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https://www.readbyqxmd.com/read/29670878/matrix-metalloproteinase-2-impairs-homing-of-intracoronary-delivered-mesenchymal-stem-cells-in-a-porcine-reperfused-myocardial-infarction-comparison-with-intramyocardial-cell-delivery
#1
Katrin Zlabinger, Dominika Lukovic, Rayyan Hemetsberger, Alfred Gugerell, Johannes Winkler, Ljubica Mandic, Denise Traxler, Andreas Spannbauer, Susanne Wolbank, Gerald Zanoni, Christoph Kaun, Aniko Posa, Andrea Gyenes, Zsolt Petrasi, Örs Petnehazy, Imre Repa, Renate Hofer-Warbinek, Rainer de Martin, Florian Gruber, Silvia Charwat, Kurt Huber, Noemi Pavo, Imre J Pavo, Noemi Nyolczas, Dara L Kraitchman, Mariann Gyöngyösi
Background: Intracoronary (IC) injection of mesenchymal stem cells (MSCs) results in a prompt decrease of absolute myocardial blood flow (AMF) with late and incomplete recovery of myocardial tissue perfusion. Here, we investigated the effect of decreased AMF on oxidative stress marker matrix metalloproteinase-2 (MMP-2) and its influence on the fate and homing and paracrine character of MSCs after IC or intramyocardial cell delivery in a closed-chest reperfused myocardial infarction (MI) model in pigs...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29669933/requisite-endothelial-reactivation-and-effective-sirna-nanoparticle-targeting-of-etv2-er71-in-tumor-angiogenesis
#2
Ashraf Ul Kabir, Tae-Jin Lee, Hua Pan, Jeffrey C Berry, Karen Krchma, Jun Wu, Fang Liu, Hee-Kyoung Kang, Kristina Hinman, Lihua Yang, Samantha Hamilton, Qingyu Zhou, Deborah J Veis, Robert P Mecham, Samuel A Wickline, Mark J Miller, Kyunghee Choi
Angiogenesis, new blood vessel formation from preexisting vessels, is critical for solid tumor growth. As such, there have been efforts to inhibit angiogenesis as a means to obstruct tumor growth. However, antiangiogenic therapy faces major challenges to the selective targeting of tumor-associated-vessels, as current antiangiogenic targets also disrupt steady-state vessels. Here, we demonstrate that the developmentally critical transcription factor Etv2 is selectively upregulated in both human and mouse tumor-associated endothelial cells (TAECs) and is required for tumor angiogenesis...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29662197/mekk2-and-mekk3-suppress-hedgehog-pathway-dependent-medulloblastoma-by-inhibiting-gli1-function
#3
Jinqiu Lu, Liansheng Liu, Mingjie Zheng, Xiaoling Li, Ailing Wu, Qingzhe Wu, Cheng Liao, Jian Zou, Hai Song
Hedgehog (Hh) pathway plays a pivotal role in diverse aspects of development and postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated oncogene 1), a dedicated transcription factor for Hh pathway, are highly associated with several cancers, such as medulloblastoma and basal cell carcinoma. Dynamic and precise control of GLI1 activity is thus important to ensure proper homeostasis and tumorigenesis. Here we show that MEKK2 (MAP3K2) and MEKK3 (MAP3K3) inhibit GLI1 transcriptional activity and oncogenic function through phosphorylation on multiple Ser/Thr sites of GLI1, which reduces GLI1 protein stability, DNA-binding ability, and increases the association of GLI1 with SUFU...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29660336/microrna-155-inversely-correlates-with-esophageal-cancer-progression-through-regulating-tumor-associated-macrophage-fgf2-expression
#4
Peng Wang, Li-Juan Xu, Jie-Jie Qin, Lu Zhang, Gui-Hua Zhuang
Esophageal cancer (EC) is one of the most common malignancies with high incidence and mortality. Tumor-associated macrophages (TAMs) in the tumor microenvironment have been linked to the accelerated tumor progression. MicroRNAs (miR) are 19-25 nucleotide-long, noncoding RNA molecules, functioning as modulators of gene expression, and mediate a variety of biological functions, including tumor growth. In the present study, the effects and molecular mechanism of miR-155 in TAMs isolated from EC were explored. The expression of miR-155 and fibroblast growth factor-2 (FGF2) in EC tissues and cell lines were analyzed using reverse transcription-quantitative PCR (qRT-PCR) and western blot assays...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29659033/gna11-differentially-mediates-fgf2-and-vegfa-induced-cellular-responses-in-human-fetoplacental-endothelial-cells
#5
Qing-Yun Zou, Ying-Jie Zhao, Hua Li, Xiang-Zhen Wang, Ai-Xia Liu, Xin-Qi Zhong, Qin Yan, Yan Li, Chi Zhou, Jing Zheng
During pregnancy, fetoplacental angiogenesis is dramatically increased in association with rapidly elevated blood flows. Any disruption of fetoplacental angiogenesis may lead to pregnancy complications such as intrauterine growth restriction. Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) are crucial regulators of fetoplacental angiogenesis. G protein α subunits q (GNAq) and 11 (GNA11), two members of Gαq/11 subfamily are involved in mediating vascular growth and basal blood pressure...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29657241/expression-dynamics-of-self-renewal-factors-for-spermatogonial-stem-cells-in-the-mouse-testis
#6
Mizuki Sakai, Kaito Masaki, Shota Aiba, Masaaki Tone, Seiji Takashima
Glial cell line-derived neurotrophic factor (GDNF) and fibroblast growth factor 2 (FGF2) are bona fide self-renewal factors for spermatogonial stem cells (SSCs). Although GDNF is indispensable for the maintenance of SSCs, the role of FGF2 in the testis remains to be elucidated. To clarify this, the expression dynamics and regulatory mechanisms of Fgf2 and Gdnf in the mouse testes were analyzed. It is well known that Sertoli cells express Gdnf, and its receptor is expressed in a subset of undifferentiated spermatogonia, including SSCs...
April 16, 2018: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29656749/tumor-associated-macrophages-support-the-growth-of-fgf9-induced-lung-adenocarcinoma-by-multiple-mechanisms
#7
Ahmed E Hegab, Mari Ozaki, Shizuko Kagawa, Junko Hamamoto, Hiroyuki Yasuda, Katsuhiko Naoki, Kenzo Soejima, Yongjun Yin, Tomonari Kinoshita, Tomonori Yaguchi, Yutaka Kawakami, David M Ornitz, Tomoko Betsuyaku
OBJECTIVES: Tumor-associated macrophages (TAMs) are known to promote tumorigenesis but the mechanism(s) remain elusive. We have developed a mouse model of lung cancer that is initiated through an inducible overexpression of fibroblast growth factor 9 (FGF9) in type-2 pneumocytes. Expression of FGF9 in adult lungs resulted in a rapid development of multiple adenocarcinoma-like tumor nodules, and is associated with an intense immunological reaction. The purpose of this study is to characterize the immune response to the FGF9-induced lung adenocarcinoma and to determine the contribution of TAMs to growth and survival of these tumors...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29649366/fgf2-enhances-odontoblast-differentiation-by-%C3%AE-sma-progenitors-in-vivo
#8
I Vidovic-Zdrilic, K H Vining, A Vijaykumar, I Kalajzic, D J Mooney, M Mina
The goal of this study was to examine the effects of early and limited exposure of perivascular cells expressing α (αSMA) to fibroblast growth factor 2 (FGF2) in vivo. We performed in vivo fate mapping by inducible Cre-loxP and experimental pulp injury in molars to induce reparative dentinogenesis. Our results demonstrate that early delivery of exogenous FGF2 to exposed pulp led to proliferative expansion of αSMA-tdTomato+ cells and their accelerated differentiation into odontoblasts. In vivo lineage-tracing experiments showed that the calcified bridge/reparative dentin in FGF2-treated pulps were lined with an increased number of Dspp+ odontoblasts and devoid of BSP+ osteoblasts...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29645000/neotuberostemonine-inhibits-the-differentiation-of-lung-fibroblasts-into-myofibroblasts-in-mice-by-regulating-hif-1%C3%AE-signaling
#9
Xin-Miao Lv, Ming-Dan Li, Si Cheng, Bao-Lin Liu, Kang Liu, Chao-Feng Zhang, Xiang-Hong Xu, Mian Zhang
Pulmonary fibrosis may be partially the result of deregulated tissue repair in response to chronic hypoxia. In this study we explored the effects of hypoxia on lung fibroblasts and the effects of neotuberostemonine (NTS), a natural alkaloid isolated from Stemona tuberosa, on activation of fibroblasts in vitro and in vivo. PLFs (primary mouse lung fibroblasts) were activated and differentiated after exposure to 1% O2 or treatment with CoCl2 (100 μmol/L), evidenced by markedly increased protein or mRNA expression of HIF-1α, TGF-β, FGF2, α-SMA and Col-1α/3α, which was blocked after silencing HIF-1α, suggesting that the activation of fibroblasts was HIF-1α-dependent...
April 12, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29643956/serum-cytokines-in-early-prediction-of-anastomotic-leakage-following-low-anterior-resection
#10
Marek Zawadzki, Małgorzata Krzystek-Korpacka, Andrzej Gamian, Wojciech Witkiewicz
Introduction: Anastomotic leakage continues to be one of the most serious complications following low anterior resections. Early diagnosis of a leak is difficult but critical to minimize morbidity and mortality. Aim: To evaluate changes in serum concentrations of 27 different cytokines following low anterior resection, with the goal of finding new, early biomarkers of anastomotic leak. Material and methods: This is a prospective observational study that includes 32 patients undergoing elective low anterior resection for rectal cancer...
March 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29630097/effect-of-fgf2-on-the-activity-of-sprys-dusp6-erk-signaling-pathway-in-endometrial-glandular-epithelial-cells-of-endometriosis
#11
X-Y Yu, X-T Wang, Y-L Chu, H-M Qu, J Liu, Y-H Zhang, M-J Li
OBJECTIVE: We aimed at exploring the positive feedback loop in eutopic and ectopic endometrial glandular epithelial cells (EuECs and EECs) in endometriosis. MATERIALS AND METHODS: Normal epithelial cells (NECs), EuECs and EECs were treated with fibroblast growth factor (FGF)2, FGF2 neutralizing antibody, mitogen-activated protein kinases (MAPKs) inhibitors U0126 and PD98059. FGF2 protein level was detected by enzyme-linked immunosorbent assay (ELISA). The expressions of FGF2, FGF receptor 1 (FGFR1), extracellular signal-regulated kinase (ERK)1/2/pERK1/2 and Sproutys (SPRYs) (Sprouty1, Sprouty2, Sprouty4) and dual specificity phosphatase 6 (DUSP6) were detected by Western blot...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29615760/human-sertoli-cells-support-high-levels-of-zika-virus-replication-and-persistence
#12
Anil Kumar, Juan Jovel, Joaquin Lopez-Orozco, Daniel Limonta, Adriana M Airo, Shangmei Hou, Iryna Stryapunina, Chad Fibke, Ronald B Moore, Tom C Hobman
Zika virus is a teratogenic mosquito-transmitted flavivirus that is associated with birth defects in newborns and Guillain-Barré syndrome in adults. The virus can also be sexually transmitted, but currently, very little is known about the cell types supporting virus replication and persistence in human testes. Using primary cell cultures, we observed that Sertoli but not Leydig cells are highly susceptible to Zika virus infection, a process that is dependent on the TAM family receptor Axl. In cell culture, Sertoli cells could be productively infected with Zika virus for at least 6-weeks...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29595072/platycodin-d-reverses-pathological-cardiac-hypertrophy-and-fibrosis-in-spontaneously-hypertensive-rats
#13
Yuan-Chuan Lin, Yu-Chen Lin, Wei-Wen Kuo, Chia-Yao Shen, Yi-Chang Cheng, Yueh-Min Lin, Ruey-Lin Chang, Vijaya V Padma, Chih-Yang Huang, Chih-Yang Huang
Platycodin D (PD) is the main active saponin isolated from Platycodon grandiflorum (PG) and is reported to exhibit anticancer, anti-angiogenic, anti-inflammation and anti-obesity biological effects. The current study aims to evaluate the therapeutic efficacy of PD in cardiac fibrosis and for hypertrophy in spontaneous hypertension rats (SHRs) and to verify inhibition of the signaling pathway. Significant increases in the cardiac functional indices of left ventricular internal diameter end diastole (LVIDd) and left ventricular internal diameter end systole (LVIDs); the eccentric hypertrophy marker p-MEK5; concentric hypertrophy markers, such as CaMKII[Formula: see text] and calcineurin; and expression levels of NFATc3, p-GATA4 and BNP were observed in spontaneously hypertensive groups...
March 29, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29580899/investigation-of-candidate-long-noncoding-rnas-and-messenger-rnas-in-the-immediate-phase-of-spinal-cord-injury-based-on-gene-expression-profiles
#14
Hengxing Zhou, Zhongju Shi, Yi Kang, Yao Wang, Lu Lu, Bin Pan, Jun Liu, Xueying Li, Lu Liu, Zhijian Wei, Xiaohong Kong, Shiqing Feng
Spinal cord injury (SCI) is a serious devastating condition and it has a high mortality rate and morbidity rate. The early pathological changes in the immediate phase of SCI may play a major part in the development of secondary injury. Alterations in the expression of many long noncoding RNAs (lncRNAs) have been shown to play fundamental roles in the diseases of the central nervous system. However, the roles of lncRNAs and messenger RNAs (mRNAs) in the immediate phase of SCI are not clear. We examined the expression of mRNAs and lncRNAs in a rat model at 2 h after SCI and identified the differentially expressed lncRNAs (DE lncRNAs) and differentially expressed mRNAs (DE mRNAs) using microarray analysis...
March 23, 2018: Gene
https://www.readbyqxmd.com/read/29575101/adherent-agarose-mold-cultures-an-in-vitro-platform-for-multi-factorial-assessment-of-passaged-chondrocyte-redifferentiation
#15
Justin Parreno, Vanessa J Bianchi, Corey Sermer, Suresh C Regmi, David Backstein, Tannin A Schmidt, Rita A, Kandel
Generating the best possible bioengineered cartilage from passaged chondrocytes requires culture condition optimization. In this study the use of adherent agarose mold (adAM) cultures to support redifferentiation of passaged twice (P2) chondrocytes and serve as a scalable platform to assess the effect of growth factor combinations on proteoglycan accumulation by cells was examined. By 2 days in adAM culture, bovine P2 cells were partially redifferentiated as demonstrated by regression of actin-based dedifferentiation signalling and fibroblast matrix and contractile gene expression...
March 25, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29566097/the-gag-specific-branched-peptide-nt4-reduces-angiogenesis-and-invasiveness-of-tumor-cells
#16
Luisa Bracci, Elisabetta Mandarini, Jlenia Brunetti, Lorenzo Depau, Alessandro Pini, Lucia Terzuoli, Silvia Scali, Chiara Falciani
Heparan sulfate proteoglycans, HSPGs, modulate major transformations of cancer cells, leading to tumor growth, invasion and metastasis. HSPGs also regulate neo-angiogenesis which prompts cancer progression and metastatic spread. A different aspect of heparin and analogs is their prominent role in the coagulation of blood. The interplay between coagulation and metastasis is being actively studied: anticoagulants such as heparin-derivatives have anticancer activity and procoagulants, such as thrombin, positively modulate proliferation, migration and invasion...
2018: PloS One
https://www.readbyqxmd.com/read/29565168/tissular-growth-factors-profile-after-teduglutide-administration-on-an-animal-model-of-intestinal-anastomosis
#17
Beatriz Pinto Costa, Ana Cristina Gonçalves, Ana Margarida Abrantes, Raquel Alves, Paulo Matafome, Raquel Seiça, Ana Bela Sarmento-Ribeiro, Maria Filomena Botelho, Francisco Castro-Sousa
BACKGROUND: Teduglutide is an enterotrophic analogue of glucagon-like peptide-2, with an indirect and poorly understood mechanism of action, approved for the rehabilitation of short-bowel syndrome. This study aims to analyze the response of tissue growth factors to surgical injury and teduglutide administration on an animal model of intestinal anastomosis. METHODS: Wistar rats (n = 59) were distributed into four groups: "ileal resection" or "laparotomy", each one subdivided into "postoperative teduglutide administration" or "no treatment"; and sacrificed at the third or the seventh day, with ileal sample harvesting...
January 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29561195/a-role-for-fgf2-in-visceral-adiposity-associated-mammary-epithelial-transformation
#18
Vanessa Benham, Debrup Chakraborty, Blair Bullard, Jamie J Bernard
Obesity is a leading risk factor for post-menopausal breast cancer, and this is concerning as 40% of cancer diagnoses in 2014 were associated with overweight/obesity. Despite this epidemiological link, the underlying mechanism responsible is unknown. We recently published that visceral adipose tissue (VAT) releases FGF2 and stimulates the transformation of skin epithelial cells. Furthermore, obesity is differentially associated with many epithelial cancers, and this mechanistic link could be translational. As FGF2 and FGFR1 are implicated in breast cancer progression, we hypothesize that VAT-derived FGF2 plays a translational role in promoting adiposity-associated mammary epithelial cell transformation...
March 21, 2018: Adipocyte
https://www.readbyqxmd.com/read/29556234/the-long-pentraxin-3-plays-a-role-in-bone-turnover-and-repair
#19
Danka Grčević, Marina Sironi, Sonia Valentino, Livija Deban, Hrvoje Cvija, Antonio Inforzato, Nataša Kovačić, Vedran Katavić, Tomislav Kelava, Ivo Kalajzić, Alberto Mantovani, Barbara Bottazzi
Pentraxin 3 (PTX3) is an inflammatory mediator acting as a fluid-phase pattern recognition molecule and playing an essential role in innate immunity and matrix remodeling. Inflammatory mediators also contribute to skeletal homeostasis, operating at multiple levels in physiological and pathological conditions. This study was designed to investigate the role of PTX3 in physiological skeletal remodeling and bone healing. Micro-computed tomography (μCT) and bone histomorphometry of distal femur showed that PTX3 gene-targeted female and male mice ( ptx3-/- ) had lower trabecular bone volume than their wild-type ( ptx3+/+ ) littermates (BV/TV by μCT: 3...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29541027/p2y-6-receptors-regulate-cxcl10-expression-and-secretion-in-mouse-intestinal-epithelial-cells
#20
Mabrouka Salem, Alain Tremblay, Julie Pelletier, Bernard Robaye, Jean Sévigny
In this study, we investigated the role of extracellular nucleotides in chemokine (KC, MIP-2, MCP-1, and CXCL10) expression and secretion by murine primary intestinal epithelial cells (IECs) with a focus on P2Y6 receptors. qRT-PCR experiments showed that P2Y6 was the dominant nucleotide receptor expressed in mouse IEC. In addition, the P2Y6 ligand UDP induced expression and secretion of CXCL10. For the other studies, we took advantage of mice deficient in P2Y6 ( P2ry6 -/- ). Similar expression levels of P2Y1 , P2Y2 , P2X2, P2X4, and A2A were detected in P2ry6 -/- and WT IEC...
2018: Frontiers in Pharmacology
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