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https://www.readbyqxmd.com/read/28087833/dysregulation-of-map-kinase-signaling-pathways-including-p38mapk-sapk-jnk-and-erk1-2-in-cultured-rat-cerebellar-astrocytes-exposed-to-diphenylarsinic-acid
#1
Takayuki Negishi, Mami Matsumoto, Yayoi Kobayashi, Mikiya Kojima, Fumika Sakaguchi, Kazuaki Takahata, Tomoko Kanehira, Rina Arakaki, Yohei Aoyama, Hikari Yoshida, Rena Yamada, Nobutaka Sumiyoshi, Tomoko Tashiro, Seishiro Hirano, Kenji Yoshida, Kazunori Yukawa
Diphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to DPAA via contaminated well water suffered from several neurological disorders, including cerebellar symptoms. We previously reported that DPAA induces cellular activation in cultured rat cerebellar astrocytes, dose-dependent promotion of cell growth (low DPAA), cell death (high DPAA), and increased phosphorylation of mitogen-activated protein (MAP) kinases (p38MAPK, SAPK/JNK, and ERK1/2)...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28057484/type-ii-cgmp-dependent-protein-kinase-negatively-regulates-fibroblast-growth-factor-signaling-by-phosphorylating-raf-1-at-serine-43-in-rat-chondrosarcoma-cells
#2
Norio Kamemura, Sara Murakami, Hiroaki Komatsu, Masahiro Sawanoi, Kenji Miyamoto, Kazumi Ishidoh, Koji Kishimoto, Akihiko Tsuji, Keizo Yuasa
Although type II cGMP-dependent protein kinase (PKGII) is a major downstream effector of cGMP in chondrocytes and attenuates the FGF receptor 3/ERK signaling pathway, its direct target proteins have not been fully explored. In the present study, we attempted to identify PKGII-targeted proteins, which are associated with the inhibition of FGF-induced MAPK activation. Although FGF2 stimulation induced the phosphorylation of ERK1/2, MEK1/2, and Raf-1 at Ser-338 in rat chondrosarcoma cells, pretreatment with a cell-permeable cGMP analog strongly inhibited their phosphorylation...
January 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28049804/episc-fgf2-medium
#3
(no author information available yet)
No abstract text is available yet for this article.
January 3, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28049803/cdm-fgf2-acta-medium
#4
(no author information available yet)
No abstract text is available yet for this article.
January 3, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28049802/fgf2-stock-solution-10-%C3%A2%C2%B5g-ml
#5
(no author information available yet)
No abstract text is available yet for this article.
January 3, 2017: Cold Spring Harbor Protocols
https://www.readbyqxmd.com/read/28045923/germline-genetic-variants-in-tek-angpt1-angpt2-mmp9-fgf2-and-vegfa-are-associated-with-pathologic-complete-response-to-bevacizumab-in-breast-cancer-patients
#6
Issam Makhoul, Valentina K Todorova, Eric R Siegel, Stephen W Erickson, Ishwori Dhakal, Vinay R Raj, Jeannette Y Lee, Mohammed S Orloff, Robert J Griffin, Ronda S Henry-Tillman, Suzanne Klimberg, Laura F Hutchins, Susan A Kadlubar
BACKGROUND: We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination with chemotherapy compared to chemotherapy alone in breast cancer patients (41% vs. 25%, p = 0.0291). In this study, we queried germline single-nucleotide polymorphisms (SNPs) in angiogenesis-related genes for their impact on pCR and overall survival (OS). METHODS: DNA for genotyping was available from 34 subjects who received bevacizumab in addition to chemotherapy and 29 subjects who did not...
2017: PloS One
https://www.readbyqxmd.com/read/28045049/mir-218-induces-neuronal-differentiation-of-ascs-in-a-temporally-sequential-manner-with-fibroblast-growth-factor-by-regulation-of-the-wnt-signaling-pathway
#7
Feihu Hu, Bo Sun, Peng Xu, Yanliang Zhu, Xian-Hui Meng, Gao-Jun Teng, Zhong-Dang Xiao
Differentiation of neural lineages from mesenchymal stem cells has raised the hope of generating functional cells as seed cells for nerve tissue engineering. As important gene regulators, microRNAs (miRNAs) have been speculated to play a vital role in accelerating stem cell differentiation and repairing neuron damage. However, miRNA roles in directing differentiation of stem cells in current protocols are underexplored and the mechanisms of miRNAs as regulators of neuronal differentiation remain ambiguous. In this study, we have determined that miR-218 serves as crucial constituent regulator in neuronal differentiation of adipose stem cells (ASCs) through Wnt signaling pathway based on comprehensive annotation of miRNA sequencing data...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28041965/analysis-of-gene-expression-in-ca-2-dependent-activator-protein-for-secretion-2-cadps2-knockout-cerebellum-using-genechip-and-kegg-pathways
#8
Tetsushi Sadakata, Yo Shinoda, Yasuki Ishizaki, Teiichi Furuichi
In the mouse cerebellum, Ca(2+)-dependent activator protein for secretion 2 (CADPS2, CAPS2) is involved in regulated secretion from dense-core vesicles (DCVs), which contain neuropeptides including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Capds2 knockout (KO) mice show impaired cerebellar development in addition to autistic-like behavioral phenotypes. To understand the molecular impact caused by loss of Capds2, we analyzed gene expression profiles in the Capds2 KO cerebellum using a GeneChip microarray and the KEGG Pathway database...
December 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28031461/heparan-sulfate-domains-required-for-fibroblast-growth-factor-1-and-2-signaling-through-fibroblast-growth-factor-receptor-1c
#9
Victor Schultz, Mathew Suflita, Xinyue Liu, Xing Zhang, Yanlei Yu, Lingyun Li, Dixy E Green, Yongmei Xu, Fuming Zhang, Paul L DeAngelis, Jian Liu, Robert J Linhardt
A small library, of well-defined heparan sulfate (HS) polysaccharides, was chemoenzymatically synthesized and used for a detailed structure-activity study of fibroblast growth factor (FGF)1 and FGF2 signaling through FGF receptor (FGFR)1c. The HS polysaccharide tested contained both undersulfated (NA) domains and highly sulfated (NS) domains as well as very well defined non-reducing termini. This study examines differences in the HS selectivity of the positive canyons of the FGF12-FGFR1c2 and FGF22-FGFR1c2 HS-binding sites of the symmetric FGF2-FGFR2HS2 signal transduction complex...
December 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28012573/fgf2-fgf3-and-fgf4-expression-pattern-during-molars-odontogenesis-in-didelphis-albiventris
#10
Íria Gabriela Dias Dos Santos, Erika Cristina Jorge, Aline Gonçalves Lio Copola, Bruno Machado Bertassoli, Alfredo Miranda de Goes, Gerluza Aparecida Borges Silva
Odontogenesis is guided by a complex signaling cascade in which several molecules, including FGF2-4, ensure all dental groups development and specificity. Most of the data on odontogenesis derives from rodents, which does not have all dental groups. Didelphis albiventris is an opossum with the closest dentition to humans, and the main odontogenesis stages occur when the newborns are in the pouch. In this study, D. albiventris postnatals were used to characterize the main stages of their molars development; and also to establish FGF2, FGF3 and FGF4 expression pattern...
December 21, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27982737/il-37-a-new-il-1-family-member-emerges-as-a-key-suppressor-of-asthma-mediated-by-mast-cells
#11
P Conti, G Ronconi, A Caraffa, G Lessiani, Kempuraj Duraisamy
: In 1986, we reported a multiple biological effect of IL-1 including immunological, inflammatory, and tumor killing activity. Since then other IL-1 family cytokines have been discovered, some with inflammatory and other with anti-inflammatory activity. In this review article, we speculate on the possible inhibitory effect of IL-37 in the light of new findings. IL-37, formerly termed IL-1 family member 7 (IL-1F7), binding IL-18 receptor α chain, acts as a cytokine with intracellular as well as extracellular functionality and as a natural inhibitor of immune responses and inflammation...
December 16, 2016: Immunological Investigations
https://www.readbyqxmd.com/read/27976512/fgf2-antagonizes-aberrant-tgf%C3%AE-regulation-of-tropomyosin-role-for-posterior-capsule-opacity
#12
Eri Kubo, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Dhirendra P Singh
Transforming growth factor (TGF) β2 and fibroblast growth factor (FGF) 2 are involved in regulation of posterior capsule opacification (PCO) and other processes of epithelial-mesenchymal transition (EMT) such as cancer progression, wound healing and tissue fibrosis as well as normal embryonic development. We previously used an in vivo rodent PCO model to show the expression of tropomyosin (Tpm) 1/2 was aberrantly up-regulated in remodelling the actin cytoskeleton during EMT. In this in vitro study, we show the Tpms family of cytoskeleton proteins are involved in regulating and stabilizing actin microfilaments (F-actin) and are induced by TGFβ2 during EMT in lens epithelial cells (LECs)...
December 15, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27967316/adipogenic-impairment-of-adipose-tissue-derived-mesenchymal-stem-cells-in-subjects-with-metabolic-syndrome-possible-protective-role-of-fgf2
#13
Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Said Lhamyani, Mercedes Clemente-Postigo, Juan Alcaide Torres, Maria Rosa Bernal-López, Rajaa El Bekay, Francisco José Tinahones
CONTEXT: The decreased expansion capacity of adipose tissue plays a crucial role in the onset of disorders associated with metabolic syndrome. Objetive: The aim of this study was to examine the state of adipose tissue-derived mesenchymal stem cells (ASCs) from obese subjects with different metabolic profiles. DESIGN: This was a 2-year study to enroll subjects who underwent bariatric surgery or cholecystectomy. SETTING: University Hospital Patients and Intervention: Patients who underwent either bariatric surgery (20 morbidly obese) or cholecystectomy (40 subjects) participated in the study...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27957715/anxiolytic-effects-of-muscarinic-acetylcholine-receptors-agonist-oxotremorine-in-chronically-stressed-rats-and-related-changes-in-bdnf-and-fgf2-levels-in-the-hippocampus-and-prefrontal-cortex
#14
Valentina Di Liberto, Monica Frinchi, Vincenzo Verdi, Angela Vitale, Fulvio Plescia, Carla Cannizzaro, Maria F Massenti, Natale Belluardo, Giuseppa Mudò
RATIONALE: In depressive disorders, one of the mechanisms proposed for antidepressant drugs is the enhancement of synaptic plasticity in the hippocampus and cerebral cortex. Previously, we showed that the muscarinic acetylcholine receptor (mAChR) agonist oxotremorine (Oxo) increases neuronal plasticity in hippocampal neurons via FGFR1 transactivation. OBJECTIVES: Here, we aimed to explore (a) whether Oxo exerts anxiolytic effect in the rat model of anxiety-depression-like behavior induced by chronic restraint stress (CRS), and (b) if the anxiolytic effect of Oxo is associated with the modulation of neurotrophic factors, brain-derived neurotrophic factor (BDNF) and fibroblast growth factor-2 (FGF2), and phosphorylated Erk1/2 (p-Erk1/2) levels in the dorsal or ventral hippocampus and in the medial prefrontal cortex...
December 12, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27951474/down-regulation-of-fibroblast-growth-factor-2-and-its-co-receptors-heparan-sulfate-proteoglycans-by-resveratrol-underlies-the-improvement-of-cardiac-dysfunction-in-experimental-diabetes
#15
Célia Maria Cássaro Strunz, Alessandra Roggerio, Paula Lázara Cruz, Ana Paula Pacanaro, Vera Maria Cury Salemi, Luiz Alberto Benvenuti, Antonio de Pádua Mansur, Maria Cláudia Irigoyen
Cardiac remodeling in diabetes involves cardiac hypertrophy and fibrosis, and fibroblast growth factor 2 (FGF2) is an important mediator of this process. Resveratrol, a polyphenolic antioxidant, reportedly promotes the improvement of cardiac dysfunction in diabetic rats. However, little information exists linking the amelioration of the cardiac function promoted by resveratrol and the expression of FGF2 and its co-receptors, heparan sulfate proteoglycans (HSPGs: Glypican-1 and Syndecan-4), in cardiac muscle of Type 2 diabetic rats...
December 2, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27932973/decline-in-proliferation-and-immature-neuron-markers-in-the-human-subependymal-zone-during-aging-relationship-to-egf-and-fgf-related-transcripts
#16
Christin Weissleder, Samantha J Fung, Matthew W Wong, Guy Barry, Kay L Double, Glenda M Halliday, Maree J Webster, Cynthia Shannon Weickert
Neuroblasts exist within the human subependymal zone (SEZ); however, it is debated to what extent neurogenesis changes during normal aging. It is also unknown how precursor proliferation may correlate with the generation of neuronal and glial cells or how expression of growth factors and receptors may change throughout the adult lifespan. We found evidence of dividing cells in the human SEZ (n D 50) in conjunction with a dramatic age-related decline (21-103 years) of mRNAs indicative of proliferating cells (Ki67) and immature neurons (doublecortin)...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27924190/network-analysis-of-human-post-mortem-microarrays-reveals-novel-genes-micrornas-and-mechanistic-scenarios-of-potential-importance-in-fighting-huntington-s-disease
#17
Sreedevi Chandrasekaran, Danail Bonchev
Huntington's disease is a progressive neurodegenerative disorder characterized by motor disturbances, cognitive decline, and neuropsychiatric symptoms. In this study, we utilized network-based analysis in an attempt to explore and understand the underlying molecular mechanism and to identify critical molecular players of this disease condition. Using human post-mortem microarrays from three brain regions (cerebellum, frontal cortex and caudate nucleus) we selected in a four-step procedure a seed set of highly modulated genes...
2016: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/27904776/microrna-195-suppresses-colorectal-cancer-cells-proliferation-via-targeting-fgf2-and-regulating-wnt-%C3%AE-catenin-pathway
#18
Xianxiang Zhang, Ji Xu, Tao Jiang, Guangwei Liu, Dongsheng Wang, Yun Lu
Colorectal cancer (CRC) is a prevalent cancer with high mortality worldwide. This study was aimed to explore the functional effects of microRNA-195 (miR-195) on CRC cells and the underling mechanism involved. quantitative PCR (qPCR) was performed to monitor the expression of miR-195 in CRC tissues and cell lines. SW480 and SW620 cells were transfected with either miR-195 mimic or antisense oligonucleotides (ASO) of miR-195. Then cell viability, cell cycle and the expressions of CyclinB1, CyclinD1 and Cyclin-Dependent Kinase 2 (CDK2) were respectively detected by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyltetrazolium bromide (MTT), flow cytometry, qPCR and Western blot...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27903483/therapeutic-benefits-and-adverse-effects-of%C3%A2-combined-proangiogenic-gene-therapy-in%C3%A2-mouse-critical-leg-ischemia
#19
Benoît Lebas, Julien Galley, Edith Renaud-Gabardos, Françoise Pujol, Françoise Lenfant, Barbara Garmy-Susini, Xavier Chaufour, Anne-Catherine Prats
BACKGROUND: Critical leg ischemia (CLI) represents the ultimate stage of peripheral arterial disease. Despite current surgery advances, patients with CLI have limited therapeutic options. Therapeutic angiogenesis thus appears as a powerful approach, aiming to stimulate vessel formation by angiogenic molecules administration. In this context, combined gene therapy has been proved to be the most efficient. The present study aims to compare, in a preclinical mouse model, the therapeutic benefit of a combination of 2 angiogenic factors fibroblast growth factor 2 (FGF2) and Cyr61 using plasmid and viral vectors, able to generate short- or long-term transgene expression in the leg, respectively...
November 27, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27898753/-oncogen-dependent-regulation-of-the-migration-and-proliferation-of-human-tumor-cells
#20
Tamás M Garay
The high mortality of solid tumors can be attributed to their invasive and metastatic potential that is based on their migration and proliferation. Importantly, growth factor receptor (GF) signaling pathways regulating proliferation and migration are often affected by oncogenic mutations and are important targets for antitumor therapy. We found positive correlation between migration and proliferation in melanoma and lung cancer cells using videomicroscopy, not supporting the "go or grow" hypothesis. Furthermore, the invasion into collagen I matrices from brain tumor spheroids was not impaired upon the inhibition of proliferation...
November 29, 2016: Magyar Onkologia
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