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https://www.readbyqxmd.com/read/29771194/preconception-antiphospholipid-antibodies-and-risk-of-subsequent-early-pregnancy-loss
#1
K J Gibbins, S L Mumford, L A Sjaarda, D W Branch, N J Perkins, A Ye, E F Schisterman, R M Silver
Objectives To prospectively estimate the association of preconception antiphospholipid antibodies (aPL) with subsequent pregnancy loss using a cohort design. aPL have been associated with recurrent early pregnancy loss (EPL) prior to 10 weeks in previous case-control studies. Prospective ascertainment of pregnancy loss is challenging, as most women do not seek care prior to EPL. Methods Secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial of preconception low-dose aspirin. Preconception anticardiolipin (aCL) and anti-β2-glycoprotein-I (a-β2-I) were assessed in 1208 women with one or two prior pregnancy losses and no more than two prior live births...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29767102/methodological-aspects-of-determining-phosphorus-digestibility-in-swine-a-review
#2
REVIEW
Yue She, Defa Li, Shuai Zhang
The role of phosphorus (P) in swine nutrition has been taken on new significance in recent years. Methods to determine the available phosphorus (AP) content of swine feeds include relative bioavailability (RBV), apparent total tract digestibility (ATTD), standardized total tract digestibility (STTD), and true total tract digestibility (TTTD). The RBV of P is determined by measuring bone ash or bone P, whereas the ATTD of P is determined by calculating the difference between P intake and P excretion in feces...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29710141/interventions-to-prevent-falls-in-community-dwelling-older-adults-us-preventive-services-task-force-recommendation-statement
#3
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Pignone, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Falls are the leading cause of injury-related morbidity and mortality among older adults in the United States. In 2014, 28.7% of community-dwelling adults 65 years or older reported falling, resulting in 29 million falls (37.5% of which needed medical treatment or restricted activity for a day or longer) and an estimated 33 000 deaths in 2015. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on the prevention of falls in community-dwelling older adults...
April 24, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29709927/effect-of-eplerenone-on-the-glomerular-filtration-rate-gfr-in-primary-aldosteronism-sequential-changes-in-the-gfr-during-preoperative-eplerenone-treatment-to-subsequent-adrenalectomy
#4
Yujiro Nakano, Takanobu Yoshimoto, Tatsuya Fukuda, Masanori Murakami, Ryotaro Bouchi, Isao Minami, Koshi Hashimoto, Yasuhisa Fujii, Kazunori Kihara, Yoshihiro Ogawa
Objective Eplerenone (EPL) is a mineralo-corticoid receptor antagonist that is highly selective and has few side effects. This study was conducted to examine whether or not EPL treatment was able to reverse glomerular hyperfiltration, as an indicator of aldosterone renal action, in primary aldosteronism (PA) patients. Methods Changes in the estimated glomerular filtration rate (ΔGFR) were examined in 102 PA patients with EPL treatment. Furthermore, the sequential ΔGFR in 40 patients initially treated with EPL followed by adrenalectomy was examined in order to evaluate the extent of the remaining glomerular hyperfiltration in the patients treated with EPL...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29694034/site-specific-antibody-functionalization-using-tetrazine-styrene-cycloaddition
#5
Benjamin J Umlauf, Kalie A Mix, Vanessa A Grosskopf, Ronald T Raines, Eric V Shusta
Biologics, such as antibody-drug conjugates, are becoming mainstream therapeutics. Consequently, methods to functionalize biologics without disrupting their native properties are essential for identifying, characterizing, and translating candidate biologics from the bench to clinical practice. Here, we present a method for site-specific, carboxy-terminal modification of single-chain antibody fragments (scFvs). ScFvs displayed on the surface of yeast were isolated and functionalized by combining intein-mediated expressed protein ligation (EPL) with inverse electron-demand Diels-Alder (IEDDA) cycloaddition using a styrene-tetrazine pair...
May 3, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29677309/vitamin-d-calcium-or-combined-supplementation-for-the-primary-prevention-of-fractures-in-community-dwelling-adults-us-preventive-services-task-force-recommendation-statement
#6
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005, and annual incidence is projected to increase to more than 3 million fractures by 2025. Within 1 year of experiencing a hip fracture, many patients are unable to walk independently, more than half require assistance with activities of daily living, and 20% to 30% of patients will die...
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29671794/phytochemical-study-of-the-ecuadorian-species-lepechinia-mutica-benth-epling-and-high-antifungal-activity-of-carnosol-against-pyricularia-oryzae
#7
Jorge Ramírez, Gianluca Gilardoni, Erika Ramón, Solveig Tosi, Anna Maria Picco, Carlo Bicchi, Giovanni Vidari
The plant Lepechinia mutica (Benth.) Epling (family Lamiaceae) is endemic to Ecuador. In the present study, we report some major non-volatile secondary metabolites from the leaves and the chemistry of the essential oil distilled from the flowers. The main identified compounds were carnosol, viridiflorol, ursolic acid, oleanolic acid, chrysothol, and 5-hydroxy-4′,7-dimethoxy flavone. Their structures were determined by X-ray diffraction and NMR and MS techniques. The essential oil showed a chemical composition similar to that distilled from the leaves, but with some qualitative and quantitative differences regarding several minor compounds...
April 19, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29661788/germline-tissues-for-optimal-somatic-variant-detection-in-myelodysplastic-syndromes-mds
#8
Eric Padron, Markus C Ball, Jamie K Teer, Jeffrey S Painter, Sean J Yoder, Chaomei Zhang, Ling Zhang, Lynn C Moscinski, Dana E Rollison, Steven D Gore, Rafael Bejar, Matthew J Walter, Mikkael A Sekeres, Rami S Komrokji, Pearlie K Epling-Burnette
No abstract text is available yet for this article.
April 16, 2018: Blood
https://www.readbyqxmd.com/read/29659534/clinical-management-of-low-vitamin-d-a-scoping-review-of-physicians-practices
#9
REVIEW
Michelle Rockwell, Vivica Kraak, Matthew Hulver, John Epling
The role of vitamin D in the prevention and treatment of non-skeletal health issues has received significant media and research attention in recent years. Costs associated with clinical management of low vitamin D (LVD) have increased exponentially. However, no clear evidence supports vitamin D screening to improve health outcomes. Authoritative bodies and professional societies do not recommend population-wide vitamin D screening in community-dwelling adults who are asymptomatic or at low risk of LVD. To assess patterns of physicians’ management of LVD in this conflicting environment, we conducted a scoping review of three electronic databases and the gray literature...
April 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29622019/in-vitro-antioxidant-and-cholinesterase-inhibitory-activities-of-elatostema-papillosum-leaves-and-correlation-with-their-phytochemical-profiles-a-study-relevant-to-the-treatment-of-alzheimer-s-disease
#10
A S M Ali Reza, Mohammad Shahadat Hossain, Sharmin Akhter, Md Rezanur Rahman, Mst Samima Nasrin, Md Josim Uddin, Golam Sadik, A H M Khurshid Alam
BACKGROUND: Alzheimer's disease (AD), one of the major causes of dementia, is an overwhelming neurodegenerative disease that particularly affects the brain, leading to memory loss and impairment of language and judgment capacity. The aim of the present study was to investigate the antioxidant and anticholinesterase properties of the leaves of Elatostema papillosum (EPL) and correlate with their phytochemical profiles, which are relevant to the treatment of AD. METHODS: The dried coarse powder of EPL was extracted with 80% methanol (EPL-M80) by cold extraction method...
April 5, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29566772/platelet-lysate-as-a-novel-serum-free-media-supplement-for-the-culture-of-equine-bone-marrow-derived-mesenchymal-stem-cells
#11
Maria C Naskou, Scarlett M Sumner, Anna Chocallo, Hannah Kemelmakher, Merrilee Thoresen, Ian Copland, Jacques Galipeau, John F Peroni
BACKGROUND: Mesenchymal stem cells (MSCs) produced for clinical purposes rely on culture media containing fetal bovine serum (FBS) which is xenogeneic and has the potential to significantly alter the MSC phenotype, rendering these cells immunogenic. As a result of bovine-derived exogenous proteins expressed on the cell surface, MSCs may be recognized by the host immune system as non-self and be rejected. Platelet lysate (PL) may obviate some of these concerns and shows promising results in human medicine as a possible alternative to FBS...
March 22, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29565745/eplerenone-modulates-interleukin-33-sst2-signaling-and-il-1%C3%AE-in-left-ventricular-systolic-dysfunction-after-acute-myocardial-infarction
#12
Bo Chen, Jing Geng, Shao-Xi Gao, Wen-Wei Yue, Qiang Liu
This study aimed to evaluate the role of eplerenone on the modulation of interleukin (IL)-1β and IL-33/sST2 signaling pathway in an experimental model of left ventricular (LV) systolic dysfunction after acute myocardial infarction (MI). MI rats were randomly assigned to no treatment (MI group, n = 10), to receive eplerenone (Epl group, n = 10), or anakinra (Ana group, n = 10). LV function was assessed by echocardiography. IL-1β, IL-33/sST2, and cardiac fibrosis biomarkers were analyzed by quantitative real-time reverse transcription polymerase chain reaction (PCR)...
March 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29558558/behavioral-counseling-to-prevent-skin-cancer-us-preventive-services-task-force-recommendation-statement
#13
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Aaron B Caughey, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Martha Kubik, Seth Landefeld, Carol M Mangione, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: Skin cancer is the most common type of cancer in the United States. Although invasive melanoma accounts for only 2% of all skin cancer cases, it is responsible for 80% of skin cancer deaths. Basal and squamous cell carcinoma, the 2 predominant types of nonmelanoma skin cancer, represent the vast majority of skin cancer cases. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on behavioral counseling for the primary prevention of skin cancer and the 2009 recommendation on screening for skin cancer with skin self-examination...
March 20, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29517999/role-of-polyamines-in-immune-cell-functions
#14
REVIEW
Rebecca S Hesterberg, John L Cleveland, Pearlie K Epling-Burnette
The immune system is remarkably responsive to a myriad of invading microorganisms and provides continuous surveillance against tissue damage and developing tumor cells. To achieve these diverse functions, multiple soluble and cellular components must react in an orchestrated cascade of events to control the specificity, magnitude and persistence of the immune response. Numerous catabolic and anabolic processes are involved in this process, and prominent roles for l-arginine and l-glutamine catabolism have been described, as these amino acids serve as precursors of nitric oxide, creatine, agmatine, tricarboxylic acid cycle intermediates, nucleotides and other amino acids, as well as for ornithine, which is used to synthesize putrescine and the polyamines spermidine and spermine...
March 8, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29500047/intracompartmental-versus-extracompartmental-transposition-of-the-extensor-pollicis-longus-for-treating-thumb-in-palm-deformity-a-biomechanical-comparison
#15
Sheriff D Akinleye, Maya Deza Culbertson, Giacomo Cappelleti, Nicholas Richardson, Jack Choueka
PURPOSE: Transecting the extensor pollicis longus (EPL) tendon and rerouting it through the first extensor compartment is an established technique for treating thumb-in-palm deformity (TIPD). An alternative technique that approximates the trajectory of the first extensor compartment without violating the compartment or transecting the EPL tendon can be accomplished by creating an artificial sheath from the extensor retinaculum to radialize the tendon glide path. This study compares this extracompartmental (EC) EPL transposition to the established, intracompartmental (IC) transposition by evaluating, in a cadaver model, the extent of thumb extension in both techniques...
February 27, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29486285/dual-effect-liposomes-with-increased-antitumor-effects-against-67-kda-laminin-receptor-overexpressing-tumor-cells
#16
Ikumi Sugiyama, Kunihiro Kaihatsu, Yukako Soma, Nobuo Kato, Yasuyuki Sadzuka
This study sought to evaluate the antitumor effects of and elucidate the mechanisms underlying (-)-epigallocatechin-3-O-gallate (EGCG) and polyethyleneglycol (PEG)-modified liposomes. EGCG functions as a target ligand of the 67-kDa laminin receptor (67LR), which is expressed on high-grade tumor cells. An EGCG derivative was synthesized for binding to the end of PEG. Doxorubicin (DOX)-loaded EGCG-PEG-modified liposome (EPL) significantly decreased tumor size in mice bearing high 67LR-high-expressing tumors. Caspase-3 activity, which indicates induction of apoptosis, was also elevated only in the EPL group...
April 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29472096/prediction-of-gtv-median-dose-differences-eases-monte-carlo-re-prescription-in-lung-sbrt
#17
D Dechambre, L Z Janvary, N Jansen, P Berkovic, C Mievis, V Baart, S Cucchiaro, A P Coucke, A Gulyban
BACKGROUND AND PURPOSE: The use of Monte Carlo (MC) dose calculation algorithm for lung patients treated with stereotactic body radiotherapy (SBRT) can be challenging. Prescription in low density media and time-consuming optimization conducted CyberKnife centers to propose an equivalent path length (EPL)-to-MC re-prescription method based on GTV median dose. Unknown at the time of planning, GTV D50% practical application remains difficult. The current study aims at creating a re-prescription predictive model in order to limit conflicting dose value during EPL optimization...
January 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29450531/screening-for-ovarian-cancer-us-preventive-services-task-force-recommendation-statement
#18
David C Grossman, Susan J Curry, Douglas K Owens, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, Maureen G Phipps, Michael Silverstein, Melissa A Simon, Chien-Wen Tseng
Importance: With approximately 14 000 deaths per year, ovarian cancer is the fifth most common cause of cancer death among US women and the leading cause of death from gynecologic cancer. More than 95% of ovarian cancer deaths occur among women 45 years and older. Objective: To update the 2012 US Preventive Services Task Force (USPSTF) recommendation on screening for ovarian cancer. Evidence Review: The USPSTF reviewed the evidence on the benefits and harms of screening for ovarian cancer in asymptomatic women not known to be at high risk for ovarian cancer (ie, high risk includes women with certain hereditary cancer syndromes that increase their risk for ovarian cancer)...
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29449372/ligand-mediated-protein-degradation-reveals-functional-conservation-among-sequence-variants-of-the-cul4-type-e3-ligase-substrate-receptor-cereblon
#19
Afua A Akuffo, Aileen Y Alontaga, Rainer Metcalf, Matthew S Beatty, Andreas Becker, Jessica M McDaniel, Rebecca S Hesterberg, William E Goodheart, Steven Gunawan, Muhammad Ayaz, Yan Yang, Md Rezaul Karim, Morgan E Orobello, Kenyon Daniel, Wayne Guida, Jeffrey A Yoder, Anjali M Rajadhyaksha, Ernst Schönbrunn, Harshani R Lawrence, Nicholas J Lawrence, Pearlie K Epling-Burnette
Upon binding to thalidomide and other immunomodulatory drugs, the E3 ligase substrate receptor cereblon (CRBN) promotes proteosomal destruction by engaging the DDB1-CUL4A-Roc1-RBX1 E3 ubiquitin ligase in human cells but not in mouse cells, suggesting that sequence variations in CRBN may cause its inactivation. Therapeutically, CRBN engagers have the potential for broad applications in cancer and immune therapy by specifically reducing protein expression through targeted ubiquitin-mediated degradation. To examine the effects of defined sequence changes on CRBN's activity, we performed a comprehensive study using complementary theoretical, biophysical, and biological assays aimed at understanding CRBN's nonprimate sequence variations...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29413750/barhl1-is-required-for-the-differentiation-of-inner-ear-hair-cell-like-cells-from-mouse-embryonic-stem-cells
#20
Chao Zhong, Zhenhuang Chen, Xiaocui Luo, Cuicui Wang, Hui Jiang, Jianzhong Shao, Minxin Guan, Liquan Huang, Xiao Huang, Jinfu Wang
Inner ear hair cells are mechanoreceptors responsible for hearing. Pathogenic defects of hair cell-specific genes are one of the major causes of deafness. The BarH class homeobox gene Barhl1 is a deafness gene expressed in developing hair cells, yet the role of Barhl1 during hair cell development remains poorly understood. In the present study, we first established an in vitro differentiation system to efficiently obtain mouse embryonic stem cell (mESC)-derived hair cell-like cells. Subsequently, a mESC line carrying a targeted disruption of Barhl1 was generated using CRISPR/Cas9 technology and subjected to the established in vitro hair cell differentiation protocol...
March 2018: International Journal of Biochemistry & Cell Biology
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