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https://www.readbyqxmd.com/read/29120328/neuropathological-and-transcriptomic-characteristics-of-the-aged-brain
#1
Jeremy A Miller, Angela Guillozet-Bongaarts, Laura E Gibbons, Nadia Postupna, Anne Renz, Allison E Beller, Susan M Sunkin, Lydia Ng, Shannon E Rose, Kimberly A Smith, Aaron Szafer, Chris Barber, Darren Bertagnolli, Kristopher Bickley, Krissy Brouner, Shiella Caldejon, Mike Chapin, Mindy L Chua, Natalie M Coleman, Eiron Cudaback, Christine Cuhaciyan, Rachel A Dalley, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadezhda I Dotson, Michael Fisher, Nathalie Gaudreault, Garrett Gee, Terri L Gilbert, Jeff Goldy, Fiona Griffin, Caroline Habel, Zeb Haradon, Nika Hejazinia, Leanne L Hellstern, Steve Horvath, Kim Howard, Robert Howard, Justin Johal, Nikolas L Jorstad, Samuel R Josephsen, Chihchau L Kuan, Florence Lai, Eric Lee, Felix Lee, Tracy Lemon, Xianwu Li, Desiree A Marshall, Jose Melchor, Shubhabrata Mukherjee, Julie Nyhus, Julie Pendergraft, Lydia Potekhina, Elizabeth Y Rha, Samantha Rice, David Rosen, Abharika Sapru, Aimee Schantz, Elaine Shen, Emily Sherfield, Shu Shi, Andy J Sodt, Nivretta Thatra, Michael Tieu, Angela M Wilson, Thomas J Montine, Eric B Larson, Amy Bernard, Paul K Crane, Richard G Ellenbogen, C Dirk Keene, Ed Lein
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors (median = 90) from the Adult Changes in Thought (ACT) study as a freely-available resource (http://aging...
November 9, 2017: ELife
https://www.readbyqxmd.com/read/29078911/resident-postgraduate-year-does-not-influence-rate-of-complications-following-inguinal-herniorrhaphy
#2
Oswaldo Renteria, Ali A Mokdad, Jonathan Imran, Sergio Huerta
BACKGROUND: Previous data indicate that patients who undergo surgery with a postgraduate year 3 (PGY-3) resident as the junior surgeon have a lower rate of recurrence compared with PGY-1 and PGY-2 after an open inguinal herniorrhaphy. Lower PGY level was also associated with increased operative time. We hypothesize that when controlling for surgeon, technique, and hernia type, the outcomes for inguinal herniorrhaphy are the same independent of PGY level. MATERIALS AND METHODS: A retrospective review of all open unilateral inguinal hernia repairs done by residents who assisted the same senior surgeon at the Veterans Affairs North Texas Health Care System was performed...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28984525/brain-networks-related-to-beta-oscillatory-activity-during-episodic-memory-retrieval
#3
Erika Nyhus
Evidence from fMRI has consistently located a widespread network of frontal, parietal, and temporal lobe regions during episodic retrieval. However, the temporal limitations of the fMRI methodology have made it difficult to assess the transient network dynamics by which these distributed regions coordinate activity. Recent evidence suggests that beta oscillations (17-20 Hz) are important for top-down control for memory suppression. However, the spatial limitations of the EEG methodology make it difficult to assess the relationship between these oscillatory signals and the distributed networks identified with fMRI...
October 6, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28960878/experiences-and-lessons-learned-for-delivery-of-micronutrient-powders-interventions
#4
Ietje Reerink, Sorrel Ml Namaste, Alia Poonawala, Christina Nyhus Dhillon, Nancy Aburto, Deepika Chaudhery, Hou Kroeun, Marcia Griffiths, Mohammad Raisul Haque, Anabelle Bonvecchio, Maria Elena Jefferds, Rahul Rawat
An effective delivery strategy coupled with relevant social and behaviour change communication (SBCC) have been identified as central to the implementation of micronutrient powders (MNP) interventions, but there has been limited documentation of what works. Under the auspices of "The Micronutrient Powders Consultation: Lessons Learned for Operational Guidance," three working groups were formed to summarize experiences and lessons across countries regarding MNP interventions for young children. This paper focuses on programmatic experiences related to MNP delivery (models, platforms, and channels), SBCC, and training...
September 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28960876/executive-summary-for-the-micronutrient-powders-consultation-lessons-learned-for-operational-guidance
#5
Christina Nyhus Dhillon, Danya Sarkar, Rolf Dw Klemm, Lynnette M Neufeld, Rahul Rawat, Alison Tumilowicz, Sorrel Ml Namaste
Iron deficiency anaemia is estimated to be the leading cause of years lived with disability among children. Young children's diets are often inadequate in iron and other micronutrients, and provision of essential vitamin and minerals has long been recommended. With the limited programmatic success of iron drop/syrup interventions, interest in micronutrient powders (MNP) has increased. MNP are a mixture of vitamins and minerals, enclosed in single-dose sachets, which are stirred into a child's portion of food immediately before consumption...
September 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28960875/experiences-and-lessons-learned-for-planning-and-supply-of-micronutrient-powders-interventions
#6
Claudia Schauer, Nigel Sunley, Carrie Hubbell Melgarejo, Christina Nyhus Dhillon, Claudia Roca, Gustavo Tapia, Pragya Mathema, Shelley Walton, Ruth Situma, Stanley Zlotkin, Rolf Dw Klemm
Realistic planning for a nutrition intervention is a critical component of implementation, yet effective approaches have been poorly documented. Under the auspices of "The Micronutrient Powders Consultation: Lessons Learned for Operational Guidance," 3 working groups were formed to summarize experiences and lessons across countries regarding micronutrient powders (MNP) interventions for young children. This paper focuses on programmatic experiences in the planning stages of an MNP intervention, encompassing assessment, enabling environment and adaptation, as well as considerations for supply...
September 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28797054/large-scale-wheat-flour-folic-acid-fortification-program-increases-plasma-folate-levels-among-women-of-reproductive-age-in-urban-tanzania
#7
Ramadhani A Noor, Ajibola I Abioye, Nzovu Ulenga, Salum Msham, George Kaishozi, Nilupa S Gunaratna, Ramadhani Mwiru, Erin Smith, Christina Nyhus Dhillon, Donna Spiegelman, Wafaie Fawzi
There is widespread vitamin and mineral deficiency problem in Tanzania with known deficiencies of at least vitamin A, iron, folate and zinc, resulting in lasting negative consequences especially on maternal health, cognitive development and thus the nation's economic potential. Folate deficiency is associated with significant adverse health effects among women of reproductive age, including a higher risk of neural tube defects. Several countries, including Tanzania, have implemented mandatory fortification of wheat and maize flour but evidence on the effectiveness of these programs in developing countries remains limited...
2017: PloS One
https://www.readbyqxmd.com/read/28767798/conventional-inguinal-hernia-repair-with-self-fixating-mesh-versus-totally-extraperitoneal-laparoscopic-repair-with-polypropylene-mesh-early-postoperative-results
#8
José Antonio Cunha-E-Silva, Flávio Malcher Martins de Oliveira, Antonio Felipe Santa Maria Coquillard Ayres, Antonio Carlos Ribeiro Garrido Iglesias
Objective: to evaluate the early postoperative results of inguinal hernia repair by the conventional technique with self-fixating mesh versus laparoscopic totally extraperitoneal repair with polypropylene mesh. We compared pain, surgical time and early complications. Methods: this is a prospective, case-series study of 80 consecutive patients treated in the surgical clinic of the Gaffrée e Guinle University Hospital (HUGG). We included patients with unilateral inguinal hernia, not relapsed and operated only on an elective basis...
May 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28688525/heterogeneous-fdg-guided-dose-escalation-for-locally-advanced-nsclc-the-narlal2-trial-design-and-early-dosimetric-results-of-a-randomized-multi-centre-phase-iii-study
#9
Ditte Sloth Møller, Tine Bjørn Nielsen, Carsten Brink, Lone Hoffmann, Christina Maria Lutz, Mikkel Drøgemüller Lund, Olfred Hansen, Tine Schytte, Azza Ahmed Khalil, Marianne Marquard Knap, Christa Haugaard Nyhus, Wiviann Ottosson, Patrik Sibolt, Svetlana Borissova, Mirjana Josipovic, Gitte Persson, Ane Lindegaard Appelt
BACKGROUND AND PURPOSE: Local recurrence is frequent in locally advanced NSCLC and is primarily located in FDG-avid parts of tumour and lymph nodes. Aiming at improving local control without increasing toxicity, we designed a multi-centre phase-III trial delivering inhomogeneous dose-escalation driven by FDG-avid volumes, while respecting normal tissue constraints and requiring no increase in mean lung dose. Dose-escalation driven by FDG-avid volumes, delivering mean doses of 95Gy (tumour) and 74Gy (lymph nodes), was pursued and compared to standard 66Gy/33F plans...
July 5, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28440021/global-patterns-and-trends-in-human-wildlife-conflict-compensation
#10
Jeremy Ravenelle, Philip J Nyhus
Human-wildlife conflict is a major conservation challenge, and compensation for wildlife damage is a widely used economic tool to mitigate this conflict. The effectiveness of this management tool is widely debated. The relative importance of factors associated with compensation success is unclear, and little is known about global geographic or taxonomic differences in the application of compensation programs. We reviewed research on wildlife-damage compensation to determine geographic and taxonomic gaps, analyze patterns of positive and negative comments related to compensation, and assess the relative magnitude of global compensation payments...
April 25, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28410809/a-randomized-phase-ii-trial-of-concurrent-chemoradiation-with-two-doses-of-radiotherapy-60gy-and-66gy-concomitant-with-a-fixed-dose-of-oral-vinorelbine-in-locally-advanced-nsclc
#11
Olfred Hansen, Marianne M Knap, Azza Khalil, Christa H Nyhus, Tine McCulloch, Bente Holm, Carsten Brink, Lone Hoffmann, Tine Schytte
INTRODUCTION: In order to test the best performing radiation dose with a convenient chemotherapy schedule of an oral formulation of radio-sensitizing vinorelbine in inoperable locally advanced non-small cell lung cancer (NSCLC), we performed a randomized phase II trial based on a "pick the winner" design. METHODS: After 2 cycles of neoadjuvant chemotherapy, 117 patients with NSCLC stage IIB-IIIB in performance status 0-1 were randomized to radiotherapy 60Gy/30 fractions or 66Gy/33 fractions concurrent with a fixed dose of oral vinorelbine 50mg administered 3 times weekly...
May 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28393306/the-effect-of-chronic-constipation-on-the-development-of-inguinal-herniation
#12
A Kartal, M Yalcın, B Citgez, A Uzunkoy
OBJECTIVE: To investigate the effect of constipation on the development of inguinal herniation and type of herniation using the Constipation severity scale. METHODS: A total of 100 patients who underwent surgical inguinal hernia repair (study group) and 100 healthy volunteers without inguinal herniation (control group) were included in this study. The constipation severity scale was administered to all patients. The type of the herniation was classified using Nyhus scale during surgery and the side of the herniation was recorded on completed questionnaires...
August 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28363623/external-hernia-of-the-supravesical-fossa-rare-or-simply-misidentified
#13
REVIEW
G Amato, G Romano, E Erdas, F Medas, L Gordini, F Podda, P Calò
BACKGROUND: External hernias of the supravesical fossa are considered rare, perhaps wrongly. Highlighting clinical and anatomical features could be useful for correct, preoperative diagnosis, thus avoiding the risk of complications such as incarceration. The study aims to demonstrate that the incidence of external protrusions of the supravesical fossa is higher that supposed. Probably, being mistaken for direct hernias, these hernia types are misidentified and not included in current classifications...
March 29, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28160083/high-intensity-aerobic-interval-training-improves-aerobic-fitness-and-hba1c-among-persons-diagnosed-with-type-2-diabetes
#14
Eva Maria Støa, Sondre Meling, Lill-Katrin Nyhus, Glenn Strømstad, Karl Magnus Mangerud, Jan Helgerud, Solfrid Bratland-Sanda, Øyvind Støren
PURPOSE: It remains to be established how high-intensity aerobic interval training (HAIT) affects risk factors associated with type 2 diabetes (TD2). This study investigated effects of HAIT on maximal oxygen uptake (VO2max), glycated Hemoglobin type A1C (HbA1c), insulin resistance (IR), fat oxidation (FatOx), body weight (BW), percent body fat (%BF), lactate threshold (LT), blood pressure (BP), and blood lipid profile (BLP) among persons with T2D. Results were compared to the effects after a moderate-intensity training (MIT) program...
March 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28095985/open-preperitoneal-groin-hernia-repair-with-mesh-a-qualitative-systematic-review
#15
REVIEW
Kristoffer Andresen, Jacob Rosenberg
BACKGROUND: For the repair of inguinal hernias, several surgical methods have been presented where the purpose is to place a mesh in the preperitoneal plane through an open access. The aim of this systematic review was to describe preperitoneal repairs with emphasis on the technique. DATA SOURCES: A systematic review was conducted and reported according to the PRISMA statement. PubMed, Cochrane library and Embase were searched systematically. Studies were included if they provided clinical data with more than 30 days follow up following repair of an inguinal hernia with an open preperitoneal mesh technique...
June 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/27970262/tct-10-physiological-testing-of-coronary-artery-stenosis-by-computation-of-invasive-coronary-angiography-the-wire-free-functional-imaging-wifi-ii-study
#16
Jelmer Westra, Shengxian Tu, Louise Nissen, Simon Winther, Mai Britt, Birgitte Krogsgaard Andersen, Emil Holck, Camilla Fox Maule, Lars Frost, Lene Nyhus Andreasen, Jo Simonsen, Yimin Zhang, Steen Dalby Kristensen, Michael Maeng, Anne Kaltoft, Christian Terkelsen, Lars Romer Krussell, Lars Jakobsen, Johan Reiber, Jens Flensted Lassen, Morten Bottcher, Hans Erik Botker, Evald Christiansen, Niels Holm
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27917481/comprehensive-cellular-resolution-atlas-of-the-adult-human-brain
#17
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S LeinReference
No abstract text is available yet for this article.
February 1, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27889845/randomized-trial-comparing-self-gripping-semi-re-absorbable-mesh-progrip-with-polypropylene-mesh-in-open-inguinal-hernioplasty-the-6%C3%A2-years-result
#18
RANDOMIZED CONTROLLED TRIAL
J K M Fan, J Yip, D C C Foo, O S H Lo, W L Law
OBJECTIVES: The use of absorbable polylactic acid hook self-gripping polypropylene mesh in open inguinal hernia may potentially reduce operative time and enhance patient recovery. The objective of this randomized trial is to compare the outcomes following self-gripping mesh repair to polypropylene mesh secured with sutures in open inguinal hernioplasty. METHOD: Eligible patients aged 18-80 years old, who had primary unilateral uncomplicated inguinal hernia, were randomized into either Polypropylene (PL) group or PROGRIP (PG) group just before the placement of mesh intra-operatively by computer generated code...
February 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/27694649/planning-and-budgeting-for-nutrition-programs-in-tanzania-lessons-learned-from-the-national-vitamin-a-supplementation-program
#19
Margaret Benjamin Lyatuu, Temina Mkumbwa, Raz Stevenson, Marissa Isidro, Francis Modaha, Heather Katcher, Christina Nyhus Dhillon
BACKGROUND: Micronutrient deficiency in Tanzania is a significant public health problem, with vitamin A deficiency (VAD) affecting 34% of children aged 6 to 59 months. Since 2007, development partners have worked closely to advocate for the inclusion of twice-yearly vitamin A supplementation and deworming (VASD) activities with budgets at the subnational level, where funding and implementation occur. As part of the advocacy work, a VASD planning and budgeting tool (PBT) was developed and is used by district officials to justify allocation of funds...
May 3, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/27418273/comprehensive-cellular-resolution-atlas-of-the-adult-human-brain
#20
Song-Lin Ding, Joshua J Royall, Susan M Sunkin, Lydia Ng, Benjamin A C Facer, Phil Lesnar, Angie Guillozet-Bongaarts, Bergen McMurray, Aaron Szafer, Tim A Dolbeare, Allison Stevens, Lee Tirrell, Thomas Benner, Shiella Caldejon, Rachel A Dalley, Nick Dee, Christopher Lau, Julie Nyhus, Melissa Reding, Zackery L Riley, David Sandman, Elaine Shen, Andre van der Kouwe, Ani Varjabedian, Michelle Write, Lilla Zollei, Chinh Dang, James A Knowles, Christof Koch, John W Phillips, Nenad Sestan, Paul Wohnoutka, H Ronald Zielke, John G Hohmann, Allan R Jones, Amy Bernard, Michael J Hawrylycz, Patrick R Hof, Bruce Fischl, Ed S Lein
Detailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole-brain coverage, relatively low image resolution, and sparse structural annotation. We present the first digital human brain atlas to incorporate neuroimaging, high-resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and 1,356 large-format cellular resolution (1 µm/pixel) Nissl and immunohistochemistry anatomical plates...
November 1, 2016: Journal of Comparative Neurology
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