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Lipid abnormalities in chronic renal failure

Abdulmoein E Al-Agha, Abrar M Alnawab, Tala M Hejazi
To determine the various etiologies of primary and secondary hyperlipidemia among children visiting the pediatric endocrine clinic. Methods: This is a retrospective, cross-sectional, cohort study conducted at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from January 2010 to 2015 that included 253 children aged from birth to 12 years old. Data were obtained by reviewing medical reports of patients who presented with hyperlipidemia to the clinic, and their laboratory investigation results using KAUH electronic "Phoenix" system...
November 2016: Saudi Medical Journal
Hari Kg Venkata, K Indira Devi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Hari Krishna Gandapalli Venkata, K Indira Devi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Hamid Nomani, Lida Hagh-Nazari, Ali Aidy, Asad Vaisi-Raygani, Amir Kiani, Zohreh Rahimi, Fariborz Bahrehmand, Ebrahim Shakiba, Hamid Reza Mozaffari, Heidar Tavilani, Tayebeh Pourmotabbed
INTRODUCTION: There are some evidences indicating DNA damage by oxidant and mutant agents has an essential role in the chronic renal failure and end stage renal disease (ESRD). To investigate the possible association of GSTs variants with ESRD, we investigated the frequency of GST- T1, M1, and P1 genotypes, and the level of malondialdehyde (MDA) in patients with ESRD. MATERIALS AND METHODS: The present case-control study consisted of 136 ESRD patients treated with maintenance hemodialysis and 137 gender- and age-matched, unrelated healthy controls from the population of west of Iran...
October 2016: Renal Failure
Christopher Babua, Robert Kalyesubula, Emmy Okello, Barbara Kakande, Elias Sebatta, Michael Mungoma, Charles Kiiza Mondo
INTRODUCTION: Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which is the primary cause of morbidity and mortality in patients with CKD. Local data about cardiovascular risk factors among CKD patients is generally scanty. OBJECTIVE: To determine the prevalence of the common cardiovascular risk factors among patients with CKD attending the nephrology out-patient clinic in Mulago national referral hospital in Uganda. METHODS: This was a cross-sectional study in which 217 patients with a mean age of 43 years were recruited over a period of nine months...
July 2015: Cardiovascular Journal of Africa
Mirosław Jędras, Magdalena Dylewska
Dyslipidemia is a risk factor of cardiovascular diseases and progression of chronic renal failure. Hypertriglyceridemia is the most common lipid abnormality among patients with chronic kidney disease, cholesterol levels may be high, normal or low. High triglycerides and cholesterol are observed in nephrotic syndrome, whereas cholesterol levels may be low in inflammation and malnutrition. Treatment of dyslipidemia includes modification of lifestyle, treatment of diabetes, hypertension, nephrotic syndrome, and therapy with statins in majority of patients over 50 years of age, with GFR < 60 ml/min, regardless of other risk factors of atherosclerosis...
2014: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Vishwam Pandya, Akhilesh Rao, Kunal Chaudhary
Patients with kidney diseases continue to experience significant cardiovascular disease (CVD) morbidity and mortality. Although there are many important risk factors playing a role in the pathogenesis of CVD in chronic kidney disease (CKD) patients, dyslipidemia (elevated triglycerides, elevated oxidized low-density lipoprotein and low/dysfunctional low high-density) represents one of the modifiable risk factors. Renal failure patients have unique lipid abnormalities which not only have complex role in pathogenesis of CVD but also cause relative resistance to usual interventions...
February 6, 2015: World Journal of Nephrology
Hong-Bo Ma, Rong Wang, Ke-Zhou Yu, Che Yu
The aim of the present study was to clarify the association between lipid metabolism and the atherosclerosis in early-stage chronic renal failure at the molecular level and to explore the efficacy of decorin on chronic renal failure. Sprague Dawley rats receiving 5/6 nephrectomy and Sham surgery were divided into control and experimental groups. Sprague Dawley rats receiving 5/6 nephrectomy were divided into control and experimental groups, and the experimental group was further subdivided into rats receiving treatment with fibroblasts (FBs) transfected either with empty vector and with a decorin (DCN) gene...
February 2015: Experimental and Therapeutic Medicine
Yen-Chun Chen, Chia Chiou, Ming-Nan Lin, Chin-Lon Lin
INTRODUCTION: Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about GSD prevalence and risk factors among Taiwanese vegetarians. METHODS: This study included 1721 vegetarians who completed a questionnaire detailing their demographics, medical history, and life-styles. GSD was ascertained by ultrasonography or surgical history of cholecystectomy for GSD...
2014: PloS One
Leonardo Cacciagiú, Ana I González, Alicia Elbert, Guillermo De'Marziani, Tetsuo Machida, Masami Murakami, Graciela I López, Regina Wikinski, Katsuyuki Nakajima, Laura Schreier
BACKGROUND: Type 2 diabetes (T2DM) and chronic renal disease constitute important risk factors of atherosclerotic cardiovascular disease, associated with lipid abnormalities, and proinflammatory states. Advances in renal replacement therapy such as hemodialysis (HD) have not reduced morbi-mortality. It has not been elucidated if the concomitant presence of T2DM or metabolic syndrome with end-stage renal disease further impairs the atherogenic profiles. METHODS: We studied 122 HD patients, among which 44 presented with T2DM (HD-T2DM) and 30 with metabolic syndrome (HD-MS); 48 had neither T2DM nor metabolic syndrome (HD-C)...
May 2014: Metabolic Syndrome and related Disorders
Dengke Yin, Juanjuan Yin, Ye Yang, Song Chen, Xiangdong Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Danshen Injection, the aqueous extracts of Radix Salvia miltiorrhiza (S. miltiorrhiza), is one of the most commonly used traditional Chinese herbs in chronic renal failure treatment. In present study, the mechanism of the renoprotective effect of Danshen Injection was analyzed on streptozocin (STZ)-induced diabetic rats. MATERIALS AND METHODS: Diabetic experimental model was established in male Sprague-Dawley (SD) rats by intraperitoneal injection of STZ...
2014: Journal of Ethnopharmacology
Hayriye Sayarlioglu, Gurkan Acar, Murat Sahin, Orcun Altunoren, Yasemin Coskun Yavuz, Alper Bugra Nacar, Ekrem Dogan
INTRODUCTION: Valvular abnormalities frequently occur in patients with chronic kidney failure. This study evaluated the prevalence of heart valve calcification (HVC) in hemodialysis patients and factors associated with it. MATERIALS AND METHODS: Medical charts of 129 hemodialysis patients were reviewed retrospectively. Demographic features and laboratory analysis of the patients were systematically recorded. Echocardiographic findings were collected, including ejection fraction, aortic valve calcification (AVC), mitral valve calcification (MVC), left ventricle mass, left ventricle mass index, and pulmonary artery pressure...
March 2013: Iranian Journal of Kidney Diseases
Tateki Yoshino, Hiroyuki Moriyama
Xanthogranulomatous pyelonephritis (XGP) is a rare entity and constitutes less than 1% of chronic pyelonephritis. A 71-year-old male was introduced to our department with general malaise and abnormal findings of computed tomography (CT). Abnormal findings of complete blood count and laboratory examination included an elevated WBC count and C-reactive protein. Urinalysis showed combined hematuria and pyuria, and Escherichia coli was detected in urine culture. Abdominal CT revealed left hydronephrosis with staghorn renal calculi and thin cortex of the left kidney...
2013: Case Reports in Urology
Wojciech Wołyniec, Julian Swierczyński, Marek Szołkiewicz, Michał Chmielewski, Przemysław Rutkowski, Bolesław Rutkowski
INTRODUCTION: Since renal replacement therapy has started to be a routine procedure in chronic kidney disease (CKD), patients no longer die of end-stage renal disease (ESRD). Today, patients with CKD live longer and the most important causes of morbidity and mortality in this group are cardiovascular events. Lipid abnormalities, such as hypertriglyceridemia (HT), are an important factor of high cardiovascular risk in this group. It is known that HT is partially caused by inhibition of lipolysis, but it is also postulated that increased lipogenesis is another cause of HT...
2013: Polskie Archiwum Medycyny Wewnętrznej
Subir Das Kumar, D M Vasudevan
After administration ethanol and its metabolites go through kidneys and are excreted into urine, and its content in the urine is higher than that of the blood and the liver. Chronic ethanol administration decreases the renal tubular reabsorption and reduces renal function. Multiple functional abnormalities of renal tubules may be associated with ethanol-induced changes in membrane composition and lipid peroxidation. The vulnerability of the kidney to oxidative damage has been partly attributed to its high content of long-chain polyunsaturated fatty acids...
January 2008: Indian Journal of Clinical Biochemistry: IJCB
R Bhagwat, S P Joshi, P Salgia, A Sepaha
Lipid abnormalities remain to be a major cause of early mortality in patients with chronic renal failure (CRF). In present study, 114 (one hundred fourteen) CRF patients without any additional cause of dyslipidemia were divided into groups on the basis of etiologies of CRF. Blood samples from each group were analyzed for total cholesterol, triglyceride and HDL cholesterol along with blood urea nitrogen and serum creatinine. 25 healthy individuals without any obvious disease were taken as control. Patients from all the groups showed a marked hypertriglyceridemia of 232 (SD±77) mg/dl (P<0...
December 1997: Indian Journal of Clinical Biochemistry: IJCB
O Balafa, R T Krediet
Cardiovascular (CV) death is the most frequent cause of dying in peritoneal dialysis (PD) patients. Risk factors include not only those that can be present in the general population, but also those related to the presence of end-stage renal disease (ESRD) and factors that are specific for PD modality. Hypertension is the most important general risk factor in PD patients, while obesity remains controversial. Inflammation, malnutrition, calcifications and probably endothelial dysfunction and oxidative stress are all CV risk factors present in ESRD that contribute to mortality in PD patients...
September 2012: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Ana Rocha, Marta Almeida, Josefina Santos, André Carvalho
A wide array of benefits has been attributed to metformin. These include attenuation of abnormal glucose metabolism (diabetes treatment and prevention), weight neutrality or weight loss, improvement in the pathophysiologic components of metabolic syndrome (insulin resistance, subclinical inflammation, and endothelial dysfunction), lipid-lowering properties, cardiovascular protection, and antineoplastic potential. Metformin itself is not a nephrotoxic drug. Initially appointed as the safest hypoglycemic agent in chronic kidney disease, its use has been limited in these patients because of the perceived risk of lactic acidosis...
January 2013: Journal of Nephrology
Roberto Bigazzi, Daniela Grimaldi, Stefano Bianchi
The prevalence of chronic kidney disease (CKD) is increasing worldwide. This clinical and social problem is mainly related to the ongoing epidemic of obesity and metabolic syndrome resulting in hypertension and diabetes mellitus. CKD is a well-recognized risk multiplier for the development of cardiovascular disease (CVD), and it is widely known that CVD is the leading cause of morbidity and mortality in patients with CKD. Lipid metabolism abnormalities are commonly associated with CKD. These consist of increased levels of low-density lipoproteins (LDL), triglycerides, very-low-density lipoproteins (VLDL) and lipoprotein(a), and reduced levels of HDL cholesterol...
March 2012: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Alain Mangé, Aurélie Goux, Stéphanie Badiou, Laure Patrier, Bernard Canaud, Thierry Maudelonde, Jean-Paul Cristol, Jérôme Solassol
Aside from a decrease in the high-density lipoprotein (HDL) cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV) risk in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis (HD). Dysfunctional HDL leads to an alteration of reverse cholesterol transport and the antioxidant and anti-inflammatory properties of HDL. In this study, a quantitative proteomics approach, based on iTRAQ labeling and nanoflow liquid chromatography mass spectrometry analysis, was used to generate detailed data on HDL-associated proteins...
2012: PloS One
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