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https://www.readbyqxmd.com/read/28097362/folic-acid-supplementation-for-the-prevention-of-neural-tube-defects-us-preventive-services-task-force-recommendation-statement
#1
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone, Michael Silverstein, Chien-Wen Tseng
Importance: Neural tube defects are among the most common major congenital anomalies in the United States and may lead to a range of disabilities or death. Daily folic acid supplementation in the periconceptional period can prevent neural tube defects. However, most women do not receive the recommended daily intake of folate from diet alone. Objective: To update the 2009 US Preventive Services Task Force (USPSTF) recommendation on folic acid supplementation in women of childbearing age...
January 10, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28067707/dural-puncture-epidural-technique-improves-labor-analgesia-quality-with-fewer-side-effects-compared-with-epidural-and-combined-spinal-epidural-techniques-a-randomized-clinical-trial
#2
Anthony Chau, Carolina Bibbo, Chuan-Chin Huang, Kelly G Elterman, Eric C Cappiello, Julian N Robinson, Lawrence C Tsen
BACKGROUND: The dural puncture epidural (DPE) technique is a modification of the combined spinal epidural (CSE) technique, where a dural perforation is created from a spinal needle but intrathecal medication administration is withheld. The DPE technique has been shown to improve caudal spread of analgesia compared with epidural (EPL) technique without the side effects observed with the CSE technique. We hypothesized that the onset of labor analgesia would follow this order: CSE > DPE > EPL techniques...
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28052869/nlrp3-inflammasome-activation-contributes-to-aldosterone-induced-podocyte-injury
#3
Mi Bai, Ying Chen, Min Zhao, Yue Zhang, John Cijiang He, Songming Huang, Zhanjun Jia, Aihua Zhang
Aldosterone (Aldo) has been shown as an important contributor of podocyte injury. However, the underlying molecular mechanisms are still elusive. Recently, the pathogenic role of NLRP3 inflammasome in mediating renal tubular damage was identified while its role in podocyte injury still needs evidence. Thus the present study was undertaken to investigate the role of NLRP3 inflammasome in Aldo-induced podocyte damage. In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1 and IL-18 expressions in dose- and time-dependent manners, indicating an activation of NLRP3 inflammasome, which was significantly blocked by a mineralocorticoid receptor antagonist Eplerenone (EPL) or an antioxidant NAC...
January 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28052836/functional-recovery-following-an-l-lengthening-local-tendon-flap-for-extensor-pollicis-longus-chronic-ruptures
#4
Luis Lobo-Escolar, Isabel López Moreno, Marta Pérez Montoya, Manel Bosch-Aguilá
PURPOSE: Extensor indicis proprius tendon transfer has been considered the reference standard technique for extensor pollicis longus (EPL) chronic ruptures, but relevant complications have been reported. We describe a new reconstructive technique for chronic EPL ruptures and assess functional recovery after this procedure. METHODS: We observed 31 patients who fulfilled inclusion criteria an average of 6.8 months after treatment. An L-shaped local tendon flap was prepared by making a transverse incision to the middle of the tendon and then longitudinally toward the end of one of the tendon stumps...
January 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28040568/in%C3%A2-vitro-drug-susceptibility-of-two-strains-of-the-wildlife-trypanosome-trypanosoma-copemani-a-comparison-with-trypanosoma-cruzi
#5
Adriana Botero, Sarah Keatley, Christopher Peacock, R C Andrew Thompson
Trypanosomes are blood protozoan parasites that are capable of producing illness in the vertebrate host. Within Australia, several native Trypanosoma species have been described infecting wildlife. However, only Trypanosoma copemani has been associated with pathological lesions in wildlife hosts and more recently has been associated with the drastic decline of the critically endangered woylie (Bettongia penicillata). The impact that some trypanosomes have on the health of the vertebrate host has led to the development of numerous drug compounds that could inhibit the growth or kill the parasite...
December 23, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28039985/on-the-estimation-of-phase-synchronization-spurious-synchronization-and-filtering
#6
Wady A Rios Herrera, Joaquín Escalona, Daniel Rivera López, Markus F Müller
Phase synchronization, viz., the adjustment of instantaneous frequencies of two interacting self-sustained nonlinear oscillators, is frequently used for the detection of a possible interrelationship between empirical data recordings. In this context, the proper estimation of the instantaneous phase from a time series is a crucial aspect. The probability that numerical estimates provide a physically relevant meaning depends sensitively on the shape of its power spectral density. For this purpose, the power spectrum should be narrow banded possessing only one prominent peak [M...
December 2016: Chaos
https://www.readbyqxmd.com/read/28012142/confinement-effect-on-the-dynamics-of-non-equilibrium-concentration-fluctuations-far-from-the-onset-of-convection
#7
Cédric Giraudet, Henri Bataller, Yifei Sun, Aleksandar Donev, José M Ortiz de Zárate, Fabrizio Croccolo
In a recent letter (C. Giraudet et al., EPL 111, 60013 (2015)) we reported preliminary data showing evidence of a slowing-down of non-equilibrium fluctuations of the concentration in thermodiffusion experiments on a binary mixture of miscible fluids. The reason for this slowing-down was attributed to the effect of confinement. Such tentative explanation is here experimentally corroborated by new measurements and theoretically substantiated by studying analytically and numerically the relevant fluctuating hydrodynamics equations...
December 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27997659/serologic-screening-for-genital-herpes-infection-us-preventive-services-task-force-recommendation-statement
#8
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Karina W Davidson, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael P Pignone, Michael Silverstein, Chien-Wen Tseng
Importance: Genital herpes is a prevalent sexually transmitted infection in the United States, occurring in almost 1 in 6 persons aged 14 to 49 years. Infection is caused by 2 subtypes of the herpes simplex virus (HSV), HSV-1 and HSV-2. Antiviral medications may provide symptomatic relief from outbreaks but do not cure HSV infection. Neonatal herpes infection, while uncommon, can result in substantial morbidity and mortality. Objective: To update the 2005 US Preventive Services Task Force (USPSTF) recommendation on screening for genital herpes...
20, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27986329/preemptive-hemodynamic-intervention-restricting-the-administration-of-fluids-attenuates-lung-edema-progression-in-oleic-acid-induced-lung-injury
#9
A Gil Cano, M Gracia Romero, M I Monge García, P Guijo González, J Ruiz Campos
OBJECTIVE: A study is made of the influence of preemptive hemodynamic intervention restricting fluid administration upon the development of oleic acid-induced lung injury. DESIGN: A randomized in vivo study in rabbits was carried out. SETTING: University research laboratory. SUBJECTS: Sixteen anesthetized, mechanically ventilated rabbits. VARIABLES: Hemodynamic measurements obtained by transesophageal Doppler signal...
December 14, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/27975252/tag-free-semi-synthesis-of-the-tau-protein
#10
Oliver Reimann, Caroline Smet-Nocca, Christian P R Hackenberger
Expressed protein ligation (EPL) is a valuable tool to study site-specific functionalities on proteins such as posttranslational modifications. The purification of such ligation products from EPL mixtures can be cumbersome due to a small size difference between the expressed protein portion and the desired ligated protein. Therefore, affinity tags are often required, which remain on the protein after purification. Herein, we present an efficient protocol to install a photocleavable biotin building block on synthetic C-terminal tau[390-441] and describe its use for purification of full-length semi-synthetic tau[1-441]...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27967036/emergent-interparticle-interactions-in-thermal-amorphous-solids
#11
Oleg Gendelman, Edan Lerner, Yoav G Pollack, Itamar Procaccia, Corrado Rainone, Birte Riechers
Amorphous media at finite temperatures, be them liquids, colloids, or glasses, are made of interacting particles that move chaotically due to thermal energy, continuously colliding and scattering off each other. When the average configuration in these systems relaxes only at long times, one can introduce effective interactions that keep the mean positions in mechanical equilibrium. We introduce a framework to determine the effective force laws that define an effective Hessian that can be employed to discuss stability properties and the density of states of the amorphous system...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27927103/mechanism-of-action-of-relaxant-effect-of-agastache-mexicana-ssp-mexicana-essential-oil-in-guinea-pig-trachea-smooth-muscle
#12
Andrés Navarrete, Natalia Ávila-Rosas, Mateo Majín-León, José Luis Balderas-López, Alejandro Alfaro-Romero, José Carlos Tavares-Carvalho
CONTEXT: Agastache mexicana ssp. mexicana (Kunth) Lint & Epling (Lamiaceae), popularly known as 'toronjil morado', is used in Mexican traditional medicine for the treatment of several diseases such as hypertension, anxiety and respiratory disorders. OBJECTIVE: This study investigates the relaxant action mechanism of A. mexicana ssp. mexicana essential oil (AMEO) in guinea-pig isolated trachea model. MATERIALS AND METHOD: AMEO was analyzed by GC/MS...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27902689/using-intrinsic-flavoprotein-and-nad-p-h-imaging-to-map-functional-circuitry-in-the-main-olfactory-bulb
#13
Cedric R Uytingco, Adam C Puche, Steven D Munger
Neurons exhibit strong coupling of electrochemical and metabolic activity. Increases in intrinsic fluorescence from either oxidized flavoproteins or reduced nicotinamide adenine dinucleotide (phosphate) [NAD(P)H] in the mitochondria have been used as an indicator of neuronal activity for the functional mapping of neural circuits. However, this technique has not been used to investigate the flow of olfactory information within the circuitry of the main olfactory bulb (MOB). We found that intrinsic flavoprotein fluorescence signals induced by electrical stimulation of single glomeruli displayed biphasic responses within both the glomerular (GL) and external plexiform layers (EPL) of the MOB...
2016: PloS One
https://www.readbyqxmd.com/read/27864926/synaptic-distribution-of-individually-labeled-mitral-cells-in-the-external-plexiform-layer-of-the-mouse-olfactory-bulb
#14
Takeshi Matsuno, Emi Kiyokage, Kazunori Toida
Mitral cells are the major projection neurons of the olfactory bulb. They receive olfactory inputs, regulate information, and project their axons to the olfactory cortex. To better understand output regulation of mitral cells, we established a method to visualize individual projection neurons and quantitatively examined their synaptic distribution. Individual mitral cells were labeled by viral injection, 3D-reconstructed with light microscopy, and serial-sectioned for electron microscopy. Synaptic distributions were analyzed in electron microscopically reconstructed cell bodies, two regions of secondary dendrites (near the somata and ≈ 200 µm from the somata), and primary dendrites...
November 16, 2016: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/27858522/hpv-vaccine-related-knowledge-beliefs-acceptability-and-uptake-among-latinas-who-prefer-english-and-those-who-prefer-spanish
#15
Kimlin Tam Ashing, Noé Rubén Chávez, Mayra Serrano
Latinas compose almost 10% of the U.S. population and suffer the highest incidence of and one of the highest mortality rates from cervical cancer. Human papillomavirus (HPV) vaccination can prevent most HPV infections that cause more than 90% of cervical cancer. Unfortunately, limited knowledge and low rates of HPV vaccination persist among Latinas. The current study compared awareness, knowledge, beliefs, acceptability, uptake, and 3-dose series completion of HPV vaccination between Latinas who prefer English (EPL) and those who prefer Spanish (SPL), ages 18-62, living in Southern California...
December 2016: Journal of Health Communication
https://www.readbyqxmd.com/read/27855915/enzymatic-modification-of-egg-lecithin-to-improve-properties
#16
Justice Asomaning, Jonathan M Curtis
This research studied the enzymatic modification of egg yolk phospholipids and its effect on physicochemical properties. Egg yolk lipids were extracted with food grade ethanol and egg phospholipids (ePL) produced by deoiling with acetone. Vegetable oils were used to interesterify ePL utilizing Lipozyme®: sn-1,3 specific lipase. The enzymatic interesterification resulted in a single phase liquid product, whereas simple blending of the ePL and vegetable oil resulted in a product with two phases. In addition solid fat content decreased by 50% at -10°C and 94% at 35°C when compared with egg yolk lipids extract...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27835059/epalrestat-an-aldose-reductase-inhibitor-prevents-glucose-induced-toxicity-in-human-retinal-pigment-epithelial-cells-in-vitro
#17
Srinivasan Senthilkumari, Rajendran Sharmila, Gowripriya Chidambaranathan, Ayyasamy Vanniarajan
PURPOSE: Aldose reductase (ALR), the first and rate-limiting enzyme involved in polyol pathway plays a central role in diabetes and its related complications, including diabetic retinopathy (DR). Inhibition of ALR may also be an ideal target for reducing the deleterious effects of DR. Therefore, the purpose of the present study was to investigate the protective effect of epalrestat (EPL), ALR inhibitor on glucose-induced toxicity in ARPE-19 cells. METHODS: ARPE-19 cells were challenged with normal glucose (NG, 5 mM) and high glucose (HG1, 25 mM and HG2, 50 mM) in the presence or absence of EPL...
January 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27824793/extensor-tendon-injury-associated-with-dorsal-entry-flexible-nailing-of-radial-shaft-fractures-in-children-a-report-of-5-new-cases-and-review-of-the-literature
#18
Hamadi A Murphy, Viral V Jain, Shital N Parikh, Eric J Wall, Roger Cornwall, Charles T Mehlman
BACKGROUND: Extensor pollicis longus (EPL) tendon injury following the dorsal approach to elastic stable intramedullary nailing (ESIN) of the radius has been reported in a growing number of cases in the literature. This study includes 5 new cases from our institution as well as a comprehensive review of previously reported cases from the literature. METHODS: We conducted a retrospective chart review of all patients undergoing ESIN between January 1, 2004 and December 31, 2013 at our institution...
November 7, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27807081/post-traumatic-stress-anxiety-and-depression-following-miscarriage-or-ectopic-pregnancy-a-prospective-cohort-study
#19
Jessica Farren, Maria Jalmbrant, Lieveke Ameye, Karen Joash, Nicola Mitchell-Jones, Sophie Tapp, Dirk Timmerman, Tom Bourne
OBJECTIVES: This is a pilot study to investigate the type and severity of emotional distress in women after early pregnancy loss (EPL), compared with a control group with ongoing pregnancies. The secondary aim was to assess whether miscarriage or ectopic pregnancy impacted differently on the type and severity of psychological morbidity. DESIGN: This was a prospective survey study. Consecutive women were recruited between January 2012 and July 2013. We emailed women a link to a survey 1, 3 and 9 months after a diagnosis of EPL, and 1 month after the diagnosis of a viable ongoing pregnancy...
November 2, 2016: BMJ Open
https://www.readbyqxmd.com/read/27796806/correlation-analysis-between-ultrasound-findings-and-abnormal-karyotypes-in-the-embryos-from-early-pregnancy-loss-after-in-vitro-fertilization-embryo-transfer
#20
Xihong Li, Yan Ouyang, Yan Yi, Yueqiu Tan, Guangxiu Lu
PURPOSE: The purpose of the study is to evaluate the correlation between ultrasound findings and abnormal karyotypes in early pregnancy losses (EPLs) after in vitro fertilization-embryo transfer (IVF-ET). METHODS: This retrospective analysis assessed 2172 cases of EPL after IVF-ET occurring between January 2008 and December 2013. The cases were examined via transvaginal ultrasonography (TVS). Embryonic tissue karyotyping following miscarriage was performed using a comparative genomic hybridization (CGH) analysis with fluorescence in situ hybridization (FISH)...
October 28, 2016: Journal of Assisted Reproduction and Genetics
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