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https://www.readbyqxmd.com/read/29668118/chiral-dna-origami-nanotubes-with-well-defined-and-addressable-inside-and-outside-surfaces
#1
Florence Benn, Natalie E C Haley, Alexandra E Lucas, Emma Silvester, Seham Helmi, Robert Schreiber, Jonathan Bath, Andrew J Turberfield
We report the design and assembly of chiral DNA nanotubes with well-defined and addressable inside and outside surfaces. We demonstrate that the outside surface can be functionalised with a chiral arrangement of gold nanoparticles to create a plasmonic device and that the inside surface can be functionalised with a track for a molecular motor allowing transport of a cargo within the central cavity.
April 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29667867/excelling-at-youth-level-in-competitive-track-and-field-athletics-is-not-a-prerequisite-for-later-success
#2
Philip E Kearney, Philip R Hayes
Enhancing our understanding of athlete development would be valuable for coaches, parents and administrators to set realistic performance expectations and to advance youth sport policy. To this end, a database of track and field performances was examined. Records of 134,313 performances by athletes aged between 12 and 35 years in sprinting, throwing, jumping and middle distance events were analysed. Results revealed that a minority (Male, 9%; Female, 13%) of top 20 ranked senior athletes were also ranked in the top 20 at Under 13 (U13)...
April 18, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29667686/rheological-characterization-of-dynamic-remodeling-of-the-pericellular-region-by-human-mesenchymal-stem-cell-secreted-enzymes-in-well-defined-synthetic-hydrogel-scaffolds
#3
Maryam Daviran, Sarah M Longwill, Jonah F Casella, Kelly M Schultz
Human mesenchymal stem cells (hMSCs) dynamically remodel their microenvironment during basic processes, such as migration and differentiation. Migration requires extracellular matrix invasion, necessitating dynamic cell-material interactions. Understanding these interactions is critical to advancing materials designs that harness and manipulate these processes for applications including wound healing and tissue regeneration. In this work, we encapsulate hMSCs in a cell-degradable poly(ethylene glycol)-peptide hydrogel to determine how cell-secreted enzymes, specifically matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), create unique pericellular microenvironments...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29667598/a-random-phased-array-for-mr-guided-transcranial-ultrasound-neuromodulation-in-non-human-primates
#4
Vandiver Chaplin, Marshal A Phipps, Charles F Caskey
Transcranial focused ultrasound (FUS) is a non-invasive technique for therapy and study of brain neural activation. Here we report on the design and characterization of a new MR-guided FUS transducer for neuromodulation in non-human primates at 650 kHz. The array is randomized with 128 elements 6.6 mm in diameter, radius of curvature 7.2 cm, opening diameter 10.3 cm (focal ratio 0.7), and 46% coverage. Simulations were used to optimize transducer geometry with respect to focus size, grating lobes, and directivity...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29667191/herbal-medicine-containing-aristolochic-acid-and-the-risk-of-hepatocellular-carcinoma-in-patients-with-hepatitis-b-virus-infection
#5
Chi-Jen Chen, Yao-Hsu Yang, Meng-Hung Lin, Chuan-Pin Lee, Yu-Tse Tsan, Ming-Nan Lai, Hsiao-Yu Yang, Wen-Chao Ho, Pau-Chung Chen
It was suspected that aristolochic acid-induced mutations may be associated with hepatitis B virus (HBV), playing an important role in liver carcinogenesis. The purpose of this study was to investigate the association between the use of Chinese herbs containing aristolochic acid and the risk of hepatocellular carcinoma (HCC) among HBV-infected patients. We conducted a retrospective, population-based, cohort study on patients older than 18 years who had a diagnosis of HBV infection between January 1, 1997 and December 31, 2010 and had visited traditional Chinese medicine clinics before one year before the diagnosis of HCC or the censor dates...
April 18, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29667162/metaunidec-high-throughput-deconvolution-of-native-mass-spectra
#6
Deseree J Reid, Jessica M Diesing, Matthew A Miller, Scott M Perry, Jessica A Wales, William R Montfort, Michael T Marty
The expansion of native mass spectrometry (MS) methods for both academic and industrial applications has created a substantial need for analysis of large native MS datasets. Existing software tools are poorly suited for high-throughput deconvolution of native electrospray mass spectra from intact proteins and protein complexes. The UniDec Bayesian deconvolution algorithm is uniquely well suited for high-throughput analysis due to its speed and robustness but was previously tailored towards individual spectra...
April 17, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29667080/surgical-management-of-fossa-navicularis-and-distal-urethral-strictures
#7
REVIEW
Michael Daneshvar, Michael Hughes, Dmitriy Nikolavsky
PURPOSE OF REVIEW: Urethral reconstruction has evolved in the last several decades with the introduction of various techniques including fasciocutaneous skin flaps and buccal mucosal grafts. However, distal urethral strictures have continued to be a reconstructive challenge due to tendency for adverse cosmetic outcomes, risks of glans dehiscence or fistula formation, and stricture recurrence. RECENT FINDINGS: The surgical options for treatment of distal urethral strictures have changed throughout the years; however, there is no one universally accepted technique for their treatment...
April 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29667012/bone-marrow-adipocyte-developmental-origin-and-biology
#8
REVIEW
Joanna Bukowska, Trivia Frazier, Stanley Smith, Theodore Brown, Robert Bender, Michelle McCarthy, Xiying Wu, Bruce A Bunnell, Jeffrey M Gimble
PURPOSE OF REVIEW: This review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal pathophysiology. RECENT FINDINGS: Recent studies have re-defined adipose tissue as a dynamic, vital organ with functions extending beyond its historic identity restricted solely to that of an energy reservoir or sink. "State of the art" methodologies provide novel insights into the developmental origin, physiology, and function of different adipose tissue depots...
April 18, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29666985/induction-of-disease-remission-with-one-cycle-of-alemtuzumab-in-relapsing-remitting-ms
#9
Alexandra S Kocsik, David E Klein, Maryana Liedke, Ulrike W Kaunzner, Nancy M Nealon, Susan A Gauthier, Timothy Vartanian, Jai S Perumal
OBJECTIVE: To investigate a single-course treatment with alemtuzumab in patients with relapsing-remitting multiple sclerosis. METHODS: We performed a retrospective chart review of all patients diagnosed with RRMS who were treated with alemtuzumab at our MS center and who had at least 12 month follow-up since the first dose. Data on radiological and clinical relapse were collected for the 2 years prior to patients' first dose of alemtuzumab and were tracked until the time of analysis...
April 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29666930/role-of-side-slip-flight-in-target-pursuit-blue-tailed-damselflies-ischnura-elegans-avoid-body-rotation-while-approaching-a-moving-perch
#10
Ziv Kassner, Gal Ribak
Visually guided flight control requires processing changes in the visual panorama (optic-flow) resulting from self-movement relative to stationary objects, as well as from moving objects passing through the field of view. We studied the ability of the blue-tailed damselfly, Ischnura elegans, to successfully land on a perch moving unpredictably. We tracked the insects landing on a vertical pole moved linearly 6 cm back and forth with sinusoidal changes in velocity. When the moving perch changed direction at frequencies higher than 1 Hz, the damselflies engaged in manoeuvres that typically involved sideways flight, with minimal changes in body orientation relative to the stationary environment...
April 17, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29666589/applications-of-functional-near-infrared-spectroscopy-fnirs-in-studying-cognitive-development-the-case-of-mathematics-and-language
#11
REVIEW
Mojtaba Soltanlou, Maria A Sitnikova, Hans-Christoph Nuerk, Thomas Dresler
In this review, we aim to highlight the application of functional near-infrared spectroscopy (fNIRS) as a useful neuroimaging technique for the investigation of cognitive development. We focus on brain activation changes during the development of mathematics and language skills in schoolchildren. We discuss how technical limitations of common neuroimaging techniques such as functional magnetic resonance imaging (fMRI) have resulted in our limited understanding of neural changes during development, while fNIRS would be a suitable and child-friendly method to examine cognitive development...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29666564/neural-induction-potential-and-mri-of-adscs-labeled-cationic-superparamagnetic-iron-oxide-nanoparticle-in-vitro
#12
Weiqiong Ma, Qi Xie, Baolin Zhang, Huixian Chen, Jianyi Tang, Zhengxian Lei, Minyi Wu, Dingxuan Zhang, Jiani Hu
Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stem cell tracking in vivo, and the aim of this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using cationic superparamagnetic iron oxide (SPIO) nanoparticle which was synthesized by the improved polyol method, in order to allow visualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure of labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES)...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29666460/cortical-classification-with-rhythm-entropy-for-error-processing-in-cocktail-party-environment-based-on-scalp-eeg-recording
#13
Yin Tian, Wei Xu, Li Yang
Using single-trial cortical signals calculated by weighted minimum norm solution estimation (WMNE), the present study explored a feature extraction method based on rhythm entropy to classify the scalp electroencephalography (EEG) signals of error response from that of correct response during performing auditory-track tasks in cocktail party environment. The classification rate achieved 89.7% with single-trial (≈700 ms) when using support vector machine(SVM) with the leave-one-out-cross-validation (LOOCV)...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666239/individuals-institutions-and-innovation-in-the-debates-of-the-french-revolution
#14
Alexander T J Barron, Jenny Huang, Rebecca L Spang, Simon DeDeo
The French Revolution brought principles of "liberty, equality, fraternity" to bear on the day-to-day challenges of governing what was then the largest country in Europe. Its experiments provided a model for future revolutions and democracies across the globe, but this first modern revolution had no model to follow. Using reconstructed transcripts of debates held in the Revolution's first parliament, we present a quantitative analysis of how this body managed innovation. We use information theory to track the creation, transmission, and destruction of word-use patterns across over 40,000 speeches and a thousand speakers...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666133/medical-overuse-in-the-iranian-healthcare-system-a-systematic-review-protocol
#15
Morteza Arab-Zozani, Mohammad Zakaria Pezeshki, Rahim Khodayari-Zarnaq, Ali Janati
INTRODUCTION: Lack of resources is one of the main problems of all healthcare systems. Recent studies have shown that reducing the overuse of medical services plays an important role in reducing healthcare system costs. Overuse of medical services is a major problem in the healthcare system, and it threatens the quality of the services, can harm patients and create excess costs for patients. So far, few studies have been conducted in this regard in Iran. The main objective of this systematic review is to perform an inclusive search for studies that report overuse of medical services in the Iranian healthcare system...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29665683/monitoring-molecular-transport-across-colloidal-membranes
#16
Emilia Victoria Silletta, Zhe Xu, Mena Youssef, Stefano Sacanna, Alexej Jerschow
The controlled shaping and surface functionalization of colloidal particles has provided opportunities for the development of new materials and responsive particles. The possibility of creating hollow particles with semi-permeable walls allows modulating molecular transport properties on colloidal length scales. While shapes and sizes can typically be observed by optical means, the underlying chemical and physical properties are often invisible. Here, we present measurements of cross-membrane transport via pulsed field gradient NMR in packings of hollow colloidal particles...
April 17, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29665567/psychological-health-challenges-of-the-hill-tracts-region-for-climate-change-in-bangladesh
#17
Syed Muhammad Sajjad Kabir
The aim of this paper is to provide an overview of the deleterious effects of climate change on psychological health of the Hill-Tracts and government to deal with these adverse psychological health impacts. Although knowledge is still limited about the connections between climate change and psychological health, the evidence is indicating that impacts can be felt at both the individual and community levels, with psychological health outcomes ranging from psychological distress, depression, and anxiety, to increased addictions and suicide rates...
April 12, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29665440/mri-compatible-ms2-nanoparticles-designed-to-cross-the-blood-brain-barrier-providing-a-path-towards-tinnitus-treatment
#18
Aaron K Apawu, Stephanie M Curley, Angela R Dixon, Mirabela Hali, Moaz Sinan, Rod D Braun, James Castracane, Anthony T Cacace, Magnus Bergkvist, Avril Genene Holt
Fundamental challenges of targeting specific brain regions for treatment using pharmacotherapeutic nanoparticle (NP) carriers include circumventing the blood-brain-barrier (BBB) and tracking delivery. Angiopep-2 (AP2) has been shown to facilitate the transport of large macromolecules and synthetic nanoparticles across the BBB. Thus, conjugation of AP2 to an MS2 bacteriophage based NP should also permit transport across the BBB. We have fabricated and tested a novel MS2 capsid-based NP conjugated to the ligand AP2...
April 14, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29664873/effects-of-a-picu-status-asthmaticus-de-escalation-pathway-on-length-of-stay-and-albuterol-use
#19
Steven Brennan, Lia Lowrie, Jamie Wooldridge
OBJECTIVES: Evaluate the effects of an asthma de-escalation clinical pathway on selected outcomes for patients admitted to a PICU with status asthmaticus. DESIGN: Time series quality improvement trial. SETTING: PICU in a tertiary care children's hospital. PATIENTS: Children age 2-18 years old with a known diagnosis of asthma presenting with status asthmaticus. INTERVENTION: One-hundred five admissions to a PICU for status asthmaticus were treated according to a new de-escalation pathway between August 15, 2015, and August 30, 2016...
April 16, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29664750/head-movements-allow-listeners-bilaterally-implanted-with-cochlear-implants-to-resolve-front-back-confusions
#20
M Torben Pastore, Sarah J Natale, William A Yost, Michael F Dorman
OBJECTIVES: We report on the ability of patients fit with bilateral cochlear implants (CIs) to distinguish the front-back location of sound sources both with and without head movements. At issue was (i) whether CI patients are more prone to front-back confusions than normal hearing listeners for wideband, high-frequency stimuli; and (ii) if CI patients can utilize dynamic binaural difference cues, in tandem with their own head rotation, to resolve these front-back confusions. Front-back confusions offer a binary metric to gain insight into CI patients' ability to localize sound sources under dynamic conditions not generally measured in laboratory settings where both the sound source and patient are static...
April 16, 2018: Ear and Hearing
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