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J K M Fan, J Yip, D C C Foo, O S H Lo, W L Law
OBJECTIVES: The use of absorbable polylactic acid hook self-gripping polypropylene mesh in open inguinal hernia may potentially reduce operative time and enhance patient recovery. The objective of this randomized trial is to compare the outcomes following self-gripping mesh repair to polypropylene mesh secured with sutures in open inguinal hernioplasty. METHOD: Eligible patients aged 18-80 years old, who had primary unilateral uncomplicated inguinal hernia, were randomized into either Polypropylene (PL) group or PROGRIP (PG) group just before the placement of mesh intra-operatively by computer generated code...
November 26, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Margaret Benjamin Lyatuu, Temina Mkumbwa, Raz Stevenson, Marissa Isidro, Francis Modaha, Heather Katcher, Christina Nyhus Dhillon
BACKGROUND: Micronutrient deficiency in Tanzania is a significant public health problem, with vitamin A deficiency (VAD) affecting 34% of children aged 6 to 59 months. Since 2007, development partners have worked closely to advocate for the inclusion of twice-yearly vitamin A supplementation and deworming (VASD) activities with budgets at the subnational level, where funding and implementation occur. As part of the advocacy work, a VASD planning and budgeting tool (PBT) was developed and is used by district officials to justify allocation of funds...
May 3, 2016: International Journal of Health Policy and Management
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S Lein
Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole-brain coverage, relatively low image resolution, and sparse structural annotation. We present the first digital human brain atlas to incorporate neuroimaging, high-resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and 1,356 large-format cellular resolution (1 µm/pixel) Nissl and immunohistochemistry anatomical plates...
November 1, 2016: Journal of Comparative Neurology
Trygve E Bakken, Jeremy A Miller, Song-Lin Ding, Susan M Sunkin, Kimberly A Smith, Lydia Ng, Aaron Szafer, Rachel A Dalley, Joshua J Royall, Tracy Lemon, Sheila Shapouri, Kaylynn Aiona, James Arnold, Jeffrey L Bennett, Darren Bertagnolli, Kristopher Bickley, Andrew Boe, Krissy Brouner, Stephanie Butler, Emi Byrnes, Shiella Caldejon, Anita Carey, Shelby Cate, Mike Chapin, Jefferey Chen, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadia Dotson, Amanda Ebbert, Erich Fulfs, Garrett Gee, Terri L Gilbert, Jeff Goldy, Lindsey Gourley, Ben Gregor, Guangyu Gu, Jon Hall, Zeb Haradon, David R Haynor, Nika Hejazinia, Anna Hoerder-Suabedissen, Robert Howard, Jay Jochim, Marty Kinnunen, Ali Kriedberg, Chihchau L Kuan, Christopher Lau, Chang-Kyu Lee, Felix Lee, Lon Luong, Naveed Mastan, Ryan May, Jose Melchor, Nerick Mosqueda, Erika Mott, Kiet Ngo, Julie Nyhus, Aaron Oldre, Eric Olson, Jody Parente, Patrick D Parker, Sheana Parry, Julie Pendergraft, Lydia Potekhina, Melissa Reding, Zackery L Riley, Tyson Roberts, Brandon Rogers, Kate Roll, David Rosen, David Sandman, Melaine Sarreal, Nadiya Shapovalova, Shu Shi, Nathan Sjoquist, Andy J Sodt, Robbie Townsend, Lissette Velasquez, Udi Wagley, Wayne B Wakeman, Cassandra White, Crissa Bennett, Jennifer Wu, Rob Young, Brian L Youngstrom, Paul Wohnoutka, Richard A Gibbs, Jeffrey Rogers, John G Hohmann, Michael J Hawrylycz, Robert F Hevner, Zoltán Molnár, John W Phillips, Chinh Dang, Allan R Jones, David G Amaral, Amy Bernard, Ed S Lein
The transcriptional underpinnings of brain development remain poorly understood, particularly in humans and closely related non-human primates. We describe a high-resolution transcriptional atlas of rhesus monkey (Macaca mulatta) brain development that combines dense temporal sampling of prenatal and postnatal periods with fine anatomical division of cortical and subcortical regions associated with human neuropsychiatric disease. Gene expression changes more rapidly before birth, both in progenitor cells and maturing neurons...
July 13, 2016: Nature
Erika Nyhus, Nancy Curtis
Electroencephalogram (EEG) is a relatively non-invasive, simple technique, and recent advances in open source analysis tools make it feasible to implement EEG as a component in undergraduate neuroscience curriculum. We have successfully led students to design novel experiments, record EEG data, and analyze event-related potentials (ERPs) during a one-semester laboratory course for undergraduates in cognitive neuroscience. First, students learned how to set up an EEG recording and completed an analysis tutorial...
2016: Journal of Undergraduate Neuroscience Education: JUNE: a Publication of FUN, Faculty for Undergraduate Neuroscience
Preston L Carter
A brief history of the seminal contributions of Stoppa and Nyhus to inguinal hernia surgery.
May 2016: American Journal of Surgery
Roland Kupka, Jennifer Nielsen, Christina Nyhus Dhillon, Jessica Blankenship, Marjorie J Haskell, Shawn K Baker, Kenneth H Brown
BACKGROUND: Vitamin A supplementation (VAS) among children 6 to 59 months of age reduces vitamin A deficiency (VAD)-related mortality. Child health days (CHDs) only reach an estimated 16.7% of children at exactly 6 months, leaving uncovered children at risk of VAD-related mortality; similarly, VAS provided at 9 months of age with measles-containing vaccine leaves infants unprotected for 3 months. OBJECTIVE: Using data from sub-Saharan Africa, we estimated the mortality benefits and safety of providing VAS at age 6 months, compared to delivery through CHDs and at 9 months...
May 5, 2016: Food and Nutrition Bulletin
Eva Maria Støa, Lill-Katrin Nyhus, Sandra Claveau Børresen, Caroline Nygaard, Åse Marie Hovet, Solfrid Bratland-Sanda, Jan Helgerud, Øyvind Støren
Indirect calorimetry is a common and noninvasive method to estimate rate of fat oxidation (FatOx) during exercise, and test-retest reliability should be considered when interpreting results. Diet also has an impact on FatOx. The aim of the present study was to investigate day to day variations in FatOx during moderate exercise given the same diet and 2 different isoenergetic diets. Nine healthy, moderately-trained females participated in the study. They performed 1 maximal oxygen uptake test and 4 FatOx tests...
April 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Yi Pan, Carsten Brink, Marianne Knap, Azza A Khalil, Christa H Nyhus, Tine McCulloch, Bente Holm, Yi-long Wu, Tine Schytte, Olfred Hansen
PURPOSE: Esophagitis is common in patients treated with definitive radiotherapy for local-regional advanced non small cell lung cancer (NSCLC). The purpose of this study was to estimate the dose-effect relationship using clinical and dosimetric parameters in patients receiving intensity modulated radiotherapy (IMRT) and concomitant chemotherapy (CCT). METHODS: Between 2009 and 2013, 117 patients with stages IIB-IIIB NSCLC were treated in a multicenter randomized phase II trial with 2 cycles of induction chemotherapy followed by IMRT and CCT...
March 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Robert S Ross, Paolo Medrano, Kaitlin Boyle, Andrew Smolen, Tim Curran, Erika Nyhus
Recognition memory is defined as the ability to recognize a previously encountered stimulus and has been associated with spatially and temporally distinct event-related potentials (ERPs). Allelic variations of the serotonin transporter gene (SLC6A4) have recently been shown to impact memory performance. Common variants of the serotonin transporter-linked polymorphic region (5HTTLPR) of the SLC6A4 gene result in long (l) and short (s) allelic variants with carriers of the s allele having lowered transcriptional efficiency...
November 2015: Neuropsychologia
Anna Kopf, Mesude Bicak, Renzo Kottmann, Julia Schnetzer, Ivaylo Kostadinov, Katja Lehmann, Antonio Fernandez-Guerra, Christian Jeanthon, Eyal Rahav, Matthias Ullrich, Antje Wichels, Gunnar Gerdts, Paraskevi Polymenakou, Giorgos Kotoulas, Rania Siam, Rehab Z Abdallah, Eva C Sonnenschein, Thierry Cariou, Fergal O'Gara, Stephen Jackson, Sandi Orlic, Michael Steinke, Julia Busch, Bernardo Duarte, Isabel Caçador, João Canning-Clode, Oleksandra Bobrova, Viggo Marteinsson, Eyjolfur Reynisson, Clara Magalhães Loureiro, Gian Marco Luna, Grazia Marina Quero, Carolin R Löscher, Anke Kremp, Marie E DeLorenzo, Lise Øvreås, Jennifer Tolman, Julie LaRoche, Antonella Penna, Marc Frischer, Timothy Davis, Barker Katherine, Christopher P Meyer, Sandra Ramos, Catarina Magalhães, Florence Jude-Lemeilleur, Ma Leopoldina Aguirre-Macedo, Shiao Wang, Nicole Poulton, Scott Jones, Rachel Collin, Jed A Fuhrman, Pascal Conan, Cecilia Alonso, Noga Stambler, Kelly Goodwin, Michael M Yakimov, Federico Baltar, Levente Bodrossy, Jodie Van De Kamp, Dion Mf Frampton, Martin Ostrowski, Paul Van Ruth, Paul Malthouse, Simon Claus, Klaas Deneudt, Jonas Mortelmans, Sophie Pitois, David Wallom, Ian Salter, Rodrigo Costa, Declan C Schroeder, Mahrous M Kandil, Valentina Amaral, Florencia Biancalana, Rafael Santana, Maria Luiza Pedrotti, Takashi Yoshida, Hiroyuki Ogata, Tim Ingleton, Kate Munnik, Naiara Rodriguez-Ezpeleta, Veronique Berteaux-Lecellier, Patricia Wecker, Ibon Cancio, Daniel Vaulot, Christina Bienhold, Hassan Ghazal, Bouchra Chaouni, Soumya Essayeh, Sara Ettamimi, El Houcine Zaid, Noureddine Boukhatem, Abderrahim Bouali, Rajaa Chahboune, Said Barrijal, Mohammed Timinouni, Fatima El Otmani, Mohamed Bennani, Marianna Mea, Nadezhda Todorova, Ventzislav Karamfilov, Petra Ten Hoopen, Guy Cochrane, Stephane L'Haridon, Kemal Can Bizsel, Alessandro Vezzi, Federico M Lauro, Patrick Martin, Rachelle M Jensen, Jamie Hinks, Susan Gebbels, Riccardo Rosselli, Fabio De Pascale, Riccardo Schiavon, Antonina Dos Santos, Emilie Villar, Stéphane Pesant, Bruno Cataletto, Francesca Malfatti, Ranjith Edirisinghe, Jorge A Herrera Silveira, Michele Barbier, Valentina Turk, Tinkara Tinta, Wayne J Fuller, Ilkay Salihoglu, Nedime Serakinci, Mahmut Cerkez Ergoren, Eileen Bresnan, Juan Iriberri, Paul Anders Fronth Nyhus, Edvardsen Bente, Hans Erik Karlsen, Peter N Golyshin, Josep M Gasol, Snejana Moncheva, Nina Dzhembekova, Zackary Johnson, Christopher David Sinigalliano, Maribeth Louise Gidley, Adriana Zingone, Roberto Danovaro, George Tsiamis, Melody S Clark, Ana Cristina Costa, Monia El Bour, Ana M Martins, R Eric Collins, Anne-Lise Ducluzeau, Jonathan Martinez, Mark J Costello, Linda A Amaral-Zettler, Jack A Gilbert, Neil Davies, Dawn Field, Frank Oliver Glöckner
Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world's oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits...
2015: GigaScience
K Tomaoglu, Y S Sarı, H Bektas, O Koc, E Gunes, G Uzum, M Kucukyılmaz
BACKGROUND: The purpose of the present randomized trial was to compare the Jean Rives (JR) technique and the laparoscopic totally extraperitoneal (TEP) repair for the treatment of primary inguinal hernias with respect to operating time, hospital stay, sick leave, chronic pain and recurrences after a follow-up of 10 years. METHODS: 110 patients with primary inguinal hernia were randomized to either a JR repair (53 patients) or to a laparoscopic (TEP) repair (57 patients)...
June 2015: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Michael J Frank, Chris Gagne, Erika Nyhus, Sean Masters, Thomas V Wiecki, James F Cavanagh, David Badre
What are the neural dynamics of choice processes during reinforcement learning? Two largely separate literatures have examined dynamics of reinforcement learning (RL) as a function of experience but assuming a static choice process, or conversely, the dynamics of choice processes in decision making but based on static decision values. Here we show that human choice processes during RL are well described by a drift diffusion model (DDM) of decision making in which the learned trial-by-trial reward values are sequentially sampled, with a choice made when the value signal crosses a decision threshold...
January 14, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Amato Giuseppe, Romano Giorgio, Agrusa Antonino, Di Buono Giuseppe, Cocorullo Gianfranco, Gulotta Gaspare
The article reports the incidence of multiple inguinal protrusions in the same groin in a patient collect who underwent open hernia repair. Multiple ipsilateral inguinal hernias compose an almost neglected topic that, if not identified during hernia repair, could lead to unclear discomfort, pain, and reoperation. A collect of 100 consecutive open anterior inguinal hernia procedures was analyzed. The patients were divided into two subsets-A: patients with a single protrusion and B: patients with more than one protrusion simultaneously arising from the inguinal floor...
November 2014: Surgical Technology International
Torun M Vatne, Ingerid Østborg Helmen, David Bahr, Øivind Kanavin, Livø Nyhus
Misconceptions or uncertainty about the rare disorder of a sibling may cause adjustment problems among children. New knowledge about their misconceptions may enable genetic counselors to provide targeted information and increase siblings' knowledge. This study aims to describe misconceptions and uncertainties of siblings of children with rare disorders. Content analysis was applied to videotapes of 11 support group sessions with 56 children aged 6 to 17. First, children's statements about the disorder (turns) were categorized into the categories "identity," "cause," "cure," "timeline," and "consequences" and then coded as medically "correct," "misunderstood," or "uncertain...
April 2015: Journal of Genetic Counseling
Linn H Trovik, Kjell Ovrebo, Martin Almquist, Hans Kristian Haugland, Pehr Rissler, Johan Eide, Jacob Engellau, Odd R Monge, Anniken B Nyhus, Ingvild K Elde, Nina L Jebsen
BACKGROUND: Currently there is no consensus on the use of adjuvant radiotherapy (RT) in retroperitoneal sarcoma (RPS). We have analysed clinical outcomes in patients with localised RPS treated at two Scandinavian Sarcoma Group (SSG) centres: Haukeland University Hospital (HUH), Bergen, Norway and Skåne University Hospital (SUH), Lund, Sweden to clarify the effects of adjuvant RT on local control and overall survival (OS). MATERIAL AND METHODS: Local databases and registers at HUH and SUH as well as the SSG central register were used to identify RPS patients...
September 2014: Acta Oncologica
S M Vasyliuk, O V Prudnikov
Complex examination and surgical treatment was performed in 220 elderly and senile patients for various types of inguinal hernia (IH) in accordance to Nyhus classification. In 103 patients (the main group) hernioplasty was performed according to Lichtenstein method or using modifications, proposed by us; in 117 (the comparison group)--the tension hernioplasty, using the patient's tissues. According to data of morphological investigation of the inguinal channel musculo-aponeurotic structures in 24 patients there was established, that in the oblique IH formation a biochemical instability of the connective tissue structures plays a leading role, while in a direct type of IH--the reduction of muscular fibrils quantity, lowering their elasticity and a contractile answer velocity...
January 2014: Klinichna Khirurhiia
Rogério de Oliveira Gonçalves, Evandro de Moraes e Silva, Gaspar de Jesus Lopes Filho
OBJECTIVE: to evaluate the role of fibrillar extracellular matrix components in the pathogenesis of inguinal hernias. METHODS: samples of the transverse fascia and of the anterior sheath of the rectus abdominis muscle were collected from 40 men aged between 20 and 60 years with type II and IIIA Nyhus inguinal hernia and from 10 fresh male cadavers (controls) without hernia in the same age range. The staining technique was immunohistochemistry for collagen I, collagen III and elastic fibers; quantification of fibrillar components was performed with an image analysis processing software...
January 2014: Revista do Colégio Brasileiro de Cirurgiões
Alejandro de la Vega, Mark S Brown, Hannah R Snyder, Debra Singel, Yuko Munakata, Marie T Banich
Individuals vary greatly in their ability to select one item or response when presented with a multitude of options. Here we investigate the neural underpinnings of these individual differences. Using magnetic resonance spectroscopy, we found that the balance of inhibitory versus excitatory neurotransmitters in pFC predicts the ability to select among task-relevant options in two language production tasks. The greater an individual's concentration of GABA relative to glutamate in the lateral pFC, the more quickly he or she could select a relevant word from among competing options...
November 2014: Journal of Cognitive Neuroscience
Jeremy A Miller, Song-Lin Ding, Susan M Sunkin, Kimberly A Smith, Lydia Ng, Aaron Szafer, Amanda Ebbert, Zackery L Riley, Joshua J Royall, Kaylynn Aiona, James M Arnold, Crissa Bennet, Darren Bertagnolli, Krissy Brouner, Stephanie Butler, Shiella Caldejon, Anita Carey, Christine Cuhaciyan, Rachel A Dalley, Nick Dee, Tim A Dolbeare, Benjamin A C Facer, David Feng, Tim P Fliss, Garrett Gee, Jeff Goldy, Lindsey Gourley, Benjamin W Gregor, Guangyu Gu, Robert E Howard, Jayson M Jochim, Chihchau L Kuan, Christopher Lau, Chang-Kyu Lee, Felix Lee, Tracy A Lemon, Phil Lesnar, Bergen McMurray, Naveed Mastan, Nerick Mosqueda, Theresa Naluai-Cecchini, Nhan-Kiet Ngo, Julie Nyhus, Aaron Oldre, Eric Olson, Jody Parente, Patrick D Parker, Sheana E Parry, Allison Stevens, Mihovil Pletikos, Melissa Reding, Kate Roll, David Sandman, Melaine Sarreal, Sheila Shapouri, Nadiya V Shapovalova, Elaine H Shen, Nathan Sjoquist, Clifford R Slaughterbeck, Michael Smith, Andy J Sodt, Derric Williams, Lilla Zöllei, Bruce Fischl, Mark B Gerstein, Daniel H Geschwind, Ian A Glass, Michael J Hawrylycz, Robert F Hevner, Hao Huang, Allan R Jones, James A Knowles, Pat Levitt, John W Phillips, Nenad Sestan, Paul Wohnoutka, Chinh Dang, Amy Bernard, John G Hohmann, Ed S Lein
The anatomical and functional architecture of the human brain is mainly determined by prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the mid-gestational human brain, including de novo reference atlases, in situ hybridization, ultra-high-resolution magnetic resonance imaging (MRI) and microarray analysis on highly discrete laser-microdissected brain regions. In developing cerebral cortex, transcriptional differences are found between different proliferative and post-mitotic layers, wherein laminar signatures reflect cellular composition and developmental processes...
April 10, 2014: Nature
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