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https://www.readbyqxmd.com/read/27891024/palliative-care-and-the-indian-neurologist
#1
REVIEW
Roop Gursahani
End-of-life care is an integral part of neurology practice, and neuropalliative medicine is an emerging neurology subspeciality. This begins with serious illness communication as a protocol-based process that depends on an evaluation of patient autonomy and accurate prognostication. Communication needs vary between chronic, life-limiting neurologic illnesses and acute brain injury. In an ideal situation, the patient's wishes are spelled out in advance care plans and living wills, and surrogates have only limited choices for implementation...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27879670/the-protective-effects-of-icariin-against-the-homocysteine-induced-neurotoxicity-in-the-primary-embryonic-cultures-of-rat-cortical-neurons
#2
Xiao-Ang Li, Yuen-Shan Ho, Lei Chen, W L Wendy Hsiao
Icariin, an ingredient in the medicinal herb Epimedium brevicornum Maxim (EbM), has been considered as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's disease (AD). Hyperhomocysteinaemia is a risk factor for AD and other associated neurological diseases. In this study we aim to investigate whether icariin can reverse homocysteine (Hcy)-induced neurotoxicity in primary embryonic cultures of rat cortical neurons. Our findings demonstrated that icariin might be able restore the cytoskeleton network damaged by Hcy through the modulation of acetyl-α-tubulin, tyrosinated-α-tubulin, and phosphorylation of the tubulin-binding protein Tau...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27849457/the-center-for-rehabilitation-sciences-research-advancing-the-rehabilitative-care-for-service-members-with-complex-trauma
#3
Brad M Isaacson, Brad D Hendershot, Seth D Messinger, Jason M Wilken, Christopher A Rábago, Elizabeth Russell Esposito, Erik Wolf, Alison L Pruziner, Christopher L Dearth, Marilynn Wyatt, Steven P Cohen, Jack W Tsao, Paul F Pasquina
The Center for Rehabilitation Sciences Research (CRSR) was established to advance the rehabilitative care for service members with combat-related injuries, particularly those with orthopedic, cognitive, and neurological complications. The center supports comprehensive research projects to optimize treatment strategies and promote the successful return to duty and community reintegration of injured service members. The center also provides a unique platform for fostering innovative research and incorporating clinical/technical advances in the rehabilitative care for service members...
November 2016: Military Medicine
https://www.readbyqxmd.com/read/27812646/one-year-after-the-zika-virus-outbreak-in-brazil-from-hypotheses-to-evidence
#4
Carlos Alexandre Antunes de Brito, Marli Tenorio Cordeiro
Zika virusis an arbovirus of the Flaviviridae family with two major strains, an Asian and an African strain. The main vectors involved in the transmission of Zika virus are the Aedes aegypti and Aedes albopictus mosquitoes. Despite its identification, discovered in 1947 in the Zika forest in Uganda, only isolated and sporadic occurrences of human infection were reported within a largely asymptomatic proportion of individuals. The first reported outbreak occurred in 2007 in the Yap Island, which belongs to the Federated States of Micronesia in the Pacific Ocean, and in French Polynesia, where high attack rates occurred and the first cases of associated Guillain-Barré syndrome were reported...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27771918/cinnamon-and-chronic-diseases
#5
Mitra Hariri, Reza Ghiasvand
Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family and is one of the most important spices used daily by people all over the world. It contains a lot of manganese, iron, dietary fiber, and calcium. Cinnamon contains derivatives, such as cinnamaldehyde, cinnamic acid, cinnamate, and numerous other components such as polyphenols and antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer effects. Several reports have dealt with the numerous properties of cinnamon in the forms of bark, essential oils, bark powder, and phenolic compounds, and each of these properties can play a key role in human health...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27761334/the-ethnobotany-of-psychoactive-plant-use-a-phylogenetic-perspective
#6
Nashmiah Aid Alrashedy, Jeanmaire Molina
Psychoactive plants contain chemicals that presumably evolved as allelochemicals but target certain neuronal receptors when consumed by humans, altering perception, emotion and cognition. These plants have been used since ancient times as medicines and in the context of religious rituals for their various psychoactive effects (e.g., as hallucinogens, stimulants, sedatives). The ubiquity of psychoactive plants in various cultures motivates investigation of the commonalities among these plants, in which a phylogenetic framework may be insightful...
2016: PeerJ
https://www.readbyqxmd.com/read/27760535/the-haiti-medical-education-project-development-and-analysis-of-a-competency-based-continuing-medical-education-course-in-haiti-through-distance-learning
#7
Robert Battat, Marc Jhonson, Lorne Wiseblatt, Cruff Renard, Laura Habib, Manouchka Normil, Brian Remillard, Timothy F Brewer, Galit Sacajiu
BACKGROUND: Recent calls for reform in healthcare training emphasize using competency-based curricula and information technology-empowered learning. Continuing Medical Education programs are essential in maintaining physician accreditation. Haitian physicians have expressed a lack access to these activities. The Haiti Medical Education Project works in alliance with Haitian medical leadership, faculty and students to support the Country's medical education system. We present the creation, delivery and evaluation of a competency-based continuing medical education curriculum for physicians in rural Haiti...
October 19, 2016: BMC Medical Education
https://www.readbyqxmd.com/read/27716084/quinine-induced-simvastatin-toxicity-through-cytochrome-inhibition-a-case-report
#8
Johannes M Just, Klaus Weckbecker, Katja S Just
BACKGROUND: Nocturnal leg cramps are painful, involuntary muscle contractions commonly seen in elderly. While mostly harmless, they can severely impair quality of life and often disrupt sleep. Adverse drug effects may be responsible for a fraction of nocturnal leg cramps but often go unrecognized, resulting in additional prescribing intended to deal with adverse effects that might be better addressed by reduction, substitution, or discontinuation of the offending agent. CASE PRESENTATION: An 87 year old female presented as outpatient in family medicine with nocturnal leg cramps which had been present for five years and increasingly burdened her quality of life...
October 1, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27692902/dnm3-and-genetic-modifiers-of-age-of-onset-in-lrrk2-gly2019ser-parkinsonism-a-genome-wide-linkage-and-association-study
#9
Joanne Trinh, Emil K Gustavsson, Carles Vilariño-Güell, Stephanie Bortnick, Jeanne Latourelle, Marna B McKenzie, Chelsea Szu Tu, Ekaterina Nosova, Jaskaran Khinda, Austen Milnerwood, Suzanne Lesage, Alexis Brice, Meriem Tazir, Jan O Aasly, Laura Parkkinen, Hazal Haytural, Tatiana Foroud, Richard H Myers, Samia Ben Sassi, Emna Hentati, Fatma Nabli, Emna Farhat, Rim Amouri, Fayçal Hentati, Matthew J Farrer
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) mutation 6055G→A (Gly2019Ser) accounts for roughly 1% of patients with Parkinson's disease in white populations, 13-30% in Ashkenazi Jewish populations, and 30-40% in North African Arab-Berber populations, although age of onset is variable. Some carriers have early-onset parkinsonism, whereas others remain asymptomatic despite advanced age. We aimed to use a genome-wide approach to identify genetic variability that directly affects LRRK2 Gly2019Ser penetrance...
November 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27642413/-severe-hemorrhagic-forms-of-rift-valley-fever-about-5-cases
#10
Mohamed Lemine Ould Salem, Sidi El Wafi Ould Baba, Fatimetou Zahra Fall-Malick, Boushab Mohamed Boushab, Sidi Mohamed Ghaber, Abdelwedoud Mokhtar
Rift Valley fever (RVF) is an arbovirus caused by an RNA virus belonging to family Bunyaviridae (genus phlebovirus). It is a zoonosis that primarily affects animals but it also has the capacity to infect humans, either by handling meat, runts of sick animals or, indirectly, by the bite of infected mosquitoes (Aedes sp, Anopheles sp, Culex sp). In most cases, RVF infection in humans is asymptomatic, but it can also manifest as moderate febrile syndrome with a favorable outcome. However, some patients may develop hemorrhagic syndrome and/or neurological damages with a fatal evolution...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27600560/a-survey-of-health-care-needs-of-physicians
#11
Khalid Benkhadra, Jayanth Adusumalli, Tamim Rajjo, Philp T Hagen, Zhen Wang, M Hassan Murad
BACKGROUND: The healthcare needs of physician are not well studied. METHODS: We surveyed physicians attending a large primary care conference about their access and perceived barriers to receiving healthcare services. RESULTS: Response rate was 46 % (270/592). The majority were trained in family medicine. The age category of above 60 years was the most common (39 %) and 46 % were women. Important difficulty in accessing healthcare services was reported by 39 % of physicians and the majority (61 %) reported reverting to self-diagnosis and self-treatment...
2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27585509/genetic-screening-of-anderson-fabry-disease-in-probands-referred-from-multispecialty-clinics
#12
Valentina Favalli, Eliana Disabella, Mariadelfina Molinaro, Marilena Tagliani, Anna Scarabotto, Alessandra Serio, Maurizia Grasso, Nupoor Narula, Carmela Giorgianni, Clelia Caspani, Monica Concardi, Manuela Agozzino, Calogero Giordano, Alexandra Smirnova, Takahide Kodama, Lorenzo Giuliani, Elena Antoniazzi, Riccardo G Borroni, Camilla Vassallo, Filippo Mangione, Laura Scelsi, Stefano Ghio, Carlo Pellegrini, Marialuisa Zedde, Laura Fancellu, GianPietro Sechi, Antonello Ganau, Stefania Piga, Annarita Colucci, Daniela Concolino, Maria Teresa Di Mascio, Danilo Toni, Marina Diomedi, Claudio Rapezzi, Elena Biagini, Massimiliano Marini, Maurizia Rasura, Maurizio Melis, Antonia Nucera, Donata Guidetti, Michelangelo Mancuso, Umberto Scoditti, Pamela Cassini, Jagat Narula, Luigi Tavazzi, Eloisa Arbustini
BACKGROUND: Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disease, caused by defects of the alpha-galactosidase A (GLA) gene. AFD can affect the heart, brain, kidney, eye, skin, peripheral nerves, and gastrointestinal tract. Cardiology (hypertrophic cardiomyopathy), neurology (cryptogenic stroke), and nephrology (end-stage renal failure) screening studies suggest the prevalence of GLA variants is 0.62%, with diagnosis confirmation in 0.12%. OBJECTIVES: This study sought to expand screening from these settings to include ophthalmology, dermatology, gastroenterology, internal medicine, pediatrics, and medical genetics to increase diagnostic yield and comprehensively evaluate organ involvement in AFD patients...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27562656/acupuncture-for-stroke-rehabilitation
#13
REVIEW
Ai Yang, Hong Mei Wu, Jin-Ling Tang, Li Xu, Ming Yang, Guan J Liu
BACKGROUND: Stroke is the second most common cause of death in the world and in China it has now become the main cause of death. It is also a main cause of adult disability and dependency. Acupuncture for stroke has been used in China for hundreds of years and is increasingly practiced in some Western countries. This is an update of the Cochrane review originally published in 2006 . OBJECTIVES: To determine the efficacy and safety of acupuncture therapy in people with subacute and chronic stroke...
August 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27559830/update-interim-guidance-for-the-evaluation-and-management-of-infants-with-possible-congenital-zika-virus-infection-united-states-august-2016
#14
Kate Russell, Sara E Oliver, Lillianne Lewis, Wanda D Barfield, Janet Cragan, Dana Meaney-Delman, J Erin Staples, Marc Fischer, Georgina Peacock, Titilope Oduyebo, Emily E Petersen, Sherif Zaki, Cynthia A Moore, Sonja A Rasmussen
CDC has updated its interim guidance for U.S. health care providers caring for infants born to mothers with possible Zika virus infection during pregnancy (1). Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results...
2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27515417/the-use-of-everolimus-in-the-treatment-of-neurocognitive-problems-in-tuberous-sclerosis-tron-study-protocol-for-a-randomised-controlled-trial
#15
Elizabeth Randell, Rachel McNamara, D Mark Davies, Eleri Owen-Jones, Nigel Kirby, Lianna Angel, Cheney Drew, Rebecca Cannings-John, Michelle Smalley, Anurag Saxena, Emer McDermott, Laura Stockwell, Petrus J de Vries, Kerry Hood, Julian R Sampson
BACKGROUND: Tuberous sclerosis complex (TSC) is a genetic disorder affecting about 1 in 6000 people and is characterised by the development of tumours in many organs, including the skin and kidneys, and by a range of neurological and neuropsychiatric manifestations. TSC-associated neuropsychiatric disorders (TAND) occur in the majority of those with TSC, and they have a significant impact on patients and their families, given the everyday impact of TAND on education, employment, family and social life...
2016: Trials
https://www.readbyqxmd.com/read/27508633/-op-2c-05-atrial-fibrillation-in-hypertensive-patients-a-single-pilot-anticoagulation-risk-management-center
#16
A Varga, C M Tatar, A Mitre, C Podoleanu, I Tilea
OBJECTIVE: Atrial fibrillation is one of the most frequent complications of hypertension. Proper management of this condition with anticoagulation treatment requires data of the atrial fibrillation events rate in hypertensive population. Adequate standards of safety and optimal level of anticoagulation for preventing further cerebrovascular events is the target of this pilot center. DESIGN AND METHOD: Medical records from a family medicine database practice were evaluated...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27476002/-insomnia-in-children-and-adolescents-a-consensus-document
#17
Gonzalo Pin Arboledas, Víctor Soto Insuga, María José Jurado Luque, Cleofe Fernandez Gomariz, Inés Hidalgo Vicario, Amalia Lluch Rosello, Pedro José Rodríguez Hernández, Juan Antonio Madrid
Insomnia is very common during childhood (30% of children under 5), and causes a serious cognitive and emotional consequence in learning, as well as significant medical comorbidity. It also affects the quality of life, not only of the child, but also of the whole family. Paediatrician training in its diagnosis and treatment is usually poor. For this reason a consensus document is presented on the management of insomnia in children and adolescents. This has been developed by members of the Spanish Paediatrics Association, the Spanish Sleep Society, the Spanish Society of Paediatric Outpatient and Primary Care, the Spanish Adolescent Medicine Society, the Spanish Child and Adolescent Society, and the Spanish Paediatric Neurology Society...
July 27, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27428679/is-migraine-headache-associated-with-concussion-in-athletes-a-case-control-study
#18
James T Eckner, Tad Seifert, Allison Pescovitz, Max Zeiger, Jeffrey S Kutcher
OBJECTIVE: The purpose of this study was to investigate the association between migraine headache and concussion in athletes. DESIGN: Case-control observational study. SETTING: A university-associated combined sports neurology and orthopedic sports medicine clinic. PARTICIPANTS: A total of 221 male (n = 140) and female (n = 81) athletes aged 12 to 24 years, including 115 concussion cases (52%) and 106 orthopedic controls (48%), were included in this study...
July 15, 2016: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/27426935/young-ischemic-stroke-in-tunisia-a-multicentric-study
#19
Asma Kefi, Thara Larbi, Meya Abdallah, Amira El Ouni, Neil Bougacha, Kamel Bouslama, Saloua Hamzaoui, Skander M'rad
PURPOSE: There is wanting data regarding young ischemic stroke in developing countries, especially in Tunisia. The purpose of this study was to investigate risk factors and etiologies of young ischemic stroke in Tunisian and make a comparison with previous reports. MATERIALS AND METHODS: A total of 102 young ischemic stroke patients (15-45 years old) were admitted, between January 1996 and August 2007, to eleven departments of internal medicine in different Tunisian hospitals...
July 18, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27422735/-reliability-of-the-profund-index-to-predict-4-year-mortality-in-polypathological-patients
#20
Jesús Díez-Manglano, Esther Del Corral Beamonte, Rosa Ramos Ibáñez, María Pilar Lambán Aranda, Carla Toyas Miazza, María Del Mar Rodero Roldán, Concepción Ortiz Domingo, Eulalia Munilla López, Begoña de Escalante Yangüela
OBJECTIVE: To determine the usefullness of the PROFUND index to assess the risk of global death after 4 years in polypathological patients. PATIENTS AND METHODS: Multicenter prospective cohort (Internal Medicine and Geriatrics) study. Polypathological patients admitted between March 1st and June 30th 2011 were included. For each patient, data concerning age, sex, living at home or in a nursing residence, polypathology categories, Charlson, Barthel and Lawton-Brody indexes, Pfeiffer questionnaire, socio-familial Gijon scale, delirium, number of drugs, hemoglobin and creatinine values were gathered, and the PROFUND index was calculated...
September 16, 2016: Medicina Clínica
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