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marine polyphenols

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https://www.readbyqxmd.com/read/29678627/structural-and-functional-insights-into-rha-p-a-bacterial-gh106-%C3%AE-l-rhamnosidase-from-novosphingobium-sp-pp1y
#1
Francesca Mensitieri, Federica De Lise, Andrea Strazzulli, Marco Moracci, Eugenio Notomista, Valeria Cafaro, Emiliano Bedini, Matthew Howard Sazinsky, Marco Trifuoggi, Alberto Di Donato, Viviana Izzo
α-L-Rhamnosidases (α-RHAs, EC 3.2.1.40) are glycosyl hydrolases (GHs) hydrolyzing terminal α-L-rhamnose residues from different substrates such as heteropolysaccharides, glycosylated proteins and natural flavonoids. Although the possibility to hydrolyze rhamnose from natural flavonoids has boosted the use of these enzymes in several biotechnological applications over the past decades, to date only few bacterial rhamnosidases have been fully characterized and only one crystal structure of a rhamnosidase of the GH106 family has been described...
April 17, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29576688/valuable-natural-products-from-marine-and-freshwater-macroalgae-obtained-from-supercritical-fluid-extracts
#2
Beata Messyasz, Izabela Michalak, Bogusława Łęska, Grzegorz Schroeder, Bogusława Górka, Karolina Korzeniowska, Jacek Lipok, Piotr Wieczorek, Edward Rój, Radosław Wilk, Agnieszka Dobrzyńska-Inger, Henryk Górecki, Katarzyna Chojnacka
The biologically active compounds (fatty acids, pigments, phenolics, and flavonoid content) were studied in supercritical fluid extracts from the biomass of marine ( Ulva clathrata , Cladophora glomerata , Polysiphonia fucoides , and their multi-species mixture) and freshwater ( C. glomerata ) macroalgae. Different extraction techniques were used in order to compare differences in the biologically active compound composition of the macroalgal extracts. The results indicated that the saturated and unsaturated fatty acids ranged from C9:0 to C22:0...
2018: Journal of Applied Phycology
https://www.readbyqxmd.com/read/29571460/analysis-of-functional-components-and-radical-scavenging-activity-of-21-algae-species-collected-from-the-japanese-coast
#3
Meiko Ito, Kaisei Koba, Risako Hikihara, Mami Ishimaru, Toshiyuki Shibata, Hideo Hatate, Ryusuke Tanaka
The functional chemical substances and the antioxidant activity of lipids in 21 marine algae along the Japanese coast were investigated. Principal component analysis was performed to detect any correlation between the chemical substances and algae phylum. Chlorophyta contained a high level of β-carotene. Rhodophyta contained high amounts of cholesterol, β-sitosterol, and saturated fatty acids. Phaeophyta were rich in fucosterol, α-tocopherol, fucoxanthin, and polyphenol. Phaeophyta algae also showed the highest antioxidant activity compared with other phylum...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29546309/supplementation-with-resveratrol-and-curcumin-does-not-affect-the-inflammatory-response-to-a-high-fat-meal-in-older-adults-with-abdominal-obesity-a-randomized-placebo-controlled-crossover-trial
#4
Cécile Vors, Charles Couillard, Marie-Eve Paradis, Iris Gigleux, Johanne Marin, Marie-Claude Vohl, Patrick Couture, Benoît Lamarche
Background: High-fat meals induce postprandial inflammation. Resveratrol is a polyphenol known to prevent comorbidities associated with cardiovascular disease and exerts an anti-inflammatory action. There is also an increasing body of evidence supporting the role of curcumin, a polyphenol from the curcuminoid family, as a modulator of proinflammatory processes. Objective: The objectives of this study were to investigate the following: 1) the bioavailability of resveratrol consumed in combination with curcumin after consumption of a high-fat meal; and 2) the acute combined effects of this combination on the postprandial inflammatory response of subjects with abdominal obesity...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29157606/high-performance-thin-layer-chromatography-hptlc-direct-bioautography-as-a-method-of-choice-for-alpha-amylase-and-antioxidant-activity-evaluation-in-marine-algae
#5
Snezana Agatonovic-Kustrin, David W Morton
High-Performance Thin-layer chromatography (HPTLC) combined with DPPH free radical method and α-amylase bioassay was used to compare antioxidant and antidiabetic activities in ethanol and ethyl acetate extracts from 10 marine macroalgae species (3 Chlorophyta, 4 Phaeophyta and 3 Rhodophyta) from Blue Lagoon beach (Malaysia). Samples were also evaluated for their phenolic and stigmasterol content. On average, higher antioxidant activity was observed in the ethyl acetate extracts (55.1mg/100g gallic acid equivalents (GAE) compared to 35...
December 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29129053/research-on-chemical-composition-and-biological-properties-including-antiquorum-sensing-activity-of-angelica-pancicii-vandas-aerial-parts-and-roots
#6
Ksenija S Mileski, Snežana S Trifunović, Ana D Ćirić, Željana M Šakić, Mihailo S Ristić, Nina M Todorović, Vlado S Matevski, Petar D Marin, Vele V Tešević, Ana M Džamić
The essential oil, different extracts, and isolated compounds of Angelica pancicii Vandas (Apiaceae) were investigated for the first time. The GC-FID and GC-MS analyses revealed sesquiterpenoids as the main constituents of A. pancicii essential oil of aerial parts with bornyl acetate (8.08%), n-octanol (5.82%), kessane (4.26%), and β-selinene (4.26%) as the main constituents. Analysis of methanol extracts, using an HPLC-DAD/ESI-ToF-MS system, showed a total of 52 compounds in the aerial parts and 53 in the roots, indicating coumarins as the main constituents...
December 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29107095/anticancer-activity-of-seaweeds
#7
REVIEW
Anllely G Gutiérrez-Rodríguez, Claudia Juárez-Portilla, Tatiana Olivares-Bañuelos, Rossana C Zepeda
Cancer is a major health problem worldwide and still lacks fully effective treatments. Therefore, alternative therapies, using natural products, have been proposed. Marine algae are an important component of the marine environment, with high biodiversity, and contain a huge number of functional compounds, including terpenes, polyphenols, phlorotannins, and polysaccharides, among others. These compounds have complex structures that have shown several biological activities, including anticancer activity, in several in vitro and in vivo models...
October 26, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29057483/the-promise-of-marine-molecules-as-cosmetic-active-ingredients
#8
REVIEW
E G Brunt, J G Burgess
The marine environment represents an underexploited resource for the discovery of novel products, despite its high level of biological and chemical diversity. With increasing awareness of the harmful effects of chronic ultraviolet exposure, and a universal desire to improve cosmetic appearance, the market for new cosmetic ingredients is growing, and current trends have generated a greater demand for products sourced from the environment. A growing number of novel molecules from marine flora and fauna exhibit potent and effective dermatological activities...
February 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#9
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
October 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28770671/marine-algae-as-attractive-source-to-skin-care
#10
Jean-Yves Berthon, Rachida Nachat-Kappes, Mathieu Bey, Jean-Paul Cadoret, Isabelle Renimel, Edith Filaire
As the largest organ in the human body, the skin has multiple functions of which one of the most important is the protection against various harmful stressors. The keratinised stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissues are important components of the skin. The environmental stressors such as ultraviolet radiation (UVR) and pollution increase the levels of reactive oxygen species (ROS), contributing to clinical manifestations such as wrinkle formation and skin aging...
June 2017: Free Radical Research
https://www.readbyqxmd.com/read/28739056/supplementation-with-vitis-vinifera-l-skin-extract-improves-insulin-resistance-and-prevents-hepatic-lipid-accumulation-and-steatosis-in-high-fat-diet-fed-mice
#11
Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Ana Paula Machado da Rocha, Gisele França da Costa, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela Castro Resende
Nonalcoholic fatty liver disease is one of the most common complications of obesity. The Vitis vinifera L. grape skin extract (ACH09) is an important source of polyphenols, which are related to its antioxidant and antihyperglycemic activities. We hypothesized that ACH09 could also exert beneficial effects on metabolic disorders associated with obesity and evaluated ACH09's influence on high-fat (HF) diet-induced hepatic steatosis and insulin resistance in C57BL/6 mice. The animals were fed a standard diet (10% fat, control) or an HF diet (60% fat, HF) with or without ACH09 (200mg/[kg d]) for 12weeks...
July 2017: Nutrition Research
https://www.readbyqxmd.com/read/28635652/fucaceae-a-source-of-bioactive-phlorotannins
#12
REVIEW
Marcelo D Catarino, Artur M S Silva, Susana M Cardoso
Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28614666/salt-triggers-the-simple-coacervation-of-an-underwater-adhesive-when-cations-meet-aromatic-%C3%AF-electrons-in-seawater
#13
Sangsik Kim, Hee Young Yoo, Jun Huang, Yongjin Lee, Sohee Park, Yeonju Park, Sila Jin, Young Mee Jung, Hongbo Zeng, Dong Soo Hwang, YongSeok Jho
Adhesive systems in many marine organisms are postulated to form complex coacervates (liquid-liquid phase separation) through a process involving oppositely charged polyelectrolytes. Despite this ubiquitous speculation, most well-characterized mussel adhesive proteins are cationic and polyphenolic, and the pursuit of the negatively charged proteins required for bulk complex coacervation formation internally remains elusive. In this study, we provide a clue for unraveling this paradox by showing the bulky fluid/fluid separation of a single cationic recombinant mussel foot protein, rmfp-1, with no additional anionic proteins or artificial molecules, that is triggered by a strong cation-π interaction in natural seawater conditions...
July 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28578033/influence-of-omega-3-pufas-on-the-metabolism-of-proanthocyanidins-in-rats
#14
Eunice Molinar-Toribio, Sara Ramos-Romero, Elisabet Fuguet, Núria Taltavull, Lucía Méndez, Marta Romeu, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez
Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28441760/supplementation-with-a-polyphenol-rich-extract-perfload-%C3%A2-improves-physical-performance-during-high-intensity-exercise-a-randomized-double-blind-crossover-trial
#15
Julien Cases, Cindy Romain, Cristian Marín-Pagán, Linda H Chung, José Miguel Rubio-Pérez, Caroline Laurent, Sylvie Gaillet, Emmanuelle Prost-Camus, Michel Prost, Pedro E Alcaraz
Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad(®), was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation...
April 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28414549/do-marine-algal-polyphenols-have-antidiabetic-antihyperlipidemic-or-anti-inflammatory-effects-in-humans-a-systematic-review
#16
Margaret Murray, Aimee L Dordevic, Maxine P Bonham, Lisa Ryan
Cardiovascular disease and type 2 diabetes are leading causes of morbidity and mortality globally. Marine algal polyphenols have potential to reduce the risk of these conditions, however, little is known about their impact in humans. This systematic review investigates the antidiabetic, antihyperlipidemic and anti-inflammatory effects of marine polyphenols in humans. Scopus, Medline, PsychInfo, Embase and Cochrane Library databases were searched in November 2016. Eligible studies included (1) human adults, (2) marine polyphenol intervention, (3) blood lipid, glucose, insulin or inflammatory marker outcomes, and (4) were a randomized-controlled trial...
April 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28397013/modulatory-efficacy-of-dieckol-on-xenobiotic-metabolizing-enzymes-cell-proliferation-apoptosis-invasion-and-angiogenesis-during-ndea-induced-rat-hepatocarcinogenesis
#17
Velayutham Sadeeshkumar, Arul Duraikannu, Samuthrapandian Ravichandran, Paulrasu Kodisundaram, Wilson Sylvester Fredrick, Rajagopal Gobalakrishnan
Dieckol (DEK) is a major polyphenol of marine brown seaweed Ecklonia cava which is a potential candidate for cancer therapy. However, the underlying mechanism of DEK as an anticancer drug remains to be elucidated. In this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of DEK in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (XMEs), apoptosis, invasion, and angiogenesis. Rats administered NDEA developed hepatocarcinogenesis that displayed apoptosis avoidance coupled to upregulation of pro-inflammatory, invasion, and angiogenesis markers...
September 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28260647/a-lipidomic-study-on-the-regulation-of-inflammation-and-oxidative-stress-targeted-by-marine-%C3%AF-3-pufa-and-polyphenols-in-high-fat-high-sucrose-diets
#18
Gabriel Dasilva, Manuel Pazos, Eduardo García-Egido, José M Gallardo, Sara Ramos-Romero, Josep Lluís Torres, Marta Romeu, María-Rosa Nogués, Isabel Medina
The ability of polyphenols to ameliorate potential oxidative damage of ω-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health is discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats...
May 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28183047/gene-expression-changes-in-colon-tissues-from-colorectal-cancer-patients-following-the-intake-of-an-ellagitannin-containing-pomegranate-extract-a-randomized-clinical-trial
#19
RANDOMIZED CONTROLLED TRIAL
María A Nuñez-Sánchez, Antonio González-Sarrías, Rocío García-Villalba, Tamara Monedero-Saiz, Noelia V García-Talavera, María B Gómez-Sánchez, Carmen Sánchez-Álvarez, Ana M García-Albert, Francisco J Rodríguez-Gil, Miguel Ruiz-Marín, Francisco A Pastor-Quirante, Francisco Martínez-Díaz, Francisco A Tomás-Barberán, Juan Carlos Espín, María-Teresa García-Conesa
The clinical evidence of dietary polyphenols as colorectal cancer (CRC) chemopreventive compounds is very weak. Verification in humans of tissue-specific molecular regulation by the intake of polyphenols requires complex clinical trials that allow for the procurement of sufficient pre- and postsupplementation tissue samples. Ellagitannins (ETs), ellagic acid (EA) and their gut microbiota-derived metabolites, the urolithins, modify gene expression in colon normal and cancer cultured cells. We conducted here the first clinical trial with 35 CRC patients daily supplemented with 900 mg of an ET-containing pomegranate extract (PE) and evaluated the expression of various CRC-related genes in normal and cancerous colon tissues before (biopsies) and after (surgical specimens) 5-35 days of supplementation...
April 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28132190/biosynthesis-of-metal-nanoparticles-using-three-marine-plant-species-anti-algal-efficiencies-against-oscillatoria-simplicissima
#20
Hala Y El-Kassas, Mary G Ghobrial
This study aims at controlling of the cyanobacteria Oscillatoria simplicissima, those that produce neurotoxins and have negative impacts on the aquatic organisms, using biosynthesized metal nanoparticles (NPs). Silver-NPs (Ag-NPs) have been successfully biosynthesized using Nannochloropsis oculata and Tetraselmis tetrathele cultures. Also, Ag-NPs and iron oxide-NPs (Fe3O4-NPs) were synthesized by Halophila stipulacea aqueous extract. The structural composition of the different biosynthesized NPs was studied...
March 2017: Environmental Science and Pollution Research International
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