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Modified ketogenic diet

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https://www.readbyqxmd.com/read/29668317/the-modified-ketogenic-diet-in-adults-with-glioblastoma-an-evaluation-of-feasibility-and-deliverability-within-the-national-health-service
#1
Kirsty J Martin-McGill, Anthony G Marson, Catrin Tudur Smith, Michael D Jenkinson
There is an increasing interest in the use of the ketogenic diet (KD) as an adjuvant therapy for glioma patients. We assessed the tolerability and feasibility of a modified ketogenic diet (MKD) in patients with glioma, along with willingness of patients to participate in future randomized controlled trials. The study was undertaken in two parts; a patient questionnaire and evaluation of the diet. One hundred and seventy-two questionnaires were completed; 69% (n = 119) of the population reported MKD should be offered to patients with glioma and 73% (n = 125) would be willing to try MKD for 3 months...
April 18, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29651419/management-of-glioblastoma-multiforme-in-a-patient-treated-with-ketogenic-metabolic-therapy-and-modified-standard-of-care-a-24-month-follow-up
#2
Ahmed M A Elsakka, Mohamed Abdel Bary, Eman Abdelzaher, Mostafa Elnaggar, Miriam Kalamian, Purna Mukherjee, Thomas N Seyfried
Few advances have been made in overall survival for glioblastoma multiforme (GBM) in more than 40 years. Here, we report the case of a 38-year-old man who presented with chronic headache, nausea, and vomiting accompanied by left partial motor seizures and upper left limb weakness. Enhanced brain magnetic resonance imaging revealed a solid cystic lesion in the right partial space suggesting GBM. Serum testing revealed vitamin D deficiency and elevated levels of insulin and triglycerides. Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast...
2018: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29605572/decreased-ghrelin-and-des-acyl-ghrelin-plasma-levels-in-patients-affected-by-pharmacoresistant-epilepsy-and-maintained-on-the-ketogenic-diet
#3
Maddalena Marchiò, Laura Roli, Carmela Giordano, Tommaso Trenti, Azzurra Guerra, Giuseppe Biagini
BACKGROUND & AIMS: The gastric hormones ghrelin and des-acyl ghrelin have been found to be altered in patients treated with antiepileptic drugs. However, it is unknown if these hormones could be modified by other antiepileptic treatments, such as the ketogenic diet. Especially, a reduction in ghrelin levels could be relevant in view of the growth retardation observed under ketogenic diet treatment. For this reason we aimed to determine the changes in ghrelin and des-acyl ghrelin plasma levels in children affected by refractory epilepsy and treated with the ketogenic diet up to 90 days...
March 23, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29483892/efficacy-of-modified-atkins-ketogenic-diet-in-chronic-cluster-headache-an-open-label-single-arm-clinical-trial
#4
Cherubino Di Lorenzo, Gianluca Coppola, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Francesco Pierelli
Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine. Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients. Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29421589/a-modified-ketogenic-gluten-free-diet-with-mct-improves-behavior-in-children-with-autism-spectrum-disorder
#5
Ryan W Y Lee, Michael J Corley, Alina Pang, Gaye Arakaki, Lisa Abbott, Michael Nishimoto, Rob Miyamoto, Erica Lee, Susan Yamamoto, Alika K Maunakea, Annette Lum-Jones, Miki Wong
No abstract text is available yet for this article.
May 1, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29209515/ketogenic-diets-as-an-adjuvant-therapy-in-glioblastoma-the-keating-trial-study-protocol-for-a-randomised-pilot-study
#6
Kirsty J Martin-McGill, Anthony G Marson, Catrin Tudur Smith, Michael D Jenkinson
Background: Glioblastoma is the commonest form of malignant brain tumour in adults, affecting 2-3 people per 100,000 per year. Despite current treatment options including surgical resection, radiotherapy and temozolomide chemotherapy, overall survival at 2 years is approximately 27%, with a median survival of 12-14 months. The ketogenic diet (KD) is postulated to work by simulating the metabolic response to fasting by promoting the utilisation of ketones as a primary energy source, and depriving the glycolytic pathways utilised by malignant glioma cells for growth...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29069983/short-term-and-long-term-efficacy-of-classical-ketogenic-diet-and-modified-atkins-diet-in-children-and-adolescents-with-epilepsy-a-systematic-review-and-meta-analysis
#7
Shahabeddin Rezaei, Ahmed Abdulahi Abdurahman, Amene Saghazadeh, Reza Shervin Badv, Maryam Mahmoudi
OBJECTIVES: Classical ketogenic diet (KD) and modified Atkins diet (MAD) are two types of KD commonly used for the treatment of intractable epilepsy throughout the world. Studies have shown the efficacy of these diets. However, no systematic review and meta-analysis study has to date compared the efficacy of KD and MAD in a time trend. Therefore, the objectives of the present study were to compare the short-term and long-term efficacy of classical KD and MAD in children and adolescents with epilepsy and to determine the efficacy of classical KD and MAD at multiple time points and in a time trend...
October 25, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29046197/-prospective-study-of-ketogenic-diet-in-treatment-of-children-with-global-developmental-delay
#8
RANDOMIZED CONTROLLED TRIAL
Deng-Na Zhu, Ping Li, Jun Wang, Jun-Ying Yuan, Guang-Yu Zhang, Jiang-Fang Liang, Ming-Mei Wang, Yun-Xia Zhao, Shuang An, Na Ma, Dan-Dan Ma
OBJECTIVE: To study the effect of ketogenic diet (KD) on neurobehavioral development, emotional and social behaviors, and life ability in children with global developmental delay (GDD). METHODS: A prospective case-control study was performed for hospitalized children with GDD, who were randomly divided into KD treatment group (n=40) and conventional treatment group (n=37). The children in both groups were given comprehensive rehabilitation training, and those in the KD treatment group were given modified Atkins diet in addition to the comprehensive rehabilitation training...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29045796/the-modification-of-the-ketogenic-diet-mitigates-its-stunting-effects-in-rodents
#9
Arkadiusz Damian Liśkiewicz, Daniela Kasprowska-Liśkiewicz, Anna Sługocka, Marta Maria Nowacka-Chmielewska, Jan Wiaderkiewicz, Halina Jędrzejowska-Szypułka, Jarosław Jerzy Barski, Joanna Lewin-Kowalik
The high-fat and low-carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketogenic rodent diets is important, both in the context of laboratory animal welfare as well as for the accuracy of the obtained results. In this study we implemented a modification to a commonly used ketogenic rodent chow by replacing non-resorbable cellulose with wheat bran...
February 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29034969/experience-with-mad-on-children-with-epilepsy-in-egypt-after-classic-kd-failure
#10
O F El Rashidy, M F Nassar, Y G El Gendy, S M Deifalla, S Gaballa
BACKGROUND AND AIM: Modified Atkins diet (MAD) is a less restrictive type of ketogenic diet (KD) as compared to the classic one. The aim of this study was to evaluate the impact of 9 months MAD treatment on the growth and seizure control in patients with intractable epilepsy as well as the quality of life (QoL) of their mothers. SUBJECTS AND METHODS: The study included 15 patients with intractable epilepsy who could not tolerate their classic KD management plan...
February 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29029389/a-ketogenic-diet-supplemented-with-medium-chain-triglycerides-enhances-the-anti-tumor-and-anti-angiogenic-efficacy-of-chemotherapy-on-neuroblastoma-xenografts-in-a-cd1-nu-mouse-model
#11
Sepideh Aminzadeh-Gohari, René Günther Feichtinger, Silvia Vidali, Felix Locker, Tricia Rutherford, Maura O'Donnel, Andrea Stöger-Kleiber, Johannes Adalbert Mayr, Wolfgang Sperl, Barbara Kofler
Neuroblastoma (NB) is a pediatric malignancy characterized by a marked reduction in aerobic energy metabolism. Recent preclinical data indicate that targeting this metabolic phenotype by a ketogenic diet (KD), especially in combination with calorie restriction, slows tumor growth and enhances metronomic cyclophosphamide (CP) therapy of NB xenografts. Because calorie restriction would be contraindicated in most cancer patients, the aim of the present study was to optimize the KD such that the tumors are sensitized to CP without the need of calorie restriction...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29024787/ketogenic-metabolism-inhibits-histone-deacetylase-hdac-and-reduces-oxidative-stress-after-spinal-cord-injury-in-rats
#12
Xiaomeng Wang, Xiaoliang Wu, Qi Liu, Ganggang Kong, Jian Zhou, Jie Jiang, Xiuhua Wu, Zhiping Huang, Wanhan Su, Qingan Zhu
The aim of this study is to investigate the effect of ketogenic metabolism, induced by different diet interventions, on histone acetylation and its potential antioxidant capacity to injured spinal cord tissue in rats. 72 male Sprague-Dawley rats were randomly divided into 4 groups, fed with ketogenic diet (KD), every other day fasting (EODF), every other day ketogenic diet (EODKD) and standard diet (SD) respectively for 2 weeks. β-Hydroxybutyrate (βOHB) concentration was measured both in serum and cerebrospinal fluid (CSF)...
December 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28970732/ketogenic-diet-poses-a-significant-effect-on-imbalanced-gut-microbiota-in-infants-with-refractory-epilepsy
#13
Gan Xie, Qian Zhou, Chuang-Zhao Qiu, Wen-Kui Dai, He-Ping Wang, Yin-Hu Li, Jian-Xiang Liao, Xin-Guo Lu, Su-Fang Lin, Jing-Hua Ye, Zhuo-Ya Ma, Wen-Jian Wang
AIM: To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota (GM), and how ketogenic diet (KD) alters GM. METHODS: A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16S rDNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR, and inter-group comparison was conducted by R software...
September 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28915401/the-modified-ketogenic-diet-for-adults-with-refractory-epilepsy-an-evaluation-of-a-set-up-service
#14
Kirsty J Martin-McGill, Michael D Jenkinson, Catrin Tudur Smith, Anthony G Marson
PURPOSE: The ketogenic diet (KD) has been proven to be effective in children with refractory epilepsy and is recommended by the National Institute of Health and Care Excellence (NICE). There is no randomised control trial (RCT) evidence for the clinical or cost effectiveness of KD in adults, for whom the KD is not currently recommended. We assessed the feasibility of the modified ketogenic diet (MKD) in adults with refractory epilepsy along with the willingness of patients to participate in a future RCT...
November 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28914421/acid-base-safety-during-the-course-of-a-very-low-calorie-ketogenic-diet
#15
Diego Gomez-Arbelaez, Ana B Crujeiras, Ana I Castro, Albert Goday, Antonio Mas-Lorenzo, Ana Bellon, Cristina Tejera, Diego Bellido, Cristobal Galban, Ignacio Sajoux, Patricio Lopez-Jaramillo, Felipe F Casanueva
BACKGROUND AND AIMS: Very low-calorie ketogenic (VLCK) diets have been consistently shown to be an effective obesity treatment, but the current evidence for its acid-base safety is limited. The aim of the current work was to evaluate the acid-base status of obese patients during the course of a VLCK diet. METHOD: Twenty obese participants undertook a VLCK diet for 4 months. Anthropometric and biochemical parameters, and venous blood gases were obtained on four subsequent visits: visit C-1 (baseline); visit C-2, (1-2 months); maximum ketosis; visit C-3 (2-3 months), ketosis declining; and visit C-4 at 4 months, no ketosis...
October 2017: Endocrine
https://www.readbyqxmd.com/read/28905672/the-influence-of-ketogenic-therapy-on-the-5-r-s-of-radiobiology
#16
Rainer J Klement
PURPOSE: Radiotherapy (RT) is a mainstay in the treatment of solid tumors and works by inducing free radical stress in tumor cells, leading to loss of reproductive integrity. The optimal treatment strategy has to consider damage to both tumor and normal cells and is determined by five factors known as the 5 R's of radiobiology: Reoxygenation, DNA repair, radiosensitivity, redistribution in the cell cycle and repopulation. The aim of this review is (i) to present evidence that these 5 R's are strongly influenced by cellular and whole-body metabolism that in turn can be modified through ketogenic therapy in form of ketogenic diets and short-term fasting and (ii) to stimulate new research into this field including some research questions deserving further study...
October 9, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28808808/ketogenic-diet-versus-gluten-free-casein-free-diet-in-autistic-children-a-case-control-study
#17
Omnia El-Rashidy, Farida El-Baz, Yasmin El-Gendy, Randa Khalaf, Dina Reda, Khaled Saad
Many diet regimens were studied for patients with autism spectrum disorder (ASD) over the past few years. Ketogenic diet is gaining attention due to its proven effect on neurological conditions like epilepsy in children. Forty-five children aged 3-8 years diagnosed with ASD based on DSM-5 criteria were enrolled in this study. Patients were equally divided into 3 groups, first group received ketogenic diet as modified Atkins diet (MAD), second group received gluten free casein free (GFCF) diet and the third group received balanced nutrition and served as a control group...
December 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28799513/ketogenic-diets-in-the-treatment-of-epilepsy
#18
Maurizio Elia, Joerg Klepper, Baerbel Leiendecker, Hans Hartmann
BACKGROUND: Although a larger number of antiepileptic drugs became available in the last decades, epilepsy remains drug-resistant in approximately a third of patients. Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not completely understood. Over the last decades, different types of ketogenic diets (KDs) have been developed, namely classical KD and modified Atkins diet (MAD). They offer an effective alternative for children and adults with drug-resistant epilepsies...
August 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28790891/adenosine-a1-receptor-antagonism-abolished-the-anti-seizure-effects-of-exogenous-ketone-supplementation-in-wistar-albino-glaxo-rijswijk-rats
#19
Zsolt Kovács, Dominic P D'Agostino, Arpád Dobolyi, Csilla Ari
The state of therapeutic ketosis can be achieved by using the ketogenic diet (KD) or exogenous ketone supplementation. It was suggested previously that the adenosinergic system may be involved in the mediating effect of KD on suppressing seizure activity in different types of epilepsies, likely by means of adenosine A1 receptors (A1Rs). Thus, we tested in the present study whether exogenous ketone supplements (ketone ester: KE, 2.5 g/kg/day; ketone salt/KS + medium chain triglyceride/MCT: KSMCT, 2.5 g/kg/day) applied sub-chronically (for 7 days) by intragastric gavage can modulate absence epileptic activity in genetically absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28762296/current-nutritional-approaches-in-managing-autism-spectrum-disorder-a-review
#20
Hande Cekici, Nevin Sanlier
The link between nutrition and autism spectrum disorder (ASD), which is a complex developmental disorder manifesting itself in significant delays or deviation in interaction and communication, has provided a fresh point of view and signals that nutrition may have a role in the aetiology of ASD, as well as play an active role in treatment by alleviating symptoms. OBJECTIVE: In this review study aimed at evaluating, with scientific and concrete proof, the current medical nutrition implementations on ASD, existing medical nutrition therapies have been addressed and their effects on ASD symptoms have been discussed in light of current research...
August 1, 2017: Nutritional Neuroscience
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