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https://www.readbyqxmd.com/read/27834493/an-emerging-trend-in-functional-foods-for-the-prevention-of-cardiovascular-disease-and-diabetes-marine-algal-polyphenols
#1
Margaret Murray, Aimee L Dordevic, Lisa Ryan, Maxine P Bonham
Marine macroalgae are gaining recognition among the scientific community as a significant source of functional food ingredients. Due to the harsh environments in which macroalgae survive, they produce unique bioactive compounds that are not found in terrestrial plants. Polyphenols are the predominant bioactive compound in brown algae and are accountable for the majority of its biological activity. Phlorotannins are a type of polyphenol that are unique to marine sources and have exhibited protective effects against hyperglycaemia, hyperlipidaemia, inflammation and oxidative stress, known risk factors for cardiovascular disease and diabetic complications, in cell culture, animal studies and some human studies...
November 11, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27784909/chemical-and-sensory-characteristics-of-orange-based-vinegar
#2
Cristina Cejudo-Bastante, Remedios Castro-Mejías, Ramón Natera-Marín, Carmelo García-Barroso, Enrique Durán-Guerrero
Several experiments were conducted to developed orange based vinegar by surface culture. The addition of sugar (sucrose and concentrated must) and the presence/absence of peel in the raw material (squeezed juice, peeled orange, non-peeled orange plus squeezed juice) have been studied during the development of the final product. Polyphenolic and volatile characterization and sensory analysis have also been carried out. The polyphenolic and volatile content of the resulting wines and vinegars showed significant differences depending upon the raw material used...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27716532/potential-anti-inflammatory-natural-products-from-marine-algae
#3
REVIEW
I P Shanura Fernando, Jae-Woon Nah, You-Jin Jeon
Inflammatory diseases have become one of the leading causes of health issue throughout the world, having a considerable influence on healthcare costs. With the emerging developments in natural product, synthetic and combinatorial chemistry, a notable success has been achieved in discovering natural products and their synthetic structural analogs with anti-inflammatory activity. However, many of these therapeutics have indicated detrimental side effects upon prolonged usage. Marine algae have been identified as an underexplored reservoir of unique anti-inflammatory compounds...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27658546/flavonoid-compounds-from-the-red-marine-alga-alsidium-corallinum-protect-against-potassium-bromate-induced-nephrotoxicity-in-adult-mice
#4
Hajer Ben Saad, Manel Gargouri, Fatma Kallel, Rim Chaabene, Tahia Boudawara, Kamel Jamoussi, Christian Magné, Khaled Mounir Zeghal, Ahmed Hakim, Ibtissem Ben Amara
Potassium bromate (KBrO3 ), an environmental pollutant, is a well-known human carcinogen and a potent nephrotoxic agent. Currently, natural products have built a well-recognized role in the management of many diseases induced by pollutants. As potent natural sources of bioactive compounds, marine algae have been demonstrated to be rich in novel secondary metabolites with a broad range of biological functions. In this study, adults male mice were orally treated for 15 days with KBrO3 (0.5 g/L) associated or not with extract of Alsidium corallinum, a red Mediterranean alga...
September 23, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27614257/extraction-of-polyphenols-in-himanthalia-elongata-and-determination-by-high-performance-liquid-chromatography-with-diode-array-detector-prior-to-its-potential-use-against-oxidative-stress
#5
Mariola Belda, Desiré Sanchez, Elena Bover, Beatriz Prieto, Carolina Padrón, Dolores Cejalvo, Jose Miguel Lloris
Several studies have demonstrated the antioxidant capacity of seaweeds, which can be used for the development of biopharmaceuticals with extensive medical application. Antioxidant therapies appear to attenuate the organic deterioration originated by an excessive oxidative stress, which could prevent the harmful effects of various injuries such as ischemia-reperfusion (I/R) among others. Marine brown seaweeds play a significant role, as they are the only organisms on earth producing phlorotannins, which are polyphenols that exhibit important biological activity...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27595387/angiotensin-i-converting-enzyme-ace-inhibitory-activity-of-fucus-spiralis-macroalgae-and-influence-of-the-extracts-storage-temperature-a-short-report
#6
Lisete Paiva, Elisabete Lima, Ana Isabel Neto, José Baptista
Recently, increasing attention has been paid to the marine algae as a natural source of novel angiotensin-I converting enzyme (ACE) inhibitors, such as the phlorotannins that are the predominant polyphenols in brown algae. This study reports, for the first time, the ACE inhibition of methanol extract/fractions from Azorean brown algae Fucus spiralis (Fs) determined by HPLC-UV method, their total phenolic content (TPC) quantified as phloroglucinol equivalents (PE) and the effect of the Fs dry powder methanol extracts (Fs-DME) storage temperature on ACE inhibition...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27537110/mango-leaf-extract-improves-central-pathology-and-cognitive-impairment-in-a-type-2-diabetes-mouse-model
#7
Carmen Infante-Garcia, Juan Jose Ramos-Rodriguez, Yolanda Marin-Zambrana, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Monica Garcia-Alloza
Epidemiological studies reveal that metabolic disorders, and specifically type 2 diabetes (T2D), are relevant risk factors to develop Alzheimer's disease (AD) and vascular dementia (VaD), the most common causes of dementia. Due to the limited success of available treatments, AD patients are in a tremendous need of new therapeutic options. Natural polyphenols, and concretely Mangifera indica Linn extract (MGF), have been reported to have antiinflammatory, antioxidant and antidiabetic activities. We have analyzed the role of MGF in central complications associated with T2D, after long-term treatment of db/db mice with MGF...
August 18, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27460368/dna-extraction-protocols-for-whole-genome-sequencing-in-marine-organisms
#8
Marina Panova, Henrik Aronsson, R Andrew Cameron, Peter Dahl, Anna Godhe, Ulrika Lind, Olga Ortega-Martinez, Ricardo Pereyra, Sylvie V M Tesson, Anna-Lisa Wrange, Anders Blomberg, Kerstin Johannesson
The marine environment harbors a large proportion of the total biodiversity on this planet, including the majority of the earths' different phyla and classes. Studying the genomes of marine organisms can bring interesting insights into genome evolution. Today, almost all marine organismal groups are understudied with respect to their genomes. One potential reason is that extraction of high-quality DNA in sufficient amounts is challenging for many marine species. This is due to high polysaccharide content, polyphenols and other secondary metabolites that will inhibit downstream DNA library preparations...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27332715/antioxidant-activity-of-marine-algal-polyphenolic-compounds-a-mechanistic-approach
#9
I P Shanura Fernando, Misook Kim, Kwang-Tae Son, Yoonhwa Jeong, You-Jin Jeon
Polyphenolic compounds isolated from marine algae exhibit a broad spectrum of beneficial biological properties, including antioxidant, anticancer, antimicrobial, anti-inflammatory, and antidiabetic activities, along with several other bioactivities centered on their antioxidant properties. Consequently, polyphenolic compounds are increasingly being investigated for their potential use in food, cosmetic, and pharmaceutical applications. The antioxidant activities of these compounds have been explored widely through experimental studies...
July 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27225823/disruption-of-fibers-from-the-tau-model-acphf6-by-naturally-occurring-aurones-and-synthetic-analogues
#10
Laurent Lunven, Hugues Bonnet, Samir Yahiaoui, Wei Yi, Laurène Da Costa, Marine Peuchmaur, Ahcène Boumendjel, Sabine Chierici
The formation of tau aggregates is strongly linked to the neurodegenerative process in tauopathies such as Alzheimer's disease (AD). Yet only a few molecules have shown to efficiently prevent the in vitro formation of those aggregates, and the identification of such molecules is still an ongoing interest in a therapeutic context. Herein, we report the in vitro evaluation of a series of aurones against the fibrillation of the tau-derived hexapeptide AcPHF6 model. Using thioflavin T-based fluorescence assays, circular dichroism and atomic force microscopy, we showed that aurones are capable of efficiently interacting with the tau-derived hexapeptide...
July 20, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27213031/infrared-spectroscopy-as-a-tool-to-study-the-antioxidant-activity-of-polyphenolic-compounds-in-isolated-rat-enterocytes
#11
Guillermo Barraza-Garza, Hiram Castillo-Michel, Laura A de la Rosa, Alejandro Martinez-Martinez, Jorge A Pérez-León, Marine Cotte, Emilio Alvarez-Parrilla
The protective effect of different polyphenols, catechin (Cat), quercetin (Qc) (flavonoids), gallic acid (GA), caffeic acid (CfA), chlorogenic acid (ChA) (phenolic acids), and capsaicin (Cap), against H2O2-induced oxidative stress was evaluated in rat enterocytes using Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) Spectroscopy and Fourier Transform Infrared Microspectroscopy (FTIRM), and results were compared to standard lipid peroxidation techniques: conjugated dienes (CD) and Thiobarbituric Acid Reactive Substances (TBARS)...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27192480/in%C3%A2-vitro-exposure-of-ulva-lactuca-linnaeus-chlorophyta-to-gasoline-biochemical-and-morphological-alterations
#12
Fernanda Kokowicz Pilatti, Fernanda Ramlov, Eder Carlos Schmidt, Marianne Kreusch, Débora Tomazi Pereira, Christopher Costa, Eva Regina de Oliveira, Cláudia M Bauer, Miguel Rocha, Zenilda Laurita Bouzon, Marcelo Maraschin
Refined fuels have considerable share of pollution of marine ecosystems. Gasoline is one of the most consumed fuel worldwide, but its effects on marine benthic primary producers are poorly investigated. In this study, Ulva lactuca was chosen as a biological model due to its cosmopolitan nature and tolerance to high levels and wide range of xenobiotics and our goal was to evaluate the effects of gasoline on ultrastructure and metabolism of that seaweed. The experimental design consisted of in vitro exposure of U...
August 2016: Chemosphere
https://www.readbyqxmd.com/read/27050199/different-recombinant-forms-of-polyphenol-oxidase-a-a-laccase-from-marinomonas-mediterranea
#13
Fabio Tonin, Elena Rosini, Luciano Piubelli, Antonio Sanchez-Amat, Loredano Pollegioni
Polyphenol oxidase from the marine bacterium Marinomonas mediterranea (MmPPOA) is a membrane-bound, blue, multi-copper laccase of 695 residues. It possesses peculiar properties that distinguish it from known laccases, such as a broad substrate specificity (common to tyrosinases) and a high redox potential. In order to push the biotechnological application of this laccase, the full-length enzyme was overexpressed in Escherichia coli cells with and without a C-terminal His-tag. The previous form, named rMmPPOA-695-His, was purified to homogeneity by HiTrap chelating chromatography following solubilization by 1% SDS in the lysis buffer with an overall yield of ≈1 mg/L fermentation broth and a specific activity of 1...
July 2016: Protein Expression and Purification
https://www.readbyqxmd.com/read/26925195/preexposure-to-olive-oil-polyphenols-extract-increases-oxidative-load-and-improves-liver-mass-restoration-after-hepatectomy-in-mice-via-stress-sensitive-genes
#14
Jelena Marinić, Dalibor Broznić, Čedomila Milin
Polyphenols can act as oxidants in some conditions, inducing redox-sensitive genes. We investigated the effect of preexposure to the olive oil polyphenols extract (PFE) on time-dependent changes in the hepatic oxidative state in a model of liver regeneration-a process in which oxidative stress associated with the metabolic overload accounts for the early events that contribute to the onset of liver self-repair. Liver regeneration was induced by one-third hepatectomy in mice. Prior to hepatectomy, mice were intraperitoneally given either PFE (50 mg/kg body weight) or saline for seven consecutive days, while respective controls received vehicle alone...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/26837269/assessment-of-anthropogenic-inputs-in-the-surface-waters-of-the-southern-coastal-area-of-sfax-during-spring-tunisia-southern-mediterranean-sea
#15
Zaher Drira, Salma Kmiha-Megdiche, Houda Sahnoun, Ahmed Hammami, Noureddine Allouche, Marc Tedetti, Habib Ayadi
The coastal marine area of Sfax (Tunisia), which is well-known for its high productivity and fisheries, is also subjected to anthropogenic inputs from diverse industrial, urban and agriculture activities. We investigated the spatial distribution of physical, chemical and biogeochemical parameters in the surface waters of the southern coastal area of Sfax. Pertinent tracers of anthropogenic inputs were identified. Twenty stations were sampled during March 2013 in the vicinity of the coastal areas reserved for waste discharge...
March 15, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/26659939/a-review-of-clinical-trials-conducted-with-oral-multicomponent-dietary-supplements-for-improving-photoaged-skin
#16
REVIEW
Jay Birnbaum, Anne Le Moigne, Lisa Dispensa, Larry Buchner
Although the FDA does not require documentation of efficacy of dietary supplements, prospective clinical studies, including randomized controlled trials, have been conducted with individual micronutrients alone and in combination with other ingredients for promoting skin health. Proposed mechanisms include antioxidation, anti-inflammation, photoprotection, collagen formation, reductions in matrix metalloproteinases, and other effects on photoaging. Literature searches were conducted to identify clinical trials assessing multicomponent dietary supplement formulations on photoaging outcomes...
December 2015: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26604338/novel-vinegar-derived-product-enriched-with-dietary-fiber-effect-on-polyphenolic-profile-volatile-composition-and-sensory-analysis
#17
Almudena Marrufo-Curtido, María Jesús Cejudo-Bastante, M Carmen Rodríguez-Dodero, Ramón Natera-Marín, Remedios Castro-Mejías, Carmelo García-Barroso, Enrique Durán-Guerrero
Dietary fiber derived from citrus fruits was added to vinegar. Different sources and quantities of fiber and storage conditions have been scrutinized. Formulated vinegars were evaluated on the basis of their phenolic profile, volatile composition and sensory analysis. The addition of citrus fiber enhanced the phenolic and volatile profile of the resulted vinegars. Whereas lemon fiber contributed mostly to the enrichment of the polyphenolic composition, orange fiber was that which increased in a higher way the volatile composition of the vinegars...
December 2015: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/26558881/mussel-inspired-materials-self-healing-through-coordination-chemistry
#18
REVIEW
Marie Krogsgaard, Vicki Nue, Henrik Birkedal
Improved understanding of the underwater attachment strategy of the blue mussels and other marine organisms has inspired researchers to find new routes to advanced materials. Mussels use polyphenols, such as the catechol-containing amino acid 3,4-dihydroxyphenylalanine (DOPA), to attach to surfaces. Catechols and their analogues can undergo both oxidative covalent cross-linking under alkaline conditions and take part in coordination chemistry. The former has resulted in the widespread use of polydopamine and related materials...
January 18, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26444365/abcg2-bcrp-interaction-with-the-sea-grass-thalassia-testudinum
#19
Verónica Miguel, Jon A Otero, Borja Barrera, Idania Rodeiro, Julio G Prieto, Gracia Merino, Ana I Álvarez
BACKGROUND: The aqueous ethanolic extract from leaves of the marine plant Thalassia testudinum has shown antioxidant, cytoprotective, and neuroprotective properties. The chemical composition of this extract, rich in polyphenols, could interfere with active transport of drugs out of the cell and circumvent the phenomenon of multidrug resistance (MDR). The extract can act as an MDR modulator through its interaction with efflux transporters. The ABCG2/BCRP has been shown to confer MDR acting in tumor cells...
December 2015: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/26276825/methyl-jasmonate-induced-lipidomic-and-biochemical-alterations-in-the-intertidal-macroalga-gracilaria-dura-gracilariaceae-rhodophyta
#20
Puja Kumari, C R K Reddy, Bhavanath Jha
The role of exogenously added methyl jasmonate (MeJA), a lipid-derived signaling compound, in inducing oxidative stress in the marine red macroalga Gracilaria dura was investigated. MeJA at a concentration of 1-100 µM was a strong stimulant of reactive oxygen species (H(2)O(2), HO· and O(2) (·-)) (P < 0.05) causing considerable oxidative stress in G. dura. This further led to lipid peroxidation and degradation of the pigments Chl a and phycocyanin, with a concomitant increase in phycoerythrin. The MeJA-induced oxidative burst also led to the induction of a fatty acid oxidation cascade, resulting in the synthesis of hydroxy-oxylipins and the up-regulation of the 13-lipoxygenase pathway...
October 2015: Plant & Cell Physiology
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