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knee joint space width in osteoarthritis

Sophie C Warner, Ana M Valdes
PURPOSE OF REVIEW: Osteoarthritis is a common complex disorder with a strong genetic component. Other identified risk factors such as increasing age and overweight do not fully explain the risk of osteoarthritis. Here, we highlight the main findings from genetic association studies on osteoarthritis to date. RECENT FINDINGS: Currently, genetic association studies have identified 21 independent susceptibility loci for osteoarthritis. Studies have focused on hip, knee and hand osteoarthritis, as well as posttotal joint replacement and minimum joint space width, a proxy for cartilage thickness...
October 17, 2016: Current Opinion in Rheumatology
Daigo Komatsu, Yukiharu Hasegawa, Toshihisa Kojima, Taisuke Seki, Yoshitoshi Higuchi, Naoki Ishiguro
OBJECTIVES: Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS: We conducted a retrospective study of 1050 individuals (424 males; 626 females; mean age 64.9 years) who underwent knee radiography as part of a health screening program, between 2011 and 2013. mJSW and tibial osteophyte area (OF) were quantified using automated software...
October 14, 2016: Modern Rheumatology
Jatupon Kongtharvonskul, Patarawan Woratanarat, Mark McEvoy, John Attia, Siwadol Wongsak, Viroj Kawinwonggowit, Ammarin Thakkinstian
BACKGROUND: Patented crystalline glucosamine sulfate (pCGS) and diacerein monotherapy have been recommended for treatment of mild to moderate osteoarthritis (OA), but evidence of efficacy for combined treatments is lacking. Therefore, the aim of this study was to compare clinical outcomes (i.e., pain and Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] score) at 6 months as well as the safety profile of treatment with combined pCGS and diacerein versus pCGS alone...
October 12, 2016: Arthritis Research & Therapy
Felix Eckstein, Robert Buck, Wolfgang Wirth
OBJECTIVE: The metric accepted by regulatory bodies for determining structural progression in clinical trials of knee osteoarthritis (OA) remains change in radiographic joint space width in the medial femorotibial compartment. However, magnetic resonance imaging has revealed that cartilage loss is spatially heterogeneous, and that it is enigmatic which knee will lose cartilage at which location. Whereas previous reviews have focused on imaging in general, the purpose of this particular perspective is to highlight availability and applications of location-independent analysis methodology in measuring structural progression in epidemiological and interventional clinical trials, and to highlight its specific advantages over existing methodologies...
August 26, 2016: Seminars in Arthritis and Rheumatism
Mehmet E Tezcan, Berna Goker, Roy Lidtke, Joel A Block
BACKGROUND: Lateral wedge insoles have been used for the treatment of medial knee osteoarthritis (OA) and have been shown to reduce loading of the medial compartment of the knee. However, as the entire lower extremity acts as a single kinetic chain, altering the biomechanics of the knee may also have significant effects at the ankles or hips. We aimed to evaluate the effects of lateral wedge orthotics on ankle and hip joints, compared to neutral orthotics, by assessing the changes in joint space width (JSW) during 36 months of continuous use...
September 21, 2016: Gait & Posture
P Pinsornsak, K Naratrikun, S Kanitnate, T Sangkomkamhang
OBJECTIVES: The purpose of this study was to compare the joint space width between one-leg and both-legs standing radiographs in order to diagnose a primary osteoarthritis of the knee. METHODS: Digital radiographs of 100 medial osteoarthritic knees in 50 patients were performed. The patients had undergone one-leg standing anteroposterior (AP) views by standing on the affected leg while a both-legs standing AP view was undertaken while standing on both legs. The severity of the osteoarthritis was evaluated using the joint space width and Kellgren-Lawrence (KL) radiographic classification...
September 2016: Bone & Joint Research
Jing Wu, Mohamed R Mahfouz
Extraction of bone contours from x-ray radiographs plays an important role in joint space width assessment, preoperative planning, and kinematics analysis. We present a robust segmentation method to accurately extract the distal femur and proximal tibia in knee radiographs of varying image quality. A spectral clustering method based on the eigensolution of an affinity matrix is utilized for x-ray image denoising. An active shape model-based segmentation method is employed for robust and accurate segmentation of the denoised x-ray images...
July 2016: Journal of Medical Imaging
José M Lamo-Espinosa, Gonzalo Mora, Juan F Blanco, Froilán Granero-Moltó, Jorge M Nuñez-Córdoba, Carmen Sánchez-Echenique, José M Bondía, Jesús Dámaso Aquerreta, Enrique J Andreu, Enrique Ornilla, Eva M Villarón, Andrés Valentí-Azcárate, Fermín Sánchez-Guijo, María Consuelo Del Cañizo, Juan Ramón Valentí-Nin, Felipe Prósper
BACKGROUND: Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchymal stromal cells (BM-MSCs) in combination with hyaluronic acid in a randomized clinical trial. MATERIALS: A phase I/II multicenter randomized clinical trial with active control was conducted. Thirty patients diagnosed with knee OA were randomly assigned to intraarticularly administered hyaluronic acid alone (control), or together with 10 × 10(6) or 100 × 10(6) cultured autologous BM-MSCs, and followed up for 12 months...
August 26, 2016: Journal of Translational Medicine
J A D van der Woude, P M Welsing, P M van Roermund, R J H Custers, N O Kuchuk, F P J G G Lafeber
BACKGROUND: For young patients (<65years), knee joint distraction (KJD) may be a joint-saving treatment option for end-stage knee osteoarthritis. Distracting the femur from the tibia by five millimeters for six to eight weeks using an external fixation frame results in cartilaginous tissue repair, in addition to clinical benefits. This study is a first attempt to predict the degree of cartilaginous tissue repair after KJD. METHODS: Fifty-seven consecutive patients received KJD...
October 2016: Knee
Neil A Segal, Eric Frick, Jeffrey Duryea, Michael C Nevitt, Jingbo Niu, James C Torner, David T Felson, Donald D Anderson
The objective of this project was to determine the relationship between medial tibiofemoral joint space width measured on fixed-flexion radiographs and the three-dimensional joint space width distribution on low-dose, standing CT (SCT) imaging. At the 84-month visit of the Multicenter Osteoarthritis Study, 20 participants were recruited. A commercial SCT scanner for the foot and ankle was modified to image knees while standing. Medial tibiofemoral joint space width was assessed on radiographs at fixed locations from 15-30% of compartment width using validated software and on SCT by mapping the distances between three-dimensional subchondral bone surfaces...
August 9, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
E A van IJsseldijk, E R Valstar, B C Stoel, R G H H Nelissen, N Baka, R Van't Klooster, B L Kaptein
OBJECTIVES: An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum joint space width (mJSW). This requires accurate alignment of the x-ray beam with the tibial plateau, which may not be accomplished in practice. We investigate the feasibility of a new mJSW measurement method from stereo radiographs using 3D statistical shape models (SSM) and evaluate its sensitivity to changes in the mJSW and its robustness to variations in patient positioning and bone geometry...
August 2016: Bone & Joint Research
M R Huizinga, J Gorter, A Demmer, S M A Bierma-Zeinstra, R W Brouwer
PURPOSE: The primary purpose of this study is to investigate the progression of medial osteoarthritis (OA) following lateral closing-wedge high tibial osteotomy (HTO). Secondary outcomes included functional and pain scores. METHODS: This prospective cohort study analysed 298 patients treated with lateral closing-wedge HTO surgery for medial compartmental OA. OA progression was measured by comparing the minimum joint space width (mJSW) and Kellgren-Lawrence (KL) score on radiographs preoperatively and postoperatively...
July 7, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Daigo Komatsu, Kazuma Ikeuchi, Toshihisa Kojima, Yasuhiko Takegami, Takafumi Amano, Masaki Tsuboi, Naoki Ishiguro, Yukiharu Hasegawa
There are few reports of the laterality in radiological knee osteoarthritis (ROA). This study aimed to evaluate laterality in terms of the minimum joint space width (mJSW) and osteophyte areas (OFs) in a cross-sectorial general population screen and elucidate the association between laterality and risk of osteoarthritis. We enrolled 330 participants (mean age 64.6 years) and examined the presence of ROA (Kellgren-Lawrence grade ≧ 2) laterality in terms of the mJSW and OF on the medial tibia using auto-measuring software...
June 27, 2016: Laterality
Virginia Byers Kraus, Jamie E Collins, David Hargrove, Elena Losina, Michael Nevitt, Jeffrey N Katz, Susanne X Wang, Linda J Sandell, Steven C Hoffmann, David J Hunter
OBJECTIVE: To investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression. METHODS: Eighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases (n=194) from the OA initiative cohort with knee OA and radiographic and persistent pain worsening from 24 to 48 M and controls (n=406) not meeting both end point criteria. Primary analyses used multivariable regression models to evaluate the association between biomarkers (baseline and time-integrated concentrations (TICs) over 12 and 24 M, transposed to z values) and case status, adjusted for age, sex, body mass index, race, baseline radiographic joint space width, Kellgren-Lawrence grade, pain and pain medication use...
June 13, 2016: Annals of the Rheumatic Diseases
Bing Lu, Jeffrey B Driban, Chang Xu, Kate L Lapane, Timothy E McAlindon, Charles B Eaton
OBJECTIVES: Few studies have investigated the role of dietary factors on knee osteoarthritis (OA) progression. We examined the prospective association of dietary fat intake with radiographic progression of knee OA. METHODS: In the Osteoarthritis Initiative, 2092 participants with radiographic knee OA and having baseline dietary data were followed at yearly intervals up to 48 months. Dietary intakes of fatty acids were assessed with the Block Brief Food Frequency Questionnaire...
June 6, 2016: Arthritis Care & Research
J A D van der Woude, R J van Heerwaarden, S Spruijt, F Eckstein, S Maschek, P M van Roermund, R J H Custers, W E van Spil, S C Mastbergen, F P J G Lafeber
BACKGROUND: Knee joint distraction (KJD) is a surgical joint-preserving treatment in which the knee joint is temporarily distracted by an external frame. It is associated with joint tissue repair and clinical improvement. Initially, patients were submitted to an eight-week distraction period, and currently patients are submitted to a six-week distraction period. This study evaluates whether a shorter distraction period influences the outcome. METHODS: Both groups consisted of 20 patients...
October 2016: Knee
Matthew R Akelman, Paul D Fadale, Michael J Hulstyn, Robert M Shalvoy, Arlene Garcia, Kaitlyn E Chin, Jeffrey Duryea, Gary J Badger, Glenn A Tung, Braden C Fleming
BACKGROUND: The "initial graft tension" applied at the time of graft fixation during anterior cruciate ligament (ACL) reconstruction surgery modulates joint contact mechanics, which in turn may promote posttraumatic osteoarthritis (OA). PURPOSE/HYPOTHESES: The study objectives were to compare clinical, functional, patient-reported, and OA imaging outcomes between 2 different initial laxity-based graft tension cohorts and a matched uninjured control group as well as to evaluate the effects of laxity-based graft tension on OA development at 84-month follow-up...
July 2016: American Journal of Sports Medicine
Hideyuki Koga, Takeshi Muneta, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Yusuke Nakagawa, Ichiro Sekiya
PURPOSE: To evaluate clinical and radiographic outcomes of arthroscopic centralization for lateral meniscal extrusion. METHODS: Twenty-one patients who underwent arthroscopic centralization of the lateral meniscus were included. In cases with an extruded lateral meniscus (9 patients) or discoid meniscus (12 patients), the capsule at the margin between the midbody of the lateral meniscus and the capsule was sutured to the lateral edge of the lateral tibial plateau and centralized using suture anchors to reduce or prevent meniscal extrusion...
April 29, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
J A D van der Woude, K Wiegant, R J van Heerwaarden, S Spruijt, P M van Roermund, R J H Custers, S C Mastbergen, F P J G Lafeber
PURPOSE: Both, knee joint distraction as a relatively new approach and valgus-producing opening-wedge high tibial osteotomy (HTO), are knee-preserving treatments for knee osteoarthritis (OA). The efficacy of knee joint distraction compared to HTO has not been reported. METHODS: Sixty-nine patients with medial knee joint OA with a varus axis deviation of <10° were randomized to either knee joint distraction (n = 23) or HTO (n = 46). Questionnaires were assessed at baseline and 3, 6, and 12 months...
April 22, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Esther Weber, Daniel Theisen, Philippe Wilmes, Jacques Menetrey, Christophe Hulet, Romain Seil
PURPOSE: Common radiologic scores to evaluate knee osteoarthritis (OA) have been widely used but are descriptive and may lack objectivity. The aim of this study was to develop a quantitative and objective radiologic measure for the evaluation of lateral knee compartment OA. Furthermore, we tested the reliability of this new measure and its correlation to well-accepted radiologic scores. METHODS: This retrospective study was performed within the context of a multi-centre long-term follow-up (15-25 years) of a patient cohort after partial or total lateral meniscectomy (n = 36 knees)...
May 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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