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https://www.readbyqxmd.com/read/29351315/large-scale-mapping-of-bioactive-peptides-in-structural-and-sequence-space
#1
Agustina E Nardo, M Cristina Añón, Gustavo Parisi
Health-enhancing potential bioactive peptide (BP) has driven an interest in food proteins as well as in the development of predictive methods. Research in this area has been especially active to use them as components in functional foods. Apparently, BPs do not have a given biological function in the containing proteins and they do not evolve under independent evolutionary constraints. In this work we performed a large-scale mapping of BPs in sequence and structural space. Using well curated BP deposited in BIOPEP database, we searched for exact matches in non-redundant sequences databases...
2018: PloS One
https://www.readbyqxmd.com/read/29351237/bioengineering-of-rfviia-biopharmaceutical-and-structure-characterization-for-biosimilarity-assessment
#2
Othman Montacir, Houda Montacir, Murat Eravci, Andreas Springer, Stephan Hinderlich, Fereidoun Mahboudi, Amirhossein Saadati, Maria Kristina Parr
Eptacog alfa (NovoSeven®) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells as a single peptide chain of 406 residues. After activation, it consists of a light chain (LC) of 152 amino and a heavy chain (HC) of 254 amino acids. Recombinant FVIIa undergoes many post-translational modifications (PTMs). The first ten glutamic acids of the N-terminal moiety are γ-carboxylated, Asn145 and Asn322 are N-glycosylated, and Ser52 and Ser60 are O-glycosylated...
January 19, 2018: Bioengineering
https://www.readbyqxmd.com/read/29347987/determinants-of-long-term-outcome-in-icu-survivors-results-from-the-frog-icu-study
#3
Etienne Gayat, Alain Cariou, Nicolas Deye, Antoine Vieillard-Baron, Samir Jaber, Charles Damoisel, Qin Lu, Xavier Monnet, Isabelle Rennuit, Elie Azoulay, Marc Léone, Heikel Oueslati, Bertrand Guidet, Diane Friedman, Antoine Tesnière, Romain Sonneville, Philippe Montravers, Sébastien Pili-Floury, Jean-Yves Lefrant, Jacques Duranteau, Pierre-François Laterre, Nicolas Brechot, Karine Chevreul, Morgane Michel, Bernard Cholley, Matthieu Legrand, Jean-Marie Launay, Eric Vicaut, Mervyn Singer, Matthieu Resche-Rigon, Alexandre Mebazaa
BACKGROUND: Intensive care unit (ICU) survivors have reduced long-term survival compared to the general population. Identifying parameters at ICU discharge that are associated with poor long-term outcomes may prove useful in targeting an at-risk population. The main objective of the study was to identify clinical and biological determinants of death in the year following ICU discharge. METHODS: FROG-ICU was a prospective, observational, multicenter cohort study of ICU survivors followed 1 year after discharge, including 21 medical, surgical or mixed ICUs in France and Belgium...
January 18, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29345033/total-synthesis-and-conformational-study-of-the-anti-tubercular-cyclic-peptide-callyaerin-a-bearing-a-rare-rigidifying-z-2-3-diaminoacrylamide-moiety
#4
Margaret Anne Brimble, Shengping Zhang, Luis De Leon Rodriguez, Ivanhoe Leung, Greg Cook, Paul Harris
The first synthesis of the anti-TB cyclic peptide callyaerin A containing a rare (Z)-2,3-diaminoacrylamide bridging motif is reported. Fmoc-formylglycine-diethylacetal was used as a masked equivalent of formylglycine in the synthesis of the linear precursor of callyaerin A. Intramolecular cyclization between the formylglycine residue and the N-terminal amine in the linear peptide precursor afforded the macrocyclic natural product callyaerin A. Synthetic callyaerin A possessed potent anti-TB activity (MIC100 = 32 µM) while its all-amide congener was inactive...
January 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29344411/emerging-roles-of-ganoderma-lucidum-in-anti-aging
#5
REVIEW
Jue Wang, Bin Cao, Haiping Zhao, Juan Feng
Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma lucidum mycelia, Ganodermasides A, B, C, D, and some bioactive components of Ganoderma lucidum, including Reishi Polysaccharide Fraction 3, Ganoderma lucidum polysaccharides I, II, III, IV, Ganoderma lucidum peptide, Ganoderma polysaccharide peptide, total G...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344085/synthesis-secretion-function-metabolism-and-application-of-natriuretic-peptides-in-heart-failure
#6
REVIEW
Shihui Fu, Ping Ping, Fengqi Wang, Leiming Luo
As a family of hormones with pleiotropic effects, natriuretic peptide (NP) system includes atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP receptor-A (guanylate cyclase-A), NP receptor-B (guanylate cyclase-B) and NP receptor-C (clearance receptor). These peptides are genetically distinct, but structurally and functionally related for regulating circulatory homeostasis in vertebrates. In humans, ANP and BNP are encoded by NP precursor A (NPPA) and NPPB genes on chromosome 1, whereas CNP is encoded by NPPC on chromosome 2...
2018: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29340654/antioxidant-angiotensin-converting-enzyme-inhibitory-activity-and-other-functional-properties-of-egg-white-proteins-and-their-derived-peptides-a-review
#7
E D N S Abeyrathne, X Huang, D U Ahn
Egg white contains many functionally important proteins: ovalbumin (54%), ovotransferrin (12%), ovomucoid (11%), ovoglobulin (G2 and G3, 8%), ovomucin (3.5%), and lysozyme (3.5%) are major proteins, while ovoinhibitors, ovomacroglobulin, ovoglycoprotein, ovoflavoprotein, thiamine-binding proteins, and avidin are minor proteins present in egg white. These proteins, as well as the peptides derived from the proteins, have been recognized for their functional importance as antioxidant, antimicrobial, metal-chelating, anti-viral, anti-tumour, and angiotensin-converting enzyme (ACE)-inhibitory activities...
January 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29340118/apelin-apj-system-a-key-therapeutic-target-for-liver-disease
#8
REVIEW
Shuang-Yu Lv, Binbin Cui, Wei-Dong Chen, Yan-Dong Wang
Apelin, a new bioactive peptide, was identified as an endogenous ligand for APJ (Angiotensin II receptor-like 1). Apelin and its receptor have an abundant distribution in central nervous system and peripheral tissues, including liver. Apelin/APJ has diverse physiological and pathological effects, including regulation of cardiovascular function, angiogenesis, fluid homeostasis and so on. Apelin/APJ system may act as a novel potential therapeutic target for liver disease. In this article, we review the role of apelin/APJ system in liver fibrosis, hepatitis, hepatic cirrhosis, liver injury and metabolic liver disease...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340060/assessment-of-antimicrobial-and-wound-healing-effects-of-brevinin-2ta-against-the-bacterium-klebsiella-pneumoniae-in-dermally-wounded-rats
#9
Siqin Liu, Qilin Long, Yang Xu, Jun Wang, Zhongwei Xu, Lei Wang, Mei Zhou, Yuxin Wu, Tianbao Chen, Chris Shaw
Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates. Here, we isolated and identified a novel AMP Brevinin-2Ta (B-2Ta) from the skin secretion of the European frog, Pelophylax kl. esculentus. In vitro studies revealed that it showed broad antimicrobial activities against S. aureus, E. coli and C...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29338238/paralithocins-antimicrobial-peptides-with-unusual-disulfide-connectivity-from-the-red-king-crab-paralithodes-camtschaticus
#10
Morten K Moe, Tor Haug, Magne O Sydnes, Sigmund V Sperstad, Chun Li, Lena C Vaagsfjord, Enrique de la Vega, Klara Stensvåg
As part of an ongoing exploration of marine invertebrates as a source of new antimicrobial peptides, hemocyte extracts from the red king crab, Paralithodes camtschaticus, were studied. Three cationic cysteine (Cys)-rich peptides, named paralithocins 1-3, were isolated by bioassay-guided purification, and their amino acid sequences determined by Edman degradation and expressed sequences tag analysis. Disulfide bond mapping was performed by high-resolution tandem mass spectrometry. The peptides (38-51 amino acids in length) share a unique Cys motif composed of eight Cys, forming four disulfide bridges with a bond connectivity of (Cys relative position) Cys1-Cys8, Cys2-Cys6, Cys3-Cys5, and Cys4-Cys7, a disulfide arrangement that has not been previously reported among antimicrobial peptides...
January 17, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29336438/zein-derived-peptides-as-nanocarriers-to-increase-the-water-solubility-and-stability-of-lutein
#11
Yan Jiao, Xiqun Zheng, Ying Chang, Dajing Li, Xiaohong Sun, Xiaolan Liu
Zein and its derived peptides have been used as nanocarriers for bioactive components. Lutein, as well as other xanthophylls, are characterized by blue light filtering and anti-oxidant properties. However, lutein is unstable and has low water solubility, poor absorption, and low bioavailability. In order to protect lutein from oxidative degradation, and to enhance its solubility and dispersibility, stability and bioactivity, lutein-loaded zein nanoparticles (LLZ-NP) and zein-derived peptide nanoparticles (LLZ-PEP-NP) were prepared by the solvent diffusion method...
January 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29332576/current-understanding-of-physicochemical-mechanisms-for-cell-membrane-penetration-of-arginine-rich-cell-penetrating-peptides-role-of-glycosaminoglycan-interactions
#12
Yuki Takechi-Haraya, Hiroyuki Saito
Arginine-rich cell penetrating peptides (CPPs) are very promising drug carriers to deliver membrane-impermeable pharmaceuticals, such as siRNA, bioactive peptides and proteins. CPPs directly penetrate into cells across cell membranes via a spontaneous energy-independent process, in which CPPs appear to interact with acidic lipids in the outer leaflet of the cell membrane. However, acidic lipids represent only 10 to 20% of the total membrane lipid content and in mammalian cell membranes they are predominantly located in the inner leaflet...
January 11, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29329977/recent-insights-in-the-use-of-nanocarriers-for-the-oral-delivery-of-bioactive-proteins-and-peptides
#13
REVIEW
Patrícia Batista, Pedro M Castro, Ana Raquel Madureira, Bruno Sarmento, Manuela Pintado
Bioactive proteins and peptides have been used with either prophylactic or therapeutic purposes, presenting inherent advantages as high specificity and biocompatibility. Nanocarriers play an important role in the stabilization of proteins and peptides, offering enhanced buccal permeation and protection while crossing the gastrointestinal tract. Moreover, preparation of nanoparticles as oral delivery systems for proteins/peptides may include tailored formulation along with functionalization aiming bioavailability enhancement of carried proteins or peptides...
January 9, 2018: Peptides
https://www.readbyqxmd.com/read/29329853/ph-controlled-fermentation-in-mild-alkaline-conditions-enhances-bioactive-compounds-and-functional-features-of-lentil-to-ameliorate-metabolic-disturbances
#14
Sara Bautista-Expósito, Elena Peñas, José Manuel Silván, Juana Frias, Cristina Martínez-Villaluenga
Lentil fermentation has a promising potential as a strategy for development of multifunctional ingredients targeting metabolic syndrome (MetS). Response surface methodology was applied to optimize lentil fermentation and study its effects on generation of peptides, soluble phenolics and bioactivities. Fermentation using Lactobacillus plantarum and Savinase® 16 L was carried out at different pH (6.5-8.5) and times (5.5-30 h). Analysis of variance was performed to evaluate linear, quadratic and interaction effects between fermentation parameters...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329748/oral-bifidobacterium-longum-expressing-glp-2-improves-nutrient-assimilation-and-nutritional-homeostasis-in-mice
#15
Qian Zhang, Mengge Liu, Shiyu Li, Zhenrui Xu, Jiajia Wang, Yuzhe Wang, Zhengbin Fei, Wenhua Huang, Hanxiao Sun
Bifidobacterium has been developed for the oral delivery of peptides and has the added beneficial effect on our bodies through its probiotic properties. Here, we utilize Bifidobacterium as a delivery system to orally deliver Glucagon like peptide-2 (GLP-2). We constructed vector derived from pET-31b(+) to construct a Bifidobacterium longum expressing GLP-2. We then determined the bioactivity of recombinant Bifidobacterium in Caco-2 cells. Finally, we quantified newly synthesized ApoB48 and chylomicron production in mice infused with exogenous GLP-2 or Bifidobacterium expressing GLP-2...
January 9, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29329501/sustained-plasma-hepcidin-suppression-and-iron-elevation-by-anticalin-derived-hepcidin-antagonist-in-cynomolgus-monkey
#16
Andreas M Hohlbaum, Hendrik Gille, Stefan Trentmann, Maria Kolodziejczyk, Barbara Rattenstetter, Coby M Laarakkers, Galina Katzmann, Hans Jürgen Christian, Nicole Andersen, Andrea Allersdorfer, Shane A Olwill, Bernd Meibohm, Laurent P Audoly, Dorine W Swinkels, Rachel P L van Swelm
BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis. Here we report the engineering of the human lipocalin-derived, small protein-based Anticalin PRS-080 hepcidin antagonist with high affinity and selectivity. EXPERIMENTAL APPROACH: Anticalin- and hepcidin-specific pharmacokinetic/pharmacodynamic modelling was used to design and select the suitable drug candidate based on half life extension and duration of hepcidin suppression...
January 12, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29327917/peptide-based-photoelectrochemical-cytosensor-using-a-hollow-tio2-eg-znin2s4-co-sensitized-structure-for-ultrasensitive-detection-of-early-apoptotic-cells-and-drug-evaluation
#17
Rong Wu, Gao-Chao Fan, Li-Ping Jiang, Jun-Jie Zhu
The ability to rapidly detect apoptotic cells and accurately evaluate therapeutic effects is significant in cancer research. To address this target, a biocompatible, ultrasensitive photoelectrochemical (PEC) cytosensing platform was developed based on electrochemically reduced graphene (EG)/ZnIn2S4 co-sensitized TiO2 coupled with specific recognition between apoptotic cells and phosphatidylserine (PS)-binding peptide (PSBP). In this strategy, HL-60 cells were selected as a model, and C005, nilotinib and imatinib were selected as apoptosis inducers to show cytosensing performance...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29327586/composite-hydrogel-modified-by-igf-1c-domain-improves-stem-cell-therapy-for-limb-ischemia
#18
Xiaomin Wang, Jimin Zhang, Weilong Cui, Yuan Fang, Li Li, Shenglu Ji, Duo Mao, Tingyu Ke, Xin Yao, Dan Ding, Guowei Feng, Deling Kong
Stem cell treatment for critical limb ischemia yields a limited therapeutic effect due to cell loss and dysfunction caused by local ischemic environment. Biomimetic scaffolds emerge as ideal cell delivery vehicles for regulating cell fate via mimicking the components of stem cell niche. Herein, we prepared a bioactive hydrogel by mixing chitosan and hyaluronic acid that is immobilized with C domain peptide of IGF-1 (IGF-1C), and examined whether this hydrogel could augment stem cell survival and therapeutic potential...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29322648/max-bergmann-award-lecture-a-rapid-way-to-discover-bioactive-nonstandard-peptides-assisted-by-the-flexizyme-and-fit-systems
#19
Hiroaki Suga
Although general review articles should cover various people's achievements related to the subject, this review is privileged to describe the technology developed by Suga (and colleagues) as a recipient of the Max-Bergmann Medal in 2016. The technology consists of 3 unique and essential tools, flexizymes, FIT, and RaPID systems. This review describes the history of the development of each tool and discusses the recent applications of the RaPID system to discover potent nonstandard peptides for therapeutic and diagnostic uses...
January 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29322315/effects-of-a-casein-hydrolysate-versus-intact-casein-on-gastric-emptying-and-amino-acid-responses
#20
Katy Horner, Elaine Drummond, Victoria O'Sullivan, Pedapati S C Sri Harsha, Lorraine Brennan
PURPOSE: Milk proteins and/or their hydrolysates have been reported to have beneficial effects for improving postprandial glycaemia. Gastric emptying is a major determinant of postprandial glycaemia, yet limited studies have examined the effects of intact milk proteins compared to hydrolysates on gastric emptying. We investigated gastric emptying of a casein hydrolysate compared to intact casein. METHODS: Nine overweight and obese adults (mean ± SD age: 59...
January 10, 2018: European Journal of Nutrition
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