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marine polyphenols

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https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#1
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28770671/marine-algae-as-attractive-source-to-skin-care
#2
Jean-Yves Berthon, Rachida Nachat-Kappes, Mathieu Bey, Jean-Paul Cadoret, Isabelle Renimel, Edith Filaire
As the largest organ in the human body, the skin has multiple functions of which one of the most important is the protection against various harmful stressors. The keratinised stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissues are important components of the skin. The environmental stressors such as ultraviolet radiation (UVR) and pollution increase the levels of reactive oxygen species (ROS), contributing to clinical manifestations such as wrinkle formation and skin aging...
June 2017: Free Radical Research
https://www.readbyqxmd.com/read/28739056/supplementation-with-vitis-vinifera-l-skin-extract-improves-insulin-resistance-and-prevents-hepatic-lipid-accumulation-and-steatosis-in-high-fat-diet-fed-mice
#3
Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Ana Paula Machado da Rocha, Gisele França da Costa, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela Castro Resende
Nonalcoholic fatty liver disease is one of the most common complications of obesity. The Vitis vinifera L. grape skin extract (ACH09) is an important source of polyphenols, which are related to its antioxidant and antihyperglycemic activities. We hypothesized that ACH09 could also exert beneficial effects on metabolic disorders associated with obesity and evaluated ACH09's influence on high-fat (HF) diet-induced hepatic steatosis and insulin resistance in C57BL/6 mice. The animals were fed a standard diet (10% fat, control) or an HF diet (60% fat, HF) with or without ACH09 (200mg/[kg d]) for 12weeks...
July 2017: Nutrition Research
https://www.readbyqxmd.com/read/28635652/fucaceae-a-source-of-bioactive-phlorotannins
#4
REVIEW
Marcelo D Catarino, Artur M S Silva, Susana M Cardoso
Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28614666/salt-triggers-the-simple-coacervation-of-an-underwater-adhesive-when-cations-meet-aromatic-%C3%AF-electrons-in-seawater
#5
Sangsik Kim, Hee Young Yoo, Jun Huang, Yongjin Lee, Sohee Park, Yeonju Park, Sila Jin, Young Mee Jung, Hongbo Zeng, Dong Soo Hwang, YongSeok Jho
Adhesive systems in many marine organisms are postulated to form complex coacervates (liquid-liquid phase separation) through a process involving oppositely charged polyelectrolytes. Despite this ubiquitous speculation, most well-characterized mussel adhesive proteins are cationic and polyphenolic, and the pursuit of the negatively charged proteins required for bulk complex coacervation formation internally remains elusive. In this study, we provide a clue for unraveling this paradox by showing the bulky fluid/fluid separation of a single cationic recombinant mussel foot protein, rmfp-1, with no additional anionic proteins or artificial molecules, that is triggered by a strong cation-π interaction in natural seawater conditions...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28578033/influence-of-omega-3-pufas-on-the-metabolism-of-proanthocyanidins-in-rats
#6
Eunice Molinar-Toribio, Sara Ramos-Romero, Elisabet Fuguet, Núria Taltavull, Lucía Méndez, Marta Romeu, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez
Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28441760/supplementation-with-a-polyphenol-rich-extract-perfload-%C3%A2-improves-physical-performance-during-high-intensity-exercise-a-randomized-double-blind-crossover-trial
#7
Julien Cases, Cindy Romain, Cristian Marín-Pagán, Linda H Chung, José Miguel Rubio-Pérez, Caroline Laurent, Sylvie Gaillet, Emmanuelle Prost-Camus, Michel Prost, Pedro E Alcaraz
Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad(®), was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation...
April 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28414549/do-marine-algal-polyphenols-have-antidiabetic-antihyperlipidemic-or-anti-inflammatory-effects-in-humans-a-systematic-review
#8
Margaret Murray, Aimee L Dordevic, Maxine P Bonham, Lisa Ryan
Cardiovascular disease and type 2 diabetes are leading causes of morbidity and mortality globally. Marine algal polyphenols have potential to reduce the risk of these conditions, however, little is known about their impact in humans. This systematic review investigates the antidiabetic, antihyperlipidemic and anti-inflammatory effects of marine polyphenols in humans. Scopus, Medline, PsychInfo, Embase and Cochrane Library databases were searched in November 2016. Eligible studies included (1) human adults, (2) marine polyphenol intervention, (3) blood lipid, glucose, insulin or inflammatory marker outcomes, and (4) were a randomized-controlled trial...
April 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28397013/modulatory-efficacy-of-dieckol-on-xenobiotic-metabolizing-enzymes-cell-proliferation-apoptosis-invasion-and-angiogenesis-during-ndea-induced-rat-hepatocarcinogenesis
#9
Velayutham Sadeeshkumar, Arul Duraikannu, Samuthrapandian Ravichandran, Paulrasu Kodisundaram, Wilson Sylvester Fredrick, Rajagopal Gobalakrishnan
Dieckol (DEK) is a major polyphenol of marine brown seaweed Ecklonia cava which is a potential candidate for cancer therapy. However, the underlying mechanism of DEK as an anticancer drug remains to be elucidated. In this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of DEK in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (XMEs), apoptosis, invasion, and angiogenesis. Rats administered NDEA developed hepatocarcinogenesis that displayed apoptosis avoidance coupled to upregulation of pro-inflammatory, invasion, and angiogenesis markers...
April 10, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28260647/a-lipidomic-study-on-the-regulation-of-inflammation-and-oxidative-stress-targeted-by-marine-%C3%AF-3-pufa-and-polyphenols-in-high-fat-high-sucrose-diets
#10
Gabriel Dasilva, Manuel Pazos, Eduardo García-Egido, José M Gallardo, Sara Ramos-Romero, Josep Lluís Torres, Marta Romeu, María-Rosa Nogués, Isabel Medina
The ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health is discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats...
May 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28183047/gene-expression-changes-in-colon-tissues-from-colorectal-cancer-patients-following-the-intake-of-an-ellagitannin-containing-pomegranate-extract-a-randomized-clinical-trial
#11
María A Nuñez-Sánchez, Antonio González-Sarrías, Rocío García-Villalba, Tamara Monedero-Saiz, Noelia V García-Talavera, María B Gómez-Sánchez, Carmen Sánchez-Álvarez, Ana M García-Albert, Francisco J Rodríguez-Gil, Miguel Ruiz-Marín, Francisco A Pastor-Quirante, Francisco Martínez-Díaz, Francisco A Tomás-Barberán, Juan Carlos Espín, María-Teresa García-Conesa
The clinical evidence of dietary polyphenols as colorectal cancer (CRC) chemopreventive compounds is very weak. Verification in humans of tissue-specific molecular regulation by the intake of polyphenols requires complex clinical trials that allow for the procurement of sufficient pre- and postsupplementation tissue samples. Ellagitannins (ETs), ellagic acid (EA) and their gut microbiota-derived metabolites, the urolithins, modify gene expression in colon normal and cancer cultured cells. We conducted here the first clinical trial with 35 CRC patients daily supplemented with 900 mg of an ET-containing pomegranate extract (PE) and evaluated the expression of various CRC-related genes in normal and cancerous colon tissues before (biopsies) and after (surgical specimens) 5-35 days of supplementation...
January 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28132190/biosynthesis-of-metal-nanoparticles-using-three-marine-plant-species-anti-algal-efficiencies-against-oscillatoria-simplicissima
#12
Hala Y El-Kassas, Mary G Ghobrial
This study aims at controlling of the cyanobacteria Oscillatoria simplicissima, those that produce neurotoxins and have negative impacts on the aquatic organisms, using biosynthesized metal nanoparticles (NPs). Silver-NPs (Ag-NPs) have been successfully biosynthesized using Nannochloropsis oculata and Tetraselmis tetrathele cultures. Also, Ag-NPs and iron oxide-NPs (Fe3O4-NPs) were synthesized by Halophila stipulacea aqueous extract. The structural composition of the different biosynthesized NPs was studied...
March 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28115221/epigallocatechin-gallate-induces-a-hepatospecific-decrease-in-the-cyp3a-expression-level-by-altering-intestinal-flora
#13
Nobutomo Ikarashi, Sosuke Ogawa, Ryuta Hirobe, Risako Kon, Yoshiki Kusunoki, Marin Yamashita, Nanaho Mizukami, Miho Kaneko, Nobuyuki Wakui, Yoshiaki Machida, Kiyoshi Sugiyama
In previous studies, we showed that a high-dose intake of green tea polyphenol (GP) induced a hepatospecific decrease in the expression and activity of the drug-metabolizing enzyme cytochrome P450 3A (CYP3A). In this study, we examined whether this decrease in CYP3A expression is induced by epigallocatechin gallate (EGCG), which is the main component of GP. After a diet containing 1.5% EGCG was given to mice, the hepatic CYP3A expression was measured. The level of intestinal bacteria of Clostridium spp., the concentration of lithocholic acid (LCA) in the feces, and the level of the translocation of pregnane X receptor (PXR) to the nucleus in the liver were examined...
March 30, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28071699/rye-polyphenols-and-the-metabolism-of-n-3-fatty-acids-in-rats-a-dose-dependent-fatty-fish-like-effect
#14
Fayçal Ounnas, Michel de Lorgeril, Patricia Salen, François Laporte, Luca Calani, Pedro Mena, Furio Brighenti, Daniele Del Rio, Christine Demeilliers
As long-chain fatty acids (LCFA) of the n-3 series are critically important for human health, fish consumption has considerably increased in recent decades, resulting in overfishing to respond to the worldwide demand, to an extent that is not sustainable for consumers' health, fisheries economy, and marine ecology. In a recent study, it has been shown that whole rye (WR) consumption improves blood and liver n-3 LCFA levels and gut microbiota composition in rats compared to refined rye. The present work demonstrates that specific colonic polyphenol metabolites may dose dependently stimulate the synthesis of n-3 LCFA, possibly through their microbial and hepatic metabolites in rats...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27834493/an-emerging-trend-in-functional-foods-for-the-prevention-of-cardiovascular-disease-and-diabetes-marine-algal-polyphenols
#15
Margaret Murray, Aimee L Dordevic, Lisa Ryan, Maxine P Bonham
Marine macroalgae are gaining recognition among the scientific community as a significant source of functional food ingredients. Due to the harsh environments in which macroalgae survive, they produce unique bioactive compounds that are not found in terrestrial plants. Polyphenols are the predominant bioactive compound in brown algae and are accountable for the majority of its biological activity. Phlorotannins are a type of polyphenol that are unique to marine sources and have exhibited protective effects against hyperglycemia, hyperlipidemia, inflammation and oxidative stress, known risk factors for cardiovascular disease and diabetic complications, in cell culture, animal studies and some human studies...
November 11, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27784909/chemical-and-sensory-characteristics-of-orange-based-vinegar
#16
Cristina Cejudo-Bastante, Remedios Castro-Mejías, Ramón Natera-Marín, Carmelo García-Barroso, Enrique Durán-Guerrero
Several experiments were conducted to developed orange based vinegar by surface culture. The addition of sugar (sucrose and concentrated must) and the presence/absence of peel in the raw material (squeezed juice, peeled orange, non-peeled orange plus squeezed juice) have been studied during the development of the final product. Polyphenolic and volatile characterization and sensory analysis have also been carried out. The polyphenolic and volatile content of the resulting wines and vinegars showed significant differences depending upon the raw material used...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27716532/potential-anti-inflammatory-natural-products-from-marine-algae
#17
REVIEW
I P Shanura Fernando, Jae-Woon Nah, You-Jin Jeon
Inflammatory diseases have become one of the leading causes of health issue throughout the world, having a considerable influence on healthcare costs. With the emerging developments in natural product, synthetic and combinatorial chemistry, a notable success has been achieved in discovering natural products and their synthetic structural analogs with anti-inflammatory activity. However, many of these therapeutics have indicated detrimental side effects upon prolonged usage. Marine algae have been identified as an underexplored reservoir of unique anti-inflammatory compounds...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27658546/flavonoid-compounds-from-the-red-marine-alga-alsidium-corallinum-protect-against-potassium-bromate-induced-nephrotoxicity-in-adult-mice
#18
Hajer Ben Saad, Manel Gargouri, Fatma Kallel, Rim Chaabene, Tahia Boudawara, Kamel Jamoussi, Christian Magné, Khaled Mounir Zeghal, Ahmed Hakim, Ibtissem Ben Amara
Potassium bromate (KBrO3 ), an environmental pollutant, is a well-known human carcinogen and a potent nephrotoxic agent. Currently, natural products have built a well-recognized role in the management of many diseases induced by pollutants. As potent natural sources of bioactive compounds, marine algae have been demonstrated to be rich in novel secondary metabolites with a broad range of biological functions. In this study, adults male mice were orally treated for 15 days with KBrO3 (0.5 g/L) associated or not with extract of Alsidium corallinum, a red Mediterranean alga...
May 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/27614257/extraction-of-polyphenols-in-himanthalia-elongata-and-determination-by-high-performance-liquid-chromatography-with-diode-array-detector-prior-to-its-potential-use-against-oxidative-stress
#19
Mariola Belda, Desiré Sanchez, Elena Bover, Beatriz Prieto, Carolina Padrón, Dolores Cejalvo, Jose Miguel Lloris
Several studies have demonstrated the antioxidant capacity of seaweeds, which can be used for the development of biopharmaceuticals with extensive medical application. Antioxidant therapies appear to attenuate the organic deterioration originated by an excessive oxidative stress, which could prevent the harmful effects of various injuries such as ischemia-reperfusion (I/R) among others. Marine brown seaweeds play a significant role, as they are the only organisms on earth producing phlorotannins, which are polyphenols that exhibit important biological activity...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27595387/angiotensin-i-converting-enzyme-ace-inhibitory-activity-of-fucus-spiralis-macroalgae-and-influence-of-the-extracts-storage-temperature-a-short-report
#20
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, José Baptista
Recently, increasing attention has been paid to the marine algae as a natural source of novel angiotensin-I converting enzyme (ACE) inhibitors, such as the phlorotannins that are the predominant polyphenols in brown algae. This study reports, for the first time, the ACE inhibition of methanol extract/fractions from Azorean brown algae Fucus spiralis (Fs) determined by HPLC-UV method, their total phenolic content (TPC) quantified as phloroglucinol equivalents (PE) and the effect of the Fs dry powder methanol extracts (Fs-DME) storage temperature on ACE inhibition...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
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