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https://www.readbyqxmd.com/read/29657587/impact-of-ranolazine-on-ventricular-arrhythmias-a-systematic-review
#1
REVIEW
George Bazoukis, Gary Tse, Konstantinos P Letsas, Costas Thomopoulos, Katerina K Naka, Panagiotis Korantzopoulos, Xenophon Bazoukis, Paschalia Michelongona, Stamatis S Papadatos, Konstantinos Vlachos, Tong Liu, Michael Efremidis, Adrian Baranchuk, Stavros Stavrakis, Costas Tsioufis
Ranolazine is a new medication for the treatment of refractory angina. However, except its anti-anginal properties, it has been found to act as an anti-arrhythmic. The aim of our systematic review is to present the existing data about the impact of ranolazine in ventricular arrhythmias. We searched MEDLINE and Cochrane databases as well clinicaltrials.gov until September 1, 2017 to find all studies (clinical trials, observational studies, case reports/series) reported data about the impact of ranolazine in ventricular arrhythmias...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29643701/higher-ventricular-premature-complex-burden-is-associated-with-lower-systolic-blood-pressure-response
#2
Jing-Wei Kang, Wei-Hsiang Yang, Jia-En Chi, Wei-Ta Chen
Background: Ventricular premature complexes (VPCs) with a burden higher than 10% to 20% of total daily heart beats can cause VPC-induced cardiomyopathy. The systolic blood pressure response (SBPR) is the difference between the SBP during maximal exercise and rest. A low SBPR was recently identified to be a marker of cardiomyopathy. The aim of this manuscript was to clarify the association between VPC burden and SBPR. Methods: From January to December 2015, all patients with a VPC burden larger than 240 beats/day on Holter recordings and treadmill exercise tests were enrolled...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29630122/analysis-of-the-correlation-between-the-neutrophil-lymphocyte-ratio-in-peripheral-blood-and-perioperative-myocardial-damage-in-pediatric-patients-with-frequent-ventricular-premature-beat
#3
J Tian, X-J An, L Niu
OBJECTIVE: The objective of the present study was to investigate the relationship between the neutrophil-lymphocyte ratio (NLR) in peripheral blood and myocardial damage in pediatric patients with frequent ventricular premature beat (FVPB), and provide a reference for myocardial preservation in these patients. PATIENTS AND METHODS: A total of 212 pediatric patients who were treated in the Department of Cardiology, Xuzhou Children's Hospital between December 2014 and March 2016 for FVPB, were selected...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628472/hcn4-overexpressing-mouse-embryonic-stem-cell-derived-cardiomyocytes-generate-a-new-rapid-rhythm-in-rats-with-bradycardia
#4
Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F Kusano, Hiroshi Ito
A biological pacemaker is expected to solve the persisting problems of an artificial cardiac pacemaker including short battery life, lead breaks, infection, and electromagnetic interference. We previously reported HCN4 overexpression enhances pacemaking ability of mouse embryonic stem cell-derived cardiomyocytes (mESC-CMs) in vitro. However, the effect of these cells on bradycardia in vivo has remained unclear. Therefore, we transplanted HCN4-overexpressing mESC-CMs into bradycardia model animals and investigated whether they could function as a biological pacemaker...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29622988/outflow-tract-ventricular-premature-beats-ablation-in-the-presence-or-absence-of-structural-heart-disease-technical-considerations-and-clinical-outcomes
#5
Haitham Badran, Rania Samir, Mohamed Amin
Background: Premature ventricular beats (PVBs) are early depolarization of the myocardium originating in the ventricle. In case of very frequent PVBs, patients are severely symptomatic with impaired quality of life and are at risk of pre-syncope, syncope, heart failure, and sudden cardiac death particularly in the presence of structural heart disease. Ventricular outflow tracts are the most common sites of origin of idiopathic PVBs especially in patients without structural heart disease...
December 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29614430/a-novel-wavelet-sequences-based-on-deep-bidirectional-lstm-network-model-for-ecg-signal-classification
#6
Özal Yildirim
Long-short term memory networks (LSTMs), which have recently emerged in sequential data analysis, are the most widely used type of recurrent neural networks (RNNs) architecture. Progress on the topic of deep learning includes successful adaptations of deep versions of these architectures. In this study, a new model for deep bidirectional LSTM network-based wavelet sequences called DBLSTM-WS was proposed for classifying electrocardiogram (ECG) signals. For this purpose, a new wavelet-based layer is implemented to generate ECG signal sequences...
March 28, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29610596/catecholaminergic-polymorphic-ventricular-tachycardia-looking-to-the-future
#7
Andreea Elena Velcea, Calin Siliste, Dragos Vinereanu
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inheritable cardiac disorder, characterized by polymorphic ventricular tachycardia (PVT) or bidirectional ventricular tachycardia, triggered by adrenergic stress, and manifested most frequently as syncope or sudden cardiac death. The disease has a heterogeneous genetic basis, with mutations in the genes encoding the ryanodine and calsequestrin channels accounting for the majority of cases. The diagnosis of CPVT is established in individuals with polymorphic ventricular premature beats, PVT or bidirectional ventricular tachycardia documented during exercise or adrenergic stress, who have a structurally normal heart and normal resting ECG...
December 2017: Mædica
https://www.readbyqxmd.com/read/29581710/electrocardiographic-measures-of-repolarization-dispersion-and-their-relationships-with-echocardiographic-indices-of-ventricular-remodeling-and-premature-ventricular-beats-in-hypertension
#8
Ana Ciobanu, Gary Tse, Tong Liu, Maria V Deaconu, Gabriela S Gheorghe, Adriana M Ilieşiu, Ioan T Nanea
Objective: To examine the relationship between Tpeak - Tend interval (Tpe) and Tpe/QT ratio with occurrence of ventricular premature beats (VPBs) and left ventricular remodeling in hypertension. Methods: A total of 52 patients with mild to moderate essential hypertension were included, undergoing echocardiography and 24-hours Holter monitoring. Ventricular remodeling was assessed by left ventricular mass index (LVMI) using the Devereux formula and diastolic function by transmitral E and A wave velocities and E/A ratio...
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29515227/structured-inpatient-evaluation-of-neonatal-cardiac-ectopy
#9
Irene A Hurst, Gregory Webster, Kerri Z Machut, Nina Gotteiner, Ahmad Sami Chaouki, Elizabeth N Groothuis, Karna Murthy
OBJECTIVE(S): In well-appearing newborns with suspected cardiac ectopy, we sought to evaluate our practice and test whether initial electrocardiogram (ECG) findings were associated with neonatal arrhythmias (NA). STUDY DESIGN: We identified well-appearing, non-anomalous infants >34 weeks' gestation with suspected ectopy over 3.5 years. NA was defined as ≥10% premature atrial contractions (PAC), ≥5 beats of atrial tachycardia, ≥2% premature ventricular contractions (PVCs), or ≥3 beats of ventricular tachycardia...
March 7, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29505006/clinically-suspected-anaphylaxis-induced-by-sugammadex-in-a-patient-with-weaver-syndrome-undergoing-restrictive-mammoplasty-surgery-a-case-report-with-the-literature-review
#10
REVIEW
Nurdan Bedirli, Berrin Işık, Mehrnoosh Bashiri, Kutluk Pampal, Ömer Kurtipek
RATIONALE: Sugammadex is a cylodextrin derivate that encapsulates steroidal neuromuscular blocker agents and is reported as a safe and well-tolerated drug. In this case report, we present a patient who developed grade 3 anaphylaxis just after sugammadex administration. PATIENT CONCERNS: A 22-year-old woman with diagnosis of Weaver syndrome was scheduled for bilateral mammoplasty and resection of unilateral accessory breast tissue resection. Anesthesia was induced and maintained by propofol, rocuronium, and remifentanil...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29483798/electrocardiographic-changes-in-children-with-diabetic-ketoacidosis-and-ketosis
#11
Deniz Aygün, Fatih Aygün, Kemal Nişli, Firdevs Baş, Agop Çıtak
Aim: We aimed to study electrocardiographic changes in children with diabetic ketoacidosis and ketosis and to evaluate the relation of the changes with serum electrolyte levels and ketosis. Material and Methods: This study was performed in Istanbul Medical Faculty, Pediatric Emergency and Intensive Care Department between May 2008 and May 2009. The electrocardiographic parameters and QT length of children with diabetic ketoacidosis and ketosis were evaluated at diagnosis and after the treatment...
December 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29463140/premature-ventricular-beats-in-the-athlete-management-considerations
#12
Tamanna K Singh, Aaron L Baggish
Premature ventricular beats (PVBs) in competitive athletes are incidentally found during pre-participation ECG screening. Their clinical significance remains debatable with several studies suggesting they are a benign reflection of athlete's heart, and others proposing they may indicate underlying structural heart disease and heightened risk for sudden cardiac death (SCD). Areas covered: Effective management of athletes with PVBs may best be accomplished using an algorithmic approach for risk stratification with a goal of differentiating benign PVBs from those reflective of underlying cardiomyopathies...
February 23, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29454476/frequency-of-electrocardiographic-abnormalities-in-patients-with-psoriasis
#13
Peter Riis Hansen, Christian Rimer Juhl, Jonas Lynggaard Isaksen, Gregor Borut Jemec, Christina Ellervik, Jørgen Kim Kanters
Psoriasis is a chronic inflammatory disease associated with cardiovascular disease, for example, myocardial infarction, stroke, cardiovascular death, and arrhythmias. The resting electrocardiogram may carry prognostic information, but limited evidence is available of electrocardiographic findings in subjects with psoriasis. The electrocardiographic results were compared between 1,131 subjects with self-reported psoriasis and 18,397 controls participating in the Danish General Suburban Population Study (GESUS)...
January 31, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29390373/ozone-therapy-induced-sinus-arrest-in-a-hypertensive-patient-with-chronic-kidney-disease-a-case-report
#14
Wen-Juan Tang, Long Jiang, Ying Wang, Ze-Min Kuang
RATIONALE: Ozone autohemotherapy as an alternative treatment method has been applied to the treatment of several diseases. Here, we report a patient used ozone autohemotherapy to treat her hypertension and diabetes. Nevertheless, the patient occurred sudden dizziness and black haze due to hyperkalemia. PATIENT CONCERNS: A 54-year-old woman who was admitted to our emergency department complaining of sudden dizziness and black haze for 5 hours. DIAGNOSES: The blood potassium test showed hyperkalemia...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377142/mechanisms-linking-t-wave-alternans-to-spontaneous-initiation-of-ventricular-arrhythmias-in-rabbit-models-of-long-qt-syndrome
#15
Weiqing Liu, Tae Yun Kim, Xiaodong Huang, Michael B Liu, Gideon Koren, Bum-Rak Choi, Zhilin Qu
T-wave alternans (TWA) and irregular beat-to-beat T-wave variability or T-wave lability (TWL), the ECG manifestations of action potential duration (APD) alternans and variability, are precursors of ventricular arrhythmias in long QT syndromes. TWA and TWL in patients tend to occur at normal heart rates and are usually potentiated by bradycardia. Whether or how TWA and TWL at normal or slow heart rates are causally linked to arrhythmogenesis remains unknown. In this study, we used computer simulations and experiments of a transgenic rabbit model of long QT syndrome to investigate the underlying mechanisms...
January 29, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29310559/arrhythmias-in-children-in-early-postoperative-period-after-cardiac-surgery
#16
Manoj Kumar Sahu, Anupam Das, Bharat Siddharth, Sachin Talwar, Sarvesh Pal Singh, Atul Abraham, Arin Choudhury
BACKGROUND: Postoperative arrhythmias are a known complication after cardiac surgical repairs for congenital heart disease. METHODS: Data were reviewed pertaining to incidence, diagnosis, potential risk factors, and management of postoperative arrhythmias in 369 consecutive patients under 18 years of age, undergoing elective open heart surgery. All children were admitted to the intensive care unit and continuous electrocardiographic monitoring was performed. Patient factors such as Aristotle Basic Complexity Score, total surgical duration, hypotension, tachycardia, serum lactate level, and inotropic score were analyzed...
January 2018: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29289261/r-wave-peak-time-at-lead-ii-in-adults-with-ventricular-premature-beats-bundle-branch-block-and-left-anterior-fascicular-block
#17
Min Yu, Tingting Chen, Shuang Hu, Shan Zou, Cantian Wang, Chujuan Zeng, Weijie Chen, Xuerui Tan
BACKGROUND: Recently, the R-wave peak time (RWPT) at lead II was reported to be a helpful and simple tool for differentiating wide QRS complex tachycardias with a RWPT ≥ 50ms for ventricular tachycardia diagnosis. Our previous study showed that the duration of RWPT at lead II in adults was ≈29ms. However, the effects of ventricular premature beats (VPBs), bundle branch block (BBB) or left anterior fascicular block (LAFB) on RWPT at lead II remain unknown. METHODS: The study was conducted in the First Affiliated Hospital of Shantou University Medical College in Southern China...
January 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29229403/detection-of-ventricular-premature-beats-based-on-the-pressure-signals-of-a-hemodialysis-machine
#18
Mattias Holmer, Juan Pablo Martínez, Eduardo Gil, Frida Sandberg, Bo Olde, Leif Sörnmo
Monitoring of ventricular premature beats (VPBs), being abundant in hemodialysis patients, can provide information on cardiovascular instability and electrolyte imbalance. In this paper, we describe a method for VPB detection which explores the signals acquired from the arterial and the venous pressure sensors, located in the extracorporeal blood circuit of a hemodialysis machine. The pressure signals are mainly composed of a pump component and a cardiac component. The cardiac component, severely overshadowed by the pump component, is estimated from the pressure signals using an earlier described iterative method...
January 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29226896/recovery-of-cardiomyopathy-induced-by-ventricular-premature-beats-of-parahisian-origin-after-successful-radiofrequency-catheter-ablation
#19
Gökhan Aksan, Ali Elitok, Mehmet Tezcan, Ahmet Kaya Bilge, Kamil Adalet
A 51-year-old male patient presented with frequent and symptomatic premature ventricular complexes (PVCs) that had induced cardiomyopathy. Radiofrequency (RF) catheter ablation of the origin of the PVCs was planned and the patient underwent electrophysiological study. During activation mapping, the earliest ventricular activation was identified at the His bundle region. Small His bundle electrogram recording by the distal ablation electrode during sinus rhythm revealed that the earliest ventricular activation during PVC preceded the QRS onset by 58 milliseconds...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29145270/study-on-the-adverse-effects-following-chemotherapy-for-breast-cancer-diagnosis-during-pregnancy-the-first-case-report-in-china
#20
Xin Ye, Qi He, Xiaoyun Zhou
RATIONALE: Treatment of breast cancer during pregnancy (BCP) remains a challenge to physicians. Surgery and chemotherapy during pregnancy are widely used for the treatment of BCP. Herein, we reported 3 Chinese patients with BCP who underwent chemotherapy during pregnancy and were followed up for adverse effects. PATIENT CONCERNS: Three female patients (case 1, case 2, and case 3) of 37-, 32-, and 28-year-old with breast masses were enrolled. Case 1 had been pregnant for over 4 months, case 2 over 7 months, and case 3 for 7 months...
November 2017: Medicine (Baltimore)
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