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https://www.readbyqxmd.com/read/28091526/a-disrupted-transsulphuration-pathway-results-in-accumulation-of-redox-metabolites-and-induction-of-gametocytogenesis-in-malaria
#1
Divya Beri, Balu Balan, Shweta Chaubey, Suraj Subramaniam, Bachu Surendra, Utpal Tatu
Intra-erythrocytic growth of malaria parasite is known to induce redox stress. In addition to haem degradation which generates reactive oxygen species (ROS), the parasite is also thought to efflux redox active homocysteine. To understand the basis underlying accumulation of homocysteine, we have examined the transsulphuration (TS) pathway in the parasite, which is known to convert homocysteine to cysteine in higher eukaryotes. Our bioinformatic analysis revealed absence of key enzymes in the biosynthesis of cysteine namely cystathionine-β-synthase and cystathionine-γ-lyase in the parasite...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28090804/choline-acetyltransferase-may-contribute-to-the-risk-of-tourette-syndrome-combination-of-family-based-analysis-and-case-control-study
#2
Xiuling Yang, Wenmiao Liu, Mingji Yi, Ru Zhang, Yinglei Xu, Zuzhou Huang, Shiguo Liu, Tang Li
OBJECTIVES: Twin and family analyses have revealed a genetic contribution to Tourette syndrome and postmortem studies have raised the intriguing possibility of a reduction in cholinergic interneuronsin TS patients. METHODS: We selected five tag SNPs (rs100824791, rs12264845, rs1880676, rs3793790 and rs3793798) of Choline Acetyltransferase (CHAT) from the Han Chinese population Hapmap database. Genotyping was conducted on 401 TS nuclear family trios and 405 control subjects...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28089402/aerobic-composting-of-digested-residue-eluted-from-dry-methane-fermentation-to-develop-a-zero-emission-process
#3
Yu-Lian Huang, Zhao-Yong Sun, Xiao-Zhong Zhong, Ting-Ting Wang, Li Tan, Yue-Qin Tang, Kenji Kida
Digested residue remained at the end of a process for the production of fuel ethanol and methane from kitchen garbage. To develop a zero-emission process, the compostability of the digested residue was assessed to obtain an added-value fertilizer. Composting of the digested residue by adding matured compost and a bulking agent was performed using a lab-scale composting reactor. The composting process showed that volatile total solid (VTS) degradation mainly occurred during the first 13days, and the highest VTS degradation efficiency was about 27% at the end...
January 12, 2017: Waste Management
https://www.readbyqxmd.com/read/28087122/human-trophoblast-stem-cells-real-or-not-real
#4
Ching-Wen Chang, Mana M Parast
Abnormal trophoblast differentiation is the root cause of many placenta-based pregnancy complications, including preeclampsia and fetal growth restriction. Human trophoblast differentiation is difficult to study due to the lack of a stem cell model. Such a multipotent "trophoblast stem" (TS) cell, with the ability to differentiate into all trophoblast subtypes, has been derived from mouse blastocysts, but attempts to derive similar human cells have failed. We consider here several possibilities for the TS cell niche in the human placenta...
January 5, 2017: Placenta
https://www.readbyqxmd.com/read/28080924/selected-plasma-biochemistry-analytes-of-healthy-captive-sulcata-african-spurred-tortoises-centrochelys-sulcata
#5
David Eshar, Ady Y Gancz, Nili Avni-Magen, Effi Wagshal, Lisa M Pohlman, Mark A Mitchell
The sulcata or African spurred tortoise (Centrochelys sulcata) is a large tortoise species that is commonly kept in zoologic collections and as a pet. The objectives of this study were to establish reference intervals for selected biochemical analytes in clinically healthy captive sulcata tortoises and to evaluate the impact of blood sampling site and sex. Blood samples were collected from 60 tortoises from either the dorsal coccygeal (tail) vein or the subcarapacial venous plexus based on their body size. The packed cell volume and refractometric total solids (TS) were determined...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079350/transcranial-approach-in-giant-pituitary-adenomas-results-and-outcome-in-a-modern-series
#6
Thomas Graillon, Frédéric Castinetti, Stéphane Fuentes, Regis Gras, Thierry Brue, Henry Dufour
BACKGROUND: Today, transcranial (TC) approach indications are particularly rare in pituitary adenomas (PA), representing 1.1% of all PA surgeries in our experience. In these rare and selected cases, the complications, advantages, and disadvantages of TC approach were also analyzed. METHODS: 19 cases of giant PA (≥40 mm) operated via TC approach alone or combined with transsphenoidal (TS) approach between 2000 and 2016 were selected. RESULTS: The most frequently observed symptom was visual disturbance...
January 12, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28074308/influence-of-ts-and-abcb1%C3%A2-gene-polymorphisms-on-survival-outcomes-of-5%C3%A2-fu-based-chemotherapy-in-a%C3%A2-chinese-population-of-advanced-gastric-cancer-patients
#7
Jun Chen, Xueming Ying, Ling Zhang, Xiaojun Xiang, Jianping Xiong
To investigate the impacts of gene variations on survival outcomes of advanced gastric cancer (AGC) patients treated with 5‑fluorouracil (5-FU)-based chemotherapy, we analyzed the associations of 2 indels of the TS gene rs34743033 (double or triple tandem repeats of a 28 bp sequence in 5'-UTR, denoted as 2R or 3R allele) and rs16430 (a 6 bp variation at 1494 bp in 3'-UTR, denoted as ins6 or del6 allele) and 2 single nucleotide polymorphisms (SNPs) of ABCB1gene rs2032582 in exon 21 and rs1045642 in exon 26, with clinical outcomes after 5‑FU treatment...
January 10, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28074022/making-home-sweet-and-sturdy-toxoplasma-gondii-ppgalnac-ts-glycosylate-in-hierarchical-order-and-confer-cyst-wall-rigidity
#8
Tadakimi Tomita, Tatsuki Sugi, Rama Yakubu, Vincent Tu, Yanfen Ma, Louis M Weiss
: The protozoan intracellular parasite Toxoplasma gondii forms latent cysts in the central nervous system (CNS) and persists for the lifetime of the host. This cyst is cloaked with a glycosylated structure called the cyst wall. Previously, we demonstrated that a mucin-like glycoprotein, CST1, localizes to the cyst wall and confers structural rigidity on brain cysts in a mucin-like domain-dependent manner. The mucin-like domain of CST1 is composed of 20 units of threonine-rich tandem repeats that are O-GalNAc glycosylated...
January 10, 2017: MBio
https://www.readbyqxmd.com/read/28073659/serotonin-norepinephrine-re-uptake-inhibitor-snri-selective-norepinephrine-reuptake-inhibitor-s-nri-and-exogenously-administered-norepinephrine-induced-takotsubo-syndrome-analysis-of-published-cases
#9
Shams Y-Hassan
BACKGROUND: Takotsubo syndrome (TS) may be triggered by numerous physical stress factors including exogenous Norepinephrine administration. The aim of this study is to report on the clinical features and outcome of serotonin-norepinephrine reuptake inhibitor (SNRI)-, selective NRI (S-NRI)-, and exogenously administered norepinephrine-induced TS in a largest possible cohort of published cases. METHODS: A computer assisted search of the electronic data base Pubmed was performed from 1990 to August 2016...
December 30, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28070288/getting-to-the-core-internal-body-temperatures-help-reveal-the-ecological-function-and-thermal-implications-of-the-lions-mane
#10
Paul Trethowan, Andrea Fuller, Anna Haw, Tom Hart, Andrew Markham, Andrew Loveridge, Robyn Hetem, Byron du Preez, David W Macdonald
It has been proposed that there is a thermal cost of the mane to male lions, potentially leading to increased body surface temperatures (Ts), increased sperm abnormalities, and to lower food intake during hot summer months. To test whether a mane imposes thermal costs on males, we measured core body temperature (Tb) continuously for approximately 1 year in 18 free-living lions. There was no difference in the 24-hr maximum Tb of males (n = 12) and females (n = 6), and males had a 24-hr mean Tb that was 0...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28069101/immune-responses-in-mice-vaccinated-with-a-dna-vaccine-expressing-serine-protease-like-protein-from-the-new-born-larval-stage-of-trichinella-spiralis
#11
Jing Xu, Xue Bai, Li Bo Wang, Hai Ning Shi, Joke W B VAN DER Giessen, Pascal Boireau, Ming Yuan Liu, Xiao Lei Liu
Trichinella spiralis is a parasitic helminth that can infect almost all mammals, including humans. Trichinella spiralis infection elicits a typical type 2 immune responses, while suppresses type 1 immune responses, which is in favour of their parasitism. DNA vaccines have been shown to be capable of eliciting balanced CD4+ and CD8+ T cell responses as well as humoral immune responses in small-animal models, which will be advantage to induce protective immune response against helminth infection. In this study, serine protease (Ts-NBLsp) was encoded by a cDNA fragment of new-born T...
January 10, 2017: Parasitology
https://www.readbyqxmd.com/read/28067847/the-impact-of-growth-hormone-therapy-on-the-apoptosis-assessment-in-cd34-hematopoietic-cells-from-children-with-growth-hormone-deficiency
#12
Miłosz Piotr Kawa, Iwona Stecewicz, Katarzyna Piecyk, Edyta Paczkowska, Dorota Rogińska, Anna Sobuś, Karolina Łuczkowska, Ewa Pius-Sadowska, Elżbieta Gawrych, Elżbieta Petriczko, Mieczysław Walczak, Bogusław Machaliński
Growth hormone (GH) modulates hematopoietic cell homeostasis and is associated with apoptosis control, but with limited mechanistic insights. Aim of the study was to determine whether GH therapeutic supplementation (GH-TS) could affect apoptosis of CD34+ cells enriched in hematopoietic progenitor cells of GH deficient (GHD) children. CD34+ cells from peripheral blood of 40 GHD children were collected before and in 3rd and 6th month of GH-TS and compared to 60 controls adjusted for bone age, sex, and pubertal development...
January 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28066668/noninvasive-computed-tomography-guided-marking-technique-for-peripheral-pulmonary-nodules
#13
Mingyon Mun, Yosuke Matsuura, Masayuki Nakao, Junji Ichinose, Ken Nakagawa, Sakae Okumura
BACKGROUND: Identification of the exact location of small peripheral pulmonary nodules during thoracoscopic wedge resection (TWR) is crucial. We describe a new method of computed tomography (CT)-guided marking without puncturing the visceral pleura (VP) for minimally palpable pulmonary nodules. METHODS: Preoperative CT scans were performed 1 day before TWR with the patient in the lateral decubitus position. Under CT guidance, we marked the skin over the pulmonary nodule...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065312/using-fast-acting-temperature-sensitive-mutants-to-study-cell-division-in-caenorhabditis-elegans
#14
T Davies, S Sundaramoorthy, S N Jordan, M Shirasu-Hiza, J Dumont, J C Canman
Fast-acting temperature-sensitive (ts) mutations are powerful conditional tools for studying transient cellular processes such as cytokinesis. Fast-acting ts cytokinesis-defective mutants are functional at the permissive temperature; yet show a fully penetrant loss-of-function cytokinesis failure phenotype when upshifted to the restrictive temperature. Fast-acting ts mutations thus allow functional tunability and rapid and reversible protein inactivation by simply shifting the temperature at precise times throughout cell division...
2017: Methods in Cell Biology
https://www.readbyqxmd.com/read/28064482/temperature-tuned-faceting-and-shape-changes-in-liquid-alkane-droplets
#15
Shani Guttman, Zvi Sapir, Benjamin M Ocko, Moshe Deutsch, Eli Sloutskin
Recent extensive studies reveal that surfactant-stabilized spherical alkane emulsion droplets spontaneously adopt polyhedral shapes upon cooling below a temperature Td, while still remaining liquid. Further cooling induces growth of tails and spontaneous droplet splitting. Two mechanisms were offered to account for these intriguing effects. One assigns the effects to the formation of an intra-droplet frame of tubules, consisting of crystalline rotator phases with cylindrically curved lattice planes. The second assigns the sphere-to-polyhedron transition to the buckling of defects in a crystalline interfacial monolayer, known to form in these systems at some Ts > Td...
January 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28064189/persistency-of-prediction-accuracy-and-genetic-gain-in-synthetic-populations-under-recurrent-genomic-selection
#16
Dominik Müller, Pascal Schopp, Albrecht E Melchinger
Recurrent selection (RS) has been used in plant breeding to successively improve synthetic and other multiparental populations. Synthetics are generated from a limited number of parents (Np), but little is known about how Np affects genomic selection (GS) in RS, especially the persistency of prediction accuracy and genetic gain. Synthetics were simulated by intermating Np= 2 to 32 parent lines from an ancestral population with short- or long-range linkage disequilibrium (LDA) and subjected to multiple cycles of GS...
January 6, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28064091/dose-response-characteristics-of-clematis-triterpenoid-saponins-and-clematichinenoside-ar-in-rheumatoid-arthritis-rats-by-liquid-chromatography-mass-spectrometry-based-serum-and-urine-metabolomics
#17
Rui Li, Lin-Xiu Guo, Yi Li, Wen-Qi Chang, Jian-Qun Liu, Li-Fang Liu, Gui-Zhong Xin
Clematidis Radix et Rhizoma is a traditional Chinese medicine widely used for treating arthritic disease. Clematis triterpenoid saponins (TS) and clematichinenoside AR (C-AR) have been considered to be responsible for its antiarthritic effects. However, the underling mechanism is still unclear because of their low bioavailability. To address of this issue, metabolomics tools were performed to determine metabolic variations associated with rheumatoid arthritis (RA) and responses to Clematis TS, C-AR and positive drug (Triptolide, TP) treatments...
December 29, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28060315/high-throughput-robotically-assisted-isolation-of-temperature-sensitive-lethal-mutants-in-chlamydomonas-reinhardtii
#18
Michal Breker, Kristi Lieberman, Frej Tulin, Frederick R Cross
Systematic identification and characterization of genetic perturbations have proven useful to decipher gene function and cellular pathways. However, the conventional approaches of permanent gene deletion cannot be applied to essential genes. We have pioneered a unique collection of ~70 temperature-sensitive (ts) lethal mutants for studying cell cycle regulation in the unicellular green algae Chlamydomonas reinhardtii(1). These mutations identify essential genes, and the ts alleles can be conditionally inactivated by temperature shift, providing valuable tools to identify and analyze essential functions...
December 5, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28058472/partial-splenectomy-is-superior-to-total-splenectomy-for-selected-patients-with-hemangiomas-or-cysts
#19
Lei Wang, Jianwei Xu, Feng Li, Hanxiang Zhan, Han Liu, Wei Chen, Sanyuan Hu
BACKGROUND: The superiority of partial splenectomy (PS) as a treatment for benign tumors has not well been confirmed. This study aimed to identify the short- and long-term outcomes of PS, to compare laparoscopic and laparotomic PS, and to demonstrate whether the effects of PS are superior to that of total splenectomy (TS). METHODS: Patients with either a hemangioma or cyst who underwent PS or TS from 2009 to 2015 at Qilu Hospital of Shandong University were included...
January 5, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28058451/application-of-thermospray-flame-furnace-atomic-absorption-spectrometry-for-investigation-of-silver-nanoparticles
#20
Natnicha Sirirat, Kornrawee Tetbuntad, Atitaya Siripinyanond
Thermospray flame furnace atomic absorption spectrometry (TS-FF-AAS) was applied to investigate the time-dependent absorption peak profile of various forms of silver. The thermospray flame furnace was set up with a 10-cm-long nickel tube with six holes, each 2.0 mm in diameter, to allow the flame to enter, and this nickel tube acted as a furnace. A sample of 300 μL was introduced into this furnace by use of water as a carrier at a flow rate of 0.5 mL min(-1) through the ceramic capillary (0.5-mm inner diameter and 2...
January 5, 2017: Analytical and Bioanalytical Chemistry
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