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https://www.readbyqxmd.com/read/28651340/linking-quality-indicators-to-clinical-trials-an-automated-approach
#1
Enrico Coiera, Miew Keen Choong, Guy Tsafnat, Peter Hibbert, William B Runciman
Objective: Quality improvement of health care requires robust measurable indicators to track performance. However identifying which indicators are supported by strong clinical evidence, typically from clinical trials, is often laborious. This study tests a novel method for automatically linking indicators to clinical trial registrations. Design: A set of 522 quality of care indicators for 22 common conditions drawn from the CareTrack study were automatically mapped to outcome measures reported in 13 971 trials from ClinicalTrials...
June 23, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28650932/incremental-value-of-right-atrial-strain-for-early-diagnosis-of-hemodynamic-deterioration-in-pulmonary-hypertension-a-new-noninvasive-tool-for-a-more-comprehensive-diagnostic-paradigma
#2
Cristina Piccinino, Ailia Giubertoni, Jacopo Zanaboni, Miriam Gravellone, Daniele Sola, Roberta Rosso, Lorena Ferrarotti, Paolo Nicola Marino
AIMS: Increased right atrial size is related to adverse prognosis in pulmonary hypertension. The potential incremental value of right atrial function assessment is still unclear. We tested the relationship between right atrial two-dimensional speckle-tracking echocardiography impairment and hemodynamic, functional and clinical deterioration in patients with pulmonary hypertension. METHODS: We prospectively evaluated 36 patients (27 female, 9 male; mean age 68 ± 13 years) with suspected pulmonary hypertension undergoing right heart catheterization and 16 matched controls...
June 24, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28650838/adaptive-neural-network-finite-time-output-feedback-control-of-quantized-nonlinear-systems
#3
Fang Wang, Bing Chen, Chong Lin, Jing Zhang, Xinzhu Meng
This paper addresses the finite-time tracking issue for nonlinear quantized systems with unmeasurable states. Compared with the existing researches, the finite-time quantized feedback control is considered for the first time. By proposing a new finite-time stability criterion and designing a state observer, a novel adaptive neural output-feedback control strategy is raised by backstepping technique. Under the presented control scheme, the finite-time quantized feedback control problem is coped with without limiting assumption for nonlinear functions...
June 26, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28650829/time-varying-system-identification-using-an-ultra-orthogonal-forward-regression-and-multiwavelet-basis-functions-with-applications-to-eeg
#4
Yang Li, Wei-Gang Cui, Yu-Zhu Guo, Tingwen Huang, Xiao-Feng Yang, Hua-Liang Wei
A new parametric approach is proposed for nonlinear and nonstationary system identification based on a time-varying nonlinear autoregressive with exogenous input (TV-NARX) model. The TV coefficients of the TV-NARX model are expanded using multiwavelet basis functions, and the model is thus transformed into a time-invariant regression problem. An ultra-orthogonal forward regression (UOFR) algorithm aided by mutual information (MI) is designed to identify a parsimonious model structure and estimate the associated model parameters...
June 22, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28650802/translational-motion-tracking-of-leg-joints-for-enhanced-prediction-of-walking-tasks
#5
Roman Mark Stolyarov, Gary Burnett, Hugh Herr
OBJECTIVE: Prediction of walking tasks in powered leg prostheses is an important problem in the development of biomimetic prosthesis controllers. This article proposes a novel method to predict upcoming walking tasks by estimating the translational motion of leg joints using an inertial measurement unit. METHODS: We asked six subjects with unilateral transtibial amputations to traverse flat ground, ramps, and stairs using a powered prosthesis while inertial signals were remotely collected...
June 22, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28650774/monte-carlo-electron-track-structure-calculations-in-liquid-water-using-a-new-model-dielectric-response-function
#6
Dimitris Emfietzoglou, George Papamichael, Hooshang Nikjoo
Monte Carlo track structure codes provide valuable information for understanding radiation effects down to the DNA level, where experimental measurements are most difficult or unavailable. It is well recognized that the performance of such codes, especially at low energies and/or subcellular level, critically depends on the reliability of the interaction cross sections that are used as input in the simulation. For biological media such as liquid water, one of the most challenging issues is the role of condensed-phase effects...
June 26, 2017: Radiation Research
https://www.readbyqxmd.com/read/28650431/illuminating-vital-surface-molecules-of-symbionts-in-health-and-disease
#7
Jason E Hudak, David Alvarez, Ashwin Skelly, Ulrich H von Andrian, Dennis L Kasper
The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's response(1,2). Recent studies have highlighted the unique and important responses elicited by commensal-derived surface macromolecules(3-5). However, the technology available to track these molecules in host cells and tissues remains primitive. We report, here, an interdisciplinary approach that uses metabolic labelling combined with bioorthogonal click chemistry (that is, reactions performed in living organisms)(6) to specifically tag up to three prominent surface immunomodulatory macromolecules-peptidoglycan, lipopolysaccharide and capsular polysaccharide-either simultaneously or individually in live anaerobic commensal bacteria...
June 26, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28650346/real-time-monitoring-through-the-use-of-technology-to-enhance-performances-throughout-hiv-cascades
#8
Matthew Avery, Stephen J Mills, Eric Stephan
PURPOSE OF REVIEW: Controlling the HIV epidemic requires strong linkages across a 'cascade' of prevention, testing, and treatment services. Information and communications technology (ICT) offers the potential to monitor and improve the performance of this HIV cascade in real time. We assessed recent (<18 months) peer-reviewed publications regarding uses of ICT to improve performance through expanded and targeted reach, improved clinical service delivery, and reduced loss to follow-up...
June 23, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28650319/somatostatin-binds-to-the-human-amyloid-%C3%AE-peptide-and-favors-the-formation-of-distinct-oligomers
#9
Hansen Wang, Lisa D Muiznieks, Punam Ghosh, Declan Williams, Michael Solarski, Andrew Fang, Alejandro Ruiz-Riquelme, Régis Pomès, Joel C Watts, Avi Chakrabartty, Holger Wille, Simon Sharpe, Gerold Schmitt-Ulms
The amyloid β peptide (Aβ) is a key player in the etiology of Alzheimer disease (AD), yet a systematic investigation of its molecular interactions has not been reported. Here we identified by quantitative mass spectrometry proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits. Remarkably, the cyclic neuroendocrine peptide somatostatin-14 (SST14) was observed to be the most selectively enriched oAβ1-42 binder. The binding interface comprises a central tryptophan within SST14 and the N-terminus of Aβ1-42...
June 26, 2017: ELife
https://www.readbyqxmd.com/read/28650183/spatial-transposition-tasks-in-indian-sloth-bears-melursus-ursinus-and-bornean-sun-bears-helarctos-malayanus-euryspilus
#10
Daniela Hartmann, Marina Davila-Ross, Siew Te Wong, Josep Call, Marina Scheumann
Spatial transposition tasks assess individuals' ability to represent nonvisible spatial object displacements. Several nonhuman mammal species have been tested on this task including primates, cats, and dogs, but to date, great apes seem the only taxon that has repeatedly and consistently solved spatial transposition tasks. The authors investigated the ability of captive sloth and sun bears to solve spatial transposition tasks. Both species belong to the same taxonomic group as cats and dogs, but unlike them and similar to apes, they have an omnivorous diet that requires them to keep track of fruit sources in space and time...
June 26, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28650141/flexible-and-foldable-fully-printed-carbon-black-conductive-nanostructures-on-paper-for-high-performance-electronic-electrochemical-and-wearable-devices
#11
Murilo Santhiago, Cátia C Côrrea, Juliana Silva Bernardes, Mariane Peres Pereira, Letícia J M Oliveira, Mathias Strauss, Carlos César Bof Bufon
In this work, we demonstrate the first example of fully-printed carbon nanomaterials on paper with unique features, aiming the fabrication of functional electronic and electrochemical devices. Bare and modified inks were prepared by combining carbon black and cellulose acetate to achieve high-performance conductive tracks with low sheet resistance. The carbon black tracks withstand extremely high folding cycles (> 20000 cycles), a new record-high with a response loss of less than 10%. The conductive tracks can also be used as 3D paper-based electrochemical cells with high heterogeneous rate constants - a feature that opens a myriad of electrochemical applications...
June 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28650053/in-situ-crystal-growth-of-gold-nanocrystals-on-upconversion-nanoparticles-for-synergistic-chemo-photothermal-therapy
#12
Ruoyan Wei, Wensong Xi, Haifang Wang, Jinliang Liu, Torsten Mayr, Liyi Shi, Lining Sun
A multifunctional cancer therapy nanocomposite was proposed and synthesized by linking the pH-responsive SH-PEG-DOX prodrug onto gold nanocrystals that were grown in situ on the surface of upconversion nanoparticles (UCNPs). In the structure of the SH-PEG-DOX prodrug, a hydrazone bond was utilized for subsequent pH-responsive drug release in the intracellular acidic microenvironment of cancer cells. This innovative assembly method is facile and mild, and can be used to obtain nanocomposites of UCNPs and gold, which show excellent photostability and biocompatibility...
June 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28649757/visual-complexity-and-its-effects-on-referring-expression-generation
#13
Micha Elsner, Alasdair Clarke, Hannah Rohde
Speakers' perception of a visual scene influences the language they use to describe it-which objects they choose to mention and how they characterize the relationships between them. We show that visual complexity can either delay or facilitate description generation, depending on how much disambiguating information is required and how useful the scene's complexity can be in providing, for example, helpful landmarks. To do so, we measure speech onset times, eye gaze, and utterance content in a reference production experiment in which the target object is either unique or non-unique in a visual scene of varying size and complexity...
June 26, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28649710/tracking-the-effect-of-emotional-distraction-in-working-memory-brain-networks-evidence-from-an-meg-study
#14
Javier García-Pacios, Pilar Garcés, David Del Río, Fernando Maestú
The active maintenance of information in visual working memory (WM) is known to rely on the sustained activity over functional networks including frontal, parietal, occipital, and temporal cortices. Previous studies have described interference-based disturbances in the functional coupling between prefrontal and posterior cortices, and that such disturbances can be restored for a successful WM performance after the presentation of the interfering stimulus. However, very few studies have applied functional connectivity measures to the analysis of the brain dynamics involved in overriding emotional distraction, and all of them have limited their analysis to the particular connections between the amygdala and prefrontal cortex...
June 25, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28649454/methods-guiding-stakeholder-engagement-in-planning-a-pragmatic-study-on-changing-stroke-systems-of-care
#15
Sabina B Gesell, Karen Potvin Klein, Jacqueline Halladay, Janet Prvu Bettger, Janet Freburger, Doyle M Cummings, Barbara J Lutz, Sylvia Coleman, Cheryl Bushnell, Wayne Rosamond, Pamela W Duncan
BACKGROUND: The Comprehensive Post-Acute Stroke Services (COMPASS) Study is one of the first large pragmatic randomized-controlled clinical trials using comparative effectiveness research methods, funded by the Patient-Centered Outcomes Research Institute. In the COMPASS Study, we compare the effectiveness of a patient-centered, transitional care intervention versus usual care for stroke patients discharged home from acute care. Outcomes include stroke patient post-discharge functional status and caregiver strain 90 days after discharge, and hospital readmissions...
April 2017: Journal of clinical and translational science
https://www.readbyqxmd.com/read/28649377/a-bibliometric-analysis-of-the-citation-classics-of-acute-appendicitis
#16
REVIEW
Manvydas Varzgalis, Dermot J Bowden, Ciaran K Mc Donald, Michael J Kerin
INTRODUCTION: Acute appendicitis is one of the most commonly encountered emergency surgical conditions. An understanding of the most highly cited research works in this field is key to good evidence based clinical practice. AIMS: To perform a bibliometric analysis on the 100 most frequently cited articles in the field of acute appendicitis. METHODS: The database of the Institute for Scientific Information (ISI) Web of Science Expanded citation index was searched to identify the 100 most frequently cited articles in the field of acute appendicitis...
July 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28649352/tracking-a-single-pigeon-using-a-shadowing-filter-algorithm
#17
Ayham Zaitouny, Thomas Stemler, Michael Small
Miniature GPS devices now allow for measurement of the movement of animals in real time and provide high- quality and high-resolution data. While these new data sets are a great improvement, one still encounters some measurement errors as well as device failures. Moreover, these devices only measure position and require further reconstruction techniques to extract the full dynamical state space with the velocity and acceleration. Direct differentiation of position is generally not adequate. We report on the successful implementation of a shadowing filter algorithm that (1) minimizes measurement errors and (2) reconstructs at the same time the full phase-space from a position recording of a flying pigeon...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28649196/estimation-of-time-varying-intrinsic-and-reflex-dynamic-joint-stiffness-during-movement-application-to-the-ankle-joint
#18
Diego L Guarín, Robert E Kearney
Dynamic joint stiffness determines the relation between joint position and torque, and plays a vital role in the control of posture and movement. Dynamic joint stiffness can be quantified during quasi-stationary conditions using disturbance experiments, where small position perturbations are applied to the joint and the torque response is recorded. Dynamic joint stiffness is composed of intrinsic and reflex mechanisms that act and change together, so that nonlinear, mathematical models and specialized system identification techniques are necessary to estimate their relative contributions to overall joint stiffness...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28649155/evaluation-of-methods-to-produce-an-image-library-for-automatic-patient-model-localization-for-dose-mapping-during-fluoroscopically-guided-procedures
#19
Josh Kilian-Meneghin, Z Xiong, A Oines, S Rudin, D R Bednarek
The purpose of this work is to evaluate methods for producing a library of 2D-radiographic images to be correlated to clinical images obtained during a fluoroscopically-guided procedure for automated patient-model localization. The localization algorithm will be used to improve the accuracy of the skin-dose map superimposed on the 3D patient-model of the real-time Dose-Tracking-System (DTS). For the library, 2D images were generated from CT datasets of the SK-150 anthropomorphic phantom using two methods: Schmid's 3D-visualization tool and Plastimatch's digitally-reconstructed-radiograph (DRR) code...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28649154/skin-dose-mapping-for-non-uniform-x-ray-fields-using-a-backscatter-point-spread-function
#20
Sarath Vijayan, Zhenyu Xiong, Alok Shankar, Stephen Rudin, Daniel R Bednarek
Beam shaping devices like ROI attenuators and compensation filters modulate the intensity distribution of the x-ray beam incident on the patient. This results in a spatial variation of skin dose due to the variation of primary radiation and also a variation in backscattered radiation from the patient. To determine the backscatter component, backscatter point spread functions (PSF) are generated using EGS Monte-Carlo software. For this study, PSF's were determined by simulating a 1 mm beam incident on the lateral surface of an anthropomorphic head phantom and a 20 cm thick PMMA block phantom...
February 11, 2017: Proceedings of SPIE
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