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https://www.readbyqxmd.com/read/29343658/differences-in-signal-intensity-and-enhancement-on-mr-images-of-the-perivascular-spaces-in-the-basal-ganglia-versus-those-in-white-matter
#1
Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
PURPOSE: To elucidate differences between the perivascular space (PVS) in the basal ganglia (BG) versus that found in white matter (WM) using heavily T2-weighted FLAIR (hT2-FL) in terms of 1) signal intensity on non-contrast enhanced images, and 2) the degree of contrast enhancement by intravenous single dose administration of gadolinium based contrast agent (IV-SD-GBCA). MATERIALS AND METHODS: Eight healthy men and 13 patients with suspected endolymphatic hydrops were included...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29336131/vestibular-schwannoma-and-ipsilateral-endolymphatic-hydrops-an-unusual-association
#2
Massimo Ralli, Antonio Greco, Giancarlo Altissimi, Rosaria Turchetta, Lucia Longo, Vittorio D'Aguanno, Mario Tombolini, Giancarlo Cianfrone, Marco de Vincentiis
Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual finding that may lead clinicians to errors and delays in diagnosis and clinical management of affected subjects. We discuss the case of a patient with an intrameatal vestibular schwannoma reporting symptoms suggestive for ipsilateral endolymphatic hydrops. The patient presented with fluctuating hearing loss, tinnitus, and acute rotatory vertigo episodes, and underwent a full audiological evaluation and imaging of the brain with contrast-enhanced Magnetic Resonance Imaging...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29335859/arginine-vasopressin-aquaporin-2-pathway-mediated-dehydration-effects-of-electroacupuncture-in-guinea-pig-model-of-avp-induced-endolymphatic-hydrops
#3
Li-Yuan Jiang, Jiao-Jun He, Xi-Xi Chen, Xue-Jiao Sun, Xue-Zhong Wang, Shan Zhong, Hua-de Chen
OBJECTIVE: To investigate the effects of electroacupuncture (EA) on endolymphatic hydrops (EH) and the regulation of arginine vasopressin (AVP)-aquaporin-2 (AQP2) pathway in guinea pigs. METHODS: EH was induced in male guinea pigs by an intraperitoneal injection of AVP. For the treatment, EA was delivered to Baihui (GV 20) and Tinggong (SI 19) acupoints, once per day for 10 consecutive days. In histomorphological studies, cochlear hydrops degree was evaluated by hematoxylin-eosin (HE) staining, and then the ratio of scala media (SM) area to SM + scala vestibuli (SV) area (R value) was calculated...
January 15, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29331020/human-phenotypes-caused-by-piezo1-mutations-one-gene-two-overlapping-phenotypes
#4
Silvia Martin-Almedina, Sahar Mansour, Pia Ostergaard
PIEZO1 is a large mechanosensitive ion channel protein. Diseases associated with PIEZO1 include autosomal recessive Generalised Lymphatic Dysplasia of Fotiou (GLDF) and autosomal dominant Dehydrated Hereditary Stomatocytosis with or without pseudohyperkalemia and/or perinatal oedema (DHS). The two disorders show overlapping features, fetal hydrops/perinatal oedema have been reported in both. Electrophysiological studies suggest opposite mechanisms of action, the mutations identified in GLDF patients cause a loss-of-function mechanism of disease and mutations in DHS patients cause gain-of-function...
January 13, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29321977/imidacloprid-exposure-cause-the-histopathological-changes-activation-of-tnf-%C3%AE-inos-8-ohdg-biomarkers-and-alteration-of-caspase-3-inos-cyp1a-mt1-gene-expression-levels-in-common-carp-cyprinus-carpio-l
#5
Selçuk Özdemir, Serdar Altun, Harun Arslan
Imidacloprid (IMI) is a neonicotinoid that is widely used for the protection of crops and carnivores from insects and parasites, respectively. It is well known that imidacloprid exposure has a harmful effect on several organisms. However, there is little information about imidacloprid toxicity in aquatic animals, particularly fish. Thus, in the current study, we assessed the histopathological changes; activation of iNOS, 8-OHdG and TNF-α; and expression levels of caspase 3, iNOS, CYP1A and MT1 genes in the common carp exposed to imidacloprid...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29321950/manifestations-of-renal-impairment-in-fructose-induced-metabolic-syndrome
#6
Kameliya Bratoeva, George S Stoyanov, Albena Merdzhanova, Mariya Radanova
Introduction International studies show an increased incidence of chronic kidney disease (CKD) in patients with metabolic syndrome (MS). It is assumed that the major components of MS - obesity, insulin resistance, dyslipidemia, and hypertension - are linked to renal damage through the systemic release of several pro-inflammatory mediators, such as uric acid (UA), C-reactive protein (CRP), and generalized oxidative stress. The aim of the present study was to investigate the extent of kidney impairment and manifestations of dysfunction in rats with fructose-induced MS...
November 7, 2017: Curēus
https://www.readbyqxmd.com/read/29320914/early-treatment-of-intrapericardial-teratoma-a-case-presentation-and-systematic-literature-review
#7
Candice Torres de Melo Bezerra Cavalcante, Valdester Cavalcante Pinto Júnior, Ronald Guedes Pompeu, João Victor Cabral Correia Férrer, Marcelo Borges Cavalcante, Edward Araujo Júnior, Alberto Borges Peixoto, Klebia Magalhães Castello Branco
OBJECTIVE: To present a case of an early treatment of cardiac intraperitoneal teratoma (IPT) in a newborn and its associated systematic literature review. METHODS: We presented a case of a newborn with IPT but without hydrops and having a good perinatal outcome after cardiac surgery. Using the PubMed database, we conducted a systematic literature review of articles regarding cases with cardiac IPT diagnosed and treated in the neonatal period and published in English from 2004 onward...
January 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29317884/evaluation-of-the-anti-schistosomal-effects-of-turmeric-curcuma-longa-versus-praziquantel-in-schistosoma-mansoni-infected-mice
#8
Atef Hussein, Samia Rashed, Ibrahim El Hayawan, Rabab El-Sayed, Hemat Ali
Background: Curcumin is the major active ingredient of Curcuma longa L., traditionally known as turmeric and has been shown to exhibit a wide range of pharmacological activities including anti-parasitic effect. However, it is found to be water-insoluble and has low bioavailability. The aim of this study was to explore the potential role of turmeric solved in olive oil either alone or in combination with praziquantel (PZQ) in treatment of schistosomiasis mansoni. Methods: The whole turmeric powder suspended in olive oil (as a solvent) is indicated to S...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29315188/relationship-between-the-extent-of-endolymphatic-hydrops-and-the-severity-and-fluctuation-of-audiovestibular-symptoms-in-patients-with-meni%C3%A3-re-s-disease-and-mri-evidence-of-hydrops
#9
Claudia Jerin, Sonja Floerke, Rebecca Maxwell, Robert Gürkov
OBJECTIVE: To characterize the short-, middle-, and long-term occurrence of vertigo attacks in a large population of Menière's disease (MD) and to investigate the relationship between the extent of endolymphatic hydrops (ELH) and the severity of audiovestibular symptoms. STUDY DESIGN: Prospective observational study. METHODS: One hundred ninety-two patients with clinically definite MD participated in this study. The degree of ELH was visualized by locally enhanced inner ear magnetic resonance imaging...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29310403/multilocular-cystic-leiomyoma-of-the-anterolateral-abdominal-wall-a-case-report-and-literature-review
#10
Kenji Yorita, Yu Tanaka, Koki Hirano, Michio Kuwahara, Kimiko Nakatani, Masaharu Fukunaga, Abbas Agaimy
RATIONALE: Leiomyomas arising from the anterolateral abdominal wall are uncommon, and their pathogenesis remains unknown. We present the 15th case of such a tumor, having this unique tumor morphology, followed by a detailed discussion on disease pathogenesis. PATIENT CONCERNS: A 48-year-old, asymptomatic perimenopausal, multiparous Japanese woman presented with a left-sided pelvic mass. She had no history of previous surgeries or uterine leiomyomas. Although a transabdominal ultrasonogram raised suspicions of an ovarian tumor, a transvaginal ultrasonogram confirmed normal ovaries...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29304545/prenatal-diagnosis-of-congenital-diaphragmatic-hernia-does-laterality-predict-perinatal-outcomes
#11
Jeffrey D Sperling, Teresa N Sparks, Victoria K Berger, Jody A Farrell, Kristen Gosnell, Roberta L Keller, Mary E Norton, Juan M Gonzalez
OBJECTIVE:  The objective of this study was to examine laterality as a predictor of outcomes among fetuses with prenatally diagnosed congenital diaphragmatic hernia (CDH). METHODS:  This is a retrospective cohort study of pregnancies with CDH evaluated at our center from 2008 to 2016 compared cases with right-sided CDH (RCDH) versus left-sided CDH (LCDH). The primary outcome was survival to discharge. Secondary outcomes included ultrasound predictors of poor prognosis (liver herniation, stomach herniation, lung area-to-head circumference ratio [LHR]), concurrent anomalies, hydrops, stillbirth, preterm birth, mode of delivery, small for gestational age, use of extracorporeal membrane oxygenation, and length of stay...
January 5, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29301093/biomolecules-in-the-treatment-of-lichen-planus-refractory-to-corticosteroid-therapy-clinical-and-histopathological-assessment
#12
Laura Piñas, Mohammad Hamdan Alkhraisat, Ricardo Suárez Fernández, Eduardo Anitua
BACKGROUND: Local deficit of several biomolecules have been described in oral lichen planus (OLP). Such a deficit impairs cellular functions and cell-matrix communication. PURPOSE: Assess the efficacy of the local application of autologous biomolecules in the treatment of erosive OLP. MATERIALS AND METHODS: In this study, the use of plasma rich in growth factors (PRGF) as a source of blood-derived and autologous growth factors and proteins were tested in erosive oral lichen planus refractory to corticosteroids...
January 1, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29300242/klf1-e325k-associated-congenital-dyserythropoietic-anemia-type-iv-insights-into-the-variable-clinical-severity
#13
Yaddanapudi Ravindranath, Robert M Johnson, Gerard Goyette, Steven Buck, Manisha Gadgeel, Patrick G Gallagher
We identified a child with KLF1-E325K congenital dyserythropoietic anemia type IV who experienced a severe clinical course, fetal anemia, hydrops fetalis, and postnatal transfusion dependence only partially responsive to splenectomy. The child also had complete sex reversal, the cause which remains undetermined. To gain insights into our patient's severe hematologic phenotype, detailed analyses were performed. Erythrocytes from the patient and parents demonstrated functional abnormalities of the erythrocyte membrane, attributed to variants in the α-spectrin gene...
January 3, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29299506/longitudinal-up-regulation-of-endolymphatic-hydrops-in-patients-with-meniere-s-disease-during-medical-treatment
#14
Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda
Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29297200/utility-of-chromosomal-microarray-in-anomalous-fetuses
#15
Jacqueline G Parchem, Teresa N Sparks, Kristen Gosnell, Mary E Norton
OBJECTIVE: To determine the association of copy number variants (CNV) with perinatal outcomes among fetuses with sonographic abnormalities. METHODS: This was a retrospective cohort study of anomalous fetuses evaluated at a single fetal center, who underwent chromosomal microarray (CMA) testing. Pathogenic CNV or variants of uncertain significance (VUS) were classified as abnormal. The primary outcome of perinatal death was compared among fetuses with normal versus abnormal CMA...
January 3, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29291552/carvacrol-attenuates-histopathogic-and-functional-impairments-induced-by-bilateral-renal-ischemia-reperfusion-in-rats
#16
Hulya Ozturk, Ayhan Cetinkaya, Selma Erdogan Duzcu, Buket Kin Tekce, Hayrettin Ozturk
BACKGROUND: Renal ischemia/reperfusion injury is the most common cause of acute kidney injury, which frequent occurrence in critically ill patients. OBJECTIVES: The aim of this study was to investigate the role of Carvacrol (CARV) against bilateral ischemia reperfusion (I/R) in rats. METHODS: Renal I/R injury were induced by clamping of the left and right renal arteries for 45 min followed by 24 h of reperfusion. Thirty male Sprague-Dawley rats were randomly allocated to three groups (n = 10): the sham-control group, the renal I/R-untreated (I/R-untreated) group, and the I/R-CARV-treated group...
December 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29287037/correlations-between-the-degree-of-endolymphatic-hydrops-and-symptoms-and-audiological-test-results-in-patients-with-meni%C3%A3-re-s-disease-a-reevaluation
#17
Shiyin Yang, Huaming Zhu, Bijun Zhu, Hui Wang, Zhengnong Chen, Yaqin Wu, Bin Chen, Haibo Shi, Yuehua Li, Jing Zou, Shankai Yin
OBJECTIVE: This study was performed to reevaluate the diagnostic significance of clinically well-accepted audiological tests in indicating endolymphatic hydrops (EH) in Menière's disease (MD). STUDY DESIGN: Retrospective case review. SETTINGS: Hospital. PATIENTS: Fifty patients (52 affected ears) diagnosed with MD were enrolled. INTERVENTION: Diagnostic. MAIN OUTCOME MEASURE: To analyze the correlations between endolymphatic hydrops and results of audiological test including the pure-tone audiometry threshold, suprathreshold function tests, electrocochleogram, and glycerol test...
December 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29282702/treatment-of-dizziness-an-interdisciplinary-update
#18
Rainer Spiegel, Heiko Rust, Thomas Baumann, Hergen Friedrich, Raoul Sutter, Martina Göldlin, Christiane Rosin, René Müri, Georgios Mantokoudis, Roland Bingisser, Michael Strupp, Roger Kalla
This review provides an update on interdisciplinary treatment for dizziness. Dizziness can have various causes and the treatment offered should depend on the cause. After reading this article, the clinician will have an overview of current treatment recommendations. Recommendations are made for the most prevalent causes of dizziness including acute and chronic vestibular syndromes, vestibular neuritis, benign paroxysmal positional vertigo, endolymphatic hydrops and Menière's disease, vestibular paroxysmia and vestibular migraine, cardiac causes, transient ischaemic attacks and strokes, episodic ataxia type 2, persistent postural-perceptual dizziness, bilateral vestibulopathy, degenerative, autoimmune and neoplastic diseases, upbeat- and downbeat nystagmus...
December 28, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29279722/current-diagnostic-procedures-for-diagnosing-vertigo-and-dizziness
#19
REVIEW
Leif Erik Walther
Vertigo is a multisensory syndrome that otolaryngologists are confronted with every day. With regard to the complex functions of the sense of orientation, vertigo is considered today as a disorder of the sense of direction, a disturbed spatial perception of the body. Beside the frequent classical syndromes for which vertigo is the leading symptom (e.g. positional vertigo, vestibular neuritis, Menière's disease), vertigo may occur as main or accompanying symptom of a multitude of ENT-related diseases involving the inner ear...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29279721/recent-surgical-options-for-vestibular-vertigo
#20
REVIEW
Stefan Volkenstein, Stefan Dazert
Vertigo is not a well-defined disease but a symptom that can occur in heterogeneous entities diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine, and primary care physicians. Most vertigo syndromes have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for a subset of patients often the only remaining option. In this paper, we describe and discuss different surgical therapy options for hydropic inner ear diseases, Menière's disease, dehiscence syndromes, perilymph fistulas, and benign paroxysmal positional vertigo...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
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