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Musculoskeletal Transplant Foundation

Jed Vanichkachorn, Timothy Peppers, Dennis Bullard, Scott K Stanley, Raymond J Linovitz, James T Ryaby
PURPOSE: This multicenter clinical study was performed to assess the safety and effectiveness of Trinity Evolution(®) (TE), a viable cellular bone allograft, in combination with a PEEK interbody spacer and supplemental anterior fixation in patients undergoing anterior cervical discectomy and fusion (ACDF). METHODS: In a prospective, multi-center study, 31 patients that presented with symptomatic cervical degeneration at one vertebral level underwent ACDF with a PEEK interbody spacer (Orthofix, Inc...
July 2016: European Spine Journal
Kyle C Ward, Kevin P Costello, Sara Baalman, Richard A Pierce, Corey R Deeken, Margaret M Frisella, L Michael Brunt, Brent D Matthews
PURPOSE: The objective of this study was to evaluate the performance of acellular human dermis reinforcement during laparoscopic hiatal hernia repair. METHODS: A prospective non-randomized, single institution study enrolled patients undergoing laparoscopic hiatal hernia repair. Acellular human dermis, FlexHD (Musculoskeletal Transplant Foundation, Edison, NJ) or AlloDerm (LifeCell Inc., Branchburg, NJ) were used to buttress the repair after primary closure. A protocol barium swallow (BAS) was performed at 6 months and then as needed due to clinical indications...
August 2015: Surgical Endoscopy
Grant V Bochicchio, Gerard P De Castro, Kelly M Bochicchio, Jennifer Weeks, Eduardo Rodriguez, Thomas M Scalea
BACKGROUND: Damage control surgery and management of the open abdomen has led to a significant improvement in survival in trauma and emergency surgical patients. However, subsequent abdominal reconstruction has become a significant challenge. The objective of this study was to compare 2 different acellular dermal matrices in regard to hernia recurrence and complications in patients who present with a large complicated ventral hernia as a result of trauma or emergency surgery. STUDY DESIGN: A prospective quasi-experimental time-interrupted series design was used to evaluate the incidence of hernia recurrence in trauma/emergency surgery patients who had a ventral hernia repair with a biologic matrix...
October 2013: Journal of the American College of Surgeons
Elizabeth N Fahrenbach, Chao Qi, Omer Ibrahim, John Y Kim, Murad Alam
IMPORTANCE: Acellular dermal matrices have many current and potential applications, but their long-term safety has not been extensively studied. In particular, limited information exists regarding such materials' resistance to infection. OBJECTIVE: To assess the resistance to microbial penetration of common acellular dermal matrix materials used in reconstruction after skin cancer excision, treatment of chronic ulcers and burns, breast reconstruction, hernia repairs, and other applications...
May 2013: JAMA Dermatology
I Z Rodríguez, M I F Uceda, R D Lobato, G S Aniceto
Defining the ideal material for frontal sinus obliteration remains controversial. Autogenous cancellous bone is effective because of its biological properties: it undergoes fast revascularization acting as an active scaffold for bone healing, but is linked to additional donor site morbidity. Bone dust harvesting from the skull surface produces no sequelae but availability is limited. Many efforts have been made to overcome these drawbacks, and an ideal bone substitute sought. Demineralized Bone Matrix (DBX; Musculoskeletal Transplant Foundation, Edison, NJ, USA) is a commercially available product composed of demineralized bone particles reduced after proper processing of human bone in combination with sodium hyaluronate...
January 2013: International Journal of Oral and Maxillofacial Surgery
Armando A Davila, Donald W Buck, David Chopp, Caitlin M Connor, Scott Persing, Vinay Rawlani, John Y S Kim
BACKGROUND: There are many products approved for aesthetic soft tissue augmentation. Despite this abundance, there is limited objective data regarding safety, longevity, and complication rates. Instead, most reports rely on subjective measures to report volume changes and outcomes, making product comparison difficult. OBJECTIVES: The authors developed and validated a mathematical model to prospectively calculate and analyze three-dimensional (3D) volumetric changes associated with nasolabial fold augmentation based on human acellular dermis...
May 2012: Aesthetic Surgery Journal
A Prub, B-D Katthagen
The regulations in the recent German Tissue Act have completely changed the working situation for musculoskeletal tissue establishments. According to the requirements of section 20b, section 20c and section 21a AMG it should be possible to maintain local bone banks but centralised regional tissue banks will dominate in the future. The transmission of viral and non-viral infectious pathogens continues to be the most serious of the potential adverse effects of allogenic tissue transplants. Accordingly, tissue banks must focus on comprehensive and robust quality assurance in the areas of donation, testing, processing and preservation...
August 2008: Der Orthopäde
Michael J Joyce
The Musculoskeletal Transplant Foundation Symposium held in September 2003, in Edinburgh, Scotland provided the opportunity for an orthopaedic surgeon experienced in tissue banking and musculoskeletal allograft transplantation to summarize to orthopaedic colleagues the past and current efforts made by the Food and Drug Administration to ensure the safety of allograft tissues, aspects of tissue banking, concerns of allograft safety and future Food and Drug Administration proposals. The review allows an orthopaedic surgeon an understanding of allograft safety issues and provides information for better informed consent to be obtained by the orthopaedic surgeon from the recipient patient...
June 2005: Clinical Orthopaedics and related Research
David J Gocke
Authors of recent reports in the medical literature indicate that allograft-associated infection primarily is attributable to violations of proper tissue processing procedures, and illustrate the need for effective quality assurance systems to avoid transplantation of potentially infectious tissue. I describe the experience of the members of the Musculoskeletal Transplant Foundation with the selection, the processing, and the safety of bone and tissue donors for allograft implantation. In 2002, the Musculoskeletal Transplant Foundation screened 10,497 potential donors, but only 4431 (42%) met stringent criteria for recovery...
June 2005: Clinical Orthopaedics and related Research
(no author information available yet)
No abstract text is available yet for this article.
June 2005: Clinical Orthopaedics and related Research
Jon K Hathaway, Jong M Choe
PURPOSE: We determined the presence, quantitated the concentration and assessed the length of DNA present in 4 commercially available human cadaver allografts. MATERIALS AND METHODS: We evaluated 10 tissue samples from each of 4 commercial sources of human allograft (Mentor Corp., Santa Barbara, California; Musculoskeletal Transplant Foundation, Edison, New Jersey; Regeneration Technologies, Inc., Alachua, Florida; and Life Cell Corp., Woodlands, Texas) for intact DNA segments...
September 2002: Journal of Urology
J M Neigel, P O Ruzicka
A retrospective study and review of the literature was performed on the use of demineralized bone implants for the correction of orbital and craniofacial defects. Demineralized bone implants heal by endochondral osteogenesis, inducing a transformation of local cells, as well as by osteoconduction, similar to autogenous grafts. They induce the chemotaxis and transformation of mesenchymal cells into chondroblasts, followed by ossification. They also act as a scaffold, with bone resorption taking place simultaneous with bone formation...
June 1996: Ophthalmic Plastic and Reconstructive Surgery
A C Wetzel, H Stich, R G Caffesse
The placement of oral implants into jaw bone has a high predictability provided an adequate bone volume surrounding the implant is present to ensure primary stability and resistance to functional loading forces after completion of osseointegration. In the distal area of the maxilla, an adequate bone volume is often lacking because of the proximity of the sinus cavities. The aim of this study was to evaluate histologically the simultaneous placement of endosseous implants into the sinus cavity and the surgical elevation of the sinus floor including filling the cavity with different grafting materials...
September 1995: Clinical Oral Implants Research
C W Hewitt, K S Black, B M Achauer, M P Patel
With the advent of cyclosporine, a powerful and selective immunosuppressant, comes resurgence of a long-sought goal: to transplant modules of allointegumentary/musculoskeletal tissues or components thereof for the repair of peripheral tissue defects. Because these modules of integumentary and/or musculoskeletal tissue are actually composites of various tissues, they are also known as composite tissue allografts. The immediate goal of the studies reviewed herein is to lay the foundation in transplant immunobiology for the clinical exploitation of composite tissue allografts...
January 1990: Journal of Burn Care & Rehabilitation
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