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JOURNAL ARTICLE
Rania Bakr, Islam Helmy, Nadia Elkanzi
In order to develop novel antimicrobial agents, we prepared quinoline bearing pyrimidine analogues 2-7, 8a-d and 9a-d and their structures were elucidated by spectroscopic techniques. Furthermore, our second aim was to predict the interactions between the active compounds and enzymes (DNA gyrase and DHFR). In this work, fourteen pyrimido[4,5-b]quinoline derivatives were prepared and assessed for their antimicrobial potential by estimating zone of inhibition. All the screened candidates displayed antibacterial potential with zone of inhibition range of 9-24 mm compared with ampicillin (20-25 mm) as a reference drug...
April 3, 2024: Chemistry & Biodiversity
#22
JOURNAL ARTICLE
Panagiotis S Kousiouris, Maria Kantzanou, Maria Dantsiou, Amalia Drosopoulou, Konstantinos Rallis, Dimitrios Papakonstantinou, Marilita M Moschos
Background Corneal diseases are the fourth most common cause of blindness worldwide. In the majority of these diseases, vision reduction is reversible and can be restored to a large extent by replacing the cornea through specific surgery and, in particular, transplantation. In Greece, due to a lack of organized eye banks as well as donors, the grafts intended for corneal transplantation usually come from eye banks abroad. This study focuses on the dynamics of cost versus value in the decision-making process for the procurement of corneal grafts, ultimately investigating the safety that the procured grafts provide to patients...
March 2024: Curēus
#23
JOURNAL ARTICLE
Anchal Kumar Jain, Yamini Gupta, Jagram Verma, Surbhi Godha, Indra Prakash Prajapati
Mucormycosis is an aggressive, fatal fungal infection. The fungal organisms are ubiquitous and easily affect immunocompromised patients. The main aim of this article is to emphasize over the knowledge of different diagnostic methods (diagnostic nasal endoscopy, ct/ contrast mri pns + orbit + brain, Wet KOH mount), the importance of practising an aggressive surgical resection, medical treatments (liposomal amphotericin B, amphotericin gel, tablet posaconazole, nasal douching, retrorbital amphotericin injection), suction cleaning and regular follow up of the patient after surgical management...
April 2024: Indian Journal of Otolaryngology and Head and Neck Surgery
#24
JOURNAL ARTICLE
Lu Cao, Junfeng Tan, Zengguang Zhang, Bin Lin, Yu Mu, Mingguo Jiang, Yi Jiang, Xueshi Huang, Li Han
Thirty-five norsesquiterpenoids were isolated from the fermentation broth of Streptomyces microflavus from the forest soil of Ailaoshan in China. The structures of new compounds ( 1 - 5 , 10 - 26 ) were elucidated by comprehensive spectroscopic analysis including data from experimental and calculated ECD spectra, as well as Mosher's reagent derivatives method. Norsesquiterpenoids showed different levels of antifungal activity with MIC80 values ranging from 25 to 200 μg/mL against Candida albicans , Candida parapsilosis , and Cryptococcus neoformans ...
April 2, 2024: Journal of Agricultural and Food Chemistry
#25
JOURNAL ARTICLE
Thayna Souza, Erica Mello, Gabriel B Taveira, Felipe Moreira, Sérgio Henrique Seabra, André O Carvalho, Valdirene M Gomes
The objective of this work was to evaluate the combination of synthetic peptides based on the γ-core motif of defensin PvD1 with amphotericin B (AmB) at different concentrations against C. albicans. We applied the checkerboard assay using different concentrations of the commercial drug AmB and the synthetic peptides γ31-45PvD1++ and γ33-41PvD1++ against C. albicans, aiming to find combinations with synergistic interactions. Between these two interactions involving γ31-45PvD1++ and AmB, an additive effect was observed...
April 2, 2024: Bioscience Reports
#26
REVIEW
Sunita Panda, Mahesh Chandra Sahu, Jyotirmayee Turuk, Sanghamitra Pati
Mucormycosis is the third most frequent invasive mycosis, following candidiasis and aspergillosis. It is frequently neglected due to its rare occurrence; but recently attend the status of notifiable disease due to its higher incidence in both developed and developing nations. India has received global notice since its estimated instances were greater than the global estimated figures. Mucormycosis has several clinical manifestations, including rhino-orbital-cerebral (ROCM), pulmonary, gastrointestinal, cutaneous, renal, and diffuse Mucormycosis...
April 1, 2024: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
#27
Abdisalam Abdullahi Yusuf, Ismail Gedi Ibrahim, Ibrahim Mohamed Hirsi, Ali Adali, Yonis Yusuf Hassan, Mehmet Zeki Yasar, Ismail Mohamoud Abdullahi, Mohamed Sheikh Hassan
Mucormycosis is a potentially fatal condition with a high mortality rate, particularly when there is extra nasal involvement, and it is rare for patients with fungal brain disease to survive. It mostly affects patients who are metabolically or immunologically compromised, which constitutes one of the three classical stages of the progression of Rhino-Orbito-Cerebral Mucormycosis (ROCM). Stage I: infection of the nasal mucosa and paranasal sinuses; Stage II: orbital involvement; Stage III: cerebral involvement...
2024: International Medical Case Reports Journal
#28
JOURNAL ARTICLE
Rizwan Suliankatchi Abdulkader, Manickam Ponnaiah, Tarun Bhatnagar, Devika S, Amanda G A Rozario, Gayathri K, Malu Mohan, Michaelraj E, Divya Saravanakumar, Aditya Moorthy, Amit Kumar Tyagi, Bhagirathsinh D Parmar, K Devaraja, Gaurav Medikeri, Jutika Ojah, Kajal Srivastava, Karthikeyan K, Nandini Das, Niharika B, Parul Sharma, Pradipta Kumar Parida, Prasanna Kumar Saravanam, Praveen Kulkarni, Priya S, Pushpa Patil S, Rahul Kumar Bagla, Ramesh D, Renuka S Melkundi, Satish S Satpute, Seetharaman Narayanan, Shubhashri Jahagirdar, Simmi Dube, Sunil Kumar Panigrahi, Surendra Babu D, Vaibhav Saini, Rita Singh Saxena, Abhinav Srivastava, Achyut Chandra Baishya, Ajai Garg, Amit Kumar Mishra, Anjan Jyoti Talukdar, Ankita Kankaria, Arathi Karat, Arul Sundaresh Kumar, Ashi Chug, Ashok Vankundre, Balakrishnan Ramaswamy, Bharathi Mb, Bhargav R Jadav, Muthuswamy Dhiwakar, Girija Ghate, Hardik V Shah, Ipsita Saha, Kavya Sivapuram, Krupal J Joshi, Mahendra Singh, Mukesh Chand Bairwa, Divya K, Karthikeyan K, Muthurajesh E, Navneh Samagh, Nethra Dinakaran, Nikhil Gupta, Nitin Gupta, Nitin M Nagarkar, Nitin Solanki, Prasan Kumar Panda, Prithvi Bachalli, Raghunath Shanbag, Rajashri Patil, Rajesh Kumar A, Rakesh Narayan Patil, Ramanikanth Thookkanaickenpalayam Vijayaraghavan, Ramesh Hanumantappa, Rathinavel A, Saleel Kumar Mandal, Sanjay Pandharinath Kishve, Sara Varghese Thomas, Saurav Sarkar, Shalini Thakur, Siddaram Patil, Somu Lakshmanan, Srinivas D Rao, Sumathi V, Tulasi Nayak, Umesh R Dixit, Unnikrishnan B, Varsha Backiavathy, Vijendra Shenoy, Vinay Kumar Hallur, Aparna Bhatnagar, Manoj V Murhekar
In India, the incidence of mucormycosis reached high levels during 2021-2022, coinciding with the COVID-19 pandemic. In response to this, we established a multicentric ambispective cohort of patients hospitalised with mucormycosis across India. In this paper, we report their baseline profile, clinical characteristics and outcomes at discharge. Patients hospitalized for mucormycosis during March-July 2021 were included. Mucormycosis was diagnosed based on mycological confirmation on direct microscopy (KOH/Calcofluor white stain), culture, histopathology, or supportive evidence from endoscopy or imaging...
2024: Mycology
#29
JOURNAL ARTICLE
Dongying Hu, Weiwei Jiang, Xinlin Zhu, Qing Hou, Min Chen, Xiaochun Xue, Jing Zhao, Macit Ilkit, Amir Arastehfar, Wenjie Fang, Shunzhang Lin, Weihua Pan, Wanqing Liao
Although rare, trans-kingdom infection features an interesting infection biology concept, in which highly versatile pathogenic attributes allow successful infections in evolutionarily highly divergent species. Corynespora cassiicola is a phytopathogenic fungus and occasionally causes human infections. Herein, we report a phaeohyphomycosis case caused by C . cassiicola . Given that sporadic reports may contribute to a lack of awareness of the transmission route, clinical manifestations, and diagnostic and clinical management, we systematically reviewed the cases reported thus far...
2024: Mycology
#30
JOURNAL ARTICLE
Joe S Smith, Grace D Malla, Jessica D Garcia, Jessica E Gebert, Charlene V Noll, Pierre-Yves Mulon, Heather K Knych
Lameness is a significant welfare concern in goats. Amphotericin B is used via intraarticular (IA) administration in models to study experimentally induced lameness in large animals. The main objective of this study was to estimate plasma pharmacokinetic (PK) parameters for amphotericin B in goats after a single IA administration. Liposomal amphotericin B was administered to ten Kiko-cross goats at a dose of 10 mg total (range: 0.34-0.51 mg/kg) via IA administration into the right hind lateral distal interphalangeal joint...
April 1, 2024: Journal of Veterinary Pharmacology and Therapeutics
#31
JOURNAL ARTICLE
Teclegiorgis Gebremariam, Sondus Alkhazraji, Yiyou Gu, Laura K Najvar, Katyna Borroto-Esoda, Thomas F Patterson, Scott G Filler, Nathan P Wiederhold, Ashraf S Ibrahim
Ibrexafungerp (formerly SCY-078) is the first member of the triterpenoid class that prevents the synthesis of the fungal cell wall polymer β-(1,3)-D-glucan by inhibiting the enzyme glucan synthase. We evaluated the in vivo efficacy of ibrexafungerp against pulmonary mucormycosis using an established murine model. Neutropenic mice were intratracheally infected with either Rhizopus delemar or Mucor circinelloides . Treatment with placebo (diluent control), ibrexafungerp (30 mg/kg, PO BID), liposomal amphotericin B (LAMB 10 mg/kg IV QD), posaconazole (PSC 30 mg/kg PO QD), or a combination of ibrexafungerp plus LAMB or ibrexafungerp plus PSC began 16 h post-infection and continued for 7 days for ibrexafungerp or PSC and through day 4 for LAMB...
April 1, 2024: Antimicrobial Agents and Chemotherapy
#32
JOURNAL ARTICLE
Hanna Stieber, Lara Junghanns, Hannah Wilhelm, Maria Batliner, Alexander Maximilian Aldejohann, Oliver Kurzai, Ronny Martin
BACKGROUND: The emergence of the pathogenic yeast Candida auris is of global concern due to its ability to cause hospital outbreaks and develop resistance against all antifungal drug classes. Based on published data for baker's yeast Saccharomyces cerevisiae, sphingolipid biosynthesis, which is essential for maintaining membrane fluidity and formation of lipid rafts, could offer a target for additive treatment. METHODS: We analysed the susceptibility of C. auris to myriocin, which is an inhibitor of the de novo synthesis of sphingolipids in eukaryotic cells in comparison to other Candida species...
April 2024: Mycoses
#33
JOURNAL ARTICLE
Jeiser Marcelo Consuegra-Asprilla, Carolina Rodríguez-Echeverri, Daniela Herrera Posada, Beatriz L Gómez, Ángel González
BACKGROUND: Recurrent vulvovaginal candidiasis (RVVC) is an important and underestimated fungal infection. OBJECTIVE: We aimed to determine the fungicidal and proliferative capacities of neutrophils and peripheral blood mononuclear cells (PBMCs), respectively and the clinical and microbiological characteristics of a cohort of Colombian patients diagnosed with RVVC. METHODS: A cross-sectional study was conducted. A total of 66 women were included (40 diagnosed with RVVC and 26 healthy women [HW])...
April 2024: Mycoses
#34
Deepthi Konda, Pradeep Balasubramanian, Saritha Mohanan, Laxmisha Chandrashekhar
Hyalohyphomycosis includes infections caused by various fungal species that produce hyaline, septate, branched hyphae. Fusarium is one such species which usually causes multiple papulo-nodules, ecthyma gangrenosum-like ulcers in immunocompromised individuals. Also, fusariosis is usually difficult to manage and responds favorably to amphotericin B, voriconazole, and posaconazole in disseminated cases. Here, we report an atypical case of cutaneous fusariosis in an immunocompetent individual who presented with multiple large cystic swellings, psoriasiform plaques, and palmoplantar keratoderma, and the patient responded completely to itraconazole...
2024: Indian Dermatology Online Journal
#35
JOURNAL ARTICLE
Haroldo C de Oliveira, Marlon D M Santos, Amanda C Camillo-Andrade, Rafael F Castelli, Flavia C G Dos Reis, Paulo C Carvalho, Marcio L Rodrigues
Cryptococcus neoformans is responsible for over 100,000 deaths annually, and the treatment of this fungal disease is expensive and not consistently effective. Unveiling new therapeutic avenues is crucial. Previous studies have suggested that the anthelmintic drug fenbendazole is an affordable and non-toxic candidate to combat cryptococcosis. However, its mechanism of anticryptococcal activity has been only superficially investigated. In this study, we examined the global cellular response of C. neoformans to fenbendazole using a proteomic approach (data are available via ProteomeXchange with identifier PXD047041)...
March 26, 2024: International Journal of Antimicrobial Agents
#36
JOURNAL ARTICLE
D Thisuri N De Silva, Michael Petrovski, Tobias Strunk, Nabeelah Mukadam, Madhu Page-Sharp, Brioni R Moore, Kevin T Batty
PURPOSE: To investigate the physicochemical compatibility of caffeine citrate and caffeine base injections with 43 secondary intravenous (IV) drugs used in Neonatal Intensive Care Unit (NICU) settings. METHODS: Caffeine citrate (20 mg/mL or 10 mg/mL) or caffeine base injection (10 mg/mL) were mixed in a volume ratio of 1:1 with the secondary drug solution to simulate Y-site co-administration procedures in NICUs. Physical compatibility was evaluated based on visual observation for 2 h, against a black and white background and under polarised light, for changes in colour, precipitation, haze and evolution of gas...
March 28, 2024: European Journal of Clinical Pharmacology
#37
REVIEW
Steven L Regen
A major challenge currently facing medicinal chemists is designing agents that can selectively destroy drug resistant fungi and bacteria that have begun to emerge. One factor that has been overlooked by virtually all drug discovery/development approaches is the supramolecular factor, in which aggregated forms of a drug candidate exhibit low selectivity in destroying targeted cells while the corresponding monomers exhibit high selectivity. This Perspective discusses how we were led to the supramolecular factor through fundamental studies with simple model systems, how we reasoned that the selectivity of monomers of the antifungal agent amphotericin B should be much greater than the selectivity of the corresponding aggregates, and how we confirmed this hypothesis using derivatives of amphotericin B...
March 28, 2024: Biochemistry
#38
JOURNAL ARTICLE
Nazia Tabassum, Fazlurrahman Khan, Geum-Jae Jeong, Du-Min Jo, Young-Mog Kim
The increasing incidence of antimicrobial resistance exhibited by biofilm-forming microbial pathogens has been recognized as one of the major issues in the healthcare sector. In the present study, nanomaterial-based controlling the biofilm and virulence properties has been considered an alternative approach. Pyoverdine (PVD) isolated from the Pseudomonas aeruginosa was utilized as a biological corona to synthesize silver nanoparticles (AgNPs), which will be helpful in a targeted action to microbial pathogens due to the recognition of the corona of the nanoparticles by the pathogenic membrane...
June 2024: Biofilm
#39
JOURNAL ARTICLE
D Thisuri N De Silva, Tobias Strunk, Michael Petrovski, Madhu Page-Sharp, Brioni R Moore, Kevin T Batty
Sildenafil is used to treat pulmonary hypertension in neonatal intensive care unit (NICU) settings. As multiple intravenous (IV) medications are co-administered in NICU settings, we sought to investigate the physicochemical compatibility of sildenafil with a range of IV drugs. Sildenafil 600 mcg/mL or 60 mcg/mL was mixed 1:1 with the secondary drug solution to simulate Y-site co-administration procedures. Physical compatibility was evaluated by visual observation against a black and white background and under polarized light for two hours for changes in colour, precipitation, haze and evolution of gas...
March 18, 2024: Pharmaceutics
#40
JOURNAL ARTICLE
Yuhao Song, Mark Hogan, Jimmy Muldoon, Paul Evans, Patrick Caffrey
Glycosylated polyene macrolides are important antifungal agents that are produced by many actinomycete species. Development of new polyenes may deliver improved antibiotics. Here, Streptomyces nodosus was genetically re-programmed to synthesise pentaene analogues of the heptaene amphotericin B. These pentaenes are of interest as surrogate substrates for enzymes catalysing unusual, late-stage biosynthetic modifications. The previous deletion of amphotericin polyketide synthase modules 5 and 6 generated S. nodosus M57, which produces an inactive pentaene...
March 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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