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Wanpei Lu, Xiaomeng Bian, Weiru Yang, Tangren Cheng, Jia Wang, Qixiang Zhang, Huitang Pan
Heteromorphic self-incompatibility (SI) is an important system for preventing inbreeding in the genus Primula . However, investigations into the molecular mechanisms of Primula SI are lacking. To explore the mechanisms of SI in Primula maximowiczii , the pollen germination and fruiting rates of self- and cross-pollinations between pin and thrum morphs were investigated, and transcriptomics analyses of the pistils after pollination were performed to assess gene expression patterns in pin and thrum SI. The results indicated that P...
June 22, 2018: International Journal of Molecular Sciences
Xialin Yan, Jishun Lu, Xia Zou, Sen Zhang, Yalu Cui, Leqi Zhou, Feng Liu, Aidong Shan, Jiaoyang Lu, Minghua Zheng, Bo Feng, Yan Zhang
The aberrant expression of mucin-type O-glycosylation plays important roles in the cancer malignancy. Polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) are a family of conserved enzymes that initiate the mucin-type O-glycosylation in cells. In human, consistent up- or down-regulation of ppGalNAc-Ts expression during the cancer development has been frequently reported. Here, we provide evidence that ppGalNAc-T4 shows a stage-dependent expression at the different stages of colorectal cancer (CRC) in the 62 pair-matched tumor/normal tissues...
June 22, 2018: FEBS Journal
Jiwook Ryu, Sung Ho Lee, Seok Keun Choi, Young Jin Lim
PURPOSE: This study evaluated the long-term tumor control rate (TCR) and symptomatic outcomes of patients treated with gamma knife radiosurgery (GKRS) for trigeminal schwannomas (TSs). METHODS: Thirty-two patients with TS who underwent GKRS between January 1994 and January 2013 with at least 2 years of follow-up were enrolled in the study. Clinical charts and surgical records were retrospectively reviewed to evaluate factors affecting TCR and symptomatic outcomes...
June 21, 2018: Journal of Neuro-oncology
Shiqi Yang, Yongsheng Wang, Ruliang Liu, Lei Xing, Zhengli Yang
Field experiments were conducted in rice-wheat rotation under conventional management to determine the effects of straw return ((half straw return, HS) and (total straw return, TS)) on crop yield, N uptake, soil properties and soil NO3 - -N leaching. We found that straw return significantly increased crop yield and N uptake. TS significantly increased soil SOM at depths of 20 cm and 30 cm. Straw return had significantly increased soil NO3 - -N leaching at a depth of 10 cm, whereas significantly decreased soil NO3 - -N leaching at depths of 30 cm and 90 cm in the rice season...
June 21, 2018: Scientific Reports
Vicente Pastor-Poquet, Stefano Papirio, Jean-Philippe Steyer, Eric Trably, Renaud Escudié, Giovanni Esposito
During high-solids anaerobic digestion (HS-AD) of the organic fraction of municipal solid waste (OFMSW), an important total solid (TS) removal occurs, leading to the modification of the reactor content mass/volume, in contrast to 'wet' anaerobic digestion (AD). Therefore, HS-AD mathematical simulations need to be approached differently than 'wet' AD simulations. This study aimed to develop a modelling tool based on the anaerobic digestion model 1 (ADM1) capable of simulating the TS and the reactor mass/volume dynamics in HS-AD of OFMSW...
June 14, 2018: Water Research
Krutika Joshi, Lily Shen, Feng Cao, Susan Dong, Zhengping Jia, Miguel A Cortez, O Carter Snead
OBJECTIVE: Infantile spasms (IS) is a catastrophic childhood seizure disorder that is characterized by extensor and/or flexor spasms, cognitive deterioration and a characteristic EEG abnormality. The latter consists of a pattern of a spike-wave followed by an electrodecremental response (EDR), which is a flattening of the EEG waveform amplitude. The mechanism/circuitry that underpins IS is unknown. Children with Down Syndrome (DS) are particularly vulnerable to IS. The standard mouse model of DS is the Ts65Dn mutant mouse (Ts)...
June 12, 2018: Epilepsy Research
Erika Durinikova, Jana Plava, Silvia Tyciakova, Pavel Skvara, Andrea Vojs Stanova, Zuzana Kozovska, Lucia Kucerova, Miroslava Matuskova
Gene-directed enzyme/prodrug therapy (GDEPT) mediated by mesenchymal stromal cells (MSC) was already approved for clinical study on a progressive disease refractory to standard therapy. In this work, we examined the effect of several GDEPT approaches on chemoresistant cells. First, we derived 5-fluorouracil (5-FU)-resistant variant of human colorectal adenocarcinoma cells HT-29 designated HT-29/EGFP/FUR. Our data show that the upregulation of thymidylate synthase (TS) and downregulation of thymidine phosphorylase (TP), orotate phosphoribosyl transferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) contributed to the 5-FU resistance in cancer cells...
June 21, 2018: Cancer Gene Therapy
Nathalia Albrecht, Tatiana Kelly DA Silva Fidalgo, Maria José Santos DE Alencar, Lucianne Cople Maia, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek, Kátia Rodrigues Reis
Two soft denture lining materials (SC-Soft Confort and TS-Trusoft) were investigated with and without the addition of 1.0% of chlorhexidine diacetate (1.0% CHX). To assess peel bond strength, specimens (75×10×6 mm) were submitted to a peel test at 10 mm/min immediately and after 24 h. To evaluate Candida albicans growth inhibition, disc of specimens (10×3 mm) were immersed in a solution with 3×106 CFU/mL of C. albicans, and spectral measurements were made following immersion in MTT solution for 2, 4, and 6 days...
June 20, 2018: Dental Materials Journal
Catherina Gasser, Jennifer Gebetsberger, Manuel Gebetsberger, Ronald Micura
Self-cleaving ribozymes are biologically relevant RNA molecules which catalyze site-specific cleavage of the phosphodiester backbone. Gathering knowledge of their three-dimensional structures is critical toward an in-depth understanding of their function and chemical mechanism. Equally important is collecting information on the folding process and the inherent dynamics of a ribozyme fold. Over the past years, Selective-2'-Hydroxyl Acylation analyzed by Primer Extension (SHAPE) turned out to be a significant tool to probe secondary and tertiary interactions of diverse RNA species at the single nucleotide level under varying environmental conditions...
June 19, 2018: Nucleic Acids Research
Hong Yan, Furong Wang, Lin Xiang, Wei Zhu, Cheng Liang
RATIONALE: Diffuse giant cell tumors of the tendon sheath (GCT-TS) in the temporomandibular joint (TMJ) are extremely rare. PATIENT CONCERNS: We reported the imaging appearance and the pathological findings of 2 male cases with diffuse GCT-TS in the TMJ (52 years for the case 1 and 50 years for the case 2) who complain of the hearing disorders of left ear when presenting to our hospital. DIAGNOSIS: Preoperative computerized tomography (CT) scan revealed an irregular mass in the left temporal fossa with the sizes of approximately 5...
June 2018: Medicine (Baltimore)
Roberta Fernanda da Silva, Riccardo Lacchini, Lucas Cezar Pinheiro, Thiago José Dionísio, AndréMourão Jacomini, José Eduardo Tanus-Santos, Sandra Lia Amaral, Carlos Ferreira Santos, Anderson Saranz Zago
OBJECTIVE: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. METHODS: A total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms...
April 2018: Journal of the Renin-angiotensin-aldosterone System: JRAAS
Sherise D Ferguson, Siyuan Zheng, Joanne Xiu, Shouhao Zhou, Mustafa Khasraw, Priscilla K Brastianos, Santosh Kesari, Jethro Hu, Jeremy Rudnick, Michael E Salacz, David Piccioni, Suyun Huang, Michael A Davies, Isabella C Glitza, John V Heymach, Jianjun Zhang, Nuhad K Ibrahim, John F DeGroot, Joseph McCarty, Barbara J O'Brien, Raymond Sawaya, Roeland G W Verhaak, Sandeep K Reddy, Waldemar Priebe, Zoran Gatalica, David Spetzler, Amy B Heimberger
We sought to compare the tumor profiles of brain metastases from common cancers with those of primary tumors and extracranial metastases in order to identify potential targets and prioritize rational treatment strategies. Tumor samples were collected from both the primary and metastatic sites of non-small cell lung cancer, breast cancer, and melanoma from patients in locations worldwide, and these were submitted to Caris Life Sciences for tumor multiplatform analysis, including gene sequencing (Sanger and next-generation sequencing with a targeted 47-gene panel), protein expression (assayed by immunohistochemistry), and gene amplification (assayed by in situ hybridization)...
June 19, 2018: International Journal of Cancer. Journal International du Cancer
Alonso A Lopez-Zavala, Eduardo Guevara-Hernandez, Luz H Vazquez-Lujan, Arturo Sanchez-Paz, Karina D Garcia-Orozco, Carmen A Contreras-Vergara, Gamaliel Lopez-Leal, Aldo A Arvizu-Flores, Adrian Ochoa-Leyva, Rogerio R Sotelo-Mundo
Thymidylate synthase (TS, E.C. is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA , which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP) using the cofactor 5,10-methylenetetrahydrofolate (mTHF) as a carbon donor. We identified the thyA gene in the genome of the Vibrio parahaemolyticus strain FIM-S1708+ that is innocuous to humans but pathogenic to crustaceans. Surprisingly, we found changes in the residues that bind the substrate dUMP and mTHF, previously postulated as invariant among all TSs known (Finer-Moore, Santi & Stroud, 2003)...
2018: PeerJ
Srikanth R Boddu, Pierre Gobin, Cristiano Oliveria, Marc Dinkin, Athos Patsalides
Purpose: To evaluate the alteration of pressure characteristics in the cerebral venous sinuses before and after venous sinus stenting (VSS) using mean sinus pressures (MSPs), sinus pressure gradient (SPG), and sinus pressure pulsatility (SPP) parameters among the idiopathic intracranial hypertension (IIH) patients. Materials and Methods: Prospective evaluation of 45 consecutive IIH patients who underwent VSS at our institution. A written informed consent approved by the Weill Cornell Institutional Review Board was signed by the study participants...
June 2018: Journal of Vascular and Interventional Neurology
Rongbo Han, Jingsun Wei, Honghong Zhang, Xinyu Su, Xia Chu, Yuetong Chen, Yang Gong, Xiujuan Wang, Junfeng Shi, Jinfei Chen
Background: This study aimed to explore the clinical correlation of single-nucleotide polymorphisms of thymidylate synthase (TS) and runt-related transcription factor 1 (RUNX1) in patients with postoperative stage II and III gastric cancer (GC). Patients and methods: Samples were obtained from 661 patients with postoperative stage II and III GC. TS (rs34743033) and RUNX1 (rs2014300) were genotyped in 261 patients who received postoperative basic platinum and fluorouracil chemotherapy regimens and 400 patients who did not accept chemotherapy...
2018: Cancer Management and Research
Hélio Sampaio-Filho, Sandra Kalil Bussadori, Marcela Leticia Leal Gonçalves, Daniela de Fátima Teixeira da Silva, Maria Cristina Borsatto, Isabel Peixoto Tortamano, Priscila Larcher Longo, Christiane Pavani, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Anna Carolina Ratto Tempestini Horliana
OBJECTIVE: Evaluate the effectiveness of LLL (Low level laser therapy) in auriculotherapy points for pain reduction following lower third molar extractions. STUDY DESIGN: Randomized, controlled, single-blinded study. METHODS: Eighty-four bilateral, symmetrical third molar surgeries were performed in 42 healthy patients using a split-mouth design. In the immediate postoperative period, each side was randomly treated in a single-blind method with an LLL at the auriculotherapy points or simulation of its use (contralateral side) over a 21-day interval...
2018: PloS One
Jianlin Luo, Yonglu Meng, Lingling Zheng, Kangkang Xu, Can Li
Chinese giant salamander (CGS) has high medicinal value and long history of clinical use in ancient China. In this study, CGS skin (CGSS) collagen was extracted and purified to prepare collagen sponge by freeze-drying. TEMPO oxidized microfibrillated cellulose (TEMPO-MFC) and genipin were adopted to improve the mechanical properties of collagen sponge. The hygroscopicity, porosity, mechanical properties, hemostatic performance, morphology, and biodegradability of the resultant sponges were investigated in detail...
June 19, 2018: Journal of Biomaterials Science. Polymer Edition
M B Al-Zghoul
This study investigated the effects of thermal manipulation (TM) during embryonic days 12 to 18 on the cloacal temperature (Tc) and the kinetics of muscle mRNA levels of heat shock proteins 70 and 60 (Hsp70 and Hsp60) and heat shock factors 3 and 4 (HSF3 and HSF4) during the first week of life and during thermal stress (TS). One thousand five hundred fertile chicken eggs were randomly divided into 5 groups: control group (37.8°C), TM1 (38.5°C for 18 h), TM2 (39°C for 18 h), TM3 (39.5°C for 18 h), and TM4 (40°C for 18 h)...
June 15, 2018: Poultry Science
Mohsin Hamid, Bilal Lashari, Irfan Ahsan, Ida Micaily, Usman Sarwar, Joseph Crocetti
Methotrexate (MTX) is a chemotherapeutic synthetic(s) phase cell cycle inhibitor, and its role has evolved as an immunological agent in autoimmune diseases like rheumatoid arthritis, psoriasis, and systemic lupus erythematosus, etc. Trimethoprim-sulfamethoxazole (TS) is one of the most widely prescribed antibiotics commonly used for urinary tract infections, exacerbations of chronic bronchitis, traveler's diarrhea, and pneumocystis pneumonia. Both MTX and TS can have significantly overlapping side effects involving dermatologic, renal, and hematological systems, and the combination of these can be deadly...
2018: Journal of Community Hospital Internal Medicine Perspectives
Aneta Monika Gawlik, Elzbieta Berdej-Szczot, Dorota Blat, Renata Klekotka, Tomasz Gawlik, Ewa Blaszczyk, Magdalena Hankus, Ewa Malecka-Tendera
Objective: The risk of autoimmune diseases (AD) in patients with Turner Syndrome (TS) is twice higher than in the general female population and four times higher than in the male population. The causes of the increased incidence of AD in TS are still under discussion. We hypothesized the presence of a specific humoral, cellular, and regulatory T cell (Treg) immunity profile which predisposes to AD, disorders of immunity, and disorders of immune regulation. Methods: The study encompassed 37 girls with TS and with no signs of infection...
2018: Frontiers in Endocrinology
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