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https://www.readbyqxmd.com/read/28334554/rapid-establishment-of-the-european-bank-for-induced-pluripotent-stem-cells-ebisc-the-hot-start-experience
#1
Paul A De Sousa, Rachel Steeg, Elisabeth Wachter, Kevin Bruce, Jason King, Marieke Hoeve, Shalinee Khadun, George McConnachie, Julie Holder, Andreas Kurtz, Stefanie Seltmann, Johannes Dewender, Sascha Reimann, Glyn Stacey, Orla O'Shea, Charlotte Chapman, Lyn Healy, Heiko Zimmermann, Bryan Bolton, Trisha Rawat, Isobel Atkin, Anna Veiga, Bernd Kuebler, Blanca Miranda Serano, Tomo Saric, Jürgen Hescheler, Oliver Brüstle, Michael Peitz, Cornelia Thiele, Niels Geijsen, Bjørn Holst, Christian Clausen, Majlinda Lako, Lyle Armstrong, Shailesh K Gupta, Alexander J Kvist, Ryan Hicks, Anna Jonebring, Gabriella Brolén, Andreas Ebneth, Alfredo Cabrera-Socorro, Patrik Foerch, Martine Geraerts, Tina C Stummann, Shawn Harmon, Carol George, Ian Streeter, Laura Clarke, Helen Parkinson, Peter W Harrison, Adam Faulconbridge, Luca Cherubin, Tony Burdett, Cesar Trigueros, Minal J Patel, Christa Lucas, Barry Hardy, Rok Predan, Joh Dokler, Maja Brajnik, Oliver Keminer, Ole Pless, Philip Gribbon, Carsten Claussen, Annette Ringwald, Beate Kreisel, Aidan Courtney, Timothy E Allsopp
A fast track "Hot Start" process was implemented to launch the European Bank for Induced Pluripotent Stem Cells (EBiSC) to provide early release of a range of established control and disease linked human induced pluripotent stem cell (hiPSC) lines. Established practice amongst consortium members was surveyed to arrive at harmonised and publically accessible Standard Operations Procedures (SOPs) for tissue procurement, bio-sample tracking, iPSC expansion, cryopreservation, qualification and distribution to the research community...
March 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28334222/qrank-a-novel-quantile-regression-tool-for-eqtl-discovery
#2
Xiaoyu Song, Gen Li, Zhenwei Zhou, Xianling Wang, Iuliana Ionita-Laza, Ying Wei
Motivation: Over the past decade, there has been a remarkable improvement in our understanding of the role of genetic variation in complex human diseases, especially via genome-wide association studies. However, the underlying molecular mechanisms are still poorly characterized, impending the development of therapeutic interventions. Identifying genetic variants that influence the expression level of a gene, i.e. expression quantitative trait loci (eQTLs), can help us understand how genetic variants influence traits at the molecular level...
March 11, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28204962/the-clinical-anatomy-of-the-insertion-of-the-rotator-cuff-tendons
#3
M Vosloo, N Keough, M A De Beer
The rotator cuff (RC) insertions according to most anatomical texts are described as being separate from one another. However, clear fusion of the RC tendon fibres exists with prior studies showing this interdigitation forming a common, continuous insertion onto and around the lesser and greater tubercles (LT and GT) of the humerus. Current surgical repair methods (especially arthroscopic techniques) rarely mention or consider these connections during repair and suture anchor implantation. The general principles of RC surgery remain a controversial subject, due to various available techniques, surgeon experience and preference, and the contradicting success rates...
February 16, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28190639/characterizing-white-matter-changes-in-chronic-schizophrenia-a-free-water-imaging-multi-site-study
#4
Lena K L Oestreich, Amanda E Lyall, Ofer Pasternak, Zora Kikinis, Dominick T Newell, Peter Savadjiev, Sylvain Bouix, Martha E Shenton, Marek Kubicki, Thomas J Whitford, Simon McCarthy-Jones
Diffusion tensor imaging (DTI) studies in chronic schizophrenia have found widespread but often inconsistent patterns of white matter abnormalities. These studies have typically used the conventional measure of fractional anisotropy, which can be contaminated by extracellular free-water. A recent free-water imaging study reported reduced free-water corrected fractional anisotropy (FAT) in chronic schizophrenia across several brain regions, but limited changes in the extracellular volume. The present study set out to validate these findings in a substantially larger sample...
February 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28157770/global-adverse-event-reports-of-breast-implant-associated-alcl-an-international-review-of-40-government-authority-databases
#5
Dhivya R Srinivasa, Roberto N Miranda, Arminder Kaura, Ashleigh M Francis, Antonella Campanale, Rosaria Boldrini, Janette Alexander, Anand Deva, Paula Gravina, L Jeffrey Medeiros, Karen Nast, Charles E Butler, Mark W Clemens
BACKGROUND: An estimated 200 patients have been reported with breast implant associated anaplastic large cell lymphoma (BI-ALCL), a rare T-cell lymphoma developing around breast prostheses. The purpose of this study was to review federal database submissions relating to BI-ALCL in 37 countries representing the majority of breast implant markets worldwide with available adverse event reporting. METHODS: Database queries were performed for Australia, Brazil, Canada, China, Columbia, Japan, Mexico, National Competent Authorities of the European Member States, New Zealand, South Korea, and United States...
January 20, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28052061/integrated-genomic-characterization-of-oesophageal-carcinoma
#6
(no author information available yet)
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopathological and epidemiologic distinctions, molecular features differentiated oesophageal squamous cell carcinomas from oesophageal adenocarcinomas. Oesophageal squamous cell carcinomas resembled squamous carcinomas of other organs more than they did oesophageal adenocarcinomas...
January 12, 2017: Nature
https://www.readbyqxmd.com/read/27837287/status-quo-of-management-of-the-human-tissue-banks-in-taiwan
#7
REVIEW
Ching-Pang Chou, Szu-Cheng Chou, Ying-Hua Chen, Yu-Hsuan Chen, Ming-Shin Lee
As the technologies associated with transplantation and biological tissue engineering continue to advance, human cells and tissues form an integral part to the practice of regenerative medicine. The patient's use of tissues entails the risk of introducing, transmitting and spreading communicable diseases. To prevent such risk and to ensure that the human organs, tissues and cells remain intact and functional after being handled and processed, the transplanted tissues must be subject to good management standards through all stages of collection, screening, processing, storage and distribution as the safety of the users is of the utmost importance...
March 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/27671727/ensuring-the-quality-of-stem-cell-derived-in-vitro-models-for-toxicity-testing
#8
Glyn N Stacey, Sandra Coecke, Anna-Bal Price, Lyn Healy, Paul Jennings, Anja Wilmes, Christian Pinset, Magnus Ingelman-Sundberg, Jochem Louisse, Simone Haupt, Darren Kidd, Andrea Robitski, Heinz-Georg Jahnke, Gilles Lemaitre, Glenn Myatt
Quality control of cell cultures used in new in vitro toxicology assays is crucial to the provision of reliable, reproducible and accurate toxicity data on new drugs or constituents of new consumer products. This chapter explores the key scientific and ethical criteria that must be addressed at the earliest stages of developing toxicology assays based on human pluripotent stem cell (hPSC) lines. It also identifies key considerations for such assays to be acceptable for regulatory, laboratory safety and commercial purposes...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27635063/new-zealand-trends-in-corneal-transplantation-over-the-25%C3%A2-years-1991-2015
#9
Bia Z Kim, Jay J Meyer, Nigel H Brookes, S Louise Moffatt, Helen C Twohill, David G Pendergrast, Trevor Sherwin, Charles N J McGhee
AIMS: To report the 25-year longitudinal trends in indications and corneal transplantation techniques in New Zealand. METHODS: Statistical analysis of prospectively acquired New Zealand National Eye Bank (NZNEB) electronic database from 1991 to 2015 inclusive. Subjects were recipients of corneal transplants in 62 centres supplied by the NZNEB. Main outcome measures were indications, recipient age and transplantation techniques. RESULTS: From January 1991 to December 2015, NZNEB supplied tissue for 5574 corneal transplants, increasing annually from 89 (1991) to 290 (2015)...
September 15, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27600653/external-dose-reconstruction-in-tooth-enamel-of-techa-riverside-residents
#10
E A Shishkina, A Yu Volchkova, Y S Timofeev, P Fattibene, A Wieser, D V Ivanov, V A Krivoschapov, V I Zalyapin, S Della Monaca, V De Coste, M O Degteva, L R Anspaugh
This study summarizes the 20-year efforts for dose reconstruction in tooth enamel of the Techa riverside residents exposed to ionizing radiation as a result of radionuclide releases into the river in 1949-1956. It represents the first combined analysis of all the data available on EPR dosimetry with teeth of permanent residents of the Techa riverside territory. Results of electron paramagnetic resonance (EPR) measurements of 302 teeth donated by 173 individuals living permanently in Techa riverside settlements over the period of 1950-1952 were analyzed...
September 6, 2016: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/27468661/accuracy-of-national-institutes-of-health-stroke-scale-score-in-predicting-the-site-of-arterial-occlusion-in-acute-stroke-a-transcranial-doppler-study
#11
Deepak Gupta, Arvind Sharma, Ken Uchino, Andrei V Alexandrov, Khurshid Khan, Ashfaq Shuaib, Maher Saqqur
BACKGROUND: In acute stroke, it is crucial to assess for intracranial large-vessel occlusion and site of occlusion. The National Institutes of Health Stroke Scale score (NIHSSS) is the frequently used clinical tool to predict the site of arterial occlusion. In this study we aimed to determine the following: (1) if there is a correlation between the site of occlusion and the NIHSSS at presentation (bNIHSSS); and (2) if there is a bNIHSSS cutoff which can distinguish proximal occlusions (PO) from distal occlusions (DO)...
September 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27466222/irradiated-hamstring-tendon-allograft-versus-autograft-for-anatomic-double-bundle-anterior-cruciate-ligament-reconstruction-midterm-clinical-outcomes
#12
Shaoqi Tian, Bin Wang, Lun Liu, Yuanhe Wang, Chengzhi Ha, Qicai Li, Xu Yang, Kang Sun
BACKGROUND: Most studies on grafts for anterior cruciate ligament (ACL) reconstruction (ACLR) have been of autografts or nonirradiated allografts with a single-bundle (SB) technique. Outcome reports evaluating anatomic double-bundle (DB) ACLR with a hamstring tendon autograft versus irradiated allograft are rare. PURPOSE: To compare the clinical outcomes of arthroscopic anatomic DB ACLR with a hamstring tendon autograft versus irradiated allograft. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2...
October 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27375837/development-of-a-fresh-osteochondral-allograft-program-outside-north-america
#13
Luís Eduardo Passarelli Tírico, Marco Kawamura Demange, Luiz Augusto Ubirajara Santos, Márcia Uchoa de Rezende, Camilo Partezani Helito, Riccardo Gomes Gobbi, José Ricardo Pécora, Alberto Tesconi Croci, William Dick Bugbee
OBJECTIVE: To standardize and to develop a fresh osteochondral allograft protocol of procurement, processing and surgical utilization in Brazil. This study describes the steps recommended to make fresh osteochondral allografts a viable treatment option in a country without previous fresh allograft availability. DESIGN: The process involves regulatory process modification, developing and establishing procurement, and processing and surgical protocols. RESULTS: Legislation: Fresh osteochondral allografts were not feasible in Brazil until 2009 because the law prohibited preservation of fresh grafts at tissue banks...
July 2016: Cartilage
https://www.readbyqxmd.com/read/27369290/new-tools-in-cytometry
#14
REVIEW
A-E Depince-Berger, C Aanei, C Iobagiu, M Jeraiby, C Lambert
Cytometry aims to analyze cells, of any type, using dedicated instruments. The quantitative aspect makes flow cytometry (FCM) a good complementary tool for morphology. Most of the identification tools are based on immunostaining of cell structure details and more and more tools are available in terms of specificities and labels. FCM is under exponential development thanks to technical, immunological and data analysis progresses. Actual generations are now routinely using 6 to 10 simultaneous immuno-labeling on 20 to 100,000 cells, at high speed and short sample preparation and can easily detect rare events at frequency below 10(-4) cells...
December 2016: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/27352286/gasless-single-port-laparoscopic-assisted-vaginal-hysterectomy-for-large-uteri-weighing-500g-or-more
#15
Akihiro Takeda, Shotaro Hayashi, Sanae Imoto, Hiromi Nakamura
OBJECTIVE: To evaluate the safety and feasibility of gasless transumbilical single-port laparoscopic-assisted vaginal hysterectomy (LAVH) for the management of large uteri weighing 500g or more. STUDY DESIGN: We conducted a retrospective comparative study of women with large uteri, each undergoing gasless multi-port or single-port LAVH. Preoperatively, gonadotropin-releasing hormone agonist was administered and autologous blood was donated except for cases requiring immediate surgery...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27351128/establishment-and-characterization-of-a-penile-cancer-cell-line-penl1-with-a-deleterious-tp53-mutation-as-a-paradigm-of-hpv-negative-penile-carcinogenesis
#16
Jieping Chen, Kai Yao, Zaishang Li, Chuangzhong Deng, Liangjiao Wang, Xingsu Yu, Peili Liang, Qiankun Xie, Peng Chen, Zike Qin, Yunlin Ye, Zhuowei Liu, Fangjian Zhou, Zhenfeng Zhang, Hui Han
PURPOSE: To establish penile cancer (PeCa) cell lines for the study of molecular mechanisms of carcinogenesis and testing therapeutic reagents. MATERIALS AND METHODS: We successfully established two PeCa cell lines from fresh tumor tissues from 21 cases. One cell line named Penl1 was isolated from a lymph node metastasis (LNM) of penile squamous cell carcinoma (PeSCC), usual type and comprehensively characterized here. Our in-depth characterization analysis of the Penl1 cell line included morphology, tumorigenicity, genetic characteristics, protein expression, biology, and chemosensitivity...
August 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27223808/population-genetic-structure-abundance-and-health-status-of-two-dominant-benthic-species-in-the-saba-bank-national-park-caribbean-netherlands-montastraea-cavernosa-and-xestospongia-muta
#17
Didier M de Bakker, Erik H W G Meesters, Judith D L van Bleijswijk, Pieternella C Luttikhuizen, Hans J A J Breeuwer, Leontine E Becking
Saba Bank, a submerged atoll in the Caribbean Sea with an area of 2,200 km2, has attained international conservation status due to the rich diversity of species that reside on the bank. In order to assess the role of Saba Bank as a potential reservoir of diversity for the surrounding reefs, we examined the population genetic structure, abundance and health status of two prominent benthic species, the coral Montastraea cavernosa and the sponge Xestospongia muta. Sequence data were collected from 34 colonies of M...
2016: PloS One
https://www.readbyqxmd.com/read/27139235/the-nsw-brain-tissue-resource-centre-banking-for-alcohol-and-major-neuropsychiatric-disorders-research
#18
G T Sutherland, D Sheedy, J Stevens, T McCrossin, C C Smith, M van Roijen, J J Kril
The New South Wales Brain Tissue Resource Centre (NSWBTRC) at the University of Sydney (Australia) is an established human brain bank providing tissue to the neuroscience research community for investigations on alcohol-related brain damage and major psychiatric illnesses such as schizophrenia. The NSWBTRC relies on wide community engagement to encourage those with and without neuropsychiatric illness to consent to donation through its allied research programs. The subsequent provision of high-quality samples relies on standardized operational protocols, associated clinical data, quality control measures, integrated information systems, robust infrastructure, and governance...
May 2016: Alcohol
https://www.readbyqxmd.com/read/27094796/health-care-professionals-knowledge-attitudes-and-practices-relating-to-umbilical-cord-blood-banking-and-donation-an-integrative-review
#19
REVIEW
Lisa Peberdy, Jeanine Young, Lauren Kearney
BACKGROUND: Collection and storage of an infant's cord blood at birth is an option available to many new parents. Antenatal health care providers have an important role in providing non-biased and evidence based information to expectant parents about cord blood and tissue banking options. The aim of this paper was to identify and review studies of health care professionals' knowledge, attitudes and practices concerning cord blood banking and the sources by which healthcare professionals obtained their information on this topic...
April 19, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26921398/structural-analyses-to-identify-selective-inhibitors-of-glyceraldehyde-3-phosphate-dehydrogenase-s-a-sperm-specific-glycolytic-enzyme
#20
Polina V Danshina, Weidong Qu, Brenda R Temple, Rafael J Rojas, Michael J Miley, Mischa Machius, Laurie Betts, Deborah A O'Brien
STUDY HYPOTHESIS: Detailed structural comparisons of sperm-specific glyceraldehyde 3-phosphate dehydrogenase, spermatogenic (GAPDHS) and the somatic glyceraldehyde 3-phosphate dehydrogenase (GAPDH) isozyme should facilitate the identification of selective GAPDHS inhibitors for contraceptive development. STUDY FINDING: This study identified a small-molecule GAPDHS inhibitor with micromolar potency and >10-fold selectivity that exerts the expected inhibitory effects on sperm glycolysis and motility...
June 2016: Molecular Human Reproduction
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