keyword
https://read.qxmd.com/read/37806848/tubg1-promotes-hepatocellular-carcinoma-via-atr-p53-apoptosis-and-cycling-pathways
#21
JOURNAL ARTICLE
Yan Zhang, Zhen-Zhen Wang, An-Qi Han, Ming-Ya Yang, Li-Xin Zhu, Fa-Ming Pan, Yong Wang
BACKGROUND: As reported, γ-tubulin (TuBG1) is related to the occurrence and development of various types of malignant tumors. However, its role in hepatocellular cancer (HCC) is not clear. The present study was to investigate the relationship between TuBG1 and clinical parameters and survival in HCC patients. METHODS: The correlation between TuBG1 and clinical parameters and survival in HCC patients was explored by bioinformatics analysis. Immunohistochemistry was used for the verification...
September 26, 2023: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/37784385/a-pilot-first-in-human-study-of-autologous-ifn-gamma-stimulated-mesenchymal-stromal-cells-for-treatment-of-radiation-induced-xerostomia
#22
JOURNAL ARTICLE
G C Blitzer, T Glazer, S Gustafson, A Burr, R Mattison, O Ganz, R Meyers, K McDowell, M Weiss, K P Nickel, R J Chappell, N Pulia, J Gallipeau, R J Kimple
PURPOSE/OBJECTIVE(S): There are no existing effective treatments for radiation-induced xerostomia (RIX), a common side effect of head and neck radiation. Mesenchymal stromal cells (MSCs) exhibit regenerative effects in multiple tissues and may represent an effective cell therapy for the treatment of RIX. Here we present the primary safety and secondary efficacy endpoints of a first-in-human pilot study of IFNγ-stimulated autologous bone marrow- derived MSCs [MSC(M)] for the treatment of RIX...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37762049/single-nucleus-rna-seq-open-the-era-of-great-navigation-for-ffpe-tissue
#23
REVIEW
Yunxia Guo, Wenjia Wang, Kaiqiang Ye, Liyong He, Qinyu Ge, Yan Huang, Xiangwei Zhao
Single-cell sequencing (scRNA-seq) has revolutionized our ability to explore heterogeneity and genetic variations at the single-cell level, opening up new avenues for understanding disease mechanisms and cell-cell interactions. Single-nucleus RNA-sequencing (snRNA-seq) is emerging as a promising solution to scRNA-seq due to its reduced ionized transcription bias and compatibility with richer samples. This approach will provide an exciting opportunity for in-depth exploration of billions of formalin-fixed paraffin-embedded (FFPE) tissues...
September 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37737767/a-management-model-in-blood-tissue-and-cell-establishments-to-ensure-rapid-and-sustainable-patient-access-to-advanced-therapy-medicinal-products-in-europe
#24
REVIEW
Joaquín Delgadillo, Erja Kerkelä, Allison Waters, Emile van den Akker, Chantal Lechanteur, Etienne Baudoux, Nicola Gardiner, John De Vos, Joaquim Vives
Blood, tissue and cell establishments (BTCs) stand out in the management of donor selection, procurement and processing of all types of substances of human origin (SoHO). In the last decades, the framework created around BTCs, including hospitals and national health system networks, and their links to research, development and innovation organizations and agencies have spurred their involvement in the study of groundbreaking advanced therapy medicinal products (ATMP). To further improve strategic synergies in the development of ATMPs, it will be required to promote intra- and inter-European collaborations by creating an international network involving BTCs and major stakeholders (i...
September 5, 2023: Cytotherapy
https://read.qxmd.com/read/37676979/in-response-to-establishing-biobanking-in-medical-curricula-the-education-program-precision-medicine-international-edubrother-in-biopreservation-and-biobanking-published-on-november-11-2022-by-seidler-d-et-al
#25
JOURNAL ARTICLE
Fayek Elkhwsky, Amal Allam, Zisis Kozlakidis, Amal Shaikhah, Asmaa Abd Elhameed
No abstract text is available yet for this article.
September 7, 2023: Biopreservation and Biobanking
https://read.qxmd.com/read/37675770/organization-of-hannover-skin-bank-sterile-culture-and-procurement-protocols-for-viable-cryopreserved-allogeneic-skin-grafts-of-living-donors
#26
JOURNAL ARTICLE
Frederik Schlottmann, Sarah Strauß, Stefan Ziesing, Christiane Reineke, Ramin Ipaktchi, Birgit Weyand, Nicco Krezdorn, Peter Maria Vogt, Vesna Bucan
Preserved allogeneic donor skin still represents one of the gold standard therapies in temporary wound coverage in severely burned patients or chronic wounds. Allogeneic skin grafts are currently commercially available as cryo- or glycerol-preserved allografts through skin tissue banks all over the world. Most of the skin tissue banks rely on human cadaveric skin donations. Due to the chronic shortage of human allogeneic transplants, such as skin, and increasing costs in the procurement of allografts from other skin tissue banks, Hannover Medical School has been building up its own skin tissue bank based on allogeneic skin grafts from living donors who underwent surgical treatment (i...
September 7, 2023: International Wound Journal
https://read.qxmd.com/read/37648379/assessment-of-oxygen-extraction-rate-changes-following-red-blood-cell-transfusion-in-the-intensive-care-unit-a-protocol-for-a-prospective-observational-non-interventional-study
#27
JOURNAL ARTICLE
Ahmet Salih Tüzen, Murat Aksun, Atilla Sencan, Senem Girgin, Birzat Emre Gölboyu, Gizem Kırbaş, Ozan Şanlı
INTRODUCTION: Haemoglobin transfusion thresholds have been used in the intensive care unit (ICU) to guide red blood cell transfusion (RBCT) decisions. Recent research has also focused on physiological indicators of tissue oxygenation as trigger points for blood transfusion. This study aims to assess the oxygen extraction rate (O2 ER) as a critical indicator of the oxygen delivery-consumption balance in tissues and investigate its potential as a reliable trigger for blood transfusion in ICU patients by analysing clinical outcomes...
August 30, 2023: BMJ Open
https://read.qxmd.com/read/37604567/p26-a125%C3%A2-donation-medicine-a-change-of-paradigm-in-procuring-ocular-tissues-for-transplantation
#28
JOURNAL ARTICLE
Ilaria Zorzi, Gary Lloyd Aubrey Jones, Diego Ponzin
PURPOSE: To reflect on the implementation of the concept of 'Donation Medicine' as a substitute for 'Procurement' to describe the Foundation's activities in the procurement of ocular tissue and donor selection, considering that the prevailing connotation of procurement (the action of obtaining materials, goods and services necessary to the functioning of a productive activity) did not express satisfactorily all the social, human and medical implications of a programme aimed at promoting ocular tissue donation and recovery...
August 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37604561/p18-a148%C3%A2-assymetrical-injector-for-endothelium-in-dmek-without-the-need-of-pull-through-technique
#29
JOURNAL ARTICLE
Mikhail Tsurkan, John Lohmeier, Staci Terrin, Simone Arndt, Sarah Tsurkan
PURPOSE: One of latest surgical development of preloaded Descemet membrane endothelial keratoplasty (DMEK) is the delivery of the graft with the endothelium inwards, which allows for a very fast operation, but requires a pull-through surgical technique. Although the tri-folded, endo-in DMEK technique has significant advantages, the absence of proper surgical instruments that could allow their use without the 'pull-through' technique still restricts the wide use of such an operation. None of the available commercial DMEK injectors could be used for tri-folded DMEK (endothelium-inward) orientation, as it requires the graft to be intently secured within the injector...
August 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37604551/p24-a114%C3%A2-bringing-together-the-eye-banking-community-throughout-europe-and-beyond-promoting-eye-donation-in-africa
#30
JOURNAL ARTICLE
Anna-Katharina Salz, Kristin Kleinhoff, Nicola Hofmann, Anna Rausch, Jan Kniese, Martin Börgel
PURPOSE: It is estimated that globally there are more than 12.7 million corneal blinds with the vast majority of those living in the developing world. There is huge demand for corneal transplants worldwide as currently only one out of 70 patients can be provided with a cornea.Following the spirit of EEBA in bringing together the international eye banking community we present on our efforts and vision in contributing to the elimination of avoidable blindness in Africa by promoting sustainable eye donation programs...
August 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37604547/p37-a124%C3%A2-smile-bank-corneal-stromal-lenticules-from-relex-smile-the-new-eye-bank-product
#31
JOURNAL ARTICLE
Magdalena Netuková, Yun Min Klimešová, Martina Poláchová, Pavel Studený
PURPOSE: The aim of our presentation is to introduce future eye bank product - corneal stromal lenticule from living donors, which can be used for allotransplantation. METHODS: ReLEx (refractive lenticule extraction) SMILE (small incision lenticule extraction) is a common approach in laser eye surgery. It is minimally invasive and flap-free procedure. During this procedure part of corneal stroma (lenticule) is created by femtosecond laser and consequently removed through small incision...
August 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37604529/p23-a137%C3%A2-cross-border-cooperation-for-corneal-donation-between-lions-eye-bank-saar-lor-lux-trier-westpfalz-in-homburg-saar-and-luxembourg
#32
JOURNAL ARTICLE
Max Bofferding, Loic Hamon, Adrien Quintin, Isabel Weinstein, Loay Daas, Berthold Seitz
PURPOSE: With the increasing demand for corneas, eye banks must optimize and extend their sources of tissue donation. On the other hand, corneal transplantation is a specialized procedure performed in hospitals with high quality standards and ideally an integrated eye bank. In this report we would like to focus on an international win-win-win agreement between the Department of Ophthalmology at Saarland University Medical Center (Homburg/Saar, Germany), the LIONS Eye Bank Saar-Lor-Lux, Trier/Westpfalz and the four major non-university hospitals without corneal transplantation competence in Luxembourg...
August 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37594516/biobanking-in-the-asia-pacific-region-the-challenges-of-international-biospecimen-sharing
#33
EDITORIAL
Annette Schmid, Zisis Kozlakidis, Marianna Bledsoe
No abstract text is available yet for this article.
August 2023: Biopreservation and Biobanking
https://read.qxmd.com/read/37331846/-terra-incognita-of-tissue-donation-a-systematic-literature-review-analyzing-institutional-factors-influencing-the-willingness-to-donate-tissue
#34
REVIEW
Katja Kirchner, Michael Lauerer, Eckhard Nagel
INTRODUCTION: Partly because of a lack of governmental commitment in educational work, tissue donation is largely unknown in the German population, although it has an increasing relevance for patient care. Due to the progress in research, the shortage of donor tissues in Germany is constantly increasing and has to be compensated by imports. In contrast, nations such as the USA are self-sufficient in donor tissue and can even export it. Since not only individual but also institutional factors (e...
June 16, 2023: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://read.qxmd.com/read/37314384/what-are-the-complications-function-and-survival-of-tumor-devitalized-autografts-used-in-patients-with-limb-sparing-surgery-for-bone-and-soft-tissue-tumors-a-japanese-musculoskeletal-oncology-group-multi-institutional-study
#35
JOURNAL ARTICLE
Akihiko Takeuchi, Hiroyuki Tsuchiya, Nokitaka Setsu, Tabu Gokita, Yasunori Tome, Naofumi Asano, Yusuke Minami, Hiroyuki Kawashima, Suguru Fukushima, Satoshi Takenaka, Hidetatsu Outani, Tomoki Nakamura, Satoshi Tsukushi, Teruya Kawamoto, Teruki Kidani, Munehisa Kito, Hiroshi Kobayashi, Takeshi Morii, Toru Akiyama, Tomoaki Torigoe, Koji Hiraoka, Akihito Nagano, Shigeki Kakunaga, Kazuhiko Hashimoto, Makoto Emori, Hisaki Aiba, Yoshikazu Tanzawa, Takafumi Ueda, Hirotaka Kawano
BACKGROUND: Tumor-devitalized autografts treated with deep freezing, pasteurization, and irradiation are biological reconstruction methods after tumor excision for aggressive or malignant bone or soft tissue tumors that involve a major long bone. Tumor-devitalized autografts do not require a bone bank, they carry no risk of viral or bacterial disease transmission, they are associated with a smaller immunologic response, and they have a better shape and size match to the site in which they are implanted...
June 14, 2023: Clinical Orthopaedics and related Research
https://read.qxmd.com/read/37285729/mscda-multi-level-semantic-guided-contrast-improves-unsupervised-domain-adaptation-for-breast-mri-segmentation-in-small-datasets
#36
JOURNAL ARTICLE
Sheng Kuang, Henry C Woodruff, Renee Granzier, Thiemo J A van Nijnatten, Marc B I Lobbes, Marjolein L Smidt, Philippe Lambin, Siamak Mehrkanoon
Deep learning (DL) applied to breast tissue segmentation in magnetic resonance imaging (MRI) has received increased attention in the last decade, however, the domain shift which arises from different vendors, acquisition protocols, and biological heterogeneity, remains an important but challenging obstacle on the path towards clinical implementation. In this paper, we propose a novel Multi-level Semantic-guided Contrastive Domain Adaptation (MSCDA) framework to address this issue in an unsupervised manner. Our approach incorporates self-training with contrastive learning to align feature representations between domains...
May 19, 2023: Neural Networks: the Official Journal of the International Neural Network Society
https://read.qxmd.com/read/37282704/15%C3%A2-increase-eyes-procured-and-transplanted-via-a-comprehensive-interoperable-and-secure-digital-donor-and-transplant-management-platform
#37
JOURNAL ARTICLE
John Piano, Wade Liu, Nicole Williams
BACKGROUND: One of the barriers to increasing the number of eye donors and transplants is the lack of an integrated, real-time clinical workflow platform with capabilities to secure interface with external systems. It is well understood that costly inefficiencies exist in the current fragmented donation and transplantation ecosystem: systems operate in silos without seamless sharing of key data. A modern, interoperable digital system can directly increase the number of eyes procured and transplanted...
November 2022: BMJ Open Ophthalmology
https://read.qxmd.com/read/37282702/11%C3%A2-growing-together-in-diversity-indo-german-cooperation-enhancing-eye-donation-in-north-india
#38
JOURNAL ARTICLE
Anna-Katharina Salz, Martha Perczak, Nea Dierolf, Nicola Hofmann, Manisha Acharya, Rakhi Nathawat, Martin Börgel, Virender Sangwan
In India, the most densely populated state is Uttar Pradesh in the Northern region. This state has a huge base of corneal blind population due to cornea infections, ocular trauma, and (chemical) burns.Successful cornea transplantation using human post-mortem donated cornea is a treatment modality. In India lack of availability of donated cornea is a public health challenge. Thus, there is great need to reduce the huge demand and supply gap by increasing the donations for supply of cornea to patients.The Eye Bank at the Dr...
November 2022: BMJ Open Ophthalmology
https://read.qxmd.com/read/37246337/first-report-of-stemphylium-leaf-blight-of-onion-allium-cepa-caused-by-stemphylium-vesicarium-in-italy
#39
JOURNAL ARTICLE
Marina Cortiello, Antonio Prodi, Emilio Stefani, Davide Giovanardi
In July 2019, severe leaf symptoms were observed on onion plants (Allium cepa L. cv. Dorata di Parma) in a commercial field located in the municipality of Medicina (Bologna, Emilia-Romagna region), in northern Italy. Diseased leaves showed yellowish-pale-brown and oval-shaped lesions, which later coalesced in larger necrotic areas, and black leaf tips. As the disease progressed, conidia developed on the necrotizing leaves, until premature desiccation of the whole plants. Disease incidence of approximately 70% was calculated in the affected field, together with yield losses that were estimated to be above 30%...
May 28, 2023: Plant Disease
https://read.qxmd.com/read/37224678/outdoor-air-pollution-and-histologic-composition-of-normal-breast-tissue
#40
JOURNAL ARTICLE
Jennifer L Ish, Mustapha Abubakar, Shaoqi Fan, Rena R Jones, Nicole M Niehoff, Jill E Henry, Gretchen L Gierach, Alexandra J White
BACKGROUND: Biologic pathways underlying the association between outdoor air pollution and breast cancer risk are poorly understood. Breast tissue composition may reflect cumulative exposure to breast cancer risk factors and has been associated with breast cancer risk among patients with benign breast disease. Herein, we evaluated whether fine particulate matter (PM2.5 ) was associated with the histologic composition of normal breast tissue. METHODS: Machine-learning algorithms were applied to digitized hematoxylin and eosin-stained biopsies of normal breast tissue to quantify the epithelium, stroma, adipose and total tissue area from 3,977 individuals aged 18-75 years from a primarily Midwestern United States population who donated breast tissue samples to the Susan G...
May 19, 2023: Environment International
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