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https://www.readbyqxmd.com/read/28653351/cutaneous-leishmania-tropica-in-children-report-of-three-imported-cases-successfully-treated-with-liposomal-amphotericin-b
#1
Nicole Knöpfel, Lucero Noguera-Morel, Daniel Azorin, Francisco Sanz, Antonio Torrelo, Angela Hernández-Martín
Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, being endemic in more than 90 countries around the world. The increasing number of international travelers to endemic areas has favored the expanding number of imported cases, making CL a mayor health issue.(1,2) Herein, we report three immunocompetent children with multifocal CL caused by Leishmania tropica who received systemic therapy with liposomal amphotericin B (L-AmB). This article is protected by copyright. All rights reserved.
June 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28653258/azole-resistance-in-aspergillus-fumigatus-in-patients-with-cystic-fibrosis-a-matter-of-concern
#2
A Hamprecht, F Morio, O Bader, P Le Pape, J Steinmann, E Dannaoui
Aspergillus fumigatus is the most frequent filamentous fungus isolated from respiratory specimens from patients with cystic fibrosis (CF). Triazoles are the most widely used antifungals in the treatment of allergic bronchopulmonary aspergillosis (ABPA) and invasive aspergillosis (IA) in CF patients. Treatment success could be severely compromised by the occurrence of azole-resistant A. fumigatus (ARAf), which is increasingly reported worldwide from both clinical samples and the environment. In previous studies, ARAf has been detected in up to 8% of CF patients...
June 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28652732/preparation-characterization-and-evaluation-of-amphotericin-b-loaded-mpeg-pcl-g-pei-micelles-for-local-treatment-of-oral-candida-albicans
#3
Li Zhou, Peipei Zhang, Zhuo Chen, Shaona Cai, Ting Jing, Huihui Fan, Fei Mo, Jiye Zhang, Rong Lin
Fatal Candida albicans infections in the mucosal system can occur in association with immune-compromised diseases and dysbacteriosis. Currently, amphotericin B (AmB) is considered to be the most effective antibiotic in the treatment of C. albicans infections, but its clinical application is limited by side effects and poor bioavailability. In order to use AmB in the local treatment of oral C. albicans infections, AmB/MPEG-PCL-g-PEI (monomethoxy poly(ethylene glycol)-poly(epsilon-caprolactone)-graft-polyethylenimine, MPP) micelles were prepared...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28649561/psd1-effects-on-candida-albicans-planktonic-cells-and-biofilms
#4
Sónia Gonçalves, Patrícia M Silva, Mário R Felício, Luciano N de Medeiros, Eleonora Kurtenbach, Nuno C Santos
Candida albicans is an important human pathogen, causing opportunistic infections. The adhesion of planktonic cells to a substrate is the first step for biofilm development. The antimicrobial peptide (AMP) Psd1 is a defensin isolated from Pisum sativum seeds. We tested the effects of this AMP on C. albicans biofilms and planktonic cells, comparing its activity with amphotericin B and fluconazole. Three C. albicans variants were studied, one of them a mutant deficient in glucosylceramide synthase, conferring resistance to Psd1 antifungal action...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28647921/proteome-profile-of-aspergillus-terreus-conidia-at-germinating-stage-identification-of-probable-virulent-factors-and-enzymes-from-mycotoxin-pathways
#5
Raman Thakur, Jata Shankar
Aspergillus terreus is an emerging opportunistic fungal pathogen that causes invasive aspergillosis in immunocompromised individuals. The main risk group of individuals for this organism is leukopenic patients, individuals having cancers, bone marrow transplant persons and those who have immunological disorders. The lack of early diagnostic marker for A. terreus and intrinsic resistance to Amphotericin B, further limits the successful therapy of A. terreus-associated infections. The germination of inhaled conidia is the key step to establish successful invasion in host tissues or organs...
June 24, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28643723/management-of-a-case-of-candida-albicans-endogenous-endophthalmitis-with-intravitreal-caspofungin
#6
Harshali Manish Yadav, Boben Thomas, Cherian Thampy, Tandava Krishnan Panaknti
We report a case of Candida albicans endogenous endophthalmitis treated with intravitreal caspofungin. The patient was a known case of acute lymphoblastic leukemia on chemotherapy and presented to us with features suggestive of endogenous endophthalmitis. He was treated initially with intravenous (IV) caspofungin and intravitreal amphotericin B. Patients condition worsened after IV caspofungin was replaced by amphotericin B necessitating a core vitrectomy. The patient was given the option of off-label caspofungin intravitreal injection for which the patient consented...
June 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28636889/complications-of-hematopoietic-stem-transplantation-fungal-infections
#7
REVIEW
Ali S Omrani, Reem S Almaghrabi
Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk of invasive fungal infections, especially during the early neutropenic phase and severe graft-versus-host disease. Mold-active prophylaxis should be limited to the highest risk groups. Empiric antifungal therapy for HSCT with persistent febrile neutropenia is associated with unacceptable response rates, unnecessary antifungal therapy, increased risk of toxicity, and inflated costs. Empiric therapy should not be a substitute for detailed work up to identify the cause of fever in such patients...
June 13, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28634301/microbial-glycoside-hydrolases-as-antibiofilm-agents-with-cross-kingdom-activity
#8
Brendan D Snarr, Perrin Baker, Natalie C Bamford, Yukiko Sato, Hong Liu, Mélanie Lehoux, Fabrice N Gravelat, Hanna Ostapska, Shane R Baistrocchi, Robert P Cerone, Elan E Filler, Matthew R Parsek, Scott G Filler, P Lynne Howell, Donald C Sheppard
Galactosaminogalactan and Pel are cationic heteropolysaccharides produced by the opportunistic pathogens Aspergillus fumigatus and Pseudomonas aeruginosa, respectively. These exopolysaccharides both contain 1,4-linked N-acetyl-d-galactosamine and play an important role in biofilm formation by these organisms. Proteins containing glycoside hydrolase domains have recently been identified within the biosynthetic pathway of each exopolysaccharide. Recombinant hydrolase domains from these proteins (Sph3h from A...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28631642/sporadic-occurrence-of-cryptococcal-meningitis-in-hiv-seronegative-patients-uncommon-etiology
#9
Shukla Das, Shyama Datt, Priyamvada Roy, Rumpa Saha, Immaculata Xess
Cryptococcosis in HIV-seronegative patients is rarely reported from India. This prospective study was conducted to look for cryptococcal meningitis in HIV-seronegative individuals and compare their laboratory features to cryptococcal meningitis in HIV-seropositive patients. Cerebrospinal fluid was collected from 153 suspected cases of meningitis and subjected to India ink preparation, antigen detection, and culture. Nineteen samples tested positive for Cryptococcus neoformans infection. Seventeen and two patients were HIV reactive and nonreactive, respectively...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28630247/saksenaea-vasiformis-infection-in-an-immunocompetent-patient-in-rural-australia
#10
Wiktor Teodor Pilch, Ned Kinnear, Derek Barry Hennessey
An 81-year-old man from rural Australia presented with right pretibial cellulitis 7 days after minor trauma against furniture. He failed to improve despite antibiotics and surgical debridement. Subsequent cultures grew the rare fungus Saksenaea vasiformis, which was treated with further surgical debridement, amphotericin B and posaconazole. This was successful and the patient made a full recovery. We present the case and discuss lessons learnt.
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28630200/treatment-of-experimental-visceral-leishmaniasis-with-single-dose-liposomal-amphotericin-b-pharmacodynamics-and-biodistribution-at-different-stages-of-disease
#11
Andrew A Voak, Andy Harris, Zeeshan Qaiser, Simon L Croft, Karin Seifert
Visceral leishmaniasis is a neglected tropical disease, which causes significant morbidity and mortality worldwide. Characterising the pharmacokinetics and pharmacodynamics of anti-leishmanial drugs in pre-clinical models is important for drug development and use. Here we investigated the pharmacodynamics and drug distribution of AmBisome® in L. donovani infected BALB/c mice at three different dose levels and two different time points after infection. We additionally compared drug levels in plasma, liver and spleen in infected and uninfected BALB/c mice over time...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28630182/study-of-biodistribution-and-in-vivo-anti-leishmanial-activity-of-a-distigmasterylhemisuccinoyl-glycero-phosphocholine-liposome-intercalated-amphotericin-b
#12
Maryam Iman, Zhaohua Huang, Seyedeh Hoda Alavizadeh, Francis C Szoka, Mahmoud R Jaafari
Distigmasterylhemisuccinoyl-sn-glycero-3- phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Our previous study revealed that a liposome-intercalated Amphotericin B prepared from DSHemsPC (DSHemsPC-Lip-AmB) possess excellent colloidal properties and in vitro antifungal and anti-leishmanial activity similar to AmBisome™. The aim of this study was to determine biodistribution and evaluate the anti-leishmanial effects of DSHemsPC-Lip-AmB in Leishmania major-infected BALB/c mice...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28625801/clinical-features-antifungal-susceptibility-and-outcome-of-candida-guilliermondii-fungemia-an-experience-in-a-tertiary-hospital-in-mid-taiwan
#13
Ting-Yu Tseng, Tsung-Chia Chen, Cheng-Mao Ho, Po-Chang Lin, Chia-Huei Chou, Chia-Ta Tsai, Jen-Hsien Wang, Chih-Yu Chi, Mao-Wang Ho
BACKGROUNDS: Candida guilliermondii is rarely isolated from clinical specimen. C. guilliermondii fungemia is seldom reported in the literature. The aims of this study were to report the clinical features, antifungal susceptibility, and outcomes of patients with C. guilliermondii fungemia. METHODS: From 2003 to 2015, we retrospectively analyzed the clinical and laboratory data of patients with C. guilliermondii fungemia in a tertiary hospital in mid-Taiwan. We performed a multivariable logistic regression analysis to identify the risk factors of mortality...
May 17, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28625762/fungal-peritonitis-by-thermoascus-crustaceus-in-a-peritoneal-dialysis-patient-from-chile
#14
Eduardo Alvarez, Alvaro Castillo, Isabel Iturrieta
BACKGROUND: Fungal peritonitis is a relatively uncommon infection in peritoneal dialysis patients. However, it can be associated with significant morbimortality. In recent reports, Candida species and other filamentous fungi have been reported as being aetiological agents. Thermoascus species are ubiquitous, thermophilic fungi, with an anamorph in the Paecilomyces genus. Here we present the first report of fungal peritonitis by Thermoascus crustaceus from Chile. CASE REPORT: We present the case of an 83-year-old female patient, with a history of cholecystectomy, hernia repair, severe arterial hypertension, hip and knee osteoarthritis and several episodes of peritoneal dialysis with a cloudy exudate...
June 15, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28623821/green-biosynthesis-of-magnetic-iron-oxide-fe3o4-nanoparticles-using-the-aqueous-extracts-of-food-processing-wastes-under-photo-catalyzed-condition-and-investigation-of-their-antimicrobial-and-antioxidant-activity
#15
Jayanta Kumar Patra, Kwang-Hyun Baek
In this study, a simple, rapid, and eco-friendly green method was introduced to synthesize magnetite iron oxide nanoparticles (Fe3O4 NPs) using the aqueous extracts of two food processing wastes, namely silky hairs of corn (Zea mays L.) and outer leaves of Chinese cabbage (Brassica rapa L. subsp. pekinensis). The boiled solutions of silky hairs (MH) and outer leaves of Chinese cabbage (CCP) were used to synthesize Fe3O4 NPs under photo exposed condition. The MH-FeNPs and CCP-FeNPs synthesized via green route were characterized by UV-Vis spectroscopy, field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential thermogravimetric (TG/DTG) analysis, and vibrating sample magnetometer (VSM) analysis...
June 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28622982/comparison-of-the-vitek-2-antifungal-susceptibility-system-with-etest-using-clinical-isolates-of-candida-species
#16
Wadha Alfouzan, Tahani Al-Enezi, Ebteehal AlRoomi, Vayalil Sandhya, Rachel Chandy, Zia Uddin Khan
BACKGROUND: Candida species are part of the normal human microbiota. However, in recent years, nosocomial bloodstream Candida infections have emerged as a significant problem ranking the fourth common cause of fungemia in intensive care units. Although microdilution methods are the ones recommended for susceptibility testing, they are difficult to undertake in the clinical practice. Thus, an automated commercially available test is ideal. AIMS: To compare minimum inhibitory concentrations (MICs) obtained with the recently introduced Vitek 2 yeast susceptibility system card (AST-YS01) with Etest...
June 13, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28622334/sterol-14%C3%AE-demethylase-mutation-leads-to-amphotericin-b-resistance-in-leishmania-mexicana
#17
Roy Mwenechanya, Julie Kovářová, Nicholas J Dickens, Mudaliar Manikhandan, Pawel Herzyk, Isabel M Vincent, Stefan K Weidt, Karl E Burgess, Richard J S Burchmore, Andrew W Pountain, Terry K Smith, Darren J Creek, Dong-Hyun Kim, Galina I Lepesheva, Michael P Barrett
Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is therefore of great importance. Here we select amphotericin B-resistant Leishmania mexicana parasites with relative ease. Metabolomic analysis demonstrated that ergosterol, the sterol known to bind the drug, is prevalent in wild-type cells, but diminished in the resistant line, where alternative sterols become prevalent...
June 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28620958/a-network-meta-analysis-of-primary-prophylaxis-for-invasive-fungal-infection-in-haematological-patients
#18
REVIEW
L P Leonart, F S Tonin, V L Ferreira, S T S Penteado, A Wiens, F A Motta, R Pontarolo
WHAT IS KNOWN AND OBJECTIVE: Antifungal prophylaxis is an option to reduce the incidence of invasive fungal infection (IFI) in haematological patients. To date, no network meta-analysis (NMA) of high-quality evidence (double-blind randomized controlled trials) has been performed on this subject. This systematic review and NMA aimed to evaluate the safety and efficacy of different antifungal agents used for prophylaxis of IFI in patients with haematological disorders. METHODS: A systematic review was performed according to PRISMA and Cochrane recommendations...
June 15, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28620270/flucytosine-and-amphotericin-b-coadministration-induces-dose-related-renal-injury
#19
Alexandra Folk, Cornel Balta, Hildegard Herman, Alexandra Ivan, Oana Maria Boldura, Lucian Paiusan, Aurel Ardelean, Anca Hermenean
Invasive fungal infections remain an important clinical problem, and despite recent approaches, they bring high morbidity and mortality. Combination therapies are the most effective; however, adverse effects need to be considered. In this study, we aimed to evaluate the nephrotoxicity induced by combined therapy of flucytosine (FL) and amphotericin B (AMF) at 3 different doses administered to mice for 14 days: 300 μg/kg AMF+50 mg/kg FL; 600 μg/kg AMF+100 mg/kg FL; 900 μg/kg AMF+150 mg/kg FL. Antifungal coadministration triggered nuclear translocation of NF-κB and upregulated nuclear factor kappa-light-chain-enhancer of activated B cells subunit p65 (NF-κB p65) messenger RNA mRNA level in dose-dependent manner...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28616635/angiostrongylus-cantonensis-an-optimized-cultivation-of-this-parasitic-nematode-under-laboratory-conditions
#20
Hui Xie, Dongjuan Yuan, Shiqi Luo, Xingda Zeng, Xin Zeng, Ping He, Zhiyue Lv, Zhongdao Wu
Angiostrongylus cantonensis (A. cantonensis), a parasitic nematode, is the important neurotropic pathogen which causes human angiostrongyliasis. It has a complex life-cycle and severe parasite-host interaction in contrast to free-living nematode. Establishment of a well-suited life-cycle and in vitro cultivation of A. cantonensis in the laboratory will be one of the key techniques to elucidate the mechanism of parasite-host interaction. However, the low survival and growth rate of worms is still to be the problem...
June 14, 2017: Parasitology Research
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