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https://www.readbyqxmd.com/read/27905923/navigating-the-journey-of-aboriginal-childhood-disability-a-qualitative-study-of-carers-interface-with-services
#1
Anna Green, Penelope Abbott, Patricia Delaney, Patrick Patradoon-Ho, John Delaney, Patricia Mary Davidson, Michelle DiGiacomo
BACKGROUND: The disadvantage experienced by Aboriginal and Torres Strait Islander children with a disability is well recognized. The long term consequences of failing to address disability on health, education and employment underlies the importance of early intervention. Caregivers experience a disproportionate burden and have challenges accessing services. The aim of this study was to describe the carer journey of accessing support and services. METHODS: We conducted in-depth semi-structured interviews with nineteen parents and carers of Aboriginal children aged 0-8 years...
December 1, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27846404/local-release-of-dexamethasone-from-macroporous-scaffolds-accelerates-islet-transplant-engraftment-by-promotion-of-anti-inflammatory-m2-macrophages
#2
Kaiyuan Jiang, Jessica D Weaver, Yangjunyi Li, Xiongjian Chen, Jiapu Liang, Cherie L Stabler
Transplant-associated inflammatory responses generate an unfavorable microenvironment for tissue engraftment, particularly for cells susceptible to inflammatory stress, such as pancreatic islets. The localized delivery of anti-inflammatory agents, such as glucocorticoids, offers a promising approach to minimize the detrimental side effects associated with systemic delivery; however, the dosage must be carefully tailored to avoid deleterious responses, such as poor engraftment. Herein, we employed a polydimethylsiloxane (PDMS)-based three-dimensional scaffold platform for the local and controlled delivery of dexamethasone (Dex)...
November 5, 2016: Biomaterials
https://www.readbyqxmd.com/read/27836596/arm-microcontroller-based-portable-nitrite-electrochemical-analyzer-using-cytochrome-c-reductase-biofunctionalized-onto-screen-printed-carbon-electrode
#3
Paulraj Santharaman, Krishna Arun Venkatesh, Kanagavel Vairamani, Alby Robson Benjamin, Niroj K Sethy, Kalpana Bhargava, Chandran Karunakaran
Nitrite (NO2(-)) supplementation limits hypoxia-induced oxidative stress and activates the alternate NO pathway which may partially account for the nitrite-mediated cardioprotection. So, sensitive and selective biosensors with point-of-care devices need to be explored to detect the physiological nitrite level due to its important role in human pathophysiology. In this work, cytochrome c reductase (CcR) biofunctionalized self assembled monolayer (SAM) functionalized on gold nanoparticles (GNPs) in polypyrrole (PPy) nanocomposite onto the screen printed carbon electrode (SPCE) was investigated as a biosensor for the detection of nitrite based on its electrochemical and catalytic properties...
October 19, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27835971/the-use-of-cam-providers-and-psychiatric-outpatient-services-in-people-with-anxiety-depression-a-cross-sectional-survey
#4
Anne Helen Hansen, Agnete E Kristoffersen
BACKGROUND: Depression has been identified as one of the most frequent predictors of CAM use. However, limited data exist about the use of CAM providers among people with anxiety/depression in Norway. The aim of this study was to investigate the use of CAM providers, and the use of CAM providers and psychiatric outpatient services in combination, among people with self-reported anxiety and/or depression. METHODS: We used questionnaire data from 12,982 participants (30-87 years) in the cross-sectional sixth Tromsø Study (conducted in 2007-8)...
November 11, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27835791/the-role-of-pdgfr-%C3%AE-activation-in-acquired-resistance-to-igf-1r-blockade-in-preclinical-models-of-rhabdomyosarcoma
#5
Christine M Heske, Choh Yeung, Arnulfo Mendoza, Joshua T Baumgart, Leah D Edessa, Xiaolin Wan, Lee J Helman
To determine what alternative pathways may act as mechanisms of bypass resistance to type 1 insulin-like growth factor receptor (IGF-1R) blockade in rhabdomyosarcoma (RMS), we compared expression of receptor tyrosine kinase activity in a number of IGF-1R antibody-resistant and -sensitive RMS cell lines. We found that platelet-derived growth factor receptor β (PDGFR-β) activity was upregulated in three xenograft-derived IGF-1R antibody-resistant cell lines that arose from a highly sensitive fusion-positive RMS cell line (Rh41)...
November 8, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27809808/planning-ttfields-treatment-using-the-novotal-system-clinical-case-series-beyond-the-use-of-mri-contrast-enhancement
#6
Jennifer Connelly, Adília Hormigo, Nimish Mohilie, Jethro Hu, Aafia Chaudhry, Nicholas Blondin
BACKGROUND: Gliomas are the most common primary brain tumors in adults and invariably carry a poor prognosis. Recent clinical studies have demonstrated the safety and compelling survival benefit when tumor treating fields (TTFields) are added to temozolomide for patients with newly diagnosed glioblastoma. TTFields are low-intensity, intermediate frequency (200 kHz) alternating electric fields, delivered directly to a patient's brain through the local application of non-invasive transducer arrays...
November 4, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27799238/patient-engagement-with-infection-management-in-secondary-care-a-qualitative-investigation-of-current-experiences
#7
Timothy M Rawson, Luke S P Moore, Bernard Hernandez, Enrique Castro-Sanchez, Esmita Charani, Pantelis Georgiou, Raheelah Ahmad, Alison H Holmes
OBJECTIVE: To understand patient engagement with decision-making for infection management in secondary care and the consequences associated with current practices. DESIGN: A qualitative investigation using in-depth focus groups. PARTICIPANTS: Fourteen members of the public who had received antimicrobials from secondary care in the preceding 12 months in the UK were identified for recruitment. Ten agreed to participate. All participants had experience of infection management in secondary care pathways across a variety of South-East England healthcare institutes...
October 31, 2016: BMJ Open
https://www.readbyqxmd.com/read/27780583/development-of-an-evidence-based-decision-pathway-for-vestibular-schwannoma-treatment-options
#8
Faina Linkov, Benita Valappil, Jacob McAfee, Sharon L Goughnour, Douglas M Hildrew, Andrew A McCall, Igor Linkov, Barry Hirsch, Carl Snyderman
OBJECTIVE: To integrate multiple sources of clinical information with patient feedback to build evidence-based decision support model to facilitate treatment selection for patients suffering from vestibular schwannomas (VS). METHODS: This was a mixed methods study utilizing focus group and survey methodology to solicit feedback on factors important for making treatment decisions among patients. Two 90-minute focus groups were conducted by an experienced facilitator...
September 30, 2016: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/27779367/codeine-use-among-children-in-the-united-states-a-nationally-representative-study-from-1996-to-2013
#9
Margaret J Livingstone, Cornelius B Groenewald, Jennifer A Rabbitts, Tonya M Palermo
BACKGROUND: Concerns regarding the safety of codeine have been raised. Cases of life-threatening respiratory depression and death in children have been attributed to codeine's polymorphic metabolic pathway. International health agencies recommend restricted use of codeine in children. Despite these recommendations, the epidemiology of codeine use among children remains unknown. AIMS: Our objective was to examine patterns of codeine use in the US among children. METHODS: A cross-sectional analysis of children of age 0-17 years from 1996 to 2013 in the US was performed...
October 25, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27769850/integrated-exposure-and-risk-characterization-of-bisphenol-a-in-europe
#10
Dimosthenis A Sarigiannis, Spyros P Karakitsios, Evangelos Handakas, Konstantina Simou, Ermioni Solomou, Alberto Gotti
The current study aims at a comprehensive risk characterization of bisphenol A (BPA) supported by an integrated exposure modelling framework that comprises far field and near field exposure modelling coupled to a dynamic lifetime PBTK model. Exposure analysis was done on European data of BPA food residues and human biomonitoring (HBM). The latter were further assimilated through an advanced exposure reconstruction modelling framework to estimate the corresponding external and internal systemic dose of BPA and its metabolites...
October 18, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27767152/a-survey-of-undergraduate-orthodontic-teaching-and-factors-affecting-pursuit-of-postgraduate-training
#11
P Jauhar, P A Mossey, H Popat, J Seehra, P S Fleming
Background Undergraduate orthodontic teaching has been focused on developing an understanding of occlusal development in an effort to equip practitioners to make appropriate referrals for specialist-delivered care. However, there is a growing interest among general dentists in delivering more specialised treatments, including short-term orthodontic alignment. This study aimed to assess the levels of knowledge of occlusal problems among final year undergraduate dental students, as well as their interest in various orthodontics techniques and training...
October 21, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27764820/on-01910-na-rigosertib-inhibits-pi3k-akt-pathway-and-activates-oxidative-stress-signals-in-head-and-neck-cancer-cell-lines
#12
Anil Prasad, Nagina Khudaynazar, Ramana V Tantravahi, Amanda M Gillum, Benjamin S Hoffman
Squamous cell carcinoma of the head and neck (HNSCC) is characterized by high morbidity and mortality. Treatment failure, drug resistance and chemoradiation toxicity have necessitated the development of alternative treatment strategies. Styryl benzyl sulfones, a family of novel small molecule inhibitors, are being evaluated as anti-neoplastic agents in multiple clinical trials. The activity of these compounds has been well characterized in several preclinical tumor studies, but their activity has yet to be fully examined in HNSCC...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27755264/understanding-value-based-reimbursement-models-and-trends-in-orthopaedic-health-policy-an-introduction-to-the-medicare-access-and-chip-reauthorization-act-macra-of-2015
#13
Khaled J Saleh, William O Shaffer
In 2015, the US Congress passed legislation entitled the Medicare Access and CHIP [Children's Health Insurance Program] Reauthorization Act (MACRA), which led to the formation of two reimbursement paradigms: the merit-based incentive payment system (MIPS) and alternative payment models (APMs). The MACRA effectively repealed the Centers for Medicare and Medicaid Services (CMS) sustainable growth rate (SGR) formula while combining several CMS quality-reporting programs. As such, MACRA represents an unparalleled acceleration toward reimbursement models that recognize value rather than volume...
November 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27753862/br-02-2-hypertension-management-in-cancer-patients-undergoing-chemotherapy
#14
Naftali Stern
As both the rate of hypertension and cancer rise with age, concomitant hypertension in patients receiving treatment for cancer is very common. Increase in blood pressure during cancer treatment requires careful clinical assessment. Distinction between discontinuation or malabsorption of antihypertensive treatment due to factors such as nausea/vomiting/diarrhea and anti-cancer drug specific effects must be first made. De-novo hypertension during cancer treatment is likely related to anticancer drugs per se. Classical chemotherapeutic agents such as cyclophosphamide, cisplatin and busulfan have been previously linked to rising blood pressure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27717057/open-access-follow-up-care-for-early-breast-cancer-a-randomised-controlled-quality-of-life-analysis
#15
M N Kirshbaum, J Dent, J Stephenson, A E Topping, V Allinson, M McCoy, S Brayford
This study evaluated the acceptability of a supportive model of follow-up. One hundred and twelve women recovering from breast cancer were randomised to receive standard breast clinic aftercare (Control n = 56) or on demand by open access aftercare by breast care nurses (Intervention n = 56). Participants attended a support-based psycho-educational programme delivered in four half-day group sessions. Three quality of life questionnaires (EORTC QLQ-C30, QLQ-BR23, HADS) were administered at baseline and 6-monthly intervals for 2 years...
September 26, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27692839/survey-and-chart-review-to-estimate-medicare-cost-savings-for-home-health-as-an-alternative-to-hospital-admission-following-emergency-department-treatment
#16
Christopher Crowley, Amy R Stuck, Tracy Martinez, Alan C Wittgrove, Feng Zeng, Jesse J Brennan, Theodore C Chan, James P Killeen, Edward M Castillo
BACKGROUND: Almost 70% of hospital admissions for Medicare beneficiaries originate in the emergency department (ED). Research suggests that some of these patients' needs may be better met through home-based care options after evaluation and treatment in the ED. OBJECTIVE: We sought to estimate Medicare cost savings resulting from using the Home Health benefit to provide treatment, when appropriate, as an alternative to inpatient admission from the ED. METHODS: This is a prospective study of patients admitted from the ED...
December 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27676908/mobile-team-rehabilitation-rehabilitation-an-activity-outside-results-of-3-years-of-functioning-to-the-p%C3%A3-le-saint-helier
#17
Aurélie Duruflé, Claire Le-Meur, Marie-Pierre Reillon, Claire Lozach, Benoit Nicolas
Many mobile teams were created over the past decade in various medical specialties including physical medicine and rehabilitation (MPR). The Pôle Saint-Helier has created a mobile team of rehabilitation-reintegration (EM2R) in December 2012 with support from the Regional Health Agency of Brittany. It operates on the health territory No. 5 of Brittany near people experiencing neurological disability. Its main mission is to implement the necessary devices to facilitate the home return of people hospitalized after a neurological event or maintaining to home people with neurological disorders...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27643099/br-02-2-hypertension-management-in-cancer-patients-undergoing-chemotherapy
#18
Naftali Stern
As both the rate of hypertension and cancer rise with age, concomitant hypertension in patients receiving treatment for cancer is very common. Increase in blood pressure during cancer treatment requires careful clinical assessment. Distinction between discontinuation or malabsorption of antihypertensive treatment due to factors such as nausea/vomiting/diarrhea and anti-cancer drug specific effects must be first made. De-novo hypertension during cancer treatment is likely related to anticancer drugs per se. Classical chemotherapeutic agents such as cyclophosphamide, cisplatin and busulfan have been previously linked to rising blood pressure...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638495/education-night-splinting-and-exercise-versus-usual-care-on-recovery-and-conversion-to-surgery-for-people-awaiting-carpal-tunnel-surgery-a-protocol-for-a-randomised-controlled-trial
#19
Karina J Lewis, Leo Ross, Michel W Coppieters, Bill Vicenzino, Annina B Schmid
INTRODUCTION: Carpal tunnel syndrome (CTS) is a prevalent upper limb condition that results in significant individual and socioeconomic costs. Large patient numbers, long outpatient waiting times and traditional referral pathways in public health systems create delays in accessing treatment for this condition. Alternative care pathways aimed at streamlining access to treatment and reducing the need for surgical intervention warrant further investigation. METHODS: A randomised, single-blind controlled clinical trial will be conducted...
2016: BMJ Open
https://www.readbyqxmd.com/read/27635622/evaluating-candidacy-for-hypofractionated-radiation-therapy-accelerated-partial-breast-irradiation-and-endocrine-therapy-after-breast-conserving-surgery-a-surveillance-epidemiology-and-end-results-seer-analysis
#20
Bindu V Manyam, Rahul Tendulkar, Sheen Cherian, Frank Vicini, Shahed N Badiyan, Chirag Shah
PURPOSE/OBJECTIVE(S): After breast conserving surgery, adjuvant radiation therapy represents the standard of care for most patients. However, multiple options exist beyond standard fractionated whole breast irradiation including hypofractionated whole breast irradiation (HFRT), accelerated partial breast irradiation (APBI), and endocrine therapy (ET) alone, which can limit treatment duration, and potentially reduce morbidity and cost. Limited data are available on the percentage of patients eligible for these alternatives; therefore, a Surveillance Epidemiology and End Results (SEER) analysis was performed to assess candidacy for these alternative options in women with early stage breast cancer...
September 15, 2016: American Journal of Clinical Oncology
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