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JOURNAL ARTICLE
Sinne Søberg Brun, Torben Frøstrup Hansen, Sara Witting Christensen Wen, Christa Haugaard Nyhus, Lisbeth Bertelsen, Anders Jakobsen, Torben Schjødt Hansen, Line Nederby
Many studies have focused on the prognostic role of soluble programmed death ligand 1 (sPD-L1) in non-small cell lung cancer (NSCLC), but outcomes are ambiguous and further investigations are needed. We addressed the matter by studying sPD-L1 in baseline samples and in longitudinal samples taken prior to three subsequent cycles of anti-PD-1/anti-PD-L1 treatments. Eighty patients with NSCLC were enrolled. Median sPD-L1 level at baseline was 52 pg/mL [95% confidence interval (CI) 49-57]. In patients treated with pembrolizumab and nivolumab, the concentration of sPD-L1 remained rather stable throughout treatment...
April 18, 2024: Scientific Reports
#2
JOURNAL ARTICLE
Angie Mejia, Kara Nyhus, Tessie Burley, Alexis Myhre, Marcela Montes, Kristin Osiecki, Anita C Randolph
BACKGROUND: Research has shown the role of identity on future health professionals' confidence and competence in addressing the sexual and reproductive health (SRH) needs of their patients. While there has been some work in increasing the sexual health literacy of future providers via various curricular approaches and comprehensive clinical-based training, there are research gaps on how social differences around identity impact future healthcare professionals' knowledge and practices around SRH...
2024: Front Reprod Health
#3
JOURNAL ARTICLE
Lynnette M Neufeld, Stella Nordhagen, Jef L Leroy, Noora-Lisa Aberman, Inka Barnett, Eric Djimeu Wouabe, Amy Webb Girard, Wendy Gonzalez, Carol E Levin, Mduduzi N N Mbuya, Eduardo Nakasone, Christina Nyhus Dhillon, Dave Prescott, Matt Smith, David Tschirley
While there is growing global momentum behind food systems strategies to improve planetary and human health-including nutrition-there is limited evidence of what types of food systems interventions work. Evaluating these types of interventions is challenging due to their complex and dynamic nature and lack of fit with standard evaluation methods. In this paper, we draw on a portfolio of six evaluations of food systems interventions in Africa and South Asia that were intended to improve nutrition. We identify key methodological challenges and formulate recommendations to improve the quality of such studies...
April 4, 2024: Journal of Nutrition
#4
JOURNAL ARTICLE
Norbert Meskó, Marta Kowal, András Láng, Ferenc Kocsor, Szabolcs A Bandi, Adam Putz, Piotr Sorokowski, David A Frederick, Felipe E García, Leonardo A Aguilar, Anna Studzinska, Chee-Seng Tan, Biljana Gjoneska, Taciano L Milfont, Merve Topcu Bulut, Dmitry Grigoryev, Toivo Aavik, Mahmoud Boussena, Alan D A Mattiassi, Reza Afhami, Rizwana Amin, Roberto Baiocco, Hamdaoui Brahim, Ali R Can, Joao Carneiro, Hakan Çetinkaya, Dimitri Chubinidze, Eliane Deschrijver, Yahya Don, Dmitrii Dubrov, Izzet Duyar, Marija Jovic, Julia A Kamburidis, Farah Khan, Hareesol Khun-Inkeeree, Maida Koso-Drljevic, David Lacko, Karlijn Massar, Mara Morelli, Jean C Natividade, Ellen K Nyhus, Ju Hee Park, Farid Pazhoohi, Ekaterine Pirtskhalava, Koen Ponnet, Pavol Prokop, Dušana Šakan, Singha Tulyakul, Austin H Wang, Sibele D Aquino, Derya D Atamtürk, Nana Burduli, Antonio Chirumbolo, Seda Dural, Edgardo Etchezahar, Nasim Ghahraman Moharrampour, Balazs Aczel, Luca Kozma, Samuel Lins, Efisio Manunta, Tiago Marot, Moises Mebarak, Kirill G Miroshnik, Katarina Misetic, Marietta Papadatou-Pastou, Bence Bakos, Fatima Zahra Sahli, Sangeeta Singh, Çağlar Solak, Tatiana Volkodav, Anna Wlodarczyk, Grace Akello, Marios Argyrides, Ogeday Çoker, Katarzyna Galasinska, Talía Gómez Yepes, Aleksander Kobylarek, Miguel Landa-Blanco, Marlon Mayorga, Barış Özener, Ma Criselda T Pacquing, Marc Eric S Reyes, Ayşegül Şahin, William Tamayo-Agudelo, Gulmira Topanova, Ezgi Toplu-Demirtaş, Belgüzar N Türkan, Marcos Zumárraga-Espinosa, Simone Grassini, Jan Antfolk, Clément Cornec, Katarzyna Pisanski, Sabrina Stöckli, Stephanie Josephine Eder, Hyemin Han
The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages...
December 21, 2023: Archives of Sexual Behavior
#5
JOURNAL ARTICLE
Berit Rein Solhaug, Maria Øyasaeter Nyhus, Rune Svenningsen, Ingrid Volløyhaug
OBJECTIVE: To evaluate rates of subjective and objective cure, treatment satisfaction, pain, and the correlation between cure and body mass index (BMI), at 10 and 20 years after tension-free vaginal tape (TVT) surgery. DESIGN: Retrospective cohort study. SETTING: Multicentre study including 19 units in Norway. POPULATION: Women undergoing TVT surgery for stress urinary incontinence (SUI) during 2001-2006 (20-year cohort) and 2011-2012 (10-year cohort)...
December 21, 2023: BJOG: An International Journal of Obstetrics and Gynaecology
#6
JOURNAL ARTICLE
Hege Nyhus Skytte, Marie Cecilie Paasche Roland, Jacob Juel Christensen, Kirsten Bjørklund Holven, Tove Lekva, Nina Gunnes, Trond Melbye Michelsen
INTRODUCTION: Increased BMI has been identified as a risk factor for most pregnancy complications, but the underlying metabolic factors mediating the detrimental effects of BMI are largely unknown. We aimed to compare metabolic profiles in overweight/obese women (body mass index [BMI] ≥ 25 kg/m2 ) and normal weight/underweight women (BMI < 25 kg/m2 ) across gestation. We also explored how gestational weight gain (GWG) affected maternal metabolic profiles...
December 11, 2023: Acta Obstetricia et Gynecologica Scandinavica
#7
RANDOMIZED CONTROLLED TRIAL
Morten Mau-Sørensen, Jonas Gerner-Rasmussen, Olfred Hansen, Bente Holm, Christa Haugaard Nyhus, Tine McCulloch, Henrik Anker Nielsen, Kim Wedervang, Carsten Rytter, Nina Jeppesen, Seppo W Langer
No abstract text is available yet for this article.
December 2023: Acta Oncologica
#8
Syanah C Wynn, Christopher D Townsend, Erika Nyhus
Theta and gamma oscillations have been linked to episodic memory processes in various studies. Both oscillations seem to be vital for processes guided by the medial temporal lobe, such as the retrieval of information from memory. While theta oscillations increase with successful memory, it is unclear what the unique contribution of theta is to various subcomponents of memory. On the other hand, memory-related gamma oscillations have been mainly reported in the hippocampus, leaving the role of neocortical gamma in memory underexplored...
October 19, 2023: bioRxiv
#9
JOURNAL ARTICLE
Wei Tian, Jingtian Zhou, Anna Bartlett, Qiurui Zeng, Hanqing Liu, Rosa G Castanon, Mia Kenworthy, Jordan Altshul, Cynthia Valadon, Andrew Aldridge, Joseph R Nery, Huaming Chen, Jiaying Xu, Nicholas D Johnson, Jacinta Lucero, Julia K Osteen, Nora Emerson, Jon Rink, Jasper Lee, Yang E Li, Kimberly Siletti, Michelle Liem, Naomi Claffey, Carolyn O'Connor, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya Shapovalova, Daniel Hirschstein, Song-Lin Ding, Rebecca Hodge, Boaz P Levi, C Dirk Keene, Sten Linnarsson, Ed Lein, Bing Ren, M Margarita Behrens, Joseph R Ecker
Delineating the gene-regulatory programs underlying complex cell types is fundamental for understanding brain function in health and disease. Here, we comprehensively examined human brain cell epigenomes by probing DNA methylation and chromatin conformation at single-cell resolution in 517 thousand cells (399 thousand neurons and 118 thousand non-neurons) from 46 regions of three adult male brains. We identified 188 cell types and characterized their molecular signatures. Integrative analyses revealed concordant changes in DNA methylation, chromatin accessibility, chromatin organization, and gene expression across cell types, cortical areas, and basal ganglia structures...
October 13, 2023: Science
#10
JOURNAL ARTICLE
Brian R Lee, Rachel Dalley, Jeremy A Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Eva Csajbok, Nicholas Donadio, Stan L W Driessens, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, Dijon Hill, Wen-Hsien Hou, Nelson Johansen, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela León, Brian Long, Matthew Mallory, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica J Melief, Gabor Molnar, Marty T Mortrud, Dakota Newman, Julie Nyhus, Ximena Opitz-Araya, Attila Ozsvár, Trangthanh Pham, Alice Pom, Lydia Potekhina, Ram Rajanbabu, Augustin Ruiz, Susan M Sunkin, Ildikó Szöts, Naz Taskin, Bargavi Thyagarajan, Michael Tieu, Jessica Trinh, Sara Vargas, David Vumbaco, Femke Waleboer, Sarah Walling-Bell, Natalie Weed, Grace Williams, Julia Wilson, Shenqin Yao, Thomas Zhou, Pál Barzó, Trygve Bakken, Charles Cobbs, Nick Dee, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin Grannan, Ryder P Gwinn, Jason S Hauptman, Rebecca Hodge, Tim Jarsky, C Dirk Keene, Andrew L Ko, Anders Rosendal Korshoej, Boaz P Levi, Kaare Meier, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly Smith, Jens Christian Sørensen, Jack Waters, Hongkui Zeng, Jim Berg, Marco Capogna, Natalia A Goriounova, Brian Kalmbach, Christiaan P J de Kock, Huib D Mansvelder, Staci A Sorensen, Gabor Tamas, Ed S Lein, Jonathan T Ting
Human cortex transcriptomic studies have revealed a hierarchical organization of γ-aminobutyric acid-producing (GABAergic) neurons from subclasses to a high diversity of more granular types. Rapid GABAergic neuron viral genetic labeling plus Patch-seq (patch-clamp electrophysiology plus single-cell RNA sequencing) sampling in human brain slices was used to reliably target and analyze GABAergic neuron subclasses and individual transcriptomic types. This characterization elucidated transitions between PVALB and SST subclasses, revealed morphological heterogeneity within an abundant transcriptomic type, identified multiple spatially distinct types of the primate-specialized double bouquet cells (DBCs), and shed light on cellular differences between homologous mouse and human neocortical GABAergic neuron types...
October 13, 2023: Science
#11
JOURNAL ARTICLE
Thomas Chartrand, Rachel Dalley, Jennie Close, Natalia A Goriounova, Brian R Lee, Rusty Mann, Jeremy A Miller, Gabor Molnar, Alice Mukora, Lauren Alfiler, Katherine Baker, Trygve E Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, Krissy Brouner, Tamara Casper, Eva Adrienn Csajbok, Nick Dee, Tom Egdorf, Rachel Enstrom, Anna A Galakhova, Amanda Gary, Emily Gelfand, Jeff Goldy, Kristen Hadley, Tim S Heistek, DiJon Hill, Nik Jorstad, Lisa Kim, Agnes Katalin Kocsis, Lauren Kruse, Michael Kunst, Gabriela Leon, Brian Long, Matthew Mallory, Medea McGraw, Delissa McMillen, Erica J Melief, Norbert Mihut, Lindsay Ng, Julie Nyhus, Gáspár Oláh, Attila Ozsvár, Victoria Omstead, Zoltan Peterfi, Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Marton Rozsa, Augustin Ruiz, Joanna Sandle, Susan M Sunkin, Ildiko Szots, Michael Tieu, Martin Toth, Jessica Trinh, Sara Vargas, David Vumbaco, Grace Williams, Julia Wilson, Zizhen Yao, Pal Barzo, Charles Cobbs, Richard G Ellenbogen, Luke Esposito, Manuel Ferreira, Nathan W Gouwens, Benjamin Grannan, Ryder P Gwinn, Jason S Hauptman, Tim Jarsky, C Dirk Keene, Andrew L Ko, Christof Koch, Jeffrey G Ojemann, Anoop Patel, Jacob Ruzevick, Daniel L Silbergeld, Kimberly Smith, Staci A Sorensen, Bosiljka Tasic, Jonathan T Ting, Jack Waters, Christiaan P J de Kock, Huib D Mansvelder, Gabor Tamas, Hongkui Zeng, Brian Kalmbach, Ed S Lein
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and feedback axons where local inhibitory signaling can profoundly shape cortical processing. Evolutionary expansion of human neocortex is marked by distinctive pyramidal neurons with extensive L1 branching, but whether L1 interneurons are similarly diverse is underexplored. Using Patch-seq recordings from human neurosurgical tissue, we identified four transcriptomic subclasses with mouse L1 homologs, along with distinct subtypes and types unmatched in mouse L1...
October 13, 2023: Science
#12
JOURNAL ARTICLE
Kimberly Siletti, Rebecca Hodge, Alejandro Mossi Albiach, Ka Wai Lee, Song-Lin Ding, Lijuan Hu, Peter Lönnerberg, Trygve Bakken, Tamara Casper, Michael Clark, Nick Dee, Jessica Gloe, Daniel Hirschstein, Nadiya V Shapovalova, C Dirk Keene, Julie Nyhus, Herman Tung, Anna Marie Yanny, Ernest Arenas, Ed S Lein, Sten Linnarsson
The human brain directs complex behaviors, ranging from fine motor skills to abstract intelligence, but the diversity of cell types that support these skills has not been fully described. In this work, we used single-nucleus RNA sequencing to systematically survey cells across the entire adult human brain. We sampled more than three million nuclei from approximately 100 dissections across the forebrain, midbrain, and hindbrain in three postmortem donors. Our analysis identified 461 clusters and 3313 subclusters organized largely according to developmental origins and revealing high diversity in midbrain and hindbrain neurons...
October 13, 2023: Science
#13
JOURNAL ARTICLE
Yang Eric Li, Sebastian Preissl, Michael Miller, Nicholas D Johnson, Zihan Wang, Henry Jiao, Chenxu Zhu, Zhaoning Wang, Yang Xie, Olivier Poirion, Colin Kern, Antonio Pinto-Duarte, Wei Tian, Kimberly Siletti, Nora Emerson, Julia Osteen, Jacinta Lucero, Lin Lin, Qian Yang, Quan Zhu, Nathan Zemke, Sarah Espinoza, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya Shapovalova, Daniel Hirschstein, Rebecca D Hodge, Sten Linnarsson, Trygve Bakken, Boaz Levi, C Dirk Keene, Jingbo Shang, Ed Lein, Allen Wang, M Margarita Behrens, Joseph R Ecker, Bing Ren
Recent advances in single-cell transcriptomics have illuminated the diverse neuronal and glial cell types within the human brain. However, the regulatory programs governing cell identity and function remain unclear. Using a single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq), we explored open chromatin landscapes across 1.1 million cells in 42 brain regions from three adults. Integrating this data unveiled 107 distinct cell types and their specific utilization of 544,735 candidate cis-regulatory DNA elements (cCREs) in the human genome...
October 13, 2023: Science
#14
JOURNAL ARTICLE
Lene Nyhus Andreasen, Evald Høj Christiansen, Lone Juul Hune Mogensen, Niels Ramsing Holm
Accurate determination of coronary reference size is essential for optimal stent selection and evaluation of stent expansion during percutaneous coronary intervention (PCI). Several approaches for reference size estimation have been published with no universal agreement. The aim of this study was to investigate if potential differences in coronary reference size estimation lead to differences in stent and balloon selection and in detection of stent under expansion. Definitions for coronary reference size estimation, stent size selection, and stent expansion were identified in 17 randomized controlled trials...
July 5, 2023: International Journal of Cardiovascular Imaging
#15
JOURNAL ARTICLE
Cathrine Nyhus Hagum, Espen Tønnessen, Jonny Hisdal, Shaher A I Shalfawi
OBJECTIVE: To evaluate the effectiveness of communication and coordination combined with designing a progressive and individualised sport-specific training program for reducing injury prevalence in youth female and male football and handball players transitioning to a sports academy high school. An additional aim was to investigate the characteristics of the reported injuries. METHODS: Forty-two Norwegian athletes were randomised into an intervention or control group...
2023: Frontiers in sports and active living
#16
REVIEW
I Bulyk, V Shkarban, S Vasyliuk, V Osadets, I Bitska, O Dmytruk
The article reviews the history of inguinal hernia surgery. At various times, different procedures and diverse materials were used for hernia repair. However, the effectiveness and safety of inguinal hernia repair emerged only after the anatomic features of the inguinal region had been elucidated in a monograph by Henri Fruchaud "Anatomie des hernies de l'aine" published in 1956. The Italian surgeon Edoardo Bassini began a new era in herniology. For a longtime, his classic procedure with its modifications was the most popular in surgical practice...
2023: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
#17
Mariano Gabitto, Kyle Travaglini, Jeannelle Ariza, Eitan Kaplan, Brian Long, Victoria Rachleff, Yi Ding, Joseph Mahoney, Nick Dee, Jeff Goldy, Erica Melief, Krissy Brouner, Jazmin Compos, John Campos, Ambrose Carr, Tamara Casper, Rushil Chakrabarty, Michael Clark, Jonah Cool, Rachel Dalley, Martin Darvas, Tim Dolbeare, Song-Lin Ding, Tom Egdorf, Luke Esposito, Rebecca Ferrer, Rohan Gala, Amanda Gary, Jessica Gloe, Nathan Guilford, Junitta Guzman, Windy Ho, Tim Jarsky, Nelson Johansen, Brian Kalmbach, Lisa Keene, Sarah Khawand, Mitchell Kilgore, Amanda Kirkland, Michael Kunst, Brian Lee, Christine Mac Donald, Jocelin Malone, Zoe Maltzer, Naomi Martin, Rachel McCue, Delissa McMillen, Emma Meyerdierks, Kelly Meyers, Tyler Mollenkopf, Mark Montine, Amber Nolan, Julie Nyhus, Paul Olsen, Maiya Pacleb, Trangthanh Pham, Christina Pom, Nadia Postupna, Augustin Ruiz, Aimee Schantz, Staci Sorensen, Brian Staats, Matt Sullivan, Susan Sunkin, Carol Thompson, Michael Tieu, Jonathan Ting, Amy Torkelson, Tracy Tran, Nasmil Valera Cuevas, Ming-Qiang Wang, Jack Waters, Angela Wilson, David Haynor, Nicole Gatto, Suman Jayadev, Shoaib Mufti, Lydia Ng, Shubhabrata Mukherjee, Paul Crane, Caitlin Latimer, Boaz Levi, Kimberly Smith, Jennie Close, Jeremy Miller, Rebecca Hodge, Eric Larson, Thomas Grabowski, Michael Hawrylycz, C Keene, Ed Lein
Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive stereotyped accumulation of protein aggregates, but the underlying molecular and cellular mechanisms driving AD progression and vulnerable cell populations affected by disease remain coarsely understood. The current study harnesses the BRAIN Initiative Cell Census Network experimental practices, combining quantitative neuropathology with single cell genomics and spatial transcriptomics, to understand the impact of disease progression on middle temporal gyrus cell types...
May 23, 2023: Research Square
#18
JOURNAL ARTICLE
Cathrine Nyhus Hagum, Espen Tønnessen, Marie Aarrestad Nesse, Shaher A I Shalfawi
BACKGROUND: Despite its small population, Norway wins a disproportionately large number of medals in international competitions. Therefore, it has been thought that the Norwegian sports model and sports school programs are influential in developing young Norwegian athletes to achieve such results. Today, more than 110 Norwegian private and public schools offer the elite sports program in Norway. Most student athletes attending those schools combine their high school education with elite sports, where they attend training sessions at both school and clubs...
May 13, 2023: Sports
#19
REVIEW
Christina Nyhus Dhillon, Flaminia Ortenzi
One in three people globally suffers from at least one form of malnutrition, leading to poor health outcomes and low productivity in the workplace. The workplace offers an important, relatively unexploited opportunity to address malnutrition in all its forms. This narrative literature review aims to understand the impact of workforce nutrition programmes on nutrition, health, and business outcomes, based on high-strength-of-evidence studies. We used PubMed as our primary research database, complemented by Google Scholar, to identify systematic reviews, meta-analyses, and randomised controlled trials published between January 2010 and October 2021...
May 5, 2023: International Journal of Environmental Research and Public Health
#20
JOURNAL ARTICLE
Sara Witting Christensen Wen, Line Nederby, Rikke Fredslund Andersen, Torben Schjødt Hansen, Christa Haugaard Nyhus, Ole Hilberg, Anders Jakobsen, Torben Frøstrup Hansen
BACKGROUND: PD-1/PD-L1 inhibitors have improved survival for patients with non-small cell lung cancer (NSCLC). We evaluated natural killer cell activity (NKA) and methylated HOXA9 circulating tumor DNA (ctDNA) as prognostic biomarkers in NSCLC patients treated with PD-1/PD-L1 inhibitors. METHODS: Plasma was prospectively collected from 71 NSCLC patients before treatment with PD-1/PD-L1 inhibitors and before cycles 2-4. We used the NK Vue® assay to measure the level of interferon gamma (IFNγ) as a surrogate for NKA...
May 3, 2023: British Journal of Cancer
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