aim of this study is to evaluate the burden of indirect causes of maternal morbidity/mortality in Brazil. METHODS:  Secondary analysis of a multicenter cross-sectional study conducted in 27 referral obstetric units within the Brazilian Network for Surveillance of Severe Maternal Morbidity. RESULTS:  A total of 82,388 women were surveilled: 9,555 women with severe maternal morbidity were included, and 942 (9.9%) of them had indirect causes of morbidity/mortality...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29601580/pyrethroid-resistance-persists-after-ten-years-without-usage-against-aedes-aegypti-in-governmental-campaigns-lessons-from-s%C3%A3-o-paulo-state-brazil
#13
Maria de Lourdes Macoris, Ademir Jesus Martins, Maria Teresa Macoris Andrighetti, José Bento Pereira Lima, Denise Valle
BACKGROUND: Aedes aegypti, vector of dengue, chikungunya and Zika viruses, is found at high densities in tropical urban areas. The dissemination of this vector is partially the consequence of failures in current vector control methods, still mainly relying upon insecticides. In the State of São Paulo (SP), Brazil, public health managers employed pyrethroids against Ae. aegypti adults from 1989 to 2000, when a robust insecticide resistance monitoring system detected resistance to pyrethroids in several Ae...
March 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29590244/-a-nonlinear-model-for-localization-of-hospital-services-as-an-indicator-of-accessibility
#14
Silviana Cirino, Louis Augusto Gonçalves, Mirian Buss Gonçalves, Eduardo Souza de Cursi
The study proposes a differentiated approach to the localization of public services (unlike methods focusing solely on locational efficiency in the distribution of such services), with a nonlinear model that incorporates an accessibility indicator and allows rejecting solutions in which accessibility fails to comply with acceptably established minimum parameters. The method aims to minimize the total time spent by a region's population to reach a public services network, while controlling the range between the highest and lowest accessibility to the services...
March 26, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29590242/-sources-of-medicines-for-chronic-patients-using-the-brazilian-unified-national-health-system
#15
Samara Ramalho Matta, Andréa Dâmaso Bertoldi, Isabel Cristina Martins Emmerick, Andréia Turmina Fontanella, Karen Sarmento Costa, Vera Lucia Luiza
The article aimed to identify the sources of medicines for users of the Brazilian Unified National Health System (SUS) that reported chronic non-communicable diseases, characterizing the group according to demographic, socioeconomic, and health variables in the different regions of Brazil. Data were analyzed from the National Survey on Access, Use, and Promotion of Rational Use of Medicines in Brazil (PNAUM), a cross-sectional population-based study. The dependent variable was "source of medicines", and the associations were analyzed with demographic, socioeconomic, and health status variables...
March 26, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29588949/understanding-the-burden-of-focal-epilepsy-as-a-function-of-seizure-frequency-in-the-united-states-europe-and-brazil
#16
Shaloo Gupta, Philippe Ryvlin, Edward Faught, Wan Tsong, Patrick Kwan
Objective: To understand the current burden of focal epilepsy (FE) as a function of seizure frequency. Methods: Patients were identified from the United States (2011, 2012, and 2013), five European countries (EU; France, Germany, Italy, Spain, United Kingdom) (2011 and 2013), and Brazil (2011 and 2012) National Health and Wellness Survey (NHWS), a nationally representative, Internet-based survey of adults (18+ years). The NHWS collected data on respondents' quality of life (QoL), health utilities, productivity loss, and healthcare resource utilization...
June 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29579099/severe-influenza-a-h1n1-pdm09-in-pregnant-women-and-neonatal-outcomes-state-of-sao-paulo-brazil-2009
#17
Ana Freitas Ribeiro, Alessandra Cristina Guedes Pellini, Beatriz Yuko Kitagawa, Daniel Marques, Geraldine Madalosso, Joao Fred, Ricardo Kerti Mangabeira Albernaz, Telma Regina Marques Pinto Carvalhanas, Dirce Maria Trevisan Zanetta
To investigate the factors associated with death and describe the gestational outcomes in pregnant women with influenza A(H1N1)pdm09, we conducted a case-control study (deaths and recovered) in hospitalized pregnant women with laboratory-confirmed influenza A(H1N1)pdm09 with severe acute respiratory illness (SARI) in the state of São Paulo from June 9 to December 1, 2009. All cases were evaluated, and four controls that were matched by the epidemiological week of hospitalization of the case were randomly selected for each case...
2018: PloS One
https://www.readbyqxmd.com/read/29569997/patterns-of-physical-activity-and-screen-time-among-brazilian-children
#18
Lia Grego Muniz de Araújo, Bruna Camilo Turi, Bruna Locci, Camila Angélica Asahi Mesquita, Natália Bonicontro Fonsati, Henrique Luiz Monteiro
OBJECTIVE: To investigate the patterns of physical activity (PA) and screen time among children and adolescents attended by the Brazilian National Health System. METHODS: This cross-sectional study was conducted in the city of Bauru, São Paulo, Brazil. The sample was composed of 270 children and adolescents attending 5 basic health care units. PA and screen time were assessed through a questionnaire. Economic status, sex, and body composition variables were used as covariates...
March 23, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29562015/decline-of-mortality-from-cervical-cancer
#19
Suelayne Gonçalves do Nascimento, Cleonice Patrícia Andrade Lima de Carvalho, Ricarlly Soares da Silva, Conceição Maria de Oliveira, Cristine Vieira do Bonfim
OBJECTIVE: To describe occurrences of mortality due to cervical cancer in Recife (PE), in northeastern Brazil. METHOD: This was a time-series ecological study using data from the Mortality Information System (SIM) regarding the total number of deaths due to cervical cancer (C53 ICD10) that occurred between 2000 and 2012. RESULTS: It was observed that the risk of death due to this form of cancer was higher among women over 60 years of age, those of mixed skin color (53...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29550241/low-bioavailability-and-high-immunogenicity-of-a-new-brand-of-e-colil-asparaginase-with-active-host-contaminating-proteins
#20
Priscila Pini Zenatti, Natacha Azussa Migita, Nathália Moreno Cury, Rosângela Aparecida Mendes-Silva, Fabio Cesar Gozzo, Pedro Otavio de Campos-Lima, José Andrés Yunes, Silvia Regina Brandalise
The drug l-asparaginase is a cornerstone in the treatment of acute lymphoblastic leukemia (ALL). The native E. colil-asparaginase used in Brazil until recently has been manufactured by Medac/Kyowa. Then a decision was taken by the Ministry of Health in 2017 to supply the National Health System with a cheaper alternative l-asparaginase manufactured by Beijing SL Pharmaceutical, called Leuginase®. As opposed to Medac, the asparaginase that has been in use in Brazil under the trade name of Aginasa®, it was not possible to find a single entry with the terms Leuginase in the Pubmed repository...
March 9, 2018: EBioMedicine
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